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Ephrin-4 (Protein male abnormal 26)

 EFN4_CAEEL              Reviewed;         348 AA.
O44516;
05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 2.
16-JAN-2019, entry version 131.
RecName: Full=Ephrin-4;
AltName: Full=Protein male abnormal 26;
Flags: Precursor;
Name=efn-4; Synonyms=mab-26; ORFNames=F56A11.3;
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
Caenorhabditis.
NCBI_TaxID=6239;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, AND
DISRUPTION PHENOTYPE.
STRAIN=Bristol N2;
PubMed=12403719; DOI=10.1242/dev.00122;
Chin-Sang I.D., Moseley S.L., Ding M., Harrington R.J., George S.E.,
Chisholm A.D.;
"The divergent C. elegans ephrin EFN-4 functions in embryonic
morphogenesis in a pathway independent of the VAB-1 Eph receptor.";
Development 129:5499-5510(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
[3]
IDENTIFICATION, AND NOMENCLATURE.
PubMed=10635316; DOI=10.1016/S1097-2765(00)80220-8;
Wang X., Roy P.J., Holland S.J., Zhang L.W., Culotti J.G., Pawson T.;
"Multiple ephrins control cell organization in C. elegans using
kinase-dependent and -independent functions of the VAB-1 Eph
receptor.";
Mol. Cell 4:903-913(1999).
[4]
FUNCTION.
PubMed=12679110; DOI=10.1016/S0012-1606(02)00129-X;
Hahn A.C., Emmons S.W.;
"The roles of an ephrin and a semaphorin in patterning cell-cell
contacts in C. elegans sensory organ development.";
Dev. Biol. 256:379-388(2003).
[5]
FUNCTION.
PubMed=15030761; DOI=10.1016/S1534-5807(04)00057-7;
Ikegami R., Zheng H., Ong S.-H., Culotti J.G.;
"Integration of semaphorin-2A/MAB-20, ephrin-4, and UNC-129 TGF-beta
signaling pathways regulates sorting of distinct sensory rays in C.
elegans.";
Dev. Cell 6:383-395(2004).
[6]
FUNCTION, INTERACTION WITH LAD-2, DEVELOPMENTAL STAGE, AND MUTAGENESIS
OF 328-SER--TYR-348.
PubMed=26903502; DOI=10.1242/dev.128934;
Dong B., Moseley-Alldredge M., Schwieterman A.A., Donelson C.J.,
McMurry J.L., Hudson M.L., Chen L.;
"EFN-4 functions in LAD-2-mediated axon guidance in Caenorhabditis
elegans.";
Development 143:1182-1191(2016).
-!- FUNCTION: Regulates the formation or stabilization of cell-cell
contacts at several stages of epithelial morphogenesis
(PubMed:12679110). In early embryonic development, involved in
ventral closure of the epidermis (PubMed:12403719). During male
tail morphogenesis, regulates precursor cell sorting together with
mab-20 and allows the formation of distinct sensory rays
(PubMed:15030761). Probably acts as a ligand for lad-2 to regulate
axon guidance of several neurons including SDQL, SDQR, SMD and PLN
neurons during neurogenesis (PubMed:26903502).
{ECO:0000269|PubMed:12403719, ECO:0000269|PubMed:12679110,
ECO:0000269|PubMed:15030761, ECO:0000269|PubMed:26903502}.
-!- SUBUNIT: Interacts with lat-2. {ECO:0000269|PubMed:26903502}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor,
GPI-anchor {ECO:0000305}.
-!- DEVELOPMENTAL STAGE: Expressed in the developing nervous system
(PubMed:12403719). Expressed in head and tail neurons, nerve ring,
ventral nerve cord, lateral neurons, CAN neuron, seam cells and
vulva cells (PubMed:26903502). {ECO:0000269|PubMed:12403719,
ECO:0000269|PubMed:26903502}.
