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Epithelial cell adhesion molecule (Ep-CAM) (Adenocarcinoma-associated antigen) (Cell surface glycoprotein Trop-1) (Epithelial cell surface antigen) (Epithelial glycoprotein) (EGP) (Epithelial glycoprotein 314) (EGP314) (hEGP314) (KS 1/4 antigen) (KSA) (Major gastrointestinal tumor-associated protein GA733-2) (Tumor-associated calcium signal transducer 1) (CD antigen CD326)

 EPCAM_HUMAN             Reviewed;         314 AA.
P16422; P18180; Q6FG26; Q6FG49; Q96C47; Q9UCD0;
01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
13-NOV-2007, sequence version 2.
07-APR-2021, entry version 201.
RecName: Full=Epithelial cell adhesion molecule;
Short=Ep-CAM;
AltName: Full=Adenocarcinoma-associated antigen;
AltName: Full=Cell surface glycoprotein Trop-1;
AltName: Full=Epithelial cell surface antigen;
AltName: Full=Epithelial glycoprotein;
Short=EGP;
AltName: Full=Epithelial glycoprotein 314;
Short=EGP314;
Short=hEGP314;
AltName: Full=KS 1/4 antigen;
AltName: Full=KSA;
AltName: Full=Major gastrointestinal tumor-associated protein GA733-2;
AltName: Full=Tumor-associated calcium signal transducer 1;
AltName: CD_antigen=CD326;
Flags: Precursor;
Name=EPCAM; Synonyms=GA733-2, M1S2, M4S1, MIC18, TACSTD1, TROP1;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT THR-115.
TISSUE=Lung adenocarcinoma;
PubMed=2463074;
Strnad J., Hamilton A.E., Beavers L.S., Gamboa G.C., Apelgren L.D.,
Taber L.D., Sportsman J.R., Bumol T.F., Sharp J.D., Gadski R.A.;
"Molecular cloning and characterization of a human
adenocarcinoma/epithelial cell surface antigen complementary DNA.";
Cancer Res. 49:314-317(1989).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT THR-115.
PubMed=2469722;
Perez M.S., Walker L.E.;
"Isolation and characterization of a cDNA encoding the KS1/4 epithelial
carcinoma marker.";
J. Immunol. 142:3662-3667(1989).
[3]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT THR-115.
PubMed=2108441; DOI=10.1073/pnas.87.7.2755;
Simon B., Podolsky D.K., Moldenhauer G., Isselbacher K.J.,
Gattoni-Celli S., Brand S.J.;
"Epithelial glycoprotein is a member of a family of epithelial cell surface
antigens homologous to nidogen, a matrix adhesion protein.";
Proc. Natl. Acad. Sci. U.S.A. 87:2755-2759(1990).
[4]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Colon carcinoma;
PubMed=2333300; DOI=10.1073/pnas.87.9.3542;
Szala S., Froehlich M., Scollon M., Kasai Y., Steplewski Z., Koprowski H.,
Linnenbach A.J.;
"Molecular cloning of cDNA for the carcinoma-associated antigen GA733-2.";
Proc. Natl. Acad. Sci. U.S.A. 87:3542-3546(1990).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Lymphoma;
PubMed=8382772; DOI=10.1128/mcb.13.3.1507;
Linnenbach A.J., Seng B.A., Wu S., Robbins S., Scollon M., Pyrc J.J.,
Druck T., Huebner K.;
"Retroposition in a family of carcinoma-associated antigen genes.";
Mol. Cell. Biol. 13:1507-1515(1993).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P.,
Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y.,
LaBaer J.;
"Cloning of human full open reading frames in Gateway(TM) system entry
vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15815621; DOI=10.1038/nature03466;
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2 and
4.";
Nature 434:724-731(2005).
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[9]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-115.
TISSUE=Ovary;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[10]
PRELIMINARY PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-126.
TISSUE=Placenta;
PubMed=2911574; DOI=10.1073/pnas.86.1.27;
Linnenbach A.J., Wojcierowski J., Wu S., Pyrc J.J., Ross A.H.,
Dietzschold B., Speicher D., Koprowski H.;
"Sequence investigation of the major gastrointestinal tumor-associated
antigen gene family, GA733.";
Proc. Natl. Acad. Sci. U.S.A. 86:27-31(1989).
