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Erythropoietin

 G9JKG7_HUMAN            Unreviewed;       193 AA.
G9JKG7;
22-FEB-2012, integrated into UniProtKB/TrEMBL.
22-FEB-2012, sequence version 1.
13-FEB-2019, entry version 67.
RecName: Full=Erythropoietin {ECO:0000256|PIRNR:PIRNR001951};
Name=EPO {ECO:0000313|EMBL:EAW76493.1};
ORFNames=hCG_20446 {ECO:0000313|EMBL:EAW76493.1};
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606 {ECO:0000313|EMBL:AEU17862.1};
[1] {ECO:0000313|EMBL:EAW76493.1}
NUCLEOTIDE SEQUENCE.
PubMed=11181995; DOI=10.1126/science.1058040;
Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G.,
Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D.,
Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q.,
Kodira C.D., Zheng X.H., Chen L., Skupski M., Subramanian G.,
Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S.,
Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J.,
Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R.,
Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A.,
Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K.,
Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V.,
Brandon R., Cargill M., Chandramouliswaran I., Charlab R.,
Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K.,
Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z.,
Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A.,
Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V.,
Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B.,
Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J.,
Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C.,
Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L.,
Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S.,
Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A.,
Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D.,
Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L.,
Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N.,
Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S.,
Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F.,
Kline L., Koduru S., Love A., Mann F., May D., McCawley S.,
McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K.,
Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M.,
Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C.,
Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N.,
Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M.,
Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F.,
Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A.,
Mi H., Lazareva B., Hatton T., Narechania A., Diemer K.,
Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R.,
Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J.,
Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H.,
Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D.,
Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A.,
Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S.,
Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L.,
Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W.,
McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M.,
Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J.,
Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E.,
Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.;
"The sequence of the human genome.";
Science 291:1304-1351(2001).
[2] {ECO:0000313|EMBL:EAW76493.1}
NUCLEOTIDE SEQUENCE.
Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|EMBL:AEU17862.1}
NUCLEOTIDE SEQUENCE.
Naveed Y., Hanif K., Noor S., Bashir B., Hussain T., Qadri I.;
Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Hormone involved in the regulation of erythrocyte
proliferation and differentiation and the maintenance of a
physiological level of circulating erythrocyte mass. Binds to EPOR
leading to EPOR dimerization and JAK2 activation thereby
activating specific downstream effectors, including STAT1 and
STAT3. {ECO:0000256|PIRNR:PIRNR001951}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR001951}.
-!- SIMILARITY: Belongs to the EPO/TPO family.
{ECO:0000256|PIRNR:PIRNR001951}.
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EMBL; JN849371; AEU17862.1; -; mRNA.
EMBL; CH471091; EAW76493.1; -; Genomic_DNA.
RefSeq; NP_000790.2; NM_000799.2.
UniGene; Hs.2303; -.
Allergome; 11697; Hom s EPO.
GeneID; 2056; -.
KEGG; hsa:2056; -.
CTD; 2056; -.
EuPathDB; HostDB:ENSG00000130427.2; -.
eggNOG; ENOG410IHW5; Eukaryota.
eggNOG; ENOG410XTRF; LUCA.
KO; K05437; -.
OMA; MGCAEGC; -.
OrthoDB; 1175751at2759; -.
GenomeRNAi; 2056; -.
Bgee; ENSG00000130427; Expressed in 66 organ(s), highest expression level in right lobe of liver.
GO; GO:0044297; C:cell body; IEA:Ensembl.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0005128; F:erythropoietin receptor binding; IEA:InterPro.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:0030295; F:protein kinase activator activity; IEA:Ensembl.
GO; GO:0006953; P:acute-phase response; IEA:Ensembl.
GO; GO:0007568; P:aging; IEA:Ensembl.
GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
GO; GO:0007566; P:embryo implantation; IEA:Ensembl.
GO; GO:0043249; P:erythrocyte maturation; IEA:UniProtKB-UniRule.
GO; GO:0042541; P:hemoglobin biosynthetic process; IEA:Ensembl.
