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Eosinophil peroxidase (EPO) (EC 1.11.1.7) [Cleaved into: Eosinophil peroxidase light chain; Eosinophil peroxidase heavy chain]

 PERE_HUMAN              Reviewed;         715 AA.
P11678; Q4TVP3;
01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
01-FEB-1996, sequence version 2.
02-JUN-2021, entry version 201.
RecName: Full=Eosinophil peroxidase;
Short=EPO;
EC=1.11.1.7;
Contains:
RecName: Full=Eosinophil peroxidase light chain;
Contains:
RecName: Full=Eosinophil peroxidase heavy chain;
Flags: Precursor;
Name=EPX; Synonyms=EPER, EPO, EPP;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Placenta;
PubMed=2550461;
Sakamaki K., Tomonaga M., Tsukui K., Nagata S.;
"Molecular cloning and characterization of a chromosomal gene for human
eosinophil peroxidase.";
J. Biol. Chem. 264:16828-16836(1989).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS MET-40; HIS-122; GLU-249;
ARG-276; LEU-292; PRO-326; LEU-358; HIS-364; THR-441; GLN-496 AND TYR-572.
NIEHS SNPs program;
Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 13-715, AND PROTEIN SEQUENCE OF 140-187 AND
251-288.
TISSUE=Blood;
PubMed=2541222; DOI=10.1084/jem.169.5.1757;
Ten R.M., Pease L.R., McKean D.J., Bell M.P., Gleich G.J.;
"Molecular cloning of the human eosinophil peroxidase. Evidence for the
existence of a peroxidase multigene family.";
J. Exp. Med. 169:1757-1769(1989).
[4]
COVALENT HEME ATTACHMENT, AND PARTIAL PROTEIN SEQUENCE.
TISSUE=Blood;
PubMed=10358043; DOI=10.1074/jbc.274.24.16953;
Oxvig C., Thomsen A.R., Overgaard M.T., Sorensen E.S., Hoejrup P.,
Bjerrum M.J., Gleich G.J., Sottrup-Jensen L.;
"Biochemical evidence for heme linkage through esters with Asp-93 and Glu-
241 in human eosinophil peroxidase. The ester with Asp-93 is only partially
formed in vivo.";
J. Biol. Chem. 274:16953-16958(1999).
[5]
FUNCTION.
PubMed=12540536; DOI=10.1128/iai.71.2.605-613.2003;
Borelli V., Vita F., Shankar S., Soranzo M.R., Banfi E., Scialino G.,
Brochetta C., Zabucchi G.;
"Human eosinophil peroxidase induces surface alteration, killing, and lysis
of Mycobacterium tuberculosis.";
Infect. Immun. 71:605-613(2003).
[6]
FUNCTION, AND NITRATION AT TYR-488.
PubMed=18694936; DOI=10.1074/jbc.m801196200;
Ulrich M., Petre A., Youhnovski N., Proemm F., Schirle M., Schumm M.,
Pero R.S., Doyle A., Checkel J., Kita H., Thiyagarajan N., Acharya K.R.,
Schmid-Grendelmeier P., Simon H.-U., Schwarz H., Tsutsui M., Shimokawa H.,
Bellon G., Lee J.J., Przybylski M., Doering G.;
"Post-translational tyrosine nitration of eosinophil granule toxins
mediated by eosinophil peroxidase.";
J. Biol. Chem. 283:28629-28640(2008).
[7]
VARIANT EPXD HIS-286.
PubMed=7809065; DOI=10.1073/pnas.91.26.12496;
Romano M., Patriarca P., Melo C., Baralle F.E., Dri P.;
"Hereditary eosinophil peroxidase deficiency: immunochemical and
spectroscopic studies and evidence for a compound heterozygosity of the
defect.";
Proc. Natl. Acad. Sci. U.S.A. 91:12496-12500(1994).
[8]
VARIANTS HIS-326; LEU-326 AND LEU-358, AND POLYMORPHISM.