[11]
PROTEIN SEQUENCE OF 82-100, AND SUBUNIT.
PubMed=7693697;
Bjoerk P., Joensson U., Svedberg H., Larsson K., Lind P., Dillner J.,
Hedlund G., Dohlsten M., Kalland T.;
"Isolation, partial characterization, and molecular cloning of a human
colon adenocarcinoma cell-surface glycoprotein recognized by the C215 mouse
monoclonal antibody.";
J. Biol. Chem. 268:24232-24241(1993).
[12]
DISULFIDE BONDS, AND GLYCOSYLATION AT ASN-74 AND ASN-111.
PubMed=11080501; DOI=10.1074/jbc.m008839200;
Chong J.M., Speicher D.W.;
"Determination of disulfide bond assignments and N-glycosylation sites of
the human gastrointestinal carcinoma antigen GA733-2 (CO17-1A, EGP, KS1-4,
KSA, and Ep-CAM).";
J. Biol. Chem. 276:5804-5813(2001).
[13]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=15195135; DOI=10.1038/sj.onc.1207610;
Muenz M., Kieu C., Mack B., Schmitt B., Zeidler R., Gires O.;
"The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell
proliferation.";
Oncogene 23:5748-5758(2004).
[14]
FUNCTION.
PubMed=15922867; DOI=10.1016/j.canlet.2004.11.048;
Muenz M., Zeidler R., Gires O.;
"The tumour-associated antigen EpCAM upregulates the fatty acid binding
protein E-FABP.";
Cancer Lett. 225:151-157(2005).
[15]
SUBCELLULAR LOCATION, AND INTERACTION WITH CLDN7.
PubMed=16054130; DOI=10.1016/j.yexcr.2005.06.013;
Ladwein M., Pape U.F., Schmidt D.S., Schnoelzer M., Fiedler S.,
Langbein L., Franke W.W., Moldenhauer G., Zoeller M.;
"The cell-cell adhesion molecule EpCAM interacts directly with the tight
junction protein claudin-7.";
Exp. Cell Res. 309:345-357(2005).
[16]
GLYCOSYLATION AT ASN-74; ASN-111 AND ASN-198, AND MUTAGENESIS OF ASN-74;
ASN-111 AND ASN-198.
PubMed=18508581; DOI=10.2741/3075;
Munz M., Fellinger K., Hofmann T., Schmitt B., Gires O.;
"Glycosylation is crucial for stability of tumour and cancer stem cell
antigen EpCAM.";
Front. Biosci. 13:5195-5201(2008).
[17]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-198.
TISSUE=Liver;
PubMed=19159218; DOI=10.1021/pr8008012;
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
"Glycoproteomics analysis of human liver tissue by combination of multiple
enzyme digestion and hydrazide chemistry.";
J. Proteome Res. 8:651-661(2009).
[18]
INVOLVEMENT IN HNPCC8.
PubMed=19098912; DOI=10.1038/ng.283;
Ligtenberg M.J., Kuiper R.P., Chan T.L., Goossens M., Hebeda K.M.,
Voorendt M., Lee T.Y., Bodmer D., Hoenselaar E., Hendriks-Cornelissen S.J.,
Tsui W.Y., Kong C.K., Brunner H.G., van Kessel A.G., Yuen S.T.,
van Krieken J.H., Leung S.Y., Hoogerbrugge N.;
"Heritable somatic methylation and inactivation of MSH2 in families with
Lynch syndrome due to deletion of the 3' exons of TACSTD1.";
Nat. Genet. 41:112-117(2009).
[19]
FUNCTION, AND TISSUE SPECIFICITY.
