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Eng protein

 Q3KR75_RAT              Unreviewed;       699 AA.
Q3KR75;
08-NOV-2005, integrated into UniProtKB/TrEMBL.
08-NOV-2005, sequence version 1.
11-DEC-2019, entry version 67.
SubName: Full=Eng protein {ECO:0000313|EMBL:AAI05861.1};
Name=Eng {ECO:0000313|EMBL:AAI05861.1, ECO:0000313|RGD:1593188};
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Rattus.
NCBI_TaxID=10116 {ECO:0000313|EMBL:AAI05861.1};
[1] {ECO:0000313|EMBL:AAI05861.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Testis {ECO:0000313|EMBL:AAI05861.1};
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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EMBL; BC105860; AAI05861.1; -; mRNA.
RefSeq; NP_001010968.1; NM_001010968.2.
PRIDE; Q3KR75; -.
GeneID; 497010; -.
KEGG; rno:497010; -.
CTD; 2022; -.
RGD; 1593188; Eng.
KO; K06526; -.
OrthoDB; 1263397at2759; -.
Genevisible; Q3KR75; RN.
GO; GO:0009986; C:cell surface; IDA:RGD.
GO; GO:0072563; C:endothelial microparticle; ISO:RGD.
GO; GO:0009897; C:external side of plasma membrane; ISO:RGD.
GO; GO:0005615; C:extracellular space; IDA:RGD.
GO; GO:0016021; C:integral component of membrane; NAS:RGD.
GO; GO:0043235; C:receptor complex; ISO:RGD.
GO; GO:0005534; F:galactose binding; ISO:RGD.
GO; GO:0005539; F:glycosaminoglycan binding; ISS:BHF-UCL.
GO; GO:0042802; F:identical protein binding; ISO:RGD.
GO; GO:0042803; F:protein homodimerization activity; ISO:RGD.
GO; GO:0050431; F:transforming growth factor beta binding; ISO:RGD.
GO; GO:0005072; F:transforming growth factor beta receptor, cytoplasmic mediator activity; ISO:RGD.
GO; GO:0005024; F:transforming growth factor beta-activated receptor activity; ISO:RGD.
GO; GO:0034713; F:type I transforming growth factor beta receptor binding; ISS:BHF-UCL.
GO; GO:0005114; F:type II transforming growth factor beta receptor binding; IPI:RGD.
GO; GO:0001525; P:angiogenesis; ISO:RGD.
GO; GO:0048844; P:artery morphogenesis; ISO:RGD.
GO; GO:0055009; P:atrial cardiac muscle tissue morphogenesis; ISO:RGD.
GO; GO:1905222; P:atrioventricular canal morphogenesis; ISO:RGD.
GO; GO:0060348; P:bone development; IEP:RGD.
GO; GO:0001569; P:branching involved in blood vessel morphogenesis; ISO:RGD.
GO; GO:0003209; P:cardiac atrium morphogenesis; ISO:RGD.
GO; GO:0003208; P:cardiac ventricle morphogenesis; ISO:RGD.
GO; GO:0060326; P:cell chemotaxis; ISO:RGD.
GO; GO:0016477; P:cell migration; ISO:RGD.
GO; GO:0003273; P:cell migration involved in endocardial cushion formation; ISO:RGD.
GO; GO:0048870; P:cell motility; ISO:RGD.
GO; GO:0071260; P:cellular response to mechanical stimulus; IEP:RGD.
GO; GO:0022009; P:central nervous system vasculogenesis; ISO:RGD.
GO; GO:0001300; P:chronological cell aging; ISO:RGD.
GO; GO:0070483; P:detection of hypoxia; ISO:RGD.
GO; GO:0035912; P:dorsal aorta morphogenesis; ISO:RGD.
GO; GO:0003203; P:endocardial cushion morphogenesis; ISO:RGD.
GO; GO:0003198; P:epithelial to mesenchymal transition involved in endocardial cushion formation; ISO:RGD.
GO; GO:0070278; P:extracellular matrix constituent secretion; IMP:RGD.
GO; GO:0022617; P:extracellular matrix disassembly; ISO:RGD.
GO; GO:0007507; P:heart development; ISO:RGD.
GO; GO:0001947; P:heart looping; ISO:RGD.
GO; GO:0030336; P:negative regulation of cell migration; ISO:RGD.
GO; GO:0001937; P:negative regulation of endothelial cell proliferation; ISO:RGD.
GO; GO:0010629; P:negative regulation of gene expression; ISO:RGD.