PubMed=14657871; DOI=10.1016/j.jaci.2003.08.051;
Nakamura H., Miyagawa K., Ogino K., Endo T., Imai T., Ozasa K.,
Motohashi Y., Matsuzaki I., Sasahara S., Hatta K., Eboshida A.;
"High contribution contrast between the genes of eosinophil peroxidase and
IL-4 receptor alpha-chain in Japanese cedar pollinosis.";
J. Allergy Clin. Immunol. 112:1127-1131(2003).
-!- FUNCTION: Mediates tyrosine nitration of secondary granule proteins in
mature resting eosinophils. Shows significant inhibitory activity
towards Mycobacterium tuberculosis H37Rv by inducing bacterial
fragmentation and lysis. {ECO:0000269|PubMed:12540536,
ECO:0000269|PubMed:18694936}.
-!- CATALYTIC ACTIVITY:
Reaction=2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2
H2O; Xref=Rhea:RHEA:56136, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240,
ChEBI:CHEBI:139520, ChEBI:CHEBI:139521; EC=1.11.1.7;
-!- COFACTOR:
Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
Evidence={ECO:0000255|PROSITE-ProRule:PRU00298};
Note=Binds 1 Ca(2+) ion per heterodimer. {ECO:0000255|PROSITE-
ProRule:PRU00298};
-!- COFACTOR:
Name=heme b; Xref=ChEBI:CHEBI:60344;
Note=Binds 1 heme b (iron(II)-protoporphyrin IX) covalently through
ester linkages to hydroxylated methyl groups formed auto-catalytically
with hydrogen peroxide at the heme C-1 and C-5 positions. The ester
linkage to Asp-232 was observed in 30% of the chains.;
-!- SUBUNIT: Tetramer of two light chains and two heavy chains.
-!- SUBCELLULAR LOCATION: Cytoplasmic granule. Note=Cytoplasmic granules of
eosinophils.
-!- POLYMORPHISM: Allelic variant in EPX is associated with Japanese cedar
pollinosis which is a type I allergic disease with ocular and nasal
symptoms that develop paroxysmally on contact with Japanese cedar
pollen. These symptoms, which occur seasonally each year, are typical
features of allergic rhinitis, such as sneezing, excessive nasal
secretion, nasal congestion, and conjunctival itching.
-!- DISEASE: Eosinophil peroxidase deficiency (EPXD) [MIM:261500]: A rare
abnormality without clinical symptoms characterized by decreased or
absent peroxidase activity and decreased volume of the granule matrix
in eosinophils. {ECO:0000269|PubMed:7809065}. Note=The disease is
caused by variants affecting the gene represented in this entry.
-!- SIMILARITY: Belongs to the peroxidase family. XPO subfamily.
{ECO:0000255|PROSITE-ProRule:PRU00298}.
-!- WEB RESOURCE: Name=NIEHS-SNPs;
URL="http://egp.gs.washington.edu/data/epx/";
---------------------------------------------------------------------------
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EMBL; M29913; AAA58458.1; -; Genomic_DNA.
EMBL; M29904; AAA58458.1; JOINED; Genomic_DNA.
EMBL; M29905; AAA58458.1; JOINED; Genomic_DNA.
EMBL; M29906; AAA58458.1; JOINED; Genomic_DNA.
EMBL; M29907; AAA58458.1; JOINED; Genomic_DNA.
EMBL; M29908; AAA58458.1; JOINED; Genomic_DNA.
EMBL; M29909; AAA58458.1; JOINED; Genomic_DNA.
EMBL; M29910; AAA58458.1; JOINED; Genomic_DNA.
EMBL; M29911; AAA58458.1; JOINED; Genomic_DNA.
EMBL; M29912; AAA58458.1; JOINED; Genomic_DNA.
EMBL; DQ054598; AAY43126.1; -; Genomic_DNA.
EMBL; X14346; CAA32530.1; -; mRNA.
CCDS; CCDS11602.1; -.
PIR; A34408; A34408.
RefSeq; NP_000493.1; NM_000502.5.
SMR; P11678; -.
BioGRID; 113893; 2.
IntAct; P11678; 4.
STRING; 9606.ENSP00000225371; -.
BindingDB; P11678; -.
ChEMBL; CHEMBL2438; -.
DrugBank; DB01065; Melatonin.
PeroxiBase; 3317; HsEPO.