PubMed=20064925; DOI=10.1074/jbc.m109.077081;
Lu T.Y., Lu R.M., Liao M.Y., Yu J., Chung C.H., Kao C.F., Wu H.C.;
"Epithelial cell adhesion molecule regulation is associated with the
maintenance of the undifferentiated phenotype of human embryonic stem
cells.";
J. Biol. Chem. 285:8719-8732(2010).
[20]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=19785009; DOI=10.1002/stem.221;
Ng V.Y., Ang S.N., Chan J.X., Choo A.B.;
"Characterization of epithelial cell adhesion molecule as a surface marker
on undifferentiated human embryonic stem cells.";
Stem Cells 28:29-35(2010).
[21]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21269460; DOI=10.1186/1752-0509-5-17;
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
Bennett K.L., Superti-Furga G., Colinge J.;
"Initial characterization of the human central proteome.";
BMC Syst. Biol. 5:17-17(2011).
[22]
VARIANT DIAR5 TYR-66.
PubMed=18572020; DOI=10.1053/j.gastro.2008.05.036;
Sivagnanam M., Mueller J.L., Lee H., Chen Z., Nelson S.F., Turner D.,
Zlotkin S.H., Pencharz P.B., Ngan B.Y., Libiger O., Schork N.J.,
Lavine J.E., Taylor S., Newbury R.O., Kolodner R.D., Hoffman H.M.;
"Identification of EpCAM as the gene for congenital tufting enteropathy.";
Gastroenterology 135:429-437(2008).
-!- FUNCTION: May act as a physical homophilic interaction molecule between
intestinal epithelial cells (IECs) and intraepithelial lymphocytes
(IELs) at the mucosal epithelium for providing immunological barrier as
a first line of defense against mucosal infection. Plays a role in
embryonic stem cells proliferation and differentiation. Up-regulates
the expression of FABP5, MYC and cyclins A and E.
{ECO:0000269|PubMed:15195135, ECO:0000269|PubMed:15922867,
ECO:0000269|PubMed:19785009, ECO:0000269|PubMed:20064925}.
-!- SUBUNIT: Monomer. Interacts with phosphorylated CLDN7.
{ECO:0000269|PubMed:16054130, ECO:0000269|PubMed:7693697}.
-!- INTERACTION:
P16422; P27797: CALR; NbExp=3; IntAct=EBI-1171184, EBI-1049597;
P16422; P12830: CDH1; NbExp=3; IntAct=EBI-1171184, EBI-727477;
P16422; Q15078: CDK5R1; NbExp=3; IntAct=EBI-1171184, EBI-746189;
P16422; P36957: DLST; NbExp=3; IntAct=EBI-1171184, EBI-351007;
P16422; Q8TDX7: NEK7; NbExp=3; IntAct=EBI-1171184, EBI-1055945;
-!- SUBCELLULAR LOCATION: Lateral cell membrane
{ECO:0000269|PubMed:15195135, ECO:0000269|PubMed:16054130,
ECO:0000269|PubMed:19785009}; Single-pass type I membrane protein
{ECO:0000269|PubMed:16054130}. Cell junction, tight junction
{ECO:0000269|PubMed:16054130}. Note=Colocalizes with CLDN7 at the
lateral cell membrane and tight junction.
{ECO:0000269|PubMed:16054130}.
-!- TISSUE SPECIFICITY: Highly and selectively expressed by
undifferentiated rather than differentiated embryonic stem cells (ESC).
Levels rapidly diminish as soon as ESC's differentiate (at protein
levels). Expressed in almost all epithelial cell membranes but not on
mesodermal or neural cell membranes. Found on the surface of
adenocarcinoma. {ECO:0000269|PubMed:20064925}.
-!- PTM: Hyperglycosylated in carcinoma tissue as compared with autologous
normal epithelia. Glycosylation at Asn-198 is crucial for protein
stability. {ECO:0000269|PubMed:11080501, ECO:0000269|PubMed:18508581,
ECO:0000269|PubMed:19159218}.
-!- DISEASE: Diarrhea 5, with tufting enteropathy, congenital (DIAR5)
[MIM:613217]: An intractable diarrhea of infancy characterized by
villous atrophy and absence of inflammation, with intestinal epithelial
cell dysplasia manifesting as focal epithelial tufts in the duodenum
and jejunum. {ECO:0000269|PubMed:18572020}. Note=The disease is caused
by variants affecting the gene represented in this entry.
