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Endoglin

 Q6Q3E8_RAT              Unreviewed;       650 AA.
Q6Q3E8;
05-JUL-2004, integrated into UniProtKB/TrEMBL.
05-JUL-2004, sequence version 1.
11-DEC-2019, entry version 77.
SubName: Full=Endoglin {ECO:0000313|EMBL:AAS67893.1};
Name=Eng {ECO:0000313|EMBL:EDL93221.1, ECO:0000313|RGD:1593188};
ORFNames=rCG_45763 {ECO:0000313|EMBL:EDL93221.1};
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Rattus.
NCBI_TaxID=10116 {ECO:0000313|EMBL:AAS67893.1};
[1] {ECO:0000313|EMBL:EDL93221.1}
NUCLEOTIDE SEQUENCE.
STRAIN=BN {ECO:0000313|EMBL:EDL93221.1};
PubMed=15632090; DOI=10.1101/gr.2889405;
Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M.,
Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z.,
Istrail S., Li P., Sutton G.;
"Gene and alternative splicing annotation with AIR.";
Genome Res. 15:54-66(2005).
[2] {ECO:0000313|EMBL:AAS67893.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Sprague-Dawley {ECO:0000313|EMBL:AAS67893.1};
PubMed=15537649; DOI=10.1074/jbc.M405411200;
Meurer S.K., Tihaa L., Lahme B., Gressner A.M., Weiskirchen R.;
"Identification of endoglin in rat hepatic stellate cells: new insights
into transforming growth factor beta receptor signaling.";
J. Biol. Chem. 280:3078-3087(2005).
[3] {ECO:0000313|EMBL:EDL93221.1}
NUCLEOTIDE SEQUENCE.
STRAIN=BN {ECO:0000313|EMBL:EDL93221.1};
Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H.,
Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M.,
Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F.,
Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G.,
Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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EMBL; AY562420; AAS67893.1; -; mRNA.
EMBL; CH474001; EDL93221.1; -; Genomic_DNA.
RefSeq; NP_001010968.1; NM_001010968.2.
GeneID; 497010; -.
KEGG; rno:497010; -.
CTD; 2022; -.
RGD; 1593188; Eng.
KO; K06526; -.
OrthoDB; 1263397at2759; -.
GO; GO:0009986; C:cell surface; IDA:RGD.
GO; GO:0072563; C:endothelial microparticle; ISO:RGD.
GO; GO:0009897; C:external side of plasma membrane; ISO:RGD.
GO; GO:0005615; C:extracellular space; IDA:RGD.
GO; GO:0016021; C:integral component of membrane; NAS:RGD.
GO; GO:0043235; C:receptor complex; ISO:RGD.
GO; GO:0005534; F:galactose binding; ISO:RGD.
GO; GO:0005539; F:glycosaminoglycan binding; ISO:RGD.
GO; GO:0042802; F:identical protein binding; ISO:RGD.
GO; GO:0042803; F:protein homodimerization activity; ISO:RGD.
GO; GO:0050431; F:transforming growth factor beta binding; ISO:RGD.
GO; GO:0005072; F:transforming growth factor beta receptor, cytoplasmic mediator activity; ISO:RGD.
GO; GO:0005024; F:transforming growth factor beta-activated receptor activity; ISO:RGD.
GO; GO:0034713; F:type I transforming growth factor beta receptor binding; ISO:RGD.
GO; GO:0005114; F:type II transforming growth factor beta receptor binding; IPI:RGD.
GO; GO:0001525; P:angiogenesis; ISO:RGD.
GO; GO:0048844; P:artery morphogenesis; ISO:RGD.
GO; GO:0055009; P:atrial cardiac muscle tissue morphogenesis; ISO:RGD.
GO; GO:1905222; P:atrioventricular canal morphogenesis; ISO:RGD.
GO; GO:0060348; P:bone development; IEP:RGD.
GO; GO:0001569; P:branching involved in blood vessel morphogenesis; ISO:RGD.
GO; GO:0003209; P:cardiac atrium morphogenesis; ISO:RGD.
GO; GO:0003208; P:cardiac ventricle morphogenesis; ISO:RGD.
GO; GO:0060326; P:cell chemotaxis; ISO:RGD.
GO; GO:0016477; P:cell migration; ISO:RGD.
GO; GO:0003273; P:cell migration involved in endocardial cushion formation; ISO:RGD.
GO; GO:0048870; P:cell motility; ISO:RGD.
GO; GO:0071260; P:cellular response to mechanical stimulus; IEP:RGD.
GO; GO:0022009; P:central nervous system vasculogenesis; ISO:RGD.
GO; GO:0001300; P:chronological cell aging; ISO:RGD.
GO; GO:0070483; P:detection of hypoxia; ISO:RGD.
GO; GO:0035912; P:dorsal aorta morphogenesis; ISO:RGD.
GO; GO:0003203; P:endocardial cushion morphogenesis; ISO:RGD.
GO; GO:0003198; P:epithelial to mesenchymal transition involved in endocardial cushion formation; ISO:RGD.
GO; GO:0070278; P:extracellular matrix constituent secretion; IMP:RGD.
