GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Endoglin (Cell surface MJ7/18 antigen) (CD antigen CD105)

 EGLN_MOUSE              Reviewed;         653 AA.
Q63961; Q61520; Q8K100;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
27-JUL-2011, sequence version 2.
17-JUN-2020, entry version 153.
RecName: Full=Endoglin;
AltName: Full=Cell surface MJ7/18 antigen;
AltName: CD_antigen=CD105 {ECO:0000303|PubMed:10625534};
Flags: Precursor;
Name=Eng; Synonyms=Edg;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND SUBCELLULAR LOCATION.
TISSUE=Brain;
PubMed=8125301; DOI=10.1016/0378-1119(94)90808-7;
Ge A.Z., Butcher E.C.;
"Cloning and expression of a cDNA encoding mouse endoglin, an endothelial
cell TGF-beta ligand.";
Gene 138:201-206(1994).
[2]
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBUNIT, AND INTERACTION
WITH TGFB1.
STRAIN=CD-1; TISSUE=Placenta;
PubMed=8194490; DOI=10.1210/endo.134.6.8194490;
St Jacques S., Cymerman U., Pece N., Letarte M.;
"Molecular characterization and in situ localization of murine endoglin
reveal that it is a transforming growth factor-beta binding protein of
endothelial and stromal cells.";
Endocrinology 134:2645-2657(1994).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of the
mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N; TISSUE=Salivary gland;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
FUNCTION.
PubMed=17540773; DOI=10.1074/jbc.m700176200;
Lee N.Y., Blobe G.C.;
"The interaction of endoglin with beta-arrestin2 regulates transforming
growth factor-beta-mediated ERK activation and migration in endothelial
cells.";
J. Biol. Chem. 282:21507-21517(2007).
[7]
FUNCTION, DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE, AND TISSUE
SPECIFICITY.
PubMed=10625534; DOI=10.1006/dbio.1999.9534;
Arthur H.M., Ure J., Smith A.J., Renforth G., Wilson D.I., Torsney E.,
Charlton R., Parums D.V., Jowett T., Marchuk D.A., Burn J., Diamond A.G.;
"Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic
angiogenesis and plays a key role in heart development.";
Dev. Biol. 217:42-53(2000).
[8]
PHOSPHORYLATION AT SER-641 AND SER-644.
PubMed=20042635; DOI=10.1093/carcin/bgp327;
Ray B.N., Lee N.Y., How T., Blobe G.C.;
"ALK5 phosphorylation of the endoglin cytoplasmic domain regulates
Smad1/5/8 signaling and endothelial cell migration.";
Carcinogenesis 31:435-441(2010).
[9]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Heart, Kidney, Lung, Pancreas, and Spleen;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and expression.";
Cell 143:1174-1189(2010).
[10]
FUNCTION, AND INTERACTION WITH GDF2 AND BMP10.
PubMed=21737454; DOI=10.1074/jbc.m111.260133;
Castonguay R., Werner E.D., Matthews R.G., Presman E., Mulivor A.W.,
Solban N., Sako D., Pearsall R.S., Underwood K.W., Seehra J., Kumar R.,
Grinberg A.V.;
"Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10
via its orphan domain, inhibits blood vessel formation, and suppresses
tumor growth.";
J. Biol. Chem. 286:30034-30046(2011).
[11]
FUNCTION.
PubMed=23300529; DOI=10.1371/journal.pone.0050920;
Nolan-Stevaux O., Zhong W., Culp S., Shaffer K., Hoover J.,
Wickramasinghe D., Ruefli-Brasse A.;
"Endoglin requirement for BMP9 signaling in endothelial cells reveals new
mechanism of action for selective anti-endoglin antibodies.";
PLoS ONE 7:E50920-E50920(2012).
[12]
FUNCTION.
PubMed=28530658; DOI=10.1038/ncb3528;
Sugden W.W., Meissner R., Aegerter-Wilmsen T., Tsaryk R., Leonard E.V.,
Bussmann J., Hamm M.J., Herzog W., Jin Y., Jakobsson L., Denz C.,
Siekmann A.F.;
"Endoglin controls blood vessel diameter through endothelial cell shape
changes in response to haemodynamic cues.";
Nat. Cell Biol. 19:653-665(2017).