-!- DISEASE: Hereditary non-polyposis colorectal cancer 8 (HNPCC8)
[MIM:613244]: An autosomal dominant disease associated with marked
increase in cancer susceptibility. It is characterized by a familial
predisposition to early-onset colorectal carcinoma (CRC) and extra-
colonic tumors of the gastrointestinal, urological and female
reproductive tracts. HNPCC is reported to be the most common form of
inherited colorectal cancer in the Western world. Clinically, HNPCC is
often divided into two subgroups. Type I is characterized by hereditary
predisposition to colorectal cancer, a young age of onset, and
carcinoma observed in the proximal colon. Type II is characterized by
increased risk for cancers in certain tissues such as the uterus,
ovary, breast, stomach, small intestine, skin, and larynx in addition
to the colon. Diagnosis of classical HNPCC is based on the Amsterdam
criteria: 3 or more relatives affected by colorectal cancer, one a
first degree relative of the other two; 2 or more generation affected;
1 or more colorectal cancers presenting before 50 years of age;
exclusion of hereditary polyposis syndromes. The term 'suspected HNPCC'
or 'incomplete HNPCC' can be used to describe families who do not or
only partially fulfill the Amsterdam criteria, but in whom a genetic
basis for colon cancer is strongly suspected.
{ECO:0000269|PubMed:19098912}. Note=The disease is caused by variants
affecting the gene represented in this entry. HNPCC8 results from
heterozygous deletion of 3-prime exons of EPCAM and intergenic regions
directly upstream of MSH2, resulting in transcriptional read-through
and epigenetic silencing of MSH2 in tissues expressing EPCAM.
-!- SIMILARITY: Belongs to the EPCAM family. {ECO:0000305}.
-!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
Haematology;
URL="http://atlasgeneticsoncology.org/Genes/TACSTD1ID42459ch2p21.html";
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EMBL; M32325; AAA36151.1; -; mRNA.
EMBL; X14758; CAA32870.1; -; mRNA.
EMBL; M26481; AAA59543.1; -; mRNA.
EMBL; M32306; AAA35723.1; -; mRNA.
EMBL; M33011; AAA35861.1; -; mRNA.
EMBL; M93036; AAB00775.1; -; Genomic_DNA.
EMBL; M93029; AAB00775.1; JOINED; Genomic_DNA.
EMBL; M93030; AAB00775.1; JOINED; Genomic_DNA.
EMBL; M93031; AAB00775.1; JOINED; Genomic_DNA.
EMBL; M93032; AAB00775.1; JOINED; Genomic_DNA.
EMBL; M93033; AAB00775.1; JOINED; Genomic_DNA.
EMBL; M93034; AAB00775.1; JOINED; Genomic_DNA.
EMBL; M93035; AAB00775.1; JOINED; Genomic_DNA.
EMBL; CR542259; CAG47055.1; -; mRNA.
EMBL; CR542283; CAG47078.1; -; mRNA.
EMBL; AC079775; AAY15095.1; -; Genomic_DNA.
EMBL; CH471053; EAX00218.1; -; Genomic_DNA.
EMBL; BC014785; AAH14785.1; -; mRNA.
CCDS; CCDS1833.1; -.
PIR; B48149; B48149.
RefSeq; NP_002345.2; NM_002354.2.
PDB; 4MZV; X-ray; 1.86 A; A=24-265.
PDB; 6I07; X-ray; 2.35 A; C/D=24-265.
PDBsum; 4MZV; -.
PDBsum; 6I07; -.
SMR; P16422; -.
BioGRID; 110250; 10.
CORUM; P16422; -.
IntAct; P16422; 11.
STRING; 9606.ENSP00000263735; -.
ChEMBL; CHEMBL3580493; -.
DrugBank; DB06607; Catumaxomab.
DrugBank; DB11075; Hypromellose.
DrugBank; DB05831; ING-1.
DrugBank; DB05319; Oportuzumab monatox.
DrugBank; DB09336; Technetium Tc-99m nofetumomab merpentan.
