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Endoribonuclease Dicer (EC 3.1.26.3)

 DICER_DANRE             Reviewed;        1865 AA.
Q6TV19;
05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
05-MAY-2009, sequence version 2.
16-JAN-2019, entry version 99.
RecName: Full=Endoribonuclease Dicer;
EC=3.1.26.3;
Name=dicer1;
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tuebingen;
PubMed=23594743; DOI=10.1038/nature12111;
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G.,
Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B.,
Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S.,
Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C.,
Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H.,
Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C.,
Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
Humphries M., Sycamore N., Barker D., Saunders D., Wallis J.,
Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S.,
Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R.,
Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R.,
Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R.,
Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A.,
Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S.,
Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J.,
Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
Stemple D.L.;
"The zebrafish reference genome sequence and its relationship to the
human genome.";
Nature 496:498-503(2013).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 612-1865.
PubMed=14528306; DOI=10.1038/ng1251;
Wienholds E., Koudijs M.J., van Eeden F.J.M., Cuppen E.,
Plasterk R.H.A.;
"The microRNA-producing enzyme Dicer1 is essential for zebrafish
development.";
Nat. Genet. 35:217-218(2003).
-!- FUNCTION: Double-stranded RNA (dsRNA) endoribonuclease playing a
central role in short dsRNA-mediated post-transcriptional gene
silencing. Cleaves naturally occurring long dsRNAs and short
hairpin pre-microRNAs (miRNA) into fragments of twenty-one to
twenty-three nucleotides with 3' overhang of two nucleotides,
producing respectively short interfering RNAs (siRNA) and mature
microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-
induced silencing complex (RISC) to complementary RNAs to degrade
them or prevent their translation. Gene silencing mediated by
siRNAs, also called RNA interference, controls the elimination of
transcripts from mobile and repetitive DNA elements of the genome
but also the degradation of exogenous RNA of viral origin for
instance. The miRNA pathway on the other side is a mean to
specifically regulate the expression of target genes (By
similarity). {ECO:0000250}.
-!- CATALYTIC ACTIVITY:
Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.;
EC=3.1.26.3;
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
Note=Binds 2 magnesium or manganese ions per subunit.
{ECO:0000250};
-!- SUBUNIT: Component of the RISC loading complex (RLC), or micro-RNA
(miRNA) loading complex (miRLC), which is composed of dicer1, ago2
and tarbp2; dicer1 and tarbp2 are required to process precursor
miRNAs (pre-miRNAs) to mature miRNAs and then load them onto ago2.
Note that the trimeric RLC/miRLC is also referred to as RISC (By
similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
-!- SIMILARITY: Belongs to the helicase family. Dicer subfamily.
{ECO:0000255|PROSITE-ProRule:PRU00657}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AL772219; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AY386319; AAQ90464.1; -; mRNA.
RefSeq; NP_001154925.1; NM_001161453.2.
RefSeq; XP_005158722.1; XM_005158665.3.
RefSeq; XP_005158723.1; XM_005158666.3.
UniGene; Dr.78137; -.
SMR; Q6TV19; -.
STRING; 7955.ENSDARP00000045880; -.
PaxDb; Q6TV19; -.
PRIDE; Q6TV19; -.
Ensembl; ENSDART00000045881; ENSDARP00000045880; ENSDARG00000001129.
GeneID; 324724; -.
KEGG; dre:324724; -.
CTD; 23405; -.
ZFIN; ZDB-GENE-030131-3445; dicer1.
eggNOG; KOG0701; Eukaryota.
eggNOG; COG0571; LUCA.
eggNOG; COG1111; LUCA.
GeneTree; ENSGT00940000156287; -.
HOGENOM; HOG000001567; -.
InParanoid; Q6TV19; -.
KO; K11592; -.
OMA; PKPDQPC; -.
OrthoDB; 1337630at2759; -.
PhylomeDB; Q6TV19; -.
TreeFam; TF330258; -.
Reactome; R-DRE-203927; MicroRNA (miRNA) biogenesis.
Reactome; R-DRE-426486; Small interfering RNA (siRNA) biogenesis.
PRO; PR:Q6TV19; -.
Proteomes; UP000000437; Chromosome 17.
Bgee; ENSDARG00000001129; Expressed in 30 organ(s), highest expression level in retina.
ExpressionAtlas; Q6TV19; baseline.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0035068; C:micro-ribonucleoprotein complex; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0016442; C:RISC complex; IBA:GO_Central.