GlyConnect; 1208; 4 N-Linked glycans (1 site).
GlyGen; P11678; 6 sites.
iPTMnet; P11678; -.
PhosphoSitePlus; P11678; -.
BioMuta; EPX; -.
DMDM; 1352738; -.
EPD; P11678; -.
jPOST; P11678; -.
MassIVE; P11678; -.
PaxDb; P11678; -.
PeptideAtlas; P11678; -.
PRIDE; P11678; -.
ProteomicsDB; 52797; -.
TopDownProteomics; P11678; -.
Antibodypedia; 30927; 373 antibodies.
DNASU; 8288; -.
Ensembl; ENST00000225371; ENSP00000225371; ENSG00000121053.
GeneID; 8288; -.
KEGG; hsa:8288; -.
UCSC; uc002ivq.4; human.
CTD; 8288; -.
DisGeNET; 8288; -.
GeneCards; EPX; -.
HGNC; HGNC:3423; EPX.
HPA; ENSG00000121053; Tissue enhanced (bone marrow, lymphoid tissue).
MalaCards; EPX; -.
MIM; 131399; gene.
MIM; 261500; phenotype.
neXtProt; NX_P11678; -.
OpenTargets; ENSG00000121053; -.
PharmGKB; PA27841; -.
VEuPathDB; HostDB:ENSG00000121053.5; -.
eggNOG; KOG2408; Eukaryota.
GeneTree; ENSGT00940000156009; -.
HOGENOM; CLU_006087_1_1_1; -.
InParanoid; P11678; -.
OMA; WRIVHEG; -.
OrthoDB; 276568at2759; -.
PhylomeDB; P11678; -.
TreeFam; TF314316; -.
PathwayCommons; P11678; -.
Reactome; R-HSA-6798695; Neutrophil degranulation.
SIGNOR; P11678; -.
BioGRID-ORCS; 8288; 27 hits in 986 CRISPR screens.
ChiTaRS; EPX; human.
GeneWiki; Eosinophil_peroxidase; -.
GenomeRNAi; 8288; -.
Pharos; P11678; Tbio.
PRO; PR:P11678; -.
Proteomes; UP000005640; Chromosome 17.
RNAct; P11678; protein.
Bgee; ENSG00000121053; Expressed in trabecular bone tissue and 71 other tissues.
Genevisible; P11678; HS.
GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
GO; GO:0005576; C:extracellular region; TAS:Reactome.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0034774; C:secretory granule lumen; TAS:Reactome.
GO; GO:0020037; F:heme binding; IEA:InterPro.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0004601; F:peroxidase activity; IBA:GO_Central.
GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
GO; GO:0002215; P:defense response to nematode; IEA:Ensembl.
GO; GO:0072677; P:eosinophil migration; IEA:Ensembl.
GO; GO:0042744; P:hydrogen peroxide catabolic process; IEA:UniProtKB-KW.
GO; GO:0032693; P:negative regulation of interleukin-10 production; IEA:Ensembl.
GO; GO:0032714; P:negative regulation of interleukin-5 production; IEA:Ensembl.
GO; GO:0043312; P:neutrophil degranulation; TAS:Reactome.
GO; GO:0032753; P:positive regulation of interleukin-4 production; IEA:Ensembl.
GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
Gene3D; 1.10.640.10; -; 1.
InterPro; IPR029599; EPX/EPO.
InterPro; IPR019791; Haem_peroxidase_animal.
InterPro; IPR010255; Haem_peroxidase_sf.
InterPro; IPR037120; Haem_peroxidase_sf_animal.
PANTHER; PTHR11475:SF63; PTHR11475:SF63; 1.
Pfam; PF03098; An_peroxidase; 1.
PRINTS; PR00457; ANPEROXIDASE.
SUPFAM; SSF48113; SSF48113; 1.
PROSITE; PS00435; PEROXIDASE_1; 1.
PROSITE; PS50292; PEROXIDASE_3; 1.
1: Evidence at protein level;
Calcium; Direct protein sequencing; Disease variant; Disulfide bond;
Glycoprotein; Heme; Hydrogen peroxide; Iron; Metal-binding; Nitration;
Oxidoreductase; Peroxidase; Reference proteome; Signal.
