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Estradiol 17-beta-dehydrogenase 11 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 11) (17-beta-HSD 11) (17bHSD11) (17betaHSD11) (17-beta-hydroxysteroid dehydrogenase XI) (17-beta-HSD XI) (17betaHSDXI) (Cutaneous T-cell lymphoma-associated antigen HD-CL-03) (CTCL-associated antigen HD-CL-03) (Dehydrogenase/reductase SDR family member 8) (Retinal short-chain dehydrogenase/reductase 2) (retSDR2) (Short chain dehydrogenase/reductase family 16C member 2)

 DHB11_HUMAN             Reviewed;         300 AA.
Q8NBQ5; Q96HF6; Q9UKU4;
16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
18-MAY-2010, sequence version 3.
07-APR-2021, entry version 162.
RecName: Full=Estradiol 17-beta-dehydrogenase 11;
EC=1.1.1.62;
AltName: Full=17-beta-hydroxysteroid dehydrogenase 11;
Short=17-beta-HSD 11;
Short=17bHSD11;
Short=17betaHSD11;
AltName: Full=17-beta-hydroxysteroid dehydrogenase XI;
Short=17-beta-HSD XI;
Short=17betaHSDXI {ECO:0000303|PubMed:12697717};
AltName: Full=Cutaneous T-cell lymphoma-associated antigen HD-CL-03;
Short=CTCL-associated antigen HD-CL-03;
AltName: Full=Dehydrogenase/reductase SDR family member 8;
AltName: Full=Retinal short-chain dehydrogenase/reductase 2;
Short=retSDR2;
AltName: Full=Short chain dehydrogenase/reductase family 16C member 2;
Flags: Precursor;
Name=HSD17B11; Synonyms=DHRS8, PAN1B, SDR16C2;
ORFNames=PSEC0029, UNQ207/PRO233;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
TISSUE=Retina;
PubMed=10800688; DOI=10.1016/s0076-6879(00)16736-9;
Haeseleer F., Palczewski K.;
"Short-chain dehydrogenases/reductases in retina.";
Methods Enzymol. 316:372-383(2000).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Lymphoma;
PubMed=14996095; DOI=10.1111/j.1365-2133.2004.05651.x;
Hartmann T.B., Thiel D., Dummer R., Schadendorf D., Eichmueller S.;
"SEREX identification of new tumour-associated antigens in cutaneous T-cell
lymphoma.";
Br. J. Dermatol. 150:252-258(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=12975309; DOI=10.1101/gr.1293003;
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to
identify novel human secreted and transmembrane proteins: a bioinformatics
assessment.";
Genome Res. 13:2265-2270(2003).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Teratocarcinoma;
PubMed=16303743; DOI=10.1093/dnares/12.2.117;
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
Isogai T.;
"Signal sequence and keyword trap in silico for selection of full-length
human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA
libraries.";
DNA Res. 12:117-126(2005).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15815621; DOI=10.1038/nature03466;
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2 and
4.";
Nature 434:724-731(2005).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Bone marrow, Colon, Kidney, Liver, and Urinary bladder;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
TISSUE SPECIFICITY.
PubMed=9888557; DOI=10.3109/07435809809032667;
Li K.X.Z., Smith R.E., Krozowski Z.S.;
"Cloning and expression of a novel tissue specific 17beta-hydroxysteroid
dehydrogenase.";
Endocr. Res. 24:663-667(1998).
[8]
TISSUE SPECIFICITY.
PubMed=11165019; DOI=10.1016/s0303-7207(00)00417-2;
Brereton P., Suzuki T., Sasano H., Li K., Duarte C., Obeyesekere V.,
Haeseleer F., Palczewski K., Smith I., Komesaroff P., Krozowski Z.;
"Pan1b (17betaHSD11)-enzymatic activity and distribution in the lung.";
Mol. Cell. Endocrinol. 171:111-117(2001).
[9]
ENZYME ACTIVITY IN VITRO, AND TISSUE SPECIFICITY.
PubMed=12697717; DOI=10.1210/en.2002-221030;
Chai Z., Brereton P., Suzuki T., Sasano H., Obeyesekere V., Escher G.,
Saffery R., Fuller P., Enriquez C., Krozowski Z.;
"17 beta-hydroxysteroid dehydrogenase type XI localizes to human
steroidogenic cells.";
Endocrinology 144:2084-2091(2003).
[10]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21269460; DOI=10.1186/1752-0509-5-17;
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
Bennett K.L., Superti-Furga G., Colinge J.;
"Initial characterization of the human central proteome.";
BMC Syst. Biol. 5:17-17(2011).
[11]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
Ye M., Zou H.;
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
phosphoproteome.";
J. Proteomics 96:253-262(2014).
[12]
X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 28-275.