GO; GO:0070578; C:RISC-loading complex; ISS:UniProtKB.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004530; F:deoxyribonuclease I activity; IBA:GO_Central.
GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0070883; F:pre-miRNA binding; IDA:ZFIN.
GO; GO:0004525; F:ribonuclease III activity; IBA:GO_Central.
GO; GO:0006309; P:apoptotic DNA fragmentation; IBA:GO_Central.
GO; GO:0035195; P:gene silencing by miRNA; IMP:ZFIN.
GO; GO:0035279; P:mRNA cleavage involved in gene silencing by miRNA; IGI:ZFIN.
GO; GO:0031054; P:pre-miRNA processing; IMP:ZFIN.
GO; GO:0035196; P:production of miRNAs involved in gene silencing by miRNA; IMP:ZFIN.
GO; GO:0030422; P:production of siRNA involved in RNA interference; ISS:UniProtKB.
GO; GO:0050767; P:regulation of neurogenesis; IMP:ZFIN.
GO; GO:0030423; P:targeting of mRNA for destruction involved in RNA interference; ISS:UniProtKB.
GO; GO:0021591; P:ventricular system development; IMP:ZFIN.
CDD; cd00048; DSRM; 1.
CDD; cd00079; HELICc; 1.
CDD; cd00593; RIBOc; 2.
Gene3D; 1.10.1520.10; -; 1.
Gene3D; 3.30.160.380; -; 1.
InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
InterPro; IPR038248; Dicer_dimer_sf.
InterPro; IPR005034; Dicer_dimerisation_dom.
InterPro; IPR014720; dsRBD_dom.
InterPro; IPR014001; Helicase_ATP-bd.
InterPro; IPR001650; Helicase_C.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR003100; PAZ_dom.
InterPro; IPR036085; PAZ_dom_sf.
InterPro; IPR000999; RNase_III_dom.
InterPro; IPR036389; RNase_III_sf.
Pfam; PF00270; DEAD; 1.
Pfam; PF03368; Dicer_dimer; 1.
Pfam; PF00271; Helicase_C; 1.
Pfam; PF02170; PAZ; 1.
Pfam; PF00636; Ribonuclease_3; 2.
SMART; SM00487; DEXDc; 1.
SMART; SM00358; DSRM; 1.
SMART; SM00490; HELICc; 1.
SMART; SM00949; PAZ; 1.
SMART; SM00535; RIBOc; 2.
SUPFAM; SSF101690; SSF101690; 1.
SUPFAM; SSF52540; SSF52540; 1.
SUPFAM; SSF69065; SSF69065; 2.
PROSITE; PS51327; DICER_DSRBF; 1.
PROSITE; PS50137; DS_RBD; 1.
PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PROSITE; PS51194; HELICASE_CTER; 1.
PROSITE; PS50821; PAZ; 1.
PROSITE; PS00517; RNASE_3_1; 1.
PROSITE; PS50142; RNASE_3_2; 2.
2: Evidence at transcript level;
ATP-binding; Complete proteome; Cytoplasm; Endonuclease; Helicase;
Hydrolase; Magnesium; Manganese; Metal-binding; Nuclease;
Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat;
RNA-binding; RNA-mediated gene silencing.
CHAIN 1 1865 Endoribonuclease Dicer.
/FTId=PRO_0000373985.
DOMAIN 41 213 Helicase ATP-binding.
{ECO:0000255|PROSITE-ProRule:PRU00541}.
DOMAIN 419 588 Helicase C-terminal.
{ECO:0000255|PROSITE-ProRule:PRU00542}.
DOMAIN 616 708 Dicer dsRNA-binding fold.
{ECO:0000255|PROSITE-ProRule:PRU00657}.
DOMAIN 877 1028 PAZ. {ECO:0000255|PROSITE-
ProRule:PRU00142}.
DOMAIN 1262 1385 RNase III 1. {ECO:0000255|PROSITE-
ProRule:PRU00177}.
DOMAIN 1609 1767 RNase III 2. {ECO:0000255|PROSITE-
ProRule:PRU00177}.
DOMAIN 1792 1857 DRBM. {ECO:0000255|PROSITE-
ProRule:PRU00266}.
NP_BIND 54 61 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00541}.
MOTIF 161 164 DECH box.