GlyConnect; 1217; 34 N-Linked glycans (3 sites).
GlyGen; P16422; 3 sites, 1 N-linked glycan (1 site).
iPTMnet; P16422; -.
MetOSite; P16422; -.
PhosphoSitePlus; P16422; -.
BioMuta; EPCAM; -.
DMDM; 160266056; -.
CPTAC; CPTAC-502; -.
CPTAC; CPTAC-503; -.
EPD; P16422; -.
jPOST; P16422; -.
MassIVE; P16422; -.
MaxQB; P16422; -.
PaxDb; P16422; -.
PeptideAtlas; P16422; -.
PRIDE; P16422; -.
ProteomicsDB; 53359; -.
ABCD; P16422; 12 sequenced antibodies.
Antibodypedia; 3539; 4386 antibodies.
DNASU; 4072; -.
Ensembl; ENST00000263735; ENSP00000263735; ENSG00000119888.
GeneID; 4072; -.
KEGG; hsa:4072; -.
UCSC; uc002rvx.4; human.
CTD; 4072; -.
DisGeNET; 4072; -.
GeneCards; EPCAM; -.
GeneReviews; EPCAM; -.
HGNC; HGNC:11529; EPCAM.
HPA; ENSG00000119888; Tissue enhanced (intestine).
MalaCards; EPCAM; -.
MIM; 185535; gene.
MIM; 613217; phenotype.
MIM; 613244; phenotype.
neXtProt; NX_P16422; -.
OpenTargets; ENSG00000119888; -.
Orphanet; 92050; Congenital tufting enteropathy.
Orphanet; 144; Lynch syndrome.
PharmGKB; PA35493; -.
VEuPathDB; HostDB:ENSG00000119888.10; -.
eggNOG; ENOG502QVSU; Eukaryota.
GeneTree; ENSGT00390000018245; -.
HOGENOM; CLU_075326_0_0_1; -.
InParanoid; P16422; -.
OMA; GRTAIYY; -.
OrthoDB; 1017141at2759; -.
PhylomeDB; P16422; -.
TreeFam; TF332767; -.
PathwayCommons; P16422; -.
Reactome; R-HSA-202733; Cell surface interactions at the vascular wall.
SIGNOR; P16422; -.
BioGRID-ORCS; 4072; 30 hits in 992 CRISPR screens.
ChiTaRS; EPCAM; human.
GeneWiki; Epithelial_cell_adhesion_molecule; -.
GenomeRNAi; 4072; -.
Pharos; P16422; Tbio.
PRO; PR:P16422; -.
Proteomes; UP000005640; Chromosome 2.
RNAct; P16422; protein.
Bgee; ENSG00000119888; Expressed in jejunal mucosa and 211 other tissues.
ExpressionAtlas; P16422; baseline and differential.
Genevisible; P16422; HS.
GO; GO:0016324; C:apical plasma membrane; IDA:MGI.
GO; GO:0016323; C:basolateral plasma membrane; IDA:MGI.
GO; GO:0005923; C:bicellular tight junction; IDA:UniProtKB.
GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0016328; C:lateral plasma membrane; IDA:UniProtKB.
GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO; GO:0098641; F:cadherin binding involved in cell-cell adhesion; IBA:GO_Central.
GO; GO:0044877; F:protein-containing complex binding; IDA:UniProtKB.
GO; GO:0050900; P:leukocyte migration; TAS:Reactome.
GO; GO:2000048; P:negative regulation of cell-cell adhesion mediated by cadherin; IDA:UniProtKB.
GO; GO:0008284; P:positive regulation of cell population proliferation; IDA:UniProtKB.
GO; GO:2000648; P:positive regulation of stem cell proliferation; IMP:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:UniProtKB.
GO; GO:0023019; P:signal transduction involved in regulation of gene expression; IMP:UniProtKB.
GO; GO:0048863; P:stem cell differentiation; IMP:UniProtKB.
CDD; cd00191; TY; 1.
Gene3D; 4.10.800.10; -; 1.
InterPro; IPR043406; EPCAM/Trop-2.