-!- PTM: May undergo proteolysis by metalloprotease sup-17 to give
rise to a soluble form. {ECO:0000305|PubMed:26903502}.
-!- DISRUPTION PHENOTYPE: Worms have widespread defects in embryonic
morphogenesis of the posterior body and defects in postembryonic
male tail morphogenesis. {ECO:0000269|PubMed:12403719}.
-!- MISCELLANEOUS: In contrast to other ephrins, does not seem to
signal through the vab-1 receptor. {ECO:0000269|PubMed:12403719}.
-!- SIMILARITY: Belongs to the ephrin family. {ECO:0000255|PROSITE-
ProRule:PRU00884}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
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EMBL; AF410936; AAL05561.1; -; mRNA.
EMBL; FO080624; CCD65257.1; -; Genomic_DNA.
PIR; T32645; T32645.
RefSeq; NP_499947.1; NM_067546.4.
UniGene; Cel.19328; -.
ProteinModelPortal; O44516; -.
SMR; O44516; -.
BioGrid; 42043; 3.
STRING; 6239.F56A11.3; -.
EPD; O44516; -.
PaxDb; O44516; -.
PRIDE; O44516; -.
EnsemblMetazoa; F56A11.3; F56A11.3; WBGene00001165.
GeneID; 176882; -.
KEGG; cel:CELE_F56A11.3; -.
UCSC; F56A11.3; c. elegans.
CTD; 176882; -.
WormBase; F56A11.3; CE29503; WBGene00001165; efn-4.
eggNOG; KOG3858; Eukaryota.
eggNOG; ENOG4111FMJ; LUCA.
GeneTree; ENSGT00940000175201; -.
HOGENOM; HOG000112341; -.
InParanoid; O44516; -.
OMA; PIPNGKE; -.
OrthoDB; 1247864at2759; -.
PhylomeDB; O44516; -.
SignaLink; O44516; -.
PRO; PR:O44516; -.
Proteomes; UP000001940; Chromosome IV.
Bgee; WBGene00001165; Expressed in 5 organ(s), highest expression level in pharyngeal muscle cell (C elegans).
GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
GO; GO:0030424; C:axon; IDA:WormBase.
GO; GO:0043025; C:neuronal cell body; IDA:WormBase.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0046875; F:ephrin receptor binding; IBA:GO_Central.
GO; GO:0007411; P:axon guidance; IBA:GO_Central.
GO; GO:0042074; P:cell migration involved in gastrulation; IMP:WormBase.
GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
GO; GO:0048013; P:ephrin receptor signaling pathway; IBA:GO_Central.
GO; GO:0016331; P:morphogenesis of embryonic epithelium; IMP:WormBase.
GO; GO:0045138; P:nematode male tail tip morphogenesis; IMP:WormBase.
GO; GO:1902667; P:regulation of axon guidance; IMP:UniProtKB.
GO; GO:0030155; P:regulation of cell adhesion; IMP:WormBase.
Gene3D; 2.60.40.420; -; 1.
InterPro; IPR008972; Cupredoxin.
InterPro; IPR031328; Ephrin.
InterPro; IPR001799; Ephrin_RBD.
PANTHER; PTHR11304; PTHR11304; 1.
Pfam; PF00812; Ephrin; 1.
ProDom; PD002533; Ephrin; 1.
SUPFAM; SSF49503; SSF49503; 1.
PROSITE; PS51551; EPHRIN_RBD_2; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Developmental protein;
Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
Neurogenesis; Reference proteome; Signal.
SIGNAL 1 20 {ECO:0000255}.
CHAIN 21 329 Ephrin-4.
/FTId=PRO_0000248550.
PROPEP 330 348 Removed in mature form. {ECO:0000255}.
/FTId=PRO_0000248551.
DOMAIN 21 178 Ephrin RBD. {ECO:0000255|PROSITE-
ProRule:PRU00884}.
LIPID 329 329 GPI-anchor amidated serine.
{ECO:0000255}.