COMPBIAS 1394 1402 Poly-Asp.
METAL 1298 1298 Magnesium or manganese 1. {ECO:0000250}.
METAL 1377 1377 Magnesium or manganese 1. {ECO:0000250}.
METAL 1380 1380 Magnesium or manganese 1. {ECO:0000250}.
METAL 1648 1648 Magnesium or manganese 2. {ECO:0000250}.
METAL 1753 1753 Magnesium or manganese 2. {ECO:0000250}.
METAL 1756 1756 Magnesium or manganese 2. {ECO:0000250}.
SITE 1749 1749 Important for activity. {ECO:0000250}.
CONFLICT 739 751 IPECLRGCYPVPE -> VK (in Ref. 2;
AAQ90464). {ECO:0000305}.
CONFLICT 921 921 R -> K (in Ref. 2; AAQ90464).
{ECO:0000305}.
SEQUENCE 1865 AA; 210817 MW; 55B1700E719B2007 CRC64;
MAGLQLVTPA SSPMGPFFGL PWQQEAIHDN IYTPRKYQVE LLEAALEHNT IVCLNTGSGK
TFIAVLLIKE LSHQIRGENG KRTVFLVNAA SSVAQQASTV RTHSDLQVGD YMSEDMTSWP
EEMWNREMIE NQVLVMTCHI FLHVLKNGVL PLSKINLLVF DECHLAITGH PYREIMKICE
GCPSCPRILG LTASILNGKC DPCDLEEKIQ NLEKILQSNA ETATDLVVLD RYASQPREEV
LDCGQYQDQS GLSERLLNEL DEALNFLNDC NLSVHREDRD PTFISKQVLN DCRAVLTVLG
PWCADKAAGI MVRELQKYIK HEQEELNRKF LLFTDTILRK IHALCEEHFS PASLDLKFVT
PKVIRLLEIL HEYKPFERQQ FESVEWYNNR NQDNYVSWSD SEDDDEDEEA EAKEKTEANF
PSPFTNILCG IIFVERRYTA VVLNRLIKEA GKQDPELAYI SSNFITGHSI GKNQPRNKQM
EVEFRKQEEV LRKFRAHETN LLIATSIVEE GVDIPKCNLV VRFDLPTEYR SYVQSKGRAR
APVSNYIMLA DSERTKTFQE DLKTYKAIEK ILRNKCSKSA ECNDFELEPV TDDDNVLPPY
VLRSEDGGPR VTMNTAIGHV NRYCARLPSD PFTHLAPKCK TVEMNTGGYR STLFLPINSP
LRVPVTGPVM NCARLAEKAV ALLCCEKLHK IGELDDHLMP VGKETVKYEE ELDLHDEEET
SVPGRPGSTK RRQCSPKAIP ECLRGCYPVP EQPCYLYVIG MVLTTPLPDE LNFRRRKLYP
PEDTTRCFGI LTAKPIPRIP HFPVYTRSGE VTISIELQKS GFSLSAEQLE LITRLHQYIF
SHILRLEKPA LEFKPVEADS AYCVLPLNIV EDSNTLDLDF KFMEDIEKSE ARIGIPNTQY
TKQNPFIFKL EDYQDAVIIP RYRNFDQPHR FYVADVYTDL TPLSKFPSPE YETFAEYYKT
KYNLDLSNVN QPLLDVDHTS SRLNLLTPRH LNQKGKALPL SSAEKRKAKW ESLQNKQILV
PELCAIHPIP ASLWRKAVCL PSILYRLHCL LTAEELRSQT AIDAGVGAQT LPPDFRYPNL
DFGWKKSIDS KSFISCPSAC MEEDDDHCKL GTSSDSNHTA PESCSMEVSQ PPEGAPNTPD
EKLETLTLPV TDLNKDCFPN LPNGTQADSD DLPHRSDVCQ CSQLGPLERD LSTQTTTSVS
VRPSPAGEPQ PWPSDECTGR SSDLCDPHVK KPTSKHCPKS ETATSTPAPS ETSSEDCRSA
CAGPAWDSPK TLGPNPGLIL QALTLSNASD GFNLERLEML GDSFLKHAIT TYLFCTYPDA
HEGRLSYMRS KKVSNCNLYR LGKKKGLPSR MVVSIFDPPV NWLPPGYVVN QDKSSTDKWD
SDENKDLANG KASDDEDEDD DDEPEEAEVE PSKEDVNVED DLEYYYEHIR FIDSMLIGSG
AFGKKISLQP TDPGYEWKAP KKAHNSHFSP DGGADEFDYS SWDAMCYLDP SKAGEEDDFV
VGFWNPSEEN CGTDIGKQSI SYDLHTEQCI ADKSIADCVE ALLGCYLTSC GERAAQLFLC
SLGLKVLPPE KQSSGGSAEL QYGWLKIPPR CMFEHPDAER TLNHLISGFL NFESKINYTF
KNKAYLLQAF THASYHYNTI TDCYQRLEFL GDAILDYLIT KHLYEDPRQH SPGVLTDLRS
ALVNNTIFAS LAVKYDYHKY FKAVSPELFH VIDDFVQFQL EKNEMQGMDS ELRRSEEDEE
KEEDIEVPKA MGDIFESLAG AIYMDSGMSL ETVWQVYYPM MRPLIEKFSA NVPRSPVREL
LEMEPETAKF SPAERTYDGK VRVTVEVVGK GKFKGVGRSY RIAKSAAARR ALRSLKANQP
QVQNN


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Pathways :