GO; GO:0033033; P:negative regulation of myeloid cell apoptotic process; IEA:Ensembl.
GO; GO:1901215; P:negative regulation of neuron death; IEA:Ensembl.
GO; GO:0018105; P:peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0010976; P:positive regulation of neuron projection development; IEA:Ensembl.
GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0048678; P:response to axon injury; IEA:Ensembl.
GO; GO:0071548; P:response to dexamethasone; IEA:Ensembl.
GO; GO:0051602; P:response to electrical stimulus; IEA:Ensembl.
GO; GO:0043627; P:response to estrogen; IEA:Ensembl.
GO; GO:0055093; P:response to hyperoxia; IEA:Ensembl.
GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
GO; GO:0070555; P:response to interleukin-1; IEA:Ensembl.
GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
GO; GO:0009651; P:response to salt stress; IEA:Ensembl.
GO; GO:0033574; P:response to testosterone; IEA:Ensembl.
GO; GO:0033189; P:response to vitamin A; IEA:Ensembl.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR019767; EPO/TPO_CS.
InterPro; IPR001323; EPO_TPO.
InterPro; IPR003013; Erythroptn.
PANTHER; PTHR10370; PTHR10370; 1.
Pfam; PF00758; EPO_TPO; 1.
PIRSF; PIRSF001951; EPO; 1.
PRINTS; PR00272; ERYTHROPTN.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00817; EPO_TPO; 1.
2: Evidence at transcript level;
Disulfide bond {ECO:0000256|PIRSR:PIRSR001951-1};
Erythrocyte maturation {ECO:0000256|PIRNR:PIRNR001951};
Hormone {ECO:0000256|PIRNR:PIRNR001951};
Secreted {ECO:0000256|PIRNR:PIRNR001951};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 27 {ECO:0000256|SAM:SignalP}.
CHAIN 28 193 Erythropoietin.
{ECO:0000256|SAM:SignalP}.
/FTId=PRO_5014304362.
DISULFID 34 188 {ECO:0000256|PIRSR:PIRSR001951-1}.
DISULFID 56 60 {ECO:0000256|PIRSR:PIRSR001951-1}.
SEQUENCE 193 AA; 21307 MW; C91F0E4C26A52033 CRC64;
MGVHECPAWL WLLLSLLSLP LGLPVLGAPP RLICDSRVLE RYLLEAKEAE NITTGCAEHC
SLNENITVPD TKVNFYAWKR MEVGQQAVEV WQGLALLSEA VLRGQALLVN SSQPWEPLQL
HVDKAVSGLR SLTTLLRALG AQKEAISPPD AASAAPLRTI TADTFRKLFR VYSNFLRGKL
KLYTGEACRT GDR


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[EPOR] Erythropoietin receptor (EPO-R)
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[EPOR] Erythropoietin receptor (EPO-R)
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Bibliography :
[30899874] Interleukin-6 Contributes to the Development of Anemia in Juvenile CKD.
[30898666] Fetal chronic hypoxia and oxidative stress in diabetic pregnancy. Could fetal erythropoietin improve offspring outcomes?
[30894885] Renal anemia and hydration status in non-dialysis chronic kidney disease: Is there a link?
[30894794] Antierythropoietin Antibody Production Is Not Associated with Malaria and Malaria-Related Anaemia in Humans.
[30894315] Erythropoietin attenuates high glucose-induced oxidative stress and inhibition of osteogenic differentiation in periodontal ligament stem cell (PDLSCs).
[30893598] Enhanced Renewal of Erythroid Progenitors in Myelodysplastic Anemia by Peripheral Serotonin.
[30893233] Pharmacological Attenuation of Electrical Effects in a Model of Compression Neuropathy.
[30888086] Recipient's effects on stored red blood cell performance: the case of uremic plasma.
[30885824] Early blood transcriptomic signature predicts patients' outcome after out-of-hospital cardiac arrest.
[30881495] Silencing of promotes the epithelial-mesenchymal transition of skin squamous cell carcinoma-derived A431 cells.
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