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Endoglin

 G1M9D6_AILME            Unreviewed;       692 AA.
G1M9D6;
19-OCT-2011, integrated into UniProtKB/TrEMBL.
19-OCT-2011, sequence version 1.
17-JUN-2020, entry version 51.
SubName: Full=Endoglin {ECO:0000313|Ensembl:ENSAMEP00000015956};
Name=ENG {ECO:0000313|Ensembl:ENSAMEP00000015956};
Ailuropoda melanoleuca (Giant panda).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000015956, ECO:0000313|Proteomes:UP000008912};
[1] {ECO:0000313|Ensembl:ENSAMEP00000015956, ECO:0000313|Proteomes:UP000008912}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=20010809; DOI=10.1038/nature08696;
Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
Wang J.;
"The sequence and de novo assembly of the giant panda genome.";
Nature 463:311-317(2010).
[2] {ECO:0000313|Ensembl:ENSAMEP00000015956}
IDENTIFICATION.
Ensembl;
Submitted (SEP-2011) to UniProtKB.
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EMBL; ACTA01089198; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ACTA01097198; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ACTA01105198; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 9646.ENSAMEP00000015956; -.
Ensembl; ENSAMET00000016623; ENSAMEP00000015956; ENSAMEG00000015119.
eggNOG; ENOG410IQ57; Eukaryota.
eggNOG; ENOG410YK9H; LUCA.
GeneTree; ENSGT00530000063861; -.
HOGENOM; CLU_027805_0_0_1; -.
InParanoid; G1M9D6; -.
OMA; VQTTPPK; -.
TreeFam; TF337375; -.
Proteomes; UP000008912; Unassembled WGS sequence.
GO; GO:0072563; C:endothelial microparticle; IEA:Ensembl.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0016604; C:nuclear body; IEA:Ensembl.
GO; GO:0043235; C:receptor complex; IEA:Ensembl.
GO; GO:0036122; F:BMP binding; IEA:Ensembl.
GO; GO:0005534; F:galactose binding; IEA:Ensembl.
GO; GO:0005539; F:glycosaminoglycan binding; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0050431; F:transforming growth factor beta binding; IEA:Ensembl.
GO; GO:0005072; F:transforming growth factor beta receptor, cytoplasmic mediator activity; IEA:Ensembl.
GO; GO:0034713; F:type I transforming growth factor beta receptor binding; IEA:Ensembl.
GO; GO:0005114; F:type II transforming growth factor beta receptor binding; IEA:Ensembl.
GO; GO:0055009; P:atrial cardiac muscle tissue morphogenesis; IEA:Ensembl.
GO; GO:1905222; P:atrioventricular canal morphogenesis; IEA:Ensembl.
GO; GO:0001569; P:branching involved in blood vessel morphogenesis; IEA:Ensembl.
GO; GO:0003273; P:cell migration involved in endocardial cushion formation; IEA:Ensembl.
GO; GO:0022009; P:central nervous system vasculogenesis; IEA:Ensembl.
GO; GO:0001300; P:chronological cell aging; IEA:Ensembl.
GO; GO:0035912; P:dorsal aorta morphogenesis; IEA:Ensembl.
GO; GO:0003198; P:epithelial to mesenchymal transition involved in endocardial cushion formation; IEA:Ensembl.
GO; GO:0001947; P:heart looping; IEA:Ensembl.
GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl.
GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
GO; GO:0031953; P:negative regulation of protein autophosphorylation; IEA:Ensembl.
GO; GO:0003148; P:outflow tract septum morphogenesis; IEA:Ensembl.
GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
GO; GO:0030513; P:positive regulation of BMP signaling pathway; IEA:Ensembl.
GO; GO:1905007; P:positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; IEA:Ensembl.
GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IEA:Ensembl.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:1905065; P:positive regulation of vascular smooth muscle cell differentiation; IEA:Ensembl.
GO; GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
GO; GO:0048745; P:smooth muscle tissue development; IEA:Ensembl.
GO; GO:0097084; P:vascular smooth muscle cell development; IEA:Ensembl.
GO; GO:0048845; P:venous blood vessel morphogenesis; IEA:Ensembl.
