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Endoglin (CD antigen CD105)

 EGLN_PIG                Reviewed;         653 AA.
P37176;
01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
01-OCT-1994, sequence version 1.
26-FEB-2020, entry version 96.
RecName: Full=Endoglin;
AltName: CD_antigen=CD105;
Flags: Precursor;
Name=ENG;
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
NCBI_TaxID=9823;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION
WITH TGFB1 AND TGFB2.
TISSUE=Uterus;
PubMed=8294451;
Yamashita H., Ichijo H., Grimsby S., Moren A., ten Dijke P., Miyazono K.;
"Endoglin forms a heteromeric complex with the signaling receptors for
transforming growth factor-beta.";
J. Biol. Chem. 269:1995-2001(1994).
-!- FUNCTION: Vascular endothelium glycoprotein that plays an important
role in the regulation of angiogenesis. Required for normal structure
and integrity of adult vasculature. Regulates the migration of vascular
endothelial cells (By similarity). Required for normal extraembryonic
angiogenesis and for embryonic heart development (By similarity). May
regulate endothelial cell shape changes in response to blood flow,
which drive vascular remodeling and establishment of normal vascular
morphology during angiogenesis (By similarity). May play a role in the
binding of endothelial cells to integrins (By similarity). Acts as TGF-
beta coreceptor and is involved in the TGF-beta/BMP signaling cascade
that ultimately leads to the activation of SMAD transcription factors
(PubMed:8294451). Required for GDF2/BMP9 signaling through SMAD1 in
endothelial cells and modulates TGFB1 signaling through SMAD3 (By
similarity). {ECO:0000250|UniProtKB:P17813,
ECO:0000250|UniProtKB:Q63961, ECO:0000269|PubMed:8294451}.
-!- SUBUNIT: Homodimer; disulfide-linked. Forms a heteromeric complex with
the signaling receptors for transforming growth factor-beta: TGFBR1
and/or TGFBR2. It is able to bind TGFB1 and TGFB2 with high affinity,
but not TGFB3 (PubMed:8294451). Interacts with GDF2, forming a
heterotetramer with a 2:2 stoichiometry. Interacts with ACVRL1. Can
form a heteromeric complex with GDF2 and ACVRL1. Interacts with BMP10.
Interacts with TCTEX1D4. Interacts with ARRB2 (By similarity).
{ECO:0000250|UniProtKB:P17813, ECO:0000269|PubMed:8294451}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:8294451};
Single-pass type I membrane protein.
-!- DOMAIN: The ZP domain mediates dimerization.
{ECO:0000250|UniProtKB:P17813}.
-!- DOMAIN: The N-terminal OR region is composed of two intertwined domains
(OR1 and OR2) with a common, novel fold. Each contains 12 beta-strands
that form a parallel beta-helix-like structure, plus a single alpha-
helix. The OR1 region mediates interaction with GDF2.
{ECO:0000250|UniProtKB:P17813}.
-!- MISCELLANEOUS: Lacks a RGD motif, contrary to the human protein.
{ECO:0000305|PubMed:8294451}.
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EMBL; Z23142; CAA80673.1; -; mRNA.
PIR; A49722; A49722.
RefSeq; NP_999196.1; NM_214031.1.
SMR; P37176; -.
STRING; 9823.ENSSSCP00000006026; -.
PaxDb; P37176; -.
PeptideAtlas; P37176; -.
PRIDE; P37176; -.
GeneID; 397096; -.
KEGG; ssc:397096; -.
CTD; 2022; -.
eggNOG; ENOG410IQ57; Eukaryota.
eggNOG; ENOG410YK9H; LUCA.
InParanoid; P37176; -.
KO; K06526; -.
OrthoDB; 1263397at2759; -.
Proteomes; UP000008227; Unplaced.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0005539; F:glycosaminoglycan binding; IDA:BHF-UCL.
GO; GO:0034713; F:type I transforming growth factor beta receptor binding; IDA:BHF-UCL.
GO; GO:0005114; F:type II transforming growth factor beta receptor binding; IDA:BHF-UCL.
GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IDA:BHF-UCL.
InterPro; IPR001507; ZP_dom.