InterPro; IPR041630; EpCAM_N.
InterPro; IPR000716; Thyroglobulin_1.
InterPro; IPR036857; Thyroglobulin_1_sf.
PANTHER; PTHR14168; PTHR14168; 1.
Pfam; PF18635; EpCAM_N; 1.
Pfam; PF00086; Thyroglobulin_1; 1.
SMART; SM00211; TY; 1.
SUPFAM; SSF57610; SSF57610; 1.
PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
1: Evidence at protein level;
3D-structure; Cell junction; Cell membrane; Direct protein sequencing;
Disease variant; Disulfide bond; Glycoprotein;
Hereditary nonpolyposis colorectal cancer; Membrane; Reference proteome;
Repeat; Signal; Tight junction; Transmembrane; Transmembrane helix;
Tumor antigen.
SIGNAL 1..23
/evidence="ECO:0000255"
CHAIN 24..314
/note="Epithelial cell adhesion molecule"
/id="PRO_0000022467"
TOPO_DOM 24..265
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 266..288
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 289..314
/note="Cytoplasmic"
/evidence="ECO:0000255"
DOMAIN 63..135
/note="Thyroglobulin type-1"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00500"
CARBOHYD 74
/note="N-linked (GlcNAc...) asparagine; partial"
/evidence="ECO:0000269|PubMed:11080501,
ECO:0000269|PubMed:18508581"
CARBOHYD 111
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000269|PubMed:11080501,
ECO:0000269|PubMed:18508581"
CARBOHYD 198
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000269|PubMed:18508581,
ECO:0000269|PubMed:19159218"
DISULFID 27..46
/evidence="ECO:0000255|PROSITE-ProRule:PRU00500,
ECO:0000269|PubMed:11080501"
DISULFID 29..59
/evidence="ECO:0000255|PROSITE-ProRule:PRU00500,
ECO:0000269|PubMed:11080501"
DISULFID 38..48
/evidence="ECO:0000255|PROSITE-ProRule:PRU00500,
ECO:0000269|PubMed:11080501"
DISULFID 66..99
/evidence="ECO:0000255|PROSITE-ProRule:PRU00500,
ECO:0000269|PubMed:11080501"
DISULFID 110..116
/evidence="ECO:0000255|PROSITE-ProRule:PRU00500,
ECO:0000269|PubMed:11080501"
DISULFID 118..135
/evidence="ECO:0000255|PROSITE-ProRule:PRU00500,
ECO:0000269|PubMed:11080501"
VARIANT 66
/note="C -> Y (in DIAR5; dbSNP:rs267606785)"
/evidence="ECO:0000269|PubMed:18572020"
/id="VAR_063829"
VARIANT 115
/note="M -> T (in dbSNP:rs1126497)"
/evidence="ECO:0000269|PubMed:15489334,
ECO:0000269|PubMed:2108441, ECO:0000269|PubMed:2463074,
ECO:0000269|PubMed:2469722"
/id="VAR_018329"
MUTAGEN 74
/note="N->A: Changed glycosylation pattern. Complete loss
of glycosylation and substantial decrease in protein
expression; when associated with A-111 and A-198."
/evidence="ECO:0000269|PubMed:18508581"
MUTAGEN 111
/note="N->A: Changed glycosylation pattern. Complete loss
of glycosylation and substantial decrease in protein
expression; when associated with A-74 and A-198."
/evidence="ECO:0000269|PubMed:18508581"
MUTAGEN 198
/note="N->A: Decreased glycosyation, reduced protein
stability and significant decrease in protein expression.
Complete loss of glycosylation and substantial decrease in
protein expression; when associated with A-74 and A-111."