SIGNAL 1..17
/evidence="ECO:0000255"
PROPEP 18..139
/evidence="ECO:0000269|PubMed:2541222"
/id="PRO_0000023639"
CHAIN 140..250
/note="Eosinophil peroxidase light chain"
/id="PRO_0000023640"
CHAIN 251..715
/note="Eosinophil peroxidase heavy chain"
/id="PRO_0000023641"
ACT_SITE 233
/note="Proton acceptor"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00298"
METAL 234
/note="Calcium"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00298"
METAL 306
/note="Calcium"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00298"
METAL 308
/note="Calcium; via carbonyl oxygen"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00298"
METAL 310
/note="Calcium"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00298"
METAL 312
/note="Calcium"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00298"
METAL 474
/note="Iron (heme axial ligand)"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00298"
BINDING 232
/note="Heme; covalent, via 2 links; partial"
BINDING 380
/note="Heme; covalent, via 2 links"
SITE 377
/note="Transition state stabilizer"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00298"
MOD_RES 488
/note="3'-nitrotyrosine"
/evidence="ECO:0000269|PubMed:18694936"
CARBOHYD 52
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 113
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 327
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 363
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 700
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 708
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 141..152
/evidence="ECO:0000255|PROSITE-ProRule:PRU00298"
DISULFID 253..263
/evidence="ECO:0000255|PROSITE-ProRule:PRU00298"
DISULFID 257..281
/evidence="ECO:0000255|PROSITE-ProRule:PRU00298"
DISULFID 359..370
/evidence="ECO:0000255|PROSITE-ProRule:PRU00298"
DISULFID 578..635
/evidence="ECO:0000255|PROSITE-ProRule:PRU00298"
DISULFID 676..701
/evidence="ECO:0000255|PROSITE-ProRule:PRU00298"
VARIANT 35
/note="V -> I (in dbSNP:rs34553736)"
/id="VAR_050485"
VARIANT 40
/note="I -> M (in dbSNP:rs11079339)"
/evidence="ECO:0000269|Ref.2"
/id="VAR_025138"
VARIANT 122
/note="Q -> H (in dbSNP:rs11652709)"
/evidence="ECO:0000269|Ref.2"
/id="VAR_025139"
VARIANT 249
/note="A -> E (in dbSNP:rs35896669)"
/evidence="ECO:0000269|Ref.2"
/id="VAR_025140"
VARIANT 276
/note="K -> R (in dbSNP:rs35074452)"
/evidence="ECO:0000269|Ref.2"
/id="VAR_025141"
VARIANT 286
/note="R -> H (in EPXD; dbSNP:rs121434566)"
/evidence="ECO:0000269|PubMed:7809065"
/id="VAR_015376"
VARIANT 292
/note="P -> L (in dbSNP:rs33971258)"
/evidence="ECO:0000269|Ref.2"
/id="VAR_025142"
VARIANT 326
/note="R -> H (in dbSNP:rs35832094)"
/evidence="ECO:0000269|PubMed:14657871"
/id="VAR_060197"
VARIANT 326
/note="R -> L"
/evidence="ECO:0000269|PubMed:14657871"
/id="VAR_060198"
VARIANT 326
/note="R -> P (in dbSNP:rs35832094)"