Pfam; PF00100; Zona_pellucida; 1.
1: Evidence at protein level;
Angiogenesis; Cell adhesion; Cell membrane; Disulfide bond; Glycoprotein;
Membrane; Phosphoprotein; Reference proteome; Signal; Transmembrane;
Transmembrane helix.
SIGNAL 1..24
/evidence="ECO:0000255"
CHAIN 25..653
/note="Endoglin"
/id="PRO_0000021158"
TOPO_DOM 25..581
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 582..606
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 607..653
/note="Cytoplasmic"
/evidence="ECO:0000255"
DOMAIN 362..512
/note="ZP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00375"
REGION 27..336
/note="Required for interaction with GDF2"
/evidence="ECO:0000250|UniProtKB:P17813"
REGION 27..44
/note="OR1, N-terminal part"
/evidence="ECO:0000250|UniProtKB:P17813"
REGION 45..198
/note="OR2"
/evidence="ECO:0000250|UniProtKB:P17813"
REGION 199..329
/note="OR1, C-terminal part"
/evidence="ECO:0000250|UniProtKB:P17813"
REGION 269..281
/note="Essential for interaction with GDF2"
/evidence="ECO:0000250|UniProtKB:P17813"
COMPBIAS 335..574
/note="Ser/Thr-rich"
MOD_RES 641
/note="Phosphoserine; by TGFBR1"
/evidence="ECO:0000250|UniProtKB:Q63961"
MOD_RES 644
/note="Phosphoserine; by TGFBR1"
/evidence="ECO:0000250|UniProtKB:Q63961"
CARBOHYD 57
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 306
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 31..206
/evidence="ECO:0000250|UniProtKB:P17813"
DISULFID 51..181
/evidence="ECO:0000250|UniProtKB:P17813"
DISULFID 241..329
/evidence="ECO:0000250|UniProtKB:P17813"
DISULFID 349..381
/evidence="ECO:0000250|UniProtKB:P17813"
DISULFID 362..442
/evidence="ECO:0000250|UniProtKB:P17813"
DISULFID 393..411
/evidence="ECO:0000250|UniProtKB:P17813"
DISULFID 493..549
/evidence="ECO:0000250|UniProtKB:P17813"
DISULFID 516
/note="Interchain"
/evidence="ECO:0000250|UniProtKB:P17813"
SEQUENCE 653 AA; 70280 MW; 7887B4A61DFE3E5A CRC64;
MDRGVLPQAI ALLLAVCSFG PTAGLAEGVQ CDLQPVDPKV TYTTSQVSEG CVAHVPNATV
GVHILFLEFS KEVSTLELTV QMTNPNGARP QEVLLILSVN KNIHLTLQVP EIPLHLAYDS
KLVFLQEAPK AVITELPPST TKNQLFLWAN TKGSIISAAE LDNPQSILLR LDQAPTSPSR
CTLEPRKDMG HTLEWKSHTQ ASVLGCHLEG VTGHKEAHIL RVLPGSEAWP RTVTVEVELS
CALRDPEAVL ILQGPPYVSW LIDANHNVKA WTTGEYSFKI FPGSNIQGVN LPDTRQGLLE
EARKLNASVI ASFVELPLAS VISLQDRSCG SGLQPSPTTV QITPPGEGCN QDLLLSLIQP
RCSDDVMTLV LRKDLISTLG CTITSLTFWD PSCQAEDTDD KFVLRGTYSS CGMKVAENVV
ISNEVVVNLL SSSSPQRKQV QCINLDSLSF QLGLYLSPHF LQASNTIELG QQGFVQVSMS
PSIPELMTQL DSCQLNLGPD VEMVDLIQNQ EAKSSCVSLL SPSPGGDMRF SFLLRGYVVP
MPTAGILSCT VALRPRTWSL DVHKTASTRL NIVSPGLPDK GLVLPAVLGI TFGAFLIGAL
LTAALWYIHS HTRHPGKREP VVAVAAPASS ESSSTNHSIG STQSTPCSTS SMA


Related products :

Catalog number Product name Quantity
20-321-175197 CD105. ENDOGLIN - MONOCLONAL ANTIBODY TO HUMAN CD105. ENDOGLIN; CD105 antigen Monoclonal 0.1 mg
103-M102 CD105, Host: Rat, Species: Anti-Mouse, Synonyms: Eng endoglin; CD105; AI528660; AI662476; S-endoglin 200 ug
103-M102 CD105 Anti-Mouse Host: Rat Eng endoglin; CD105; AI528660; AI662476; S-endoglin 200
1P-453-T100 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 100 tests
A6-298-T025 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 25 tests
A6-298-T100 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 100 tests
1D-298-T100 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 100 tests
1D-298-T025 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 25 tests
A7-298-T025 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 25 tests
A7-298-T100 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 100 tests