WP394: RNA interference and miRNA

Related Genes :
[DICER1 DICER HERNA KIAA0928] Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI)
[Dicer1 Dicer Mdcr] Endoribonuclease Dicer (EC 3.1.26.3) (Double-strand-specific ribonuclease mDCR-1)
[dicer1] Endoribonuclease Dicer (EC 3.1.26.3)
[DCL3 At3g43920 T15B3.60] Endoribonuclease Dicer homolog 3 (EC 3.1.26.-) (Dicer-like protein 3) (AtDCL3)
[DCL1 ASU1 CAF SIN1 SUS1 At1g01040 T25K16.4] Endoribonuclease Dicer homolog 1 (EC 3.1.26.-) (Dicer-like protein 1) (AtDCL1) (Protein ABNORMAL SUSPENSOR 1) (Protein CARPEL FACTORY) (Protein SHORT INTEGUMENTS 1) (Protein SUSPENSOR 1)
[DICER1 DICER] Endoribonuclease Dicer (EC 3.1.26.3)
[dcr1 SPCC188.13c SPCC584.10c] Protein Dicer (Cell cycle control protein dcr1) (RNA interference pathway protein dcr1) [Includes: Endoribonuclease dcr1 (EC 3.1.26.-); ATP-dependent helicase dcr1 (EC 3.6.4.-)]
[DCL1 Os03g0121800 LOC_Os03g02970 OJ1705B08.11 OsJ_09217] Endoribonuclease Dicer homolog 1 (Dicer-like protein 1) (OsDCL1) (EC 3.1.26.-)
[DCL4 SHO1 Os04g0509300 LOC_Os04g43050 OSJNBb0065L13.5] Endoribonuclease Dicer homolog 4 (EC 3.1.26.-) (Dicer-like protein 4) (OsDCL4) (Protein SHOOT ORGANIZATION 1)
[Dcr-1 CG4792] Endoribonuclease Dcr-1 (Protein dicer-1) (EC 3.1.26.-)
[At3g03300 T17B22.1] Endoribonuclease Dicer homolog 2 (EC 3.1.26.-) (Dicer-like protein 2) (AtDCL2)
[DICER1 DICER] Endoribonuclease Dicer (EC 3.1.26.3)
[DICER1 DICER] Endoribonuclease Dicer (EC 3.1.26.3)
[dicer1] Endoribonuclease Dicer (EC 3.1.26.3)
[dcl-2 B14D6.490 NCU06766] Dicer-like protein 2 [Includes: Endoribonuclease dcl-2 (EC 3.1.26.-); ATP-dependent helicase dcl-2 (EC 3.6.4.-)]
[dcl-1 NCU08270] Dicer-like protein 1 [Includes: Endoribonuclease dcl-1 (EC 3.1.26.-); ATP-dependent helicase dcl-1 (EC 3.6.4.-)]
[hchA A8C65_13880 A9R57_25255 AKG99_20940 AMK83_16550 B7C53_22525 B9M99_11580 B9T59_01945 BJJ90_15205 BMT49_12710 BMT53_00170 BUE81_10670 BW690_17225 BZL69_29425 C2U48_24800 C5715_19445 C5N07_21380 C6669_19295 C7B06_02290 C7B07_03930 CDL37_00765 CG691_19145 CG705_13560 CG706_14580 CIJ94_05515 COD46_23180 CRD98_26150 D3I61_11545 DL800_09215 DNQ41_14245 DQE83_22775 DTL43_21780 DTL84_23375 DTM25_06080 EC95NR1_00961 ERS085379_01273 ERS085386_05041 HMPREF3040_01583 HW43_13705 NCTC10082_04431 NCTC10418_03071 NCTC10767_03558 NCTC11022_01867 NCTC11126_04427 NCTC11181_05650 NCTC12950_02263 NCTC13462_05714 NCTC8985_00529 NCTC9111_05933 NCTC9703_00277 PU06_24500 SAMEA3472055_03589 SAMEA3472056_01268 SAMEA3472070_00654 SAMEA3472080_04213 SAMEA3472090_03376 SAMEA3472110_00060 SAMEA3472112_00448 SAMEA3752372_00752 SAMEA3753106_00003 SAMEA3753391_00513 UN91_23615 WQ89_10695] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.-) (EC 3.5.1.124) (Maillard deglycase)