/evidence="ECO:0000269|Ref.2"
/id="VAR_025143"
VARIANT 358
/note="P -> L (associated with Japanese cedar pollinosis;
dbSNP:rs35135976)"
/evidence="ECO:0000269|PubMed:14657871, ECO:0000269|Ref.2"
/id="VAR_025144"
VARIANT 364
/note="R -> H (in dbSNP:rs35232062)"
/evidence="ECO:0000269|Ref.2"
/id="VAR_025145"
VARIANT 441
/note="K -> T (in dbSNP:rs35750729)"
/evidence="ECO:0000269|Ref.2"
/id="VAR_025146"
VARIANT 458
/note="V -> M (in dbSNP:rs34817773)"
/id="VAR_050486"
VARIANT 496
/note="H -> Q (in dbSNP:rs33955150)"
/evidence="ECO:0000269|Ref.2"
/id="VAR_025147"
VARIANT 572
/note="N -> Y (in dbSNP:rs2302311)"
/evidence="ECO:0000269|Ref.2"
/id="VAR_020031"
CONFLICT 13..18
/note="TLVLAQ -> EFRGQD (in Ref. 3; AA sequence)"
/evidence="ECO:0000305"
CONFLICT 21
/note="E -> Q (in Ref. 3; AA sequence)"
/evidence="ECO:0000305"
CONFLICT 113
/note="N -> I (in Ref. 3; CAA32530)"
/evidence="ECO:0000305"
CONFLICT 163
/note="S -> C (in Ref. 3; AA sequence)"
/evidence="ECO:0000305"
CONFLICT 645..660
/note="RDGDRFWWQKRGVFTK -> ETETGSGGRTRCFHQ (in Ref. 3; AA
sequence)"
/evidence="ECO:0000305"
SEQUENCE 715 AA; 81040 MW; CEB4E689A6C46374 CRC64;
MHLLPALAGV LATLVLAQPC EGTDPASPGA VETSVLRDCI AEAKLLVDAA YNWTQKSIKQ
RLRSGSASPM DLLSYFKQPV AATRTVVRAA DYMHVALGLL EEKLQPQRSG PFNVTDVLTE
PQLRLLSQAS GCALRDQAER CSDKYRTITG RCNNKRRPLL GASNQALARW LPAEYEDGLS
LPFGWTPSRR RNGFLLPLVR AVSNQIVRFP NERLTSDRGR ALMFMQWGQF IDHDLDFSPE
SPARVAFTAG VDCERTCAQL PPCFPIKIPP NDPRIKNQRD CIPFFRSAPS CPQNKNRVRN
QINALTSFVD ASMVYGSEVS LSLRLRNRTN YLGLLAINQR FQDNGRALLP FDNLHDDPCL
LTNRSARIPC FLAGDTRSTE TPKLAAMHTL FMREHNRLAT ELRRLNPRWN GDKLYNEARK
IMGAMVQIIT YRDFLPLVLG KARARRTLGH YRGYCSNVDP RVANVFTLAF RFGHTMLQPF
MFRLDSQYRA SAPNSHVPLS SAFFASWRIV YEGGIDPILR GLMATPAKLN RQDAMLVDEL
RDRLFRQVRR IGLDLAALNM QRSRDHGLPG YNAWRRFCGL SQPRNLAQLS RVLKNQDLAR
KFLNLYGTPD NIDIWIGAIA EPLLPGARVG PLLACLFENQ FRRARDGDRF WWQKRGVFTK
RQRKALSRIS LSRIICDNTG ITTVSRDIFR ANIYPRGFVN CSRIPRLNLS AWRGT


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WP293: Eicosanoid Synthesis
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WP318: Eicosanoid Synthesis
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WP1090: Eicosanoid Synthesis
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WP1626: Benzoate degradation via CoA ligation
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WP1654: gamma-Hexachlorocyclohexane degradation
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WP2347: vitamin B5 (pantothenate) and CoA biosynthesis Pathway

Related Genes :
[EPX EPER EPO EPP] Eosinophil peroxidase (EPO) (EC 1.11.1.7) [Cleaved into: Eosinophil peroxidase light chain; Eosinophil peroxidase heavy chain]
[Ccl11 Scya11] Eotaxin (C-C motif chemokine 11) (Eosinophil chemotactic protein) (Small-inducible cytokine A11)
[CCL11 SCYA11] Eotaxin (C-C motif chemokine 11) (Eosinophil chemotactic protein) (Small-inducible cytokine A11)