11-453-C100 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 0.1 mg
1F-298-T025 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 25 tests
1F-298-T100 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 100 tests
A4-298-T100 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 100 tests
A4-298-T025 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 25 tests
1P-453-T025 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 25 tests
1P-298-T100 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 100 tests
1P-298-T025 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 25 tests
11-298-C025 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 0.025 mg
11-298-C100 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 0.1 mg
1F-453-T100 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 100 tests
1F-453-T025 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 25 tests
1A-298-T100 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 100 tests
1A-298-T025 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 25 tests
PB-298-T100 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 100 tests
Pathways :
WP1424: Globo Sphingolipid Metabolism
WP2328: Allograft rejection

Related Genes :
[Eng Edg] Endoglin (Cell surface MJ7/18 antigen) (CD antigen CD105)
[ENG END] Endoglin (CD antigen CD105)
[ENG] Endoglin (CD antigen CD105)
[Ceacam1 Bgp Bgp1] Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (Biliary glycoprotein D) (MHVR1) (Murine hepatitis virus receptor) (MHV-R) (CD antigen CD66a)
[CD14] Monocyte differentiation antigen CD14 (Myeloid cell-specific leucine-rich glycoprotein) (CD antigen CD14) [Cleaved into: Monocyte differentiation antigen CD14, urinary form; Monocyte differentiation antigen CD14, membrane-bound form]
[CD19] B-lymphocyte antigen CD19 (B-lymphocyte surface antigen B4) (Differentiation antigen CD19) (T-cell surface antigen Leu-12) (CD antigen CD19)
[Cd19] B-lymphocyte antigen CD19 (Differentiation antigen CD19) (CD antigen CD19)
[Cd44 Ly-24] CD44 antigen (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Hermes antigen) (Hyaluronate receptor) (Lymphocyte antigen 24) (Ly-24) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)
[Cd160 By55] CD160 antigen (Natural killer cell receptor BY55) (CD antigen CD160) [Cleaved into: CD160 antigen, soluble form]
[Ms4a1 Cd20 Ly-44 Ms4a2] B-lymphocyte antigen CD20 (B-cell differentiation antigen Ly-44) (Lymphocyte antigen 44) (Membrane-spanning 4-domains subfamily A member 1) (CD antigen CD20)
[Cd48 Bcm-1] CD48 antigen (BCM1 surface antigen) (BLAST-1) (HM48-1) (MRC OX-45 surface antigen) (SLAM family member 2) (SLAMF2) (Signaling lymphocytic activation molecule 2) (sgp-60) (CD antigen CD48)
[CD160 BY55] CD160 antigen (Natural killer cell receptor BY55) (CD antigen CD160) [Cleaved into: CD160 antigen, soluble form]
[CD80 CD28LG CD28LG1 LAB7] T-lymphocyte activation antigen CD80 (Activation B7-1 antigen) (BB1) (CTLA-4 counter-receptor B7.1) (B7) (CD antigen CD80)
[atpE CDFC105_74180 IM33_18800] ATP synthase subunit c (ATP synthase F(0) sector subunit c) (F-type ATPase subunit c) (F-ATPase subunit c) (Lipid-binding protein)
[CD1A] T-cell surface glycoprotein CD1a (T-cell surface antigen T6/Leu-6) (hTa1 thymocyte antigen) (CD antigen CD1a)
[Cd44] CD44 antigen (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)
[CD44] CD44 antigen (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HAM1 antigen) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)