-!- FUNCTION: Vascular endothelium glycoprotein that plays an important
role in the regulation of angiogenesis (PubMed:10625534). Required for
normal structure and integrity of adult vasculature (By similarity).
Regulates the migration of vascular endothelial cells
(PubMed:17540773). Required for normal extraembryonic angiogenesis and
for embryonic heart development (PubMed:10625534). May regulate
endothelial cell shape changes in response to blood flow, which drive
vascular remodeling and establishment of normal vascular morphology
during angiogenesis (PubMed:28530658). May play a role in the binding
of endothelial cells to integrins. Acts as TGF-beta coreceptor and is
involved in the TGF-beta/BMP signaling cascade that ultimately leads to
the activation of SMAD transcription factors (PubMed:23300529).
Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and
modulates TGFB1 signaling through SMAD3 (By similarity).
{ECO:0000250|UniProtKB:P17813, ECO:0000269|PubMed:10625534,
ECO:0000269|PubMed:17540773, ECO:0000269|PubMed:23300529,
ECO:0000269|PubMed:28530658}.
-!- SUBUNIT: Homodimer; disulfide-linked (PubMed:8194490). Forms a
heteromeric complex with the signaling receptors for transforming
growth factor-beta: TGFBR1 and/or TGFBR2. Interacts with TGFB1
(PubMed:8194490). It is able to bind TGFB1 and TGFB2 with high
affinity, but not TGFB3. Interacts with GDF2, forming a heterotetramer
with a 2:2 stoichiometry. Interacts with ACVRL1. Can form a heteromeric
complex with GDF2 and ACVRL1. Interacts with BMP10. Interacts with
TCTEX1D4. Interacts with ARRB2. {ECO:0000250|UniProtKB:P17813,
ECO:0000269|PubMed:8194490}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8125301};
Single-pass type I membrane protein {ECO:0000305|PubMed:8125301}.
-!- TISSUE SPECIFICITY: Detected on blood vessels (at protein level)
(PubMed:8194490). Detected on adult pulmonary artery, capillaries
supporting the heart muscle and lung alveolar capillary endothelial
cells (PubMed:10625534). Endoglin is restricted to endothelial cells in
all tissues except bone marrow and is also found in stromal cells
within the connective tissue of intestine, stomach, heart, skeletal
muscle, uterus, ovary, oviduct, testis and thymus (PubMed:8194490).
{ECO:0000269|PubMed:8194490}.
-!- DEVELOPMENTAL STAGE: Detected in embryo (at protein level). Detected in
endothelium from yolk sac vessels. {ECO:0000269|PubMed:10625534}.
-!- DOMAIN: The ZP domain mediates dimerization.
{ECO:0000250|UniProtKB:P17813}.
-!- DOMAIN: The N-terminal OR region is composed of two intertwined domains
(OR1 and OR2) with a common, novel fold. Each contains 12 beta-strands
that form a parallel beta-helix-like structure, plus a single alpha-
helix. The OR1 region mediates interaction with GDF2.
{ECO:0000250|UniProtKB:P17813}.
-!- DISRUPTION PHENOTYPE: Full embryonic lethality at about 10.5 dpc. At
9.5 dpc, embryos display abnormal yolk sac vasculature and yolk sac
anemia. Mutant embryos are also anemic, probably due to defective
hematopoiesis in the yolk sac. In contrast, the embryonic vasculature
appears grossly normal in most cases, but heart development is
abnormal, and nearly all mutant embryos had enlarged ventricles and
dilated outflow tracts. Besides, many had abnormal cardiac looping and
displayed pericardial effusion. Heterozygous mice have occasionally
abnormally convoluted and dilated blood vessels with disorganized
smooth muscle cells surrounding them; these blood vessels are very
fragile and rupture easily. {ECO:0000269|PubMed:10625534}.
-!- MISCELLANEOUS: Lacks a RGD motif, contrary to the human protein.
{ECO:0000305}.
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; S69407; AAB30196.1; -; mRNA.