[Chil3 Chi3l3 Ym1] Chitinase-like protein 3 (EC 3.2.1.52) (Beta-N-acetylhexosaminidase Ym1) (Chitinase-3-like protein 3) (ECF-L) (Eosinophil chemotactic cytokine) (Secreted protein Ym1)
[CLC LGALS10 LGALS10A] Galectin-10 (Gal-10) (Charcot-Leyden crystal protein) (CLC) (Eosinophil lysophospholipase) (Lysolecithin acylhydrolase)
[Ccl11 Scya11] Eotaxin (C-C motif chemokine 11) (Eosinophil chemotactic protein) (Small-inducible cytokine A11)
[Ccl24 Scya24] C-C motif chemokine 24 (Eosinophil chemotactic protein 2) (Eotaxin-2) (Small-inducible cytokine A24)
[dyp1] Dye-decolorizing peroxidase AauDyP1 (EC 1.11.1.19) (EC 1.11.1.7) (AjP I) (Manganese-independent peroxidase I) [Cleaved into: Dye-decolorizing peroxidase AauDyP2 (EC 1.11.1.19) (EC 1.11.1.7) (AjP II) (Manganese-independent peroxidase II)]
[katG cat-2 NCU05770] Catalase-peroxidase (CP) (EC 1.11.1.21) (Catalase-2) (Peroxidase/catalase)
[F2RL1 GPR11 PAR2] Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1) [Cleaved into: Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate cleaved 2]
[PER33 P33 PRXCA At3g49110 F2K15.4 T2J13.50] Peroxidase 33 (Atperox P33) (EC 1.11.1.7) (ATPCa) (Neutral peroxidase C) (PERC)
[CCL11 SCYA11] Eotaxin (C-C motif chemokine 11) (Eosinophil chemotactic protein) (Small-inducible cytokine A11)
[] Botulinum neurotoxin type C (BoNT/C) (Bontoxilysin-C1) (BoNT/C1) (Botulinum neurotoxin type C1) [Cleaved into: Botulinum neurotoxin C light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin C heavy chain (HC)]
[GPX3 GPXP] Glutathione peroxidase 3 (GPx-3) (GSHPx-3) (EC 1.11.1.9) (Extracellular glutathione peroxidase) (Plasma glutathione peroxidase) (GPx-P) (GSHPx-P)
[HYR1 GPX3 ORP1 YIR037W] Glutathione peroxidase-like peroxiredoxin HYR1 (EC 1.11.1.24) (Glutathione peroxidase homolog 3) (GPx 3) (Hydrogen peroxide resistance protein 1) (Oxidant receptor peroxidase 1) (Phospholipid hydroperoxide glutathione peroxidase 3) (PHGPx3)
[PRX1 YBL064C YBL0503 YBL0524] Peroxiredoxin PRX1, mitochondrial (Prx) (EC 1.11.1.25) (EC 1.11.1.27) (1-Cys PRX) (Glutaredoxin-dependent peroxiredoxin) (Glutathione-dependent peroxiredoxin) (Mitochondrial thiol peroxidase) (mTPx) (Thioredoxin peroxidase)
[PRDX6 AOP2 GPX PHGPX] Peroxiredoxin-6 (EC 1.11.1.27) (1-Cys peroxiredoxin) (1-Cys PRX) (Acidic calcium-independent phospholipase A2) (aiPLA2) (EC 3.1.1.4) (Antioxidant protein 2) (Ciliary body glutathione peroxidase) (Glutathione-dependent peroxiredoxin) (Lysophosphatidylcholine acyltransferase 5) (LPC acyltransferase 5) (LPCAT-5) (Lyso-PC acyltransferase 5) (EC 2.3.1.23) (Non-selenium glutathione peroxidase) (NSGPx) (PHGPx)
[GSTA1] Glutathione S-transferase A1 (EC 2.5.1.18) (13-hydroperoxyoctadecadienoate peroxidase) (EC 1.11.1.-) (Androst-5-ene-3,17-dione isomerase) (EC 5.3.3.-) (GST HA subunit 1) (GST class-alpha member 1) (GST-epsilon) (GSTA1-1) (GTH1) [Cleaved into: Glutathione S-transferase A1, N-terminally processed]