GO; GO:0022617; P:extracellular matrix disassembly; ISO:RGD.
GO; GO:0007507; P:heart development; ISO:RGD.
GO; GO:0001947; P:heart looping; ISO:RGD.
GO; GO:0030336; P:negative regulation of cell migration; ISO:RGD.
GO; GO:0001937; P:negative regulation of endothelial cell proliferation; ISO:RGD.
GO; GO:0010629; P:negative regulation of gene expression; ISO:RGD.
GO; GO:0051001; P:negative regulation of nitric-oxide synthase activity; ISO:RGD.
GO; GO:0060394; P:negative regulation of pathway-restricted SMAD protein phosphorylation; ISO:RGD.
GO; GO:0031953; P:negative regulation of protein autophosphorylation; ISO:RGD.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
GO; GO:0003148; P:outflow tract septum morphogenesis; ISO:RGD.
GO; GO:0045766; P:positive regulation of angiogenesis; ISO:RGD.
GO; GO:0030513; P:positive regulation of BMP signaling pathway; ISO:RGD.
GO; GO:0032967; P:positive regulation of collagen biosynthetic process; IMP:RGD.
GO; GO:1905007; P:positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; ISO:RGD.
GO; GO:0010628; P:positive regulation of gene expression; IMP:RGD.
GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; ISO:RGD.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; ISO:RGD.
GO; GO:0001934; P:positive regulation of protein phosphorylation; IMP:RGD.
GO; GO:0003084; P:positive regulation of systemic arterial blood pressure; ISO:RGD.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
GO; GO:1905065; P:positive regulation of vascular smooth muscle cell differentiation; ISO:RGD.
GO; GO:0006355; P:regulation of transcription, DNA-templated; ISO:RGD.
GO; GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; IDA:RGD.
GO; GO:0031960; P:response to corticosteroid; IEP:RGD.
GO; GO:0042493; P:response to drug; IEP:RGD.
GO; GO:0001666; P:response to hypoxia; ISO:RGD.
GO; GO:0071559; P:response to transforming growth factor beta; IEP:RGD.
GO; GO:0048745; P:smooth muscle tissue development; ISO:RGD.
GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; ISO:RGD.
GO; GO:0097084; P:vascular smooth muscle cell development; ISO:RGD.
GO; GO:0001570; P:vasculogenesis; ISO:RGD.
GO; GO:0048845; P:venous blood vessel morphogenesis; ISO:RGD.
GO; GO:0003222; P:ventricular trabecula myocardium morphogenesis; ISO:RGD.
GO; GO:0042060; P:wound healing; ISO:RGD.
InterPro; IPR001507; ZP_dom.
Pfam; PF00100; Zona_pellucida; 1.
2: Evidence at transcript level;
Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
SIGNAL 1..25
/evidence="ECO:0000256|SAM:SignalP"
CHAIN 26..650
/evidence="ECO:0000256|SAM:SignalP"
/id="PRO_5013533443"
TRANSMEM 579..606
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
DOMAIN 360..505
/note="ZP"
/evidence="ECO:0000259|Pfam:PF00100"
REGION 622..650
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 624..650
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 650 AA; 69944 MW; 3E7DBC6A178E1E4B CRC64;
MDRSMLPLVI TLLLVIYSFV PTSLAERVGC DLQRVDSTRG EVTYTTSQVS EGCVAQVANA
AHEVHVLFLN LSRRKSEVEL TLQASKQNGT ETREVFLVFI SNENVLVKLQ APEIPLHLVY
NSSLEVFKGP KVNSTPLPSF TSKTQILDWA ATKGTITSIA ALDDPKSIVL RLGQDPKAPP
FCFPEAQKDM GVTLEWQPRT QTPVQGCHLE GVTGHKEAYV LRIRSGSEAG PRTVTVTVKL
SCTSGDAVLI LQGPPYVSWL IDTNHNMQIW TTGEYSIKIF PENNIKGFEL PDTPQGLIGE
ARKLNASIVT FVEIPLTSDV SLTVSSCGGG LQTSPAPVVT TPPKDTCSPE LLMSLIQPKC
GNDVMTLALN KKLVQTLQCT ITGLAFWDSS CQAKDQDGHL VLSSTYSSCG MKVTDHVISN
EVIINLPSGL PPLRKKVQCI DMDSLSFQLG LYLSPHFLQA SNTIELGQQG FVQVSMSPLT
SEVTVQLDSC HLDLGPEGDM VELIQSRAAK GSCVSLLSPS PEGDPRFSFL LRVYMVPTPA
AGTLSCNLAL HPSTLSQEVY KTVSMRLNIV SPDLSGKGLV LPSVLGITFG AFLIGALLTA
ALWYIYSHTR APSKREPVVA VAAPASSESS STNHSIGSTQ STPCSTSSMA


Related products :

Catalog number Product name Quantity
103-M60 CD105_Endoglin Anti-Mouse Host: Rat Eng endoglin; CD105; AI528660; AI662476; S-endoglin 100
103-MBi60 CD105_Endoglin Anti-Mouse Host: Rat Eng endoglin; CD105; AI528660; AI662476; S-endoglin 50