EMBL; X77952; CAA54917.1; -; mRNA.
EMBL; AL772271; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH466542; EDL08562.1; -; Genomic_DNA.
EMBL; BC029080; AAH29080.1; -; mRNA.
CCDS; CCDS15925.1; -.
PIR; I48341; I48341.
RefSeq; NP_031958.2; NM_007932.2.
SMR; Q63961; -.
DIP; DIP-47636N; -.
IntAct; Q63961; 7.
MINT; Q63961; -.
STRING; 10090.ENSMUSP00000009705; -.
iPTMnet; Q63961; -.
PhosphoSitePlus; Q63961; -.
EPD; Q63961; -.
jPOST; Q63961; -.
MaxQB; Q63961; -.
PaxDb; Q63961; -.
PRIDE; Q63961; -.
Antibodypedia; 2321; 2335 antibodies.
Ensembl; ENSMUST00000009705; ENSMUSP00000009705; ENSMUSG00000026814.
GeneID; 13805; -.
KEGG; mmu:13805; -.
UCSC; uc008jgk.2; mouse.
CTD; 2022; -.
MGI; MGI:95392; Eng.
eggNOG; ENOG410IQ57; Eukaryota.
eggNOG; ENOG410YK9H; LUCA.
GeneTree; ENSGT00530000063861; -.
InParanoid; Q63961; -.
KO; K06526; -.
OrthoDB; 1263397at2759; -.
TreeFam; TF337375; -.
BioGRID-ORCS; 13805; 1 hit in 12 CRISPR screens.
ChiTaRS; Eng; mouse.
PRO; PR:Q63961; -.
Proteomes; UP000000589; Chromosome 2.
RNAct; Q63961; protein.
Bgee; ENSMUSG00000026814; Expressed in heart and 280 other tissues.
ExpressionAtlas; Q63961; baseline and differential.
Genevisible; Q63961; MM.
GO; GO:0009986; C:cell surface; ISO:MGI.
GO; GO:0072563; C:endothelial microparticle; IDA:BHF-UCL.
GO; GO:0009897; C:external side of plasma membrane; ISO:MGI.
GO; GO:0005615; C:extracellular space; ISO:MGI.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0016604; C:nuclear body; ISO:MGI.
GO; GO:0005886; C:plasma membrane; ISO:MGI.
GO; GO:0043235; C:receptor complex; ISO:MGI.
GO; GO:0036122; F:BMP binding; IEA:Ensembl.
GO; GO:0005534; F:galactose binding; ISO:MGI.
GO; GO:0005539; F:glycosaminoglycan binding; ISO:MGI.
GO; GO:0042802; F:identical protein binding; ISO:MGI.
GO; GO:0042803; F:protein homodimerization activity; IPI:BHF-UCL.
GO; GO:0050431; F:transforming growth factor beta binding; IDA:BHF-UCL.
GO; GO:0005072; F:transforming growth factor beta receptor, cytoplasmic mediator activity; ISO:MGI.
GO; GO:0005024; F:transforming growth factor beta-activated receptor activity; ISO:MGI.
GO; GO:0034713; F:type I transforming growth factor beta receptor binding; ISO:MGI.
GO; GO:0005114; F:type II transforming growth factor beta receptor binding; ISO:MGI.
GO; GO:0001525; P:angiogenesis; IMP:MGI.
GO; GO:0048844; P:artery morphogenesis; IMP:BHF-UCL.
GO; GO:0055009; P:atrial cardiac muscle tissue morphogenesis; IMP:BHF-UCL.
GO; GO:1905222; P:atrioventricular canal morphogenesis; IMP:BHF-UCL.
GO; GO:0001569; P:branching involved in blood vessel morphogenesis; IMP:BHF-UCL.
GO; GO:0003209; P:cardiac atrium morphogenesis; IMP:BHF-UCL.
GO; GO:0003208; P:cardiac ventricle morphogenesis; IMP:BHF-UCL.
GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
GO; GO:0060326; P:cell chemotaxis; ISO:MGI.
GO; GO:0016477; P:cell migration; ISO:MGI.