[CD44 LHR MDU2 MDU3 MIC4] CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)
[CD59 MIC11 MIN1 MIN2 MIN3 MSK21] CD59 glycoprotein (1F5 antigen) (20 kDa homologous restriction factor) (HRF-20) (HRF20) (MAC-inhibitory protein) (MAC-IP) (MEM43 antigen) (Membrane attack complex inhibition factor) (MACIF) (Membrane inhibitor of reactive lysis) (MIRL) (Protectin) (CD antigen CD59)
[Cd4] T-cell surface glycoprotein CD4 (T-cell differentiation antigen L3T4) (T-cell surface antigen T4/Leu-3) (CD antigen CD4)
[CD69 CLEC2C] Early activation antigen CD69 (Activation inducer molecule) (AIM) (BL-AC/P26) (C-type lectin domain family 2 member C) (EA1) (Early T-cell activation antigen p60) (GP32/28) (Leukocyte surface antigen Leu-23) (MLR-3) (CD antigen CD69)
[CD86 CD28LG2] T-lymphocyte activation antigen CD86 (Activation B7-2 antigen) (B70) (BU63) (CTLA-4 counter-receptor B7.2) (FUN-1) (CD antigen CD86)
[Cd63] CD63 antigen (Mast cell antigen AD1) (CD antigen CD63)
[CD27 TNFRSF7] CD27 antigen (CD27L receptor) (T-cell activation antigen CD27) (T14) (Tumor necrosis factor receptor superfamily member 7) (CD antigen CD27)
[Cd80 B7] T-lymphocyte activation antigen CD80 (Activation B7-1 antigen) (B7) (CD antigen CD80)
[Cd4] T-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3) (W3/25 antigen) (CD antigen CD4)
[CD84 SLAMF5] SLAM family member 5 (Cell surface antigen MAX.3) (Hly9-beta) (Leukocyte differentiation antigen CD84) (Signaling lymphocytic activation molecule 5) (CD antigen CD84)
[CD44] CD44 antigen (Extracellular matrix receptor-III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44) (Fragment)
[MUC1 PUM] Mucin-1 (MUC-1) (Breast carcinoma-associated antigen DF3) (Cancer antigen 15-3) (CA 15-3) (Carcinoma-associated mucin) (Episialin) (H23AG) (Krebs von den Lungen-6) (KL-6) (PEMT) (Peanut-reactive urinary mucin) (PUM) (Polymorphic epithelial mucin) (PEM) (Tumor-associated epithelial membrane antigen) (EMA) (Tumor-associated mucin) (CD antigen CD227) [Cleaved into: Mucin-1 subunit alpha (MUC1-NT) (MUC1-alpha); Mucin-1 subunit beta (MUC1-beta) (MUC1-CT)]
[CD82 KAI1 SAR2 ST6 TSPAN27] CD82 antigen (C33 antigen) (IA4) (Inducible membrane protein R2) (Metastasis suppressor Kangai-1) (Suppressor of tumorigenicity 6 protein) (Tetraspanin-27) (Tspan-27) (CD antigen CD82)

Bibliography :
[32550557] (CD166) as a gene expression marker for human mesenchymal stromal cell characterisation.
[31828297] CAF-induced placental growth factor facilitates neoangiogenesis in hepatocellular carcinoma.
[31495050] Prognostic value of blood and lymphatic vessel markers in tongue cancer: A systematic review.
[31133253] Canine amniotic membrane mesenchymal stromal/stem cells: Isolation, characterization and differentiation.
[30197335] Comparison of microvessel density using CD34 and CD105 in oral submucous fibrosis and its correlation with clinicopathological features: An immunohistochemical study.
[29964301] Immunohistochemical analysis of neutrophils, interleukin-17, matrix metalloproteinase-9, and neoformed vessels in oral squamous cell carcinoma.
[29892805] Thymidine phosphorylase and angiogenesis in early stage esophageal squamous cell carcinoma.
[29860454] CD160 Expression in Retinal Vessels Is Associated With Retinal Neovascular Diseases.
[29748768] Microvessel density in head and neck squamous cell carcinoma.
[29402914] Neuroprotection of the hypoxic-ischemic mouse brain by human CD117CD90CD105 amniotic fluid stem cells.