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Endoglin

 G1PMZ6_MYOLU            Unreviewed;       652 AA.
G1PMZ6;
19-OCT-2011, integrated into UniProtKB/TrEMBL.
19-OCT-2011, sequence version 1.
26-FEB-2020, entry version 50.
SubName: Full=Endoglin {ECO:0000313|Ensembl:ENSMLUP00000012291};
Name=ENG {ECO:0000313|Ensembl:ENSMLUP00000012291};
Myotis lucifugus (Little brown bat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
Myotis.
NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000012291, ECO:0000313|Proteomes:UP000001074};
[1] {ECO:0000313|Ensembl:ENSMLUP00000012291, ECO:0000313|Proteomes:UP000001074}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=21993624; DOI=10.1038/nature10530;
Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
"A high-resolution map of human evolutionary constraint using 29 mammals.";
Nature 478:476-482(2011).
[2] {ECO:0000313|Ensembl:ENSMLUP00000012291}
IDENTIFICATION.
Ensembl;
Submitted (SEP-2011) to UniProtKB.
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EMBL; AAPE02044248; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 59463.ENSMLUP00000012291; -.
Ensembl; ENSMLUT00000013507; ENSMLUP00000012291; ENSMLUG00000013502.
eggNOG; ENOG410IQ57; Eukaryota.
eggNOG; ENOG410YK9H; LUCA.
GeneTree; ENSGT00530000063861; -.
HOGENOM; CLU_027805_0_0_1; -.
InParanoid; G1PMZ6; -.
OMA; VQTTPPK; -.
TreeFam; TF337375; -.
Proteomes; UP000001074; Unassembled WGS sequence.
GO; GO:0072563; C:endothelial microparticle; IEA:Ensembl.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0016604; C:nuclear body; IEA:Ensembl.
GO; GO:0043235; C:receptor complex; IEA:Ensembl.
GO; GO:0036122; F:BMP binding; IEA:Ensembl.
GO; GO:0005534; F:galactose binding; IEA:Ensembl.
GO; GO:0005539; F:glycosaminoglycan binding; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0050431; F:transforming growth factor beta binding; IEA:Ensembl.
GO; GO:0005072; F:transforming growth factor beta receptor, cytoplasmic mediator activity; IEA:Ensembl.
GO; GO:0034713; F:type I transforming growth factor beta receptor binding; IEA:Ensembl.
GO; GO:0005114; F:type II transforming growth factor beta receptor binding; IEA:Ensembl.
GO; GO:0055009; P:atrial cardiac muscle tissue morphogenesis; IEA:Ensembl.
GO; GO:1905222; P:atrioventricular canal morphogenesis; IEA:Ensembl.
GO; GO:0001569; P:branching involved in blood vessel morphogenesis; IEA:Ensembl.
GO; GO:0003273; P:cell migration involved in endocardial cushion formation; IEA:Ensembl.
GO; GO:0022009; P:central nervous system vasculogenesis; IEA:Ensembl.
GO; GO:0001300; P:chronological cell aging; IEA:Ensembl.
GO; GO:0035912; P:dorsal aorta morphogenesis; IEA:Ensembl.
GO; GO:0003198; P:epithelial to mesenchymal transition involved in endocardial cushion formation; IEA:Ensembl.
GO; GO:0001947; P:heart looping; IEA:Ensembl.
GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl.
GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
GO; GO:0031953; P:negative regulation of protein autophosphorylation; IEA:Ensembl.
GO; GO:0003148; P:outflow tract septum morphogenesis; IEA:Ensembl.
GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
GO; GO:0030513; P:positive regulation of BMP signaling pathway; IEA:Ensembl.
GO; GO:1905007; P:positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; IEA:Ensembl.
GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IEA:Ensembl.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:1905065; P:positive regulation of vascular smooth muscle cell differentiation; IEA:Ensembl.
GO; GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
GO; GO:0048745; P:smooth muscle tissue development; IEA:Ensembl.
GO; GO:0097084; P:vascular smooth muscle cell development; IEA:Ensembl.