GO; GO:0003273; P:cell migration involved in endocardial cushion formation; IMP:MGI.
GO; GO:0048870; P:cell motility; ISO:MGI.
GO; GO:0022009; P:central nervous system vasculogenesis; ISO:MGI.
GO; GO:0001300; P:chronological cell aging; IEP:BHF-UCL.
GO; GO:0070483; P:detection of hypoxia; ISO:MGI.
GO; GO:0035912; P:dorsal aorta morphogenesis; IMP:BHF-UCL.
GO; GO:0003203; P:endocardial cushion morphogenesis; IMP:BHF-UCL.
GO; GO:0003198; P:epithelial to mesenchymal transition involved in endocardial cushion formation; IMP:BHF-UCL.
GO; GO:0070278; P:extracellular matrix constituent secretion; ISO:MGI.
GO; GO:0022617; P:extracellular matrix disassembly; ISO:MGI.
GO; GO:0007507; P:heart development; IMP:MGI.
GO; GO:0001947; P:heart looping; IMP:BHF-UCL.
GO; GO:0030336; P:negative regulation of cell migration; ISO:MGI.
GO; GO:0001937; P:negative regulation of endothelial cell proliferation; ISO:MGI.
GO; GO:0010629; P:negative regulation of gene expression; IMP:BHF-UCL.
GO; GO:0051001; P:negative regulation of nitric-oxide synthase activity; ISO:MGI.
GO; GO:0060394; P:negative regulation of pathway-restricted SMAD protein phosphorylation; ISO:MGI.
GO; GO:0031953; P:negative regulation of protein autophosphorylation; ISO:MGI.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:MGI.
GO; GO:0003148; P:outflow tract septum morphogenesis; IGI:BHF-UCL.
GO; GO:0045766; P:positive regulation of angiogenesis; IGI:MGI.
GO; GO:0030513; P:positive regulation of BMP signaling pathway; ISO:MGI.
GO; GO:0032967; P:positive regulation of collagen biosynthetic process; ISO:MGI.
GO; GO:1905007; P:positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; IMP:BHF-UCL.
GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI.
GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; ISO:MGI.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; ISO:MGI.
GO; GO:0001934; P:positive regulation of protein phosphorylation; ISO:MGI.
GO; GO:0003084; P:positive regulation of systemic arterial blood pressure; ISO:MGI.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:BHF-UCL.
GO; GO:1905065; P:positive regulation of vascular smooth muscle cell differentiation; IMP:BHF-UCL.
GO; GO:0006355; P:regulation of transcription, DNA-templated; ISO:MGI.
GO; GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; ISO:MGI.
GO; GO:0001666; P:response to hypoxia; ISO:MGI.
GO; GO:0048745; P:smooth muscle tissue development; IMP:BHF-UCL.
GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IC:BHF-UCL.
GO; GO:0097084; P:vascular smooth muscle cell development; IMP:BHF-UCL.
GO; GO:0001570; P:vasculogenesis; IMP:BHF-UCL.
GO; GO:0048845; P:venous blood vessel morphogenesis; IMP:BHF-UCL.
GO; GO:0003222; P:ventricular trabecula myocardium morphogenesis; IMP:BHF-UCL.
GO; GO:0042060; P:wound healing; ISO:MGI.
InterPro; IPR001507; ZP_dom.
Pfam; PF00100; Zona_pellucida; 1.
1: Evidence at protein level;
Angiogenesis; Cell adhesion; Cell membrane; Disulfide bond; Glycoprotein;
Membrane; Phosphoprotein; Reference proteome; Signal; Transmembrane;
Transmembrane helix.