[dcr-1 K12H4.8] Endoribonuclease dcr-1 (EC 3.1.26.-) [Cleaved into: Death-promoting deoxyribonuclease (tDCR-1) (EC 3.1.21.-)]
[gag-pol] Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide 1 (SP1) (p2); Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.16) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2) (p66 RT); p51 RT; p15; Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[DCL4 At5g20320 F5O24.210] Dicer-like protein 4 (EC 3.1.26.-)
[ZC3H12A MCPIP MCPIP1] Endoribonuclease ZC3H12A (EC 3.1.-.-) (Monocyte chemotactic protein-induced protein 1) (MCP-induced protein 1) (MCPIP-1) (Regnase-1) (Reg1) (Zinc finger CCCH domain-containing protein 12A)
[mazF chpA chpAK b2782 JW2753] Endoribonuclease toxin MazF (EC 3.1.27.-) (Toxin MazF) (mRNA interferase MazF)
[phoQ b1129 JW1115] Sensor protein PhoQ (EC 2.7.13.3) (EC 3.1.3.-) (Sensor histidine protein kinase/phosphatase PhoQ)
[pyrG A6592_02570 A8M42_16405 A9R57_06965 AC067_22330 AC789_1c31020 ACN002_2797 ACN77_07080 ACN81_20385 ACU57_24415 ACU90_23015 AJ318_22735 AKG99_03555 AM270_00945 AM446_06950 AM464_05605 AM465_10605 AML07_12460 AML35_05300 APT94_17890 APU18_18535 APZ14_09290 ARC77_10140 AU473_08010 AUQ13_17535 AUS26_15660 AW059_10675 AW106_00665 AWP75_20610 AZZ83_003241 B1K96_20050 B7C53_10055 B9M99_21725 B9N33_09475 B9T59_19685 BB545_13920 BE963_03670 BEN53_16995 BET08_07180 BH694_13410 BHF46_05050 BHS81_16640 BHS87_15735 BIQ87_15835 BIU72_09520 BIZ41_16885 BJJ90_05265 BK248_12970 BK292_23205 BK334_11935 BK373_15870 BK375_10085 BK383_11680 BK400_05820 BMT49_17330 BMT53_21250 BMT91_11105 BN17_26661 BTQ04_11510 BTQ06_23845 BUE81_06975 BVL39_12970 BW690_04975 BWP17_05185 BXT93_24405 BZL31_00820 BZL69_02125 C1I57_04860 C2M16_17770 C2U48_20025 C3K24_08940 C4J69_11655 C4K41_05275 C4M78_00835 C5715_23540 C5N07_06155 C5P01_05005 C5P43_15935 C5P44_09340 C6669_14670 C6986_17750 C6B13_03370 C7235_05745 C7B02_19400 C7B06_11630 C7B07_14530 C7B08_01430 C9E25_03325 CA593_12975 CCZ14_04445 CCZ17_10850 CDL37_13440 CG691_07365 CG692_07005 CG705_05530 CG706_07860 CIJ94_12220 COD30_01795 COD46_07095 CR538_05495 CR539_18815 CRE06_03485 CRM83_26360 CSB64_15850 CT143_09630 CT146_00680 CV83915_03339 CVH05_06295 CWM24_00790 CWS33_03125 CXB56_08765 D0X26_06660 D1900_12730 D2183_19100 D2F89_14380 D3I61_16000 DD762_13665 DIV22_29760 DIV25_29790 DL545_05995 DL800_20505 DNQ41_18960 DNR41_08670 DQE83_04685 DS732_20695 DS966_06010 DTL43_09355 DTL84_00105 DTL90_02675 DTM10_03745 DTM25_22630 DTM27_13675 DTM45_13530 EC1094V2_904 EC3234A_48c00890 EC95NR1_02021 ECONIH1_15890 ECs3640 EL75_0914 EL79_0915 EL80_0918 ERS085365_02427 ERS085366_03042 ERS085374_03279 ERS085386_03410 ERS085416_02898 ERS139211_02072 ERS150873_02003 ERS150876_01467 FORC28_1110 GJ11_18025 HMPREF3040_01161 