[APX1 At1g07890 F24B9.2] L-ascorbate peroxidase 1, cytosolic (AP) (AtAPx01) (EC 1.11.1.11)
[PER34 P34 PRXCB At3g49120 F2K15.3 T2J13.40] Peroxidase 34 (Atperox P34) (EC 1.11.1.7) (ATPCb)
[katG Rv1908c MTCY180.10] Catalase-peroxidase (CP) (EC 1.11.1.21) (Peroxidase/catalase)
[CTSC CPPI] Dipeptidyl peptidase 1 (EC 3.4.14.1) (Cathepsin C) (Cathepsin J) (Dipeptidyl peptidase I) (DPP-I) (DPPI) (Dipeptidyl transferase) [Cleaved into: Dipeptidyl peptidase 1 exclusion domain chain (Dipeptidyl peptidase I exclusion domain chain); Dipeptidyl peptidase 1 heavy chain (Dipeptidyl peptidase I heavy chain); Dipeptidyl peptidase 1 light chain (Dipeptidyl peptidase I light chain)]
[PXDN KIAA0230 MG50 PRG2 VPO VPO1] Peroxidasin homolog (EC 1.11.1.7) (Melanoma-associated antigen MG50) (Vascular peroxidase 1) (p53-responsive gene 2 protein)
[cyp119 Saci_2081] Cytochrome P450 119 (EC 1.14.-.-) (Peroxidase) (EC 1.11.1.7)
[APX3 APX APXIII At4g35000 M4E13.60] L-ascorbate peroxidase 3 (AtAPx03) (EC 1.11.1.11)
[PAP26 At5g34850 T5E15.10] Bifunctional purple acid phosphatase 26 [Includes: Acid phosphatase (EC 3.1.3.2); Peroxidase (EC 1.11.1.7)]
[GPX1 YKL026C] Glutathione peroxidase-like peroxiredoxin 1 (EC 1.11.1.24) (EC 1.11.1.9) (Glutathione peroxidase homolog 1) (GPx 1)
[katG katG1 katG_1 katG_2 katG_5 A6581_22075 A6V01_26630 A9X72_24170 AC067_20060 AC789_1c43370 ACN002_4036 ACN68_18280 ACN81_01855 AM270_21745 AML35_25120 ARC77_16780 AU473_01085 AW059_17460 B7C53_12740 BANRA_04828 BANRA_05016 BB545_13585 BER14_23155 BFL24_26845 BHF03_12835 BN17_39101 BOH76_13450 BON63_24355 BON65_03275 BON69_01720 BON72_22810 BON76_21340 BON94_24495 BON95_02145 BTQ04_19155 BTQ06_03870 BvCms28BK_01018 BvCms35BK_03418 BvCmsHHP056_02797 BvCmsKSNP073_05528 BvCmsKSNP081_00055 BvCmsKSNP120_01226 BvCmsKSP058_04061 BvCmsNSP006_04397 BvCmsNSP007_04051 BvCmsNSP072_04872 BvCmsSIP019_04634 BVL39_05620 BW690_28275 BWP17_20450 C5P44_11455 C6669_07850 C7235_23960 C7B02_24685 C7B06_20770 C7B07_22890 C9162_25325 C9306_23080 C9E63_27935 C9E67_28900 C9Z23_12860 C9Z28_11225 C9Z37_19780 C9Z68_10640 C9Z70_22435 CO706_19250 COD30_28105 COD46_21460 CR538_24465 CR539_01430 CRD98_20705 CRE06_22835 CRM83_18885 CV83915_02119 CVH05_23745 CWS33_22735 D2184_23140 D4M06_17780 D5H35_25005 D6004_24400 D6D43_21365 D6T60_23035 D6X76_24065 D7K63_23435 D7K66_22580 D7Z75_21100 D8Y65_19780 D9610_23755 D9D20_11725 D9E73_15245 D9F87_23115 D9G42_21950 D9G95_24095 D9H68_18400 D9H70_16565 D9H94_17720 D9I87_13095 D9K48_23000 D9K54_19430 D9L89_21730 D9X97_21970 DAH18_24285 DAH30_23755 DEN86_08530 DEN89_24765 DEO04_23515 DEO20_16020 DIV22_14065 DL455_20420 DL473_18975 DL530_24290 DL705_19770 DL800_27430 DM155_24830 DM962_19800 