SIGNAL 1..26
/evidence="ECO:0000255"
CHAIN 27..653
/note="Endoglin"
/id="PRO_0000021157"
TOPO_DOM 27..581
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 582..606
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 607..653
/note="Cytoplasmic"
/evidence="ECO:0000255"
DOMAIN 363..510
/note="ZP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00375"
REGION 27..337
/note="Required for interaction with GDF2"
/evidence="ECO:0000250|UniProtKB:P17813"
REGION 27..47
/note="OR1, N-terminal part"
/evidence="ECO:0000250|UniProtKB:P17813"
REGION 48..201
/note="OR2"
/evidence="ECO:0000250|UniProtKB:P17813"
REGION 202..330
/note="OR1, C-terminal part"
/evidence="ECO:0000250|UniProtKB:P17813"
REGION 270..282
/note="Essential for interaction with GDF2"
/evidence="ECO:0000250|UniProtKB:P17813"
COMPBIAS 336..574
/note="Ser/Thr-rich"
MOD_RES 641
/note="Phosphoserine; by TGFBR1"
/evidence="ECO:0000269|PubMed:20042635"
MOD_RES 644
/note="Phosphoserine; by TGFBR1"
/evidence="ECO:0000269|PubMed:20042635"
CARBOHYD 89
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 135
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 266
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 307
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 322
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 31..209
/evidence="ECO:0000250|UniProtKB:P17813"
DISULFID 54..184
/evidence="ECO:0000250|UniProtKB:P17813"
DISULFID 244..330
/evidence="ECO:0000250|UniProtKB:P17813"
DISULFID 350..382
/evidence="ECO:0000250|UniProtKB:P17813"
DISULFID 363..442
/evidence="ECO:0000250|UniProtKB:P17813"
DISULFID 394..412
/evidence="ECO:0000250|UniProtKB:P17813"
DISULFID 493..549
/evidence="ECO:0000250|UniProtKB:P17813"
DISULFID 516
/note="Interchain"
/evidence="ECO:0000250|UniProtKB:P17813"
CONFLICT 94
/note="Q -> R (in Ref. 2; CAA54917)"
/evidence="ECO:0000305"
CONFLICT 287
/note="V -> D (in Ref. 1; AAB30196)"
/evidence="ECO:0000305"
CONFLICT 572
/note="I -> V (in Ref. 2; CAA54917)"
/evidence="ECO:0000305"
SEQUENCE 653 AA; 70021 MW; AD9DD2F823FB06A1 CRC64;
MDRGVLPLPI TLLFVIYSFV PTTGLAERVG CDLQPVDPTR GEVTFTTSQV SEGCVAQAAN
AVREVHVLFL DFPGMLSHLE LTLQASKQNG TETQEVFLVL VSNKNVFVKF QAPEIPLHLA
YDSSLVIFQG QPRVNITVLP SLTSRKQILD WAATKGAITS IAALDDPQSI VLQLGQDPKA
PFLCLPEAHK DMGATLEWQP RAQTPVQSCR LEGVSGHKEA YILRILPGSE AGPRTVTVMM
ELSCTSGDAI LILHGPPYVS WFIDINHSMQ ILTTGEYSVK IFPGSKVKGV ELPDTPQGLI
AEARKLNASI VTSFVELPLV SNVSLRASSC GGVFQTTPAP VVTTPPKDTC SPVLLMSLIQ
PKCGNQVMTL ALNKKHVQTL QCTITGLTFW DSSCQAEDTD DHLVLSSAYS SCGMKVTAHV
VSNEVIISFP SGSPPLRKKV QCIDMDSLSF QLGLYLSPHF LQASNTIELG QQAFVQVSVS
PLTSEVTVQL DSCHLDLGPE GDMVELIQSR TAKGSCVTLL SPSPEGDPRF SFLLRVYMVP
TPTAGTLSCN LALRPSTLSQ EVYKTVSMRL NIVSPDLSGK GLVLPSVLGI TFGAFLIGAL
LTAALWYIYS HTRGPSKREP VVAVAAPASS ESSSTNHSIG STQSTPCSTS SMA


Related products :

Catalog number Product name Quantity
20-321-175197 CD105. ENDOGLIN - MONOCLONAL ANTIBODY TO HUMAN CD105. ENDOGLIN; CD105 antigen Monoclonal 0.1 mg
E1576m ELISA kit Cd2,LFA-2,LFA-3 receptor,Ly-37,Ly-37,Lymphocyte antigen 37,Mouse,Mus musculus,T-cell surface antigen CD2,T-cell surface antigen T11_Leu-5 96T
E1576m ELISA Cd2,LFA-2,LFA-3 receptor,Ly-37,Ly-37,Lymphocyte antigen 37,Mouse,Mus musculus,T-cell surface antigen CD2,T-cell surface antigen T11_Leu-5 96T
U1576m CLIA Cd2,LFA-2,LFA-3 receptor,Ly-37,Ly-37,Lymphocyte antigen 37,Mouse,Mus musculus,T-cell surface antigen CD2,T-cell surface antigen T11_Leu-5 96T
A6-298-T100 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 100 tests