GO; GO:0003222; P:ventricular trabecula myocardium morphogenesis; IEA:Ensembl.
InterPro; IPR001507; ZP_dom.
Pfam; PF00100; Zona_pellucida; 1.
4: Predicted;
Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
Reference proteome {ECO:0000313|Proteomes:UP000008912};
Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
SIGNAL 1..24
/evidence="ECO:0000256|SAM:SignalP"
CHAIN 25..692
/evidence="ECO:0000256|SAM:SignalP"
/id="PRO_5003414710"
TRANSMEM 578..605
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
DOMAIN 359..528
/note="ZP"
/evidence="ECO:0000259|Pfam:PF00100"
REGION 632..692
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COILED 64..84
/evidence="ECO:0000256|SAM:Coils"
COMPBIAS 666..692
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 692 AA; 74485 MW; D99386561F45CBE9 CRC64;
RRRGSFPLPV LAVVSRCAFP TGLAETVHCD LQPVDAEVTY ITSQVSEGCV AQVPNATVEV
HILFLESSRE LSELELTLQK AKQNGTRPRE VLLVLGANKN TLLRLQAPGI ALNLAFNPKL
IFQGHPGVNT TQLPPFTTKK QFLDWAETKG PIASIAELND PQSILLRLDQ APRAPSSCNL
EPLKDMGHTL EWSPLTPASV QGCRLEGVPG HKEAHIVRVL PGTEAGPRTV TVKVELRCAS
GDPDAVLILQ GPPYVSWLID ANHNMQIWTT GEYSFKIFPE KNIRGFVLPD TPQGLLGEAR
RLNASMVASF VELPLASVVS LQAHSCGGGL QTSPPPIRTT PPKESCNQEL LLSLIQPKCS
EDVMTVVLKK DLISTLRCTI TSLTFSDPRC QAEDRDDQLV LRSAYSNCGM KVTENVVRNE
VVVNLLSSSS PQWKKVHCIN MDSLSLQLGL FLSPHFLQAS NTIELGQQGF VQVSMSPPIP
ELMLQLDSCH LDLGPDADTV ELIQSQTAKG SCVSLLSPGP AGDVRFSFLL RGYMVPTPTP
GTLSCTVALR SRSLSPDVHR TISLRLNIVS PGLPDKGLVL PAVLGITFGA FLIGALLTAA
LWYIYSHTRE YPPLHECSGP LCHHHLGEPG GASGGVGSPG RGPDLRPCPQ VPPASGSPWW
RWLAAPASSE SSSTNHSIGS TQSTPCSTSS MA


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Pathways :
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[ENG hCG_18549] Endoglin (Osler-Rendu-Weber syndrome 1), isoform CRA_a
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[ENG] Endoglin
[ENG] Endoglin
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[ENG] Endoglin
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[ENG] Endoglin
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[ENG] Endoglin
[ENG] Endoglin
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Bibliography :
[32611689] Correction for Kwon et al., "Hepatitis C Virus Core Protein Modulates Endoglin (CD105) Signaling Pathway for Liver Pathogenesis".
[32592434] Repeatable and objective method for evaluating angiogenesis using real-time RT-PCR of endoglin expression in canine tumors.
[32587778] Bevacizumab promotes active biological behaviors of human umbilical vein endothelial cells by activating TGFβ1 pathways off-VEGF signaling.
[32573726] Mutational and phenotypic characterisation of hereditary hemorrhagic telangiectasia.
[32550557] (CD166) as a gene expression marker for human mesenchymal stromal cell characterisation.
[32541930] PS1 FAD mutants decrease ephrinB2-regulated angiogenic functions, ischemia-induced brain neovascularization and neuronal survival.
[32538908] Whole-Mount In Situ Hybridization in Zebrafish Embryos and Tube Formation Assay in iPSC-ECs to Study the Role of Endoglin in Vascular Development.
[32530126] The Follistatin-like Protein 1 Pathway Is Important for Maintaining Healthy Articular Cartilage.
[32523017] Association of Alk1 and Endoglin Polymorphisms with Cardiovascular Damage.
[32522605] Bone morphogenetic protein receptors: Structure, function and targeting by selective small molecule kinase inhibitors.