/evidence="ECO:0000269|PubMed:18508581"
CONFLICT 277
/note="I -> M (in Ref. 1; AAA36151/CAA32870 and 2;
AAA59543)"
/evidence="ECO:0000305"
CONFLICT 303
/note="K -> R (in Ref. 6; CAG47055)"
/evidence="ECO:0000305"
STRAND 35..40
/evidence="ECO:0007744|PDB:4MZV"
STRAND 46..50
/evidence="ECO:0007744|PDB:4MZV"
STRAND 56..58
/evidence="ECO:0007744|PDB:4MZV"
HELIX 65..72
/evidence="ECO:0007744|PDB:4MZV"
TURN 73..75
/evidence="ECO:0007744|PDB:4MZV"
STRAND 107..111
/evidence="ECO:0007744|PDB:4MZV"
TURN 112..114
/evidence="ECO:0007744|PDB:4MZV"
STRAND 115..120
/evidence="ECO:0007744|PDB:4MZV"
STRAND 130..132
/evidence="ECO:0007744|PDB:4MZV"
STRAND 141..150
/evidence="ECO:0007744|PDB:4MZV"
HELIX 159..173
/evidence="ECO:0007744|PDB:4MZV"
HELIX 178..180
/evidence="ECO:0007744|PDB:4MZV"
STRAND 181..187
/evidence="ECO:0007744|PDB:4MZV"
STRAND 190..196
/evidence="ECO:0007744|PDB:4MZV"
TURN 199..201
/evidence="ECO:0007744|PDB:4MZV"
HELIX 209..220
/evidence="ECO:0007744|PDB:4MZV"
STRAND 226..228
/evidence="ECO:0007744|PDB:4MZV"
STRAND 234..237
/evidence="ECO:0007744|PDB:6I07"
HELIX 244..246
/evidence="ECO:0007744|PDB:4MZV"
STRAND 248..255
/evidence="ECO:0007744|PDB:4MZV"
SEQUENCE 314 AA; 34932 MW; 023FCE418B2F1079 CRC64;
MAPPQVLAFG LLLAAATATF AAAQEECVCE NYKLAVNCFV NNNRQCQCTS VGAQNTVICS
KLAAKCLVMK AEMNGSKLGR RAKPEGALQN NDGLYDPDCD ESGLFKAKQC NGTSMCWCVN
TAGVRRTDKD TEITCSERVR TYWIIIELKH KAREKPYDSK SLRTALQKEI TTRYQLDPKF
ITSILYENNV ITIDLVQNSS QKTQNDVDIA DVAYYFEKDV KGESLFHSKK MDLTVNGEQL
DLDPGQTLIY YVDEKAPEFS MQGLKAGVIA VIVVVVIAVV AGIVVLVISR KKRMAKYEKA
EIKEMGEMHR ELNA


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WP1365: Calcium Regulation in the Cardiac Cell
WP326: Calcium Regulation in the Cardiac Cell
WP1424: Globo Sphingolipid Metabolism
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WP1185: Integrin-mediated cell adhesion
WP1043: Calcium Regulation in the Cardiac Cell
WP1386: Integrin-mediated cell adhesion
WP74: Integrin-mediated cell adhesion
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WP1069: Integrin-mediated cell adhesion
WP553: Calcium Regulation in the Cardiac Cell
WP6: Integrin-mediated cell adhesion
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Related Genes :
[EPCAM GA733-2 M1S2 M4S1 MIC18 TACSTD1 TROP1] Epithelial cell adhesion molecule (Ep-CAM) (Adenocarcinoma-associated antigen) (Cell surface glycoprotein Trop-1) (Epithelial cell surface antigen) (Epithelial glycoprotein) (EGP) (Epithelial glycoprotein 314) (EGP314) (hEGP314) (KS 1/4 antigen) (KSA) (Major gastrointestinal tumor-associated protein GA733-2) (Tumor-associated calcium signal transducer 1) (CD antigen CD326)
[MUC1 PUM] Mucin-1 (MUC-1) (Breast carcinoma-associated antigen DF3) (Cancer antigen 15-3) (CA 15-3) (Carcinoma-associated mucin) (Episialin) (H23AG) (Krebs von den Lungen-6) (KL-6) (PEMT) (Peanut-reactive urinary mucin) (PUM) (Polymorphic epithelial mucin) (PEM) (Tumor-associated epithelial membrane antigen) (EMA) (Tumor-associated mucin) (CD antigen CD227) [Cleaved into: Mucin-1 subunit alpha (MUC1-NT) (MUC1-alpha); Mucin-1 subunit beta (MUC1-beta) (MUC1-CT)]
[Ceacam1 Bgp Bgp1] Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (Biliary glycoprotein D) (MHVR1) (Murine hepatitis virus receptor) (MHV-R) (CD antigen CD66a)
[BCAM LU MSK19] Basal cell adhesion molecule (Auberger B antigen) (B-CAM cell surface glycoprotein) (F8/G253 antigen) (Lutheran antigen) (Lutheran blood group glycoprotein) (CD antigen CD239)