HW43_18180 JD73_16335 MJ49_17095 MS6198_30910 MS8345_02965 NCTC10082_03473 NCTC10090_04050 NCTC10418_01701 NCTC10764_00296 NCTC10766_00690 NCTC10767_02309 NCTC11022_02860 NCTC11112_00121 NCTC11181_03277 NCTC12950_01251 NCTC13125_04353 NCTC13127_01436 NCTC13462_04807 NCTC13846_01212 NCTC7152_00995 NCTC7927_01209 NCTC8500_01090 NCTC8960_03783 NCTC9007_03892 NCTC9010_01168 NCTC9036_01135 NCTC9037_01243 NCTC9045_01221 NCTC9050_04166 NCTC9058_00847 NCTC9062_02131 NCTC9075_01630 NCTC9077_01409 NCTC9081_05851 NCTC9117_01609 NCTC9119_01271 NCTC9434_01004 NCTC9706_03296 NCTC9775_04845 NCTC9777_02704 NCTC9969_01292 PU06_02080 RG28_07675 RK56_023165 SAMEA3472033_01264 SAMEA3472044_02272 SAMEA3472047_00339 SAMEA3472056_05455 SAMEA3472067_02540 SAMEA3472070_01673 SAMEA3472080_03155 SAMEA3472090_00131 SAMEA3472108_00527 SAMEA3472110_03462 SAMEA3472112_03722 SAMEA3472114_02432 SAMEA3472147_03296 SAMEA3484427_03298 SAMEA3484429_03415 SAMEA3484433_01660 SAMEA3484434_01581 SAMEA3485101_02257 SAMEA3485113_02257 SAMEA3752372_03639 SAMEA3752557_03040 SAMEA3752559_02995 SAMEA3752620_01282 SAMEA3753064_02287 SAMEA3753097_02219 SAMEA3753106_03183 SAMEA3753164_01192 SAMEA3753290_02847 SAMEA3753300_01107 SAMEA3753391_02580 SAMEA3753397_04005 SK85_03024 SY51_15605 UC41_20365 UN91_03645 WM48_14990 WQ89_10170 WR15_06090 YDC107_1339] CTP synthase (EC 6.3.4.2) (Cytidine 5'-triphosphate synthase) (Cytidine triphosphate synthetase) (CTP synthetase) (CTPS) (UTP--ammonia ligase)
[Zc3h12a Mcpip Mcpip1] Endoribonuclease ZC3H12A (EC 3.1.-.-) (Monocyte chemotactic protein-induced protein 1) (MCP-induced protein 1) (MCPIP-1) (Regnase-1) (Reg1) (Zinc finger CCCH domain-containing protein 12A)
[gag-pol] Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide 1 (SP1) (p2); Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.16) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2) (p66 RT); p51 RT; p15; Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[DCL3A Os01g0909200 LOC_Os01g68120 P0456E05.21] Endoribonuclease Dicer homolog 3a (Dicer-like protein 3a) (OsDCL3a) (EC 3.1.26.-)
[pol] Pro-Pol polyprotein (Pr125Pol) [Cleaved into: Protease/Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (EC 3.4.23.-) (p87Pro-RT-RNaseH); Protease/Reverse transcriptase (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.4.23.-) (p65Pro-RT); Ribonuclease H (RNase H) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-) (p42In)]
[gag-pol] Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide 1 (SP1) (p2); Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.16) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2) (p66 RT); p51 RT; p15; Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]

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