CARBOHYD 28 28 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 157 157 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 53 91 {ECO:0000255|PROSITE-ProRule:PRU00884}.
DISULFID 79 167 {ECO:0000255|PROSITE-ProRule:PRU00884}.
MUTAGEN 328 348 Missing: No defect in SDQL axon
migration. Restores SDQL axon migration
in a sup-17 (n316) mutant background.
{ECO:0000269|PubMed:26903502}.
SEQUENCE 348 AA; 39593 MW; 851E9EB07C0048FF CRC64;
MKQFFEFLIT TFLLLGLAAA DEHIVYWNST NSLFRNRQPT IEVRMGDVVR FVCPDNEEGR
NDGEYLIVYE VTEFAMDDCA LESHSREVIR CAPEGTAEKV LRTQQLSGGR REDWKKQKVP
PKNVAQLIRQ LNPIPNGKEY QPGQTYYYMT TSTGKANGTN HRMYGLCESQ NMRLSMKVSA
SQPHPTRRAP TRRQEDFVTT ASAELMGGQE DEDSDNDNAH LLPRDLEGST NPKFRRPSQL
ETAGVENQQF MKVVQMAQAG KTGTFENEKE AIAQKSSEKD GWHPVNVQYV ADLMNNAYQN
ADERISYQRD FEIHEENDLA VKSLEYSSSS TSLSTNFAIL LAVIYVLY


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Kits Elisa; taq POLYMERASE

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Pathways :
WP2199: Seed Development
WP1049: G Protein Signaling Pathways
WP1165: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways
WP1438: Influenza A virus infection
WP1493: Carbon assimilation C4 pathway
WP1502: Mitochondrial biogenesis
WP1531: Vitamin D synthesis
WP1566: Citrate cycle (TCA cycle)
WP1613: 1,4-Dichlorobenzene degradation
WP1616: ABC transporters
WP1624: Bacterial secretion system
WP1625: Base excision repair
WP1644: DNA replication
WP1650: Fluorobenzoate degradation
WP1654: gamma-Hexachlorocyclohexane degradation
WP1657: Glycerolipid metabolism
WP1659: Glycine, serine and threonine metabolism
WP1661: Glyoxylate and dicarboxylate metabolism
WP1663: Homologous recombination
WP1665: Limonene and pinene degradation
WP1672: Mismatch repair
WP1673: Naphthalene and anthracene degradation
WP1675: Nitrogen metabolism
WP1676: Non-homologous end-joining

Related Genes :
[efn-4 mab-26 F56A11.3] Ephrin-4 (Protein male abnormal 26)
[mab-20 Y71G12B.20] Semaphorin-2A (Sema-2a) (Protein male abnormal 20)
[vab-1 M03A1.1] Ephrin receptor 1 (EC 2.7.10.1) (Tyrosine-protein kinase Eph receptor) (Variable abnormal protein 1)
[EFNB1 EFL3 EPLG2 LERK2] Ephrin-B1 (EFL-3) (ELK ligand) (ELK-L) (EPH-related receptor tyrosine kinase ligand 2) (LERK-2) [Cleaved into: Ephrin-B1 C-terminal fragment (Ephrin-B1 CTF); Ephrin-B1 intracellular domain (Ephrin-B1 ICD)]
[Ephb2 Epth3 Nuk Sek3] Ephrin type-B receptor 2 (EC 2.7.10.1) (Neural kinase) (Nuk receptor tyrosine kinase) (Tyrosine-protein kinase receptor EPH-3) (Tyrosine-protein kinase receptor SEK-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2]
[EPHA4 HEK8 SEK TYRO1] Ephrin type-A receptor 4 (EC 2.7.10.1) (EPH-like kinase 8) (EK8) (hEK8) (Tyrosine-protein kinase TYRO1) (Tyrosine-protein kinase receptor SEK)
[EPHB4 HTK MYK1 TYRO11] Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11)
[Epha4 Sek Sek1] Ephrin type-A receptor 4 (EC 2.7.10.1) (Tyrosine-protein kinase receptor MPK-3) (Tyrosine-protein kinase receptor SEK-1)