GO; GO:0048845; P:venous blood vessel morphogenesis; IEA:Ensembl.
GO; GO:0003222; P:ventricular trabecula myocardium morphogenesis; IEA:Ensembl.
InterPro; IPR001507; ZP_dom.
Pfam; PF00100; Zona_pellucida; 1.
4: Predicted;
Membrane {ECO:0000256|SAM:Phobius};
Reference proteome {ECO:0000313|Proteomes:UP000001074};
Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
SIGNAL 1..25
/evidence="ECO:0000256|SAM:SignalP"
CHAIN 26..652
/evidence="ECO:0000256|SAM:SignalP"
/id="PRO_5003418120"
TRANSMEM 581..608
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
DOMAIN 360..529
/note="ZP"
/evidence="ECO:0000259|Pfam:PF00100"
REGION 618..652
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 626..652
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 652 AA; 70192 MW; 9C757844439F8608 CRC64;
MDRSTLYPVV ALLLAVCSLS PTSLAEAVHC DLQPVDNKVT YITNQAPKGC VAHVPNATVE
VHILFLEFPR PLSQLDLTVQ MSKQNGTRAR EVLLVLDLDK IVHLRLQAPG IPLQLAYNHQ
HVIADMPQGV STVPLTASRS QVLTWAGSKG AITSVAELND PKNILLRLDP APRSPSSCSL
QPNMDMGHRL EWWPHTEGLV RGCGLEGVAG HKEAHILRVL PGSEARPRTV TVEVKLSCTS
GDPDAVLILQ GPPYVSWLID ANHNMKIRAT GNYSIKIFPG KSFREEHLVL PDTPQGLLEE
AQRLNASKVA SFVEVPLASA ISLQASSCGG LQTSPPPVQT TPLKETCNEG LLMSLLQPNC
SGDTMTLELK KNLMWSLKCD ISSLTFLDPR CQAEDRGDQL VLHSTYSSCG MKVTESVVNN
EVVVSLLSSS SLQRKAVQCI DMKSLSFQLG LYLTPQYLQA SNALELGQQG FVQVSMSPPT
PEIMPKLDSC QLDLKPEADT VELIQNQAAK GSCVSLLDAS PHGVMRFSFL LRGHMVPTPK
AGTLSCTVAM RLGTSSLVRR TVSMRLNIVS PDMPGCTGKT LVLPAVLGIT FGAFLIGALL
TAALWYIYSH TRPPSKREPV VAVAAPASSE SSSTNHSIGS TQSTPCSTSS MA


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Pathways :
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[ENG hCG_18549] Endoglin (Osler-Rendu-Weber syndrome 1), isoform CRA_a
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[ENG] Endoglin
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[ENG] Endoglin
[ENG] Endoglin
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Bibliography :
[32643086] Salivary and serum markers of angiogenesis in periodontitis in relation to smoking.
[32611689] Correction for Kwon et al., "Hepatitis C Virus Core Protein Modulates Endoglin (CD105) Signaling Pathway for Liver Pathogenesis".
[32592434] Repeatable and objective method for evaluating angiogenesis using real-time RT-PCR of endoglin expression in canine tumors.
[32587778] Bevacizumab promotes active biological behaviors of human umbilical vein endothelial cells by activating TGFβ1 pathways off-VEGF signaling.
[32573726] Mutational and phenotypic characterisation of hereditary hemorrhagic telangiectasia.
[32550557] (CD166) as a gene expression marker for human mesenchymal stromal cell characterisation.
[32541930] PS1 FAD mutants decrease ephrinB2-regulated angiogenic functions, ischemia-induced brain neovascularization and neuronal survival.
[32538908] Whole-Mount In Situ Hybridization in Zebrafish Embryos and Tube Formation Assay in iPSC-ECs to Study the Role of Endoglin in Vascular Development.
[32530126] The Follistatin-like Protein 1 Pathway Is Important for Maintaining Healthy Articular Cartilage.
[32523017] Association of Alk1 and Endoglin Polymorphisms with Cardiovascular Damage.