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Erythropoietin

 J9NYY7_CANLF            Unreviewed;       205 AA.
J9NYY7;
31-OCT-2012, integrated into UniProtKB/TrEMBL.
31-OCT-2012, sequence version 1.
13-FEB-2019, entry version 36.
RecName: Full=Erythropoietin {ECO:0000256|PIRNR:PIRNR001951};
Name=EPO {ECO:0000313|Ensembl:ENSCAFP00000038507,
ECO:0000313|VGNC:VGNC:40422};
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000038507, ECO:0000313|Proteomes:UP000002254};
[1] {ECO:0000313|Ensembl:ENSCAFP00000038507, ECO:0000313|Proteomes:UP000002254}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000038507,
ECO:0000313|Proteomes:UP000002254};
PubMed=16341006; DOI=10.1038/nature04338;
Broad Sequencing Platform;
Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C.,
Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A.,
Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F.,
Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A.,
Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M.,
Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L.,
Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J.,
Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L.,
Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A.,
Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L.,
Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N.,
Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A.,
Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N.,
Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N.,
Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K.,
Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G.,
Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E.,
Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C.,
Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L.,
Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C.,
Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T.,
Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J.,
Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J.,
Marabella R., Maru K., Matthews C., McDonough S., Mehta T.,
Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K.,
Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J.,
Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K.,
Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F.,
Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C.,
Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S.,
Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J.,
Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S.,
Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S.,
Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T.,
Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T.,
Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X.,
Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.;
"Genome sequence, comparative analysis and haplotype structure of the
domestic dog.";
Nature 438:803-819(2005).
[2] {ECO:0000313|Ensembl:ENSCAFP00000038507}
IDENTIFICATION.
STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000038507};
Ensembl;
Submitted (SEP-2012) to UniProtKB.
-!- FUNCTION: Hormone involved in the regulation of erythrocyte
proliferation and differentiation and the maintenance of a
physiological level of circulating erythrocyte mass. Binds to EPOR
leading to EPOR dimerization and JAK2 activation thereby
activating specific downstream effectors, including STAT1 and
STAT3. {ECO:0000256|PIRNR:PIRNR001951}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR001951}.
-!- SIMILARITY: Belongs to the EPO/TPO family.
{ECO:0000256|PIRNR:PIRNR001951}.
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EMBL; AAEX03004272; -; NOT_ANNOTATED_CDS; Genomic_DNA.
Ensembl; ENSCAFT00000045767; ENSCAFP00000038507; ENSCAFG00000014203.
VGNC; VGNC:40422; EPO.
eggNOG; ENOG410IHW5; Eukaryota.
eggNOG; ENOG410XTRF; LUCA.
GeneTree; ENSGT00390000017226; -.
OMA; MGCAEGC; -.
TreeFam; TF333413; -.
Reactome; R-CFA-9027276; Erythropoietin activates Phosphoinositide-3-kinase (PI3K).
Reactome; R-CFA-9027284; Erythropoietin activates RAS.
Proteomes; UP000002254; Chromosome 6.
Bgee; ENSCAFG00000014203; Expressed in 1 organ(s), highest expression level in adult mammalian kidney.
GO; GO:0009986; C:cell surface; IEA:Ensembl.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0005125; F:cytokine activity; IEA:Ensembl.
GO; GO:0005128; F:erythropoietin receptor binding; IEA:Ensembl.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:0030295; F:protein kinase activator activity; IEA:Ensembl.
GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
GO; GO:0071474; P:cellular hyperosmotic response; IEA:Ensembl.
GO; GO:0007566; P:embryo implantation; IEA:Ensembl.
GO; GO:0043249; P:erythrocyte maturation; IEA:UniProtKB-UniRule.
GO; GO:0038162; P:erythropoietin-mediated signaling pathway; IEA:Ensembl.
GO; GO:0042541; P:hemoglobin biosynthetic process; IEA:Ensembl.
GO; GO:0010523; P:negative regulation of calcium ion transport into cytosol; IEA:Ensembl.
GO; GO:2001258; P:negative regulation of cation channel activity; IEA:Ensembl.
GO; GO:1902251; P:negative regulation of erythrocyte apoptotic process; IEA:Ensembl.
GO; GO:1902219; P:negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0018105; P:peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
GO; GO:0046579; P:positive regulation of Ras protein signal transduction; IEA:Ensembl.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR019767; EPO/TPO_CS.
InterPro; IPR001323; EPO_TPO.
InterPro; IPR003013; Erythroptn.
PANTHER; PTHR10370; PTHR10370; 1.
Pfam; PF00758; EPO_TPO; 1.
PIRSF; PIRSF001951; EPO; 1.
PRINTS; PR00272; ERYTHROPTN.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00817; EPO_TPO; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000002254};
Disulfide bond {ECO:0000256|PIRSR:PIRSR001951-1};
Erythrocyte maturation {ECO:0000256|PIRNR:PIRNR001951};
Hormone {ECO:0000256|PIRNR:PIRNR001951};
Reference proteome {ECO:0000313|Proteomes:UP000002254};
Secreted {ECO:0000256|PIRNR:PIRNR001951};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 39 {ECO:0000256|SAM:SignalP}.
CHAIN 40 205 Erythropoietin.
{ECO:0000256|SAM:SignalP}.
/FTId=PRO_5003825844.
DISULFID 46 200 {ECO:0000256|PIRSR:PIRSR001951-1}.
DISULFID 68 72 {ECO:0000256|PIRSR:PIRSR001951-1}.
SEQUENCE 205 AA; 22572 MW; E3A00B366AD73844 CRC64;
MCEPAPPPTQ SAWHSFPECP ALFLLLSLLL LPLGLPVLGA PPRLICDSRV LERYILEARE
AENVTMGCAQ GCSFSENITV PDTKVNFYTW KRMDVGQQAL EVWQGLALLS EAILRGQALL
ANASQPSETP QLHVDKAVSS LRSLTSLLRA LGAQKEAMSL PEEASPAPLR TFTVDTLCKL
FRIYSNFLRG KLTLYTGEAC RRGDR


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Bibliography :
[30899874] Interleukin-6 Contributes to the Development of Anemia in Juvenile CKD.
[30898666] Fetal chronic hypoxia and oxidative stress in diabetic pregnancy. Could fetal erythropoietin improve offspring outcomes?
[30894885] Renal anemia and hydration status in non-dialysis chronic kidney disease: Is there a link?
[30894794] Antierythropoietin Antibody Production Is Not Associated with Malaria and Malaria-Related Anaemia in Humans.
[30894315] Erythropoietin attenuates high glucose-induced oxidative stress and inhibition of osteogenic differentiation in periodontal ligament stem cell (PDLSCs).
[30893598] Enhanced Renewal of Erythroid Progenitors in Myelodysplastic Anemia by Peripheral Serotonin.
[30893233] Pharmacological Attenuation of Electrical Effects in a Model of Compression Neuropathy.
[30888086] Recipient's effects on stored red blood cell performance: the case of uremic plasma.
[30885824] Early blood transcriptomic signature predicts patients' outcome after out-of-hospital cardiac arrest.
[30881495] Silencing of promotes the epithelial-mesenchymal transition of skin squamous cell carcinoma-derived A431 cells.
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