[ASPM MCPH5] Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog)
[MSL3 MSL3L1] Male-specific lethal 3 homolog (Male-specific lethal-3 homolog 1) (Male-specific lethal-3 protein-like 1) (MSL3-like 1)
[EPHA4 CEK8] Ephrin type-A receptor 4 (EC 2.7.10.1) (EPH-like kinase 8) (EK8) (cEK8)
[Epha2 Eck Myk2 Sek2] Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK) (Tyrosine-protein kinase receptor MPK-5) (Tyrosine-protein kinase receptor SEK-2)
[lin-10 C09H6.2] Protein lin-10 (Abnormal cell lineage protein 10)
[EPHB2 DRT EPHT3 EPTH3 ERK HEK5 TYRO5] Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2]
[eat-4 ZK512.6] Probable vesicular glutamate transporter eat-4 (Abnormal pharyngeal pumping eat-4)
[EPHA2 ECK] Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
[WDR26 CDW2 MIP2 PRO0852] WD repeat-containing protein 26 (CUL4- and DDB1-associated WDR protein 2) (Myocardial ischemic preconditioning up-regulated protein 2)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[lin-26 lin-26B F18A1.2] Transcription factor lin-26 (Abnormal cell lineage protein 26)
[lin-44 E01A2.3] Abnormal cell lineage protein 44 (Wnt protein)
[MYB101 ABS7 At2g32460] Transcription factor MYB101 (Myb-related protein 101) (AtM1) (AtMYB101) (Protein ABNORMAL SHOOT 7)
[TY1B-OR YORWTy1-2 POL YOR142W-B O3367 YOR3367W] Transposon Ty1-OR Gag-Pol polyprotein (Gag-Pol-p199) (TY1A-TY1B) (Transposon Ty1 TYA-TYB polyprotein) (p190) [Cleaved into: Capsid protein (CA) (Gag-p45) (p54); Ty1 protease (PR) (EC 3.4.23.-) (Pol-p20) (p23); Integrase (IN) (Pol-p71) (p84) (p90); Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (Pol-p63) (p60)]
[TY2B-OR1 YORCTy2-1 POL YOR192C-B O4785] Transposon Ty2-OR1 Gag-Pol polyprotein (TY2A-TY2B) (Transposon Ty2 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA); Ty2 protease (PR) (EC 3.4.23.-); Integrase (IN); Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4)]
[TY2B-OR2 YORWTy2-2 POL YOR343W-B O6304] Transposon Ty2-OR2 Gag-Pol polyprotein (TY2A-TY2B) (Transposon Ty2 TYA-TYB polyprotein) [Cleaved into: Capsid protein (CA); Ty2 protease (PR) (EC 3.4.23.-); Integrase (IN); Reverse transcriptase/ribonuclease H (RT) (RT-RH) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4)]
[mig-13 F43C9.4] Abnormal cell migration protein 13
[Ttc26 Hop Ift56] Intraflagellar transport protein 56 (Protein hop-sterile) (Tetratricopeptide repeat protein 26) (TPR repeat protein 26)
[daf-18 T07A9.6] Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18 (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Abnormal dauer formation protein 18)
[EPHA2] Ephrin type-A receptor 2 (EC 2.7.10.1)
[EPHB1 ELK EPHT2 HEK6 NET] Ephrin type-B receptor 1 (EC 2.7.10.1) (ELK) (EPH tyrosine kinase 2) (EPH-like kinase 6) (EK6) (hEK6) (Neuronally-expressed EPH-related tyrosine kinase) (NET) (Tyrosine-protein kinase receptor EPH-2)
[SP Acp70A PAPB CG17673] Accessory gland-specific peptide 70A (Paragonial peptide B) (Sex peptide) (SP)

Bibliography :
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