1F-298-T100 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 100 tests
A6-298-T025 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 25 tests
1P-453-T100 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 100 tests
1F-453-T025 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 25 tests
1F-453-T100 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 100 tests
1A-298-T100 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 100 tests
1A-298-T025 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 25 tests
A7-298-T100 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 100 tests
A7-298-T025 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 25 tests
A4-298-T100 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 100 tests
11-453-C025 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 0.025 mg
A4-298-T025 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 25 tests
1P-298-T025 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 25 tests
1P-298-T100 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 100 tests
1P-453-T025 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 25 tests
11-453-C100 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 0.1 mg
1F-298-T025 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 25 tests
1D-298-T100 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 100 tests
PB-298-T025 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 25 tests
1D-298-T025 Mouse Monoclonal to CD105 _ Endoglin Antigen CD105 Isotype IgG2a Antigen CD105 Isotype IgG2a 25 tests
Pathways :
WP2328: Allograft rejection
WP1424: Globo Sphingolipid Metabolism
WP1794: Cell surface interactions at the vascular wall
WP1833: Integrin cell surface interactions
WP2414: Quercetin and Nf-kB/ AP-1 induced cell apoptosis
WP964: Cell cycle
WP1011: T Cell Receptor Signaling Pathway
WP2005: Muscle cell TarBase
WP536: Calcium Regulation in the Cardiac Cell
WP1393: Cell cycle
WP6: Integrin-mediated cell adhesion
WP1775: Cell Cycle Checkpoints
WP285: B Cell Receptor Signaling Pathway
WP1069: Integrin-mediated cell adhesion
WP2023: Cell Differentiation - meta
WP1130: T Cell Receptor Signaling Pathway
WP2082: Cell Differentiation - Index
WP794: B Cell Receptor Signaling Pathway
WP1792: Cell Cycle, Mitotic
WP326: Calcium Regulation in the Cardiac Cell
WP1829: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
WP367: Programmed Cell Death
WP1185: Integrin-mediated cell adhesion
WP2152: BDNF
WP840: G1 to S cell cycle control

Related Genes :
[Eng Edg] Endoglin (Cell surface MJ7/18 antigen) (CD antigen CD105)
[ENG END] Endoglin (CD antigen CD105)
[ENG] Endoglin (CD antigen CD105)
[EPCAM GA733-2 M1S2 M4S1 MIC18 TACSTD1 TROP1] Epithelial cell adhesion molecule (Ep-CAM) (Adenocarcinoma-associated antigen) (Cell surface glycoprotein Trop-1) (Epithelial cell surface antigen) (Epithelial glycoprotein) (EGP) (Epithelial glycoprotein 314) (EGP314) (hEGP314) (KS 1/4 antigen) (KSA) (Major gastrointestinal tumor-associated protein GA733-2) (Tumor-associated calcium signal transducer 1) (CD antigen CD326)
[CD1A] T-cell surface glycoprotein CD1a (T-cell surface antigen T6/Leu-6) (hTa1 thymocyte antigen) (CD antigen CD1a)
[CD19] B-lymphocyte antigen CD19 (B-lymphocyte surface antigen B4) (Differentiation antigen CD19) (T-cell surface antigen Leu-12) (CD antigen CD19)
[Cd4] T-cell surface glycoprotein CD4 (T-cell differentiation antigen L3T4) (T-cell surface antigen T4/Leu-3) (CD antigen CD4)