DMZ30_22715 DN660_22170 DN808_11415 DND79_21640 DOT59_20770 DOY67_16310 DP277_19475 DQF57_22550 DQO13_22105 DQP61_18145 DRW19_22510 DS143_26375 DS732_01295 DSZ60_13895 DTL90_15290 DXT69_21320 DXX80_013870 E2112_12910 E2855_04957 E5P24_17900 E5S34_20065 E5S38_20780 E5S44_21565 E5S56_21400 EA184_14400 EAM59_26200 EAN77_11660 EAX79_18620 EB510_22380 EB515_22090 EB525_RS13110 EBM08_23775 EBP16_20325 EC382_16465 EC95NR1_03405 ECs4871 ED225_21490 ED600_25015 ED607_16610 ED611_22725 ED648_08850 ED903_13070 ED944_22065 EEA45_18815 EF173_23595 EG599_24345 EH412_25510 EHD79_21335 EHH55_00485 EHJ36_26515 EIA21_20675 EJC75_19400 EKI52_16420 ELV08_01585 EO241_15605 EQ825_23360 ERS085379_02852 ERS085404_04107 ETECE1373_04511 ETECE36_05457 EXX06_21615 EXX13_22665 EXX24_22135 EXX55_22155 EXX87_17900 EYY78_19900 F6V70_15250 F7F23_24660 F7F26_26195 F7F56_22035 F7F79_22375 F7G03_22165 F7G05_20175 FQ915_17595 FRV13_16445 FV438_21355 FVB16_15480 FY127_05800 G5668_24155 G5670_18415 G5680_24470 G6Z99_18300 G9448_13705 GP650_22210 GP662_19380 GP666_21360 GP698_21835 GP720_19390 GP935_22795 GP945_21335 GP946_21260 GQA06_13165 GQF59_22685 GQM09_17680 GQM10_23225 GQN24_21640 GRW30_21915 HAP53_00725 HCR07_16455 HF065_004009 HF527_23230 HFD31_004848 HFD39_004713 HFD59_004809 HFD69_004909 HFU80_004142 HGT58_20270 HH830_004355 HHH24_004659 HI083_003700 HIN76_003873 HIO03_003482 HIO61_002017 HIQ74_002131 HIQ82_004593 HJO53_004083 HJP34_004635 HJQ03_004619 HJR60_004364 HJR92_004599 HKA14_004424 HKA45_004364 HKA57_004011 HLQ75_24285 HLQ92_24995 HmCmsJML079_03241 HMG20_24980 HMG24_20920 HMG27_20235 HMG35_23785 HNC40_25425 HNC80_22330 HNC88_22890 HNC94_21480 HND23_21375 HNO03_20235 HNV91_18115 HP431_12635 HV021_21350 HV022_22480 HV156_12470 HV159_15000 HV168_14045 HV188_00325 HV226_03965 HV244_21160 HVV73_22285 HVV78_00330 HVW09_00315 HVW11_09145 HVW33_14070 HVW37_23235 HVW43_15210 HVW45_22780 HVW59_13115 HVW60_21825 HVW90_12865 HVW98_00335 HVX00_23170 HVX28_21940 HVX33_12985 HVX51_23205 HVX96_13465 HVY01_22010 HVZ53_23130 HVZ62_13495 HVZ71_24095 HZT35_16590 IEM32_02560 IMQ59_22550 JE86ST02C_44890 JE86ST05C_44980 NCTC10090_02831 NCTC13127_06217 NCTC8960_02388 NCTC9036_04696 NCTC9055_01717 NCTC9111_05004 NCTC9119_05104 NCTC9701_05046 NCTC9703_04266 PU06_06605 RG28_25115 RG36_24355 RM34_09815 RX35_03709 SAMEA3472043_04408 SAMEA3472055_04331 SAMEA3472070_04258 SAMEA3472114_04880 SAMEA3485101_03862 SAMEA3753064_05206 SAMEA3753290_05260 TUM18780_42060 UN86_23550 UN91_00445 WQ89_24360] Catalase-peroxidase (CP) (EC 1.11.1.21) (Peroxidase/catalase)
[katG2 katH MSMEG_3461 MSMEI_3380] Catalase-peroxidase 2 (CP 2) (EC 1.11.1.21) (Peroxidase/catalase 2)
[GPX2 YBR244W YBR1632] Glutathione peroxidase-like peroxiredoxin 2 (EC 1.11.1.24) (Glutathione peroxidase homolog 2) (GPx 2)

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