[DDR1 CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE] Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a)
[CEACAM1 BGP BGP1] Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (CD antigen CD66a)
[Ceacam1] Carcinoembryonic antigen-related cell adhesion molecule 1 (ATP-dependent taurocolate-carrier protein) (Cell-CAM 105) (C-CAM 105) (Ecto-ATPase) (GP110) (pp120) (CD antigen CD66a)
[CD44 LHR MDU2 MDU3 MIC4] CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)
[STEAP3 TSAP6] Metalloreductase STEAP3 (EC 1.16.1.-) (Dudulin-2) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde)
[BSG UNQ6505/PRO21383] Basigin (5F7) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (Hepatoma-associated antigen) (HAb18G) (Leukocyte activation antigen M6) (OK blood group antigen) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (CD antigen CD147)
[SLC3A2 MDU1] 4F2 cell-surface antigen heavy chain (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98)
[CD4] T-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3) (CD antigen CD4)
[DDR1 EDDR1] Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Discoidin receptor tyrosine kinase) (Tyrosine kinase DDR) (CD antigen CD167a)
[Cd4] T-cell surface glycoprotein CD4 (T-cell differentiation antigen L3T4) (T-cell surface antigen T4/Leu-3) (CD antigen CD4)
[Cd4] T-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3) (W3/25 antigen) (CD antigen CD4)
[CD1A] T-cell surface glycoprotein CD1a (T-cell surface antigen T6/Leu-6) (hTa1 thymocyte antigen) (CD antigen CD1a)
[TP53 P53] Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
[CD8A MAL] T-cell surface glycoprotein CD8 alpha chain (T-lymphocyte differentiation antigen T8/Leu-2) (CD antigen CD8a)
[ALCAM MEMD] CD166 antigen (Activated leukocyte cell adhesion molecule) (CD antigen CD166)
[CD4] T-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3) (CD antigen CD4)
[Cd14] Monocyte differentiation antigen CD14 (Myeloid cell-specific leucine-rich glycoprotein) (CD antigen CD14)
[Cd79a Iga Mb-1] B-cell antigen receptor complex-associated protein alpha chain (Ig-alpha) (MB-1 membrane glycoprotein) (Membrane-bound immunoglobulin-associated protein) (Surface IgM-associated protein) (CD antigen CD79a)
[CD4] T-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3) (CD antigen CD4)
[CD3E T3E] T-cell surface glycoprotein CD3 epsilon chain (T-cell surface antigen T3/Leu-4 epsilon chain) (CD antigen CD3e)
[CD40 TNFRSF5] Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (Bp50) (CD40L receptor) (CDw40) (CD antigen CD40)
[Enpp1 Npps Pc1 Pdnp1] Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (E-NPP 1) (Lymphocyte antigen 41) (Ly-41) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Cleaved into: Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form] [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (NPPase) (EC 3.6.1.9) (Nucleotide diphosphatase)]
[Cd44 Ly-24] CD44 antigen (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Hermes antigen) (Hyaluronate receptor) (Lymphocyte antigen 24) (Ly-24) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)
[Slc3a2 Mdu1] 4F2 cell-surface antigen heavy chain (4F2hc) (Solute carrier family 3 member 2) (CD antigen CD98)
[Ceacam2 Bgp2] Carcinoembryonic antigen-related cell adhesion molecule 2 (CEA-related cell adhesion molecule 2) (Biliary glycoprotein 2) (BGP-2)
[ITGAM CD11B CR3A] Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (Neutrophil adherence receptor) (CD antigen CD11b)

Bibliography :