[Cd4] T-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3) (W3/25 antigen) (CD antigen CD4)
[SLC3A2 MDU1] 4F2 cell-surface antigen heavy chain (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98)
[CD84 SLAMF5] SLAM family member 5 (Cell surface antigen MAX.3) (Hly9-beta) (Leukocyte differentiation antigen CD84) (Signaling lymphocytic activation molecule 5) (CD antigen CD84)
[CD69 CLEC2C] Early activation antigen CD69 (Activation inducer molecule) (AIM) (BL-AC/P26) (C-type lectin domain family 2 member C) (EA1) (Early T-cell activation antigen p60) (GP32/28) (Leukocyte surface antigen Leu-23) (MLR-3) (CD antigen CD69)
[CD3E T3E] T-cell surface glycoprotein CD3 epsilon chain (T-cell surface antigen T3/Leu-4 epsilon chain) (CD antigen CD3e)
[CD53 MOX44 TSPAN25] Leukocyte surface antigen CD53 (Cell surface glycoprotein CD53) (Tetraspanin-25) (Tspan-25) (CD antigen CD53)
[Ceacam1 Bgp Bgp1] Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (Biliary glycoprotein D) (MHVR1) (Murine hepatitis virus receptor) (MHV-R) (CD antigen CD66a)
[CD81 TAPA1 TSPAN28] CD81 antigen (26 kDa cell surface protein TAPA-1) (Target of the antiproliferative antibody 1) (Tetraspanin-28) (Tspan-28) (CD antigen CD81)
[CD96] T-cell surface protein tactile (Cell surface antigen CD96) (T cell-activated increased late expression protein) (CD antigen CD96)
[CD4] T-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3) (CD antigen CD4)
[BCAM LU MSK19] Basal cell adhesion molecule (Auberger B antigen) (B-CAM cell surface glycoprotein) (F8/G253 antigen) (Lutheran antigen) (Lutheran blood group glycoprotein) (CD antigen CD239)
[CD4] T-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3) (CD antigen CD4)
[LY9 CDABP0070] T-lymphocyte surface antigen Ly-9 (Cell surface molecule Ly-9) (Lymphocyte antigen 9) (SLAM family member 3) (SLAMF3) (Signaling lymphocytic activation molecule 3) (CD antigen CD229)
[Ly9 Ly-9] T-lymphocyte surface antigen Ly-9 (Cell surface molecule Ly-9) (Lymphocyte antigen 9) (SLAM family member 3) (SLAMF3) (Signaling lymphocytic activation molecule 3) (CD antigen CD229)
[Cd81 Tapa1] CD81 antigen (26 kDa cell surface protein TAPA-1) (Target of the antiproliferative antibody 1) (CD antigen CD81)
[Cd79a Iga Mb-1] B-cell antigen receptor complex-associated protein alpha chain (Ig-alpha) (MB-1 membrane glycoprotein) (Membrane-bound immunoglobulin-associated protein) (Surface IgM-associated protein) (CD antigen CD79a)
[CD8A MAL] T-cell surface glycoprotein CD8 alpha chain (T-lymphocyte differentiation antigen T8/Leu-2) (CD antigen CD8a)
[CD79A IGA MB1] B-cell antigen receptor complex-associated protein alpha chain (Ig-alpha) (MB-1 membrane glycoprotein) (Membrane-bound immunoglobulin-associated protein) (Surface IgM-associated protein) (CD antigen CD79a)
[CD83] CD83 antigen (hCD83) (B-cell activation protein) (Cell surface protein HB15) (CD antigen CD83)
[CD4] T-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3) (CD antigen CD4)
[Cd81 Tapa1] CD81 antigen (26 kDa cell surface protein TAPA-1) (Target of the antiproliferative antibody 1) (CD antigen CD81)
[CD33 SIGLEC3] Myeloid cell surface antigen CD33 (Sialic acid-binding Ig-like lectin 3) (Siglec-3) (gp67) (CD antigen CD33)
[CD40 TNFRSF5] Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (Bp50) (CD40L receptor) (CDw40) (CD antigen CD40)

Bibliography :
[23076642] In vitro and in vivo effects of an anti-mouse endoglin (CD105)-immunotoxin on the early stages of mouse B16MEL4A5 melanoma tumours.