103-PA60 CD105_Endoglin Anti-Mouse Host: Rabbit Eng endoglin; CD105; AI528660; AI662476; S-endoglin 200
103-PA60S CD105_Endoglin Anti-Mouse Host: Rabbit Eng endoglin; CD105; AI528660; AI662476; S-endoglin 100
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103-M60 CD105_Endoglin , Host: Rat, Species: Anti-Mouse, Synonyms: Eng endoglin; CD105; AI528660; AI662476; S-endoglin 100 ug
103-MBi60 CD105_Endoglin, Host: Rat, Species: Anti-Mouse, Synonyms: Eng endoglin; CD105; AI528660; AI662476; S-endoglin 50 ug
103-PA60 CD105_Endoglin, Host: Rabbit, Species: Anti-Mouse, Synonyms: Eng endoglin; CD105; AI528660; AI662476; S-endoglin 200 ug
103-PA60S CD105_Endoglin, Host: Rabbit, Species: Anti-Mouse, Synonyms: Eng endoglin; CD105; AI528660; AI662476; S-endoglin 100 ug
103-PA60AG CD105_Endoglin, Host: Rabbit, Species: Anti-Mouse, Synonyms: Eng endoglin; CD105; AI528660; AI662476; S-endoglin 50 ug
103-M102 CD105, Host: Rat, Species: Anti-Mouse, Synonyms: Eng endoglin; CD105; AI528660; AI662476; S-endoglin 200 ug
cyt-525 Recombinant Human Endoglin Endoglin 10
cyt-389 Recombinant Human Endoglin, Sf9 Endoglin Sf9 100
cyt-525 Recombinant Human Endoglin Endoglin 5
cyt-389 Recombinant Human Endoglin, Sf9 Endoglin Sf9 2
cyt-525 Recombinant Human Endoglin Endoglin 2
cyt-389 Recombinant Human Endoglin, Sf9 Endoglin Sf9 10
103-M102 CD105 Anti-Mouse Host: Rat Eng endoglin; CD105; AI528660; AI662476; S-endoglin 200
20-321-175197 CD105. ENDOGLIN - MONOCLONAL ANTIBODY TO HUMAN CD105. ENDOGLIN; CD105 antigen Monoclonal 0.1 mg
ELH-Endoglin-001 Human Endoglin ELISA ELISA One 96-Well Strip Microplate Kit
CYT-525 Endoglin 2µg
RP17638930002 Endoglin, Sf9 2 µg
RP17652530010 Endoglin 10 µg
RP17652530005 Endoglin 5 µg
RP17652530002 Endoglin 2 µg
Pathways :
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Related Genes :
[ENG END] Endoglin (CD antigen CD105)
[Eng Edg] Endoglin (Cell surface MJ7/18 antigen) (CD antigen CD105)
[ENG] Endoglin (CD antigen CD105)
[Eng rCG_45763] Endoglin
[eng] Endoglin
[Eng] Endoglin
[Eng] Endoglin
[ENG] Endoglin
[ENG hCG_18549] Endoglin (Osler-Rendu-Weber syndrome 1), isoform CRA_a
[ENG] Endoglin
[ENG] Endoglin
[ENG] Endoglin
[ENG] Endoglin
[ENG] Endoglin
[ENG] Endoglin
[ENG] Endoglin
[ENG] Endoglin
[ENG] Endoglin
[ENG] Endoglin
[ENG] Endoglin
[ENG] Endoglin
[] Endoglin
[ENG] Endoglin
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[ENG] Endoglin
[ENG] Endoglin
[ENG] Endoglin
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[Gdf2 Bmp9] Growth/differentiation factor 2 (GDF-2) (Bone morphogenetic protein 9) (BMP-9)

Bibliography :
[32643086] Salivary and serum markers of angiogenesis in periodontitis in relation to smoking.
[32611689] Correction for Kwon et al., "Hepatitis C Virus Core Protein Modulates Endoglin (CD105) Signaling Pathway for Liver Pathogenesis".
[32592434] Repeatable and objective method for evaluating angiogenesis using real-time RT-PCR of endoglin expression in canine tumors.
[32587778] Bevacizumab promotes active biological behaviors of human umbilical vein endothelial cells by activating TGFβ1 pathways off-VEGF signaling.
[32573726] Mutational and phenotypic characterisation of hereditary hemorrhagic telangiectasia.
[32550557] (CD166) as a gene expression marker for human mesenchymal stromal cell characterisation.
[32541930] PS1 FAD mutants decrease ephrinB2-regulated angiogenic functions, ischemia-induced brain neovascularization and neuronal survival.
[32538908] Whole-Mount In Situ Hybridization in Zebrafish Embryos and Tube Formation Assay in iPSC-ECs to Study the Role of Endoglin in Vascular Development.
[32530126] The Follistatin-like Protein 1 Pathway Is Important for Maintaining Healthy Articular Cartilage.
[32523017] Association of Alk1 and Endoglin Polymorphisms with Cardiovascular Damage.