GO; GO:0051001; P:negative regulation of nitric-oxide synthase activity; ISO:RGD.
GO; GO:0060394; P:negative regulation of pathway-restricted SMAD protein phosphorylation; ISO:RGD.
GO; GO:0031953; P:negative regulation of protein autophosphorylation; ISO:RGD.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
GO; GO:0003148; P:outflow tract septum morphogenesis; ISO:RGD.
GO; GO:0045766; P:positive regulation of angiogenesis; ISO:RGD.
GO; GO:0030513; P:positive regulation of BMP signaling pathway; ISO:RGD.
GO; GO:0032967; P:positive regulation of collagen biosynthetic process; IMP:RGD.
GO; GO:1905007; P:positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; ISO:RGD.
GO; GO:0010628; P:positive regulation of gene expression; IMP:RGD.
GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; ISO:RGD.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; ISO:RGD.
GO; GO:0001934; P:positive regulation of protein phosphorylation; IMP:RGD.
GO; GO:0003084; P:positive regulation of systemic arterial blood pressure; ISO:RGD.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
GO; GO:1905065; P:positive regulation of vascular smooth muscle cell differentiation; ISO:RGD.
GO; GO:0006355; P:regulation of transcription, DNA-templated; ISO:RGD.
GO; GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; IDA:RGD.
GO; GO:0031960; P:response to corticosteroid; IEP:RGD.
GO; GO:0042493; P:response to drug; IEP:RGD.
GO; GO:0001666; P:response to hypoxia; ISO:RGD.
GO; GO:0071559; P:response to transforming growth factor beta; IEP:RGD.
GO; GO:0048745; P:smooth muscle tissue development; ISO:RGD.
GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; ISS:BHF-UCL.
GO; GO:0097084; P:vascular smooth muscle cell development; ISO:RGD.
GO; GO:0001570; P:vasculogenesis; ISO:RGD.
GO; GO:0048845; P:venous blood vessel morphogenesis; ISO:RGD.
GO; GO:0003222; P:ventricular trabecula myocardium morphogenesis; ISO:RGD.
GO; GO:0042060; P:wound healing; ISO:RGD.
InterPro; IPR001507; ZP_dom.
Pfam; PF00100; Zona_pellucida; 1.
2: Evidence at transcript level;
Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
SIGNAL 1..25
/evidence="ECO:0000256|SAM:SignalP"
CHAIN 26..699
/evidence="ECO:0000256|SAM:SignalP"
/id="PRO_5004227630"
TRANSMEM 579..606
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
DOMAIN 360..505
/note="ZP"
/evidence="ECO:0000259|Pfam:PF00100"
REGION 617..699
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 673..699
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 699 AA; 75109 MW; AFCC940100B1CA89 CRC64;
MDRSMLPLVI TLLLVIYSFV PTSLAERVGC DLQRVDSTRG EVTYTTSQVS EGCVAQVANA
AHEVHVLFLN LSRRKSEVEL TLQASKQNGT ETREVFLVFI SNENVLVKLQ APEIPLHLVY
NSSLEVFKGP KVNSTPLPSF TSKTQILDWA ATKGTITSIA ALDDPKSIVL RLGQDPKAPP
FCFPEAQKDM GVTLEWQPRT QTPVQGCHLE GVTGHKEAYV LRIRSGSEAG PRTVTVTVKL
SCTSGDAVLI LQGPPYVSWL IDTNHNMQIW TTGEYSIKIF PENNIKGFEL PDTPQGLIGE
ARKLNASIVT FVEIPLTSDV SLTVSSCGGG LQTSPAPVVT TPPKDTCSPE LLMSLIQPKC
GNDVMTLALN KKLVQTLQCT ITGLAFWDSS CQAKDQDGHL VLSSTYSSCG MKVTDHVISN
EVIINLPSGL PPLRKKVQCI DMDSLSFQLG LYLSPHFLQA SNTIELGQQG FVQVSMSPLT
SEVTVQLDSC HLDLGPEGDM VELIQSRAAK GSCVSLLSPS PEGDPRFSFL LRVYMVPTPA
AGTLSCNLAL HPSTLSQEVY KTVSMRLNIV SPDLSGKGLV LPSVLGITFG AFLIGALLTA
ALWYIYSHTR EYPKPLHPLP TVSAQGRSTP PQGTPWEASE EVGSPGWGPD LHPCPHLSGA
PSKREPVVAV AAPASSESSS TNHSIGSTQS TPCSTSSMA


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