Lukacik P., Bunkoczi G., Kavanagh K., Ng S., Von delft F., Bray J.,
Edwards A., Arrowsmith C., Sundstrom M., Oppermann U.;
"Crystal structure of human 17-beta-hydroxysteroid dehydrogenase type XI.";
Submitted (DEC-2004) to the PDB data bank.
-!- FUNCTION: Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to
androsterone in vitro, suggesting that it may participate in androgen
metabolism during steroidogenesis. May act by metabolizing compounds
that stimulate steroid synthesis and/or by generating metabolites that
inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-
dione (4-androste-3,17-dione), and only a slight activity toward
testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell
lymphoma.
-!- CATALYTIC ACTIVITY:
Reaction=17beta-estradiol + NAD(+) = estrone + H(+) + NADH;
Xref=Rhea:RHEA:24612, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469,
ChEBI:CHEBI:17263, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.62;
Evidence={ECO:0000269|PubMed:12697717};
-!- CATALYTIC ACTIVITY:
Reaction=17beta-estradiol + NADP(+) = estrone + H(+) + NADPH;
Xref=Rhea:RHEA:24616, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469,
ChEBI:CHEBI:17263, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.62;
Evidence={ECO:0000269|PubMed:12697717};
-!- INTERACTION:
Q8NBQ5; Q15848: ADIPOQ; NbExp=3; IntAct=EBI-1052304, EBI-10827839;
Q8NBQ5; Q9NRZ7: AGPAT3; NbExp=3; IntAct=EBI-1052304, EBI-2803601;
Q8NBQ5; Q9NRZ5: AGPAT4; NbExp=3; IntAct=EBI-1052304, EBI-1754287;
Q8NBQ5; Q86W74-2: ANKRD46; NbExp=3; IntAct=EBI-1052304, EBI-12109402;
Q8NBQ5; Q12981: BNIP1; NbExp=3; IntAct=EBI-1052304, EBI-4402847;
Q8NBQ5; Q96MX0: CMTM3; NbExp=3; IntAct=EBI-1052304, EBI-7247651;
Q8NBQ5; Q8N6G5: CSGALNACT2; NbExp=3; IntAct=EBI-1052304, EBI-10267100;
Q8NBQ5; Q9BQA9: CYBC1; NbExp=3; IntAct=EBI-1052304, EBI-2680384;
Q8NBQ5; Q6ZPD8: DGAT2L6; NbExp=3; IntAct=EBI-1052304, EBI-12831978;
Q8NBQ5; Q8N5I4: DHRSX; NbExp=3; IntAct=EBI-1052304, EBI-3923585;
Q8NBQ5; Q08426: EHHADH; NbExp=3; IntAct=EBI-1052304, EBI-2339219;
Q8NBQ5; Q9UKR5: ERG28; NbExp=3; IntAct=EBI-1052304, EBI-711490;
Q8NBQ5; Q96D05-2: FAM241B; NbExp=3; IntAct=EBI-1052304, EBI-12118888;
Q8NBQ5; Q8WWP7: GIMAP1; NbExp=3; IntAct=EBI-1052304, EBI-11991950;
Q8NBQ5; Q6ZVE7: GOLT1A; NbExp=3; IntAct=EBI-1052304, EBI-17231387;
Q8NBQ5; Q9BUP3-3: HTATIP2; NbExp=3; IntAct=EBI-1052304, EBI-12937691;
Q8NBQ5; Q9UIQ6-2: LNPEP; NbExp=3; IntAct=EBI-1052304, EBI-12133176;
Q8NBQ5; O75427: LRCH4; NbExp=3; IntAct=EBI-1052304, EBI-718707;
Q8NBQ5; P11836: MS4A1; NbExp=3; IntAct=EBI-1052304, EBI-2808234;
Q8NBQ5; Q99519: NEU1; NbExp=3; IntAct=EBI-1052304, EBI-721517;
Q8NBQ5; Q9P0S3: ORMDL1; NbExp=3; IntAct=EBI-1052304, EBI-1054848;
Q8NBQ5; Q9NUU6: OTULINL; NbExp=3; IntAct=EBI-1052304, EBI-6916492;
Q8NBQ5; Q04941: PLP2; NbExp=3; IntAct=EBI-1052304, EBI-608347;
Q8NBQ5; O60831: PRAF2; NbExp=3; IntAct=EBI-1052304, EBI-2506064;
Q8NBQ5; P43378: PTPN9; NbExp=3; IntAct=EBI-1052304, EBI-742898;
Q8NBQ5; Q8IV61: RASGRP3; NbExp=3; IntAct=EBI-1052304, EBI-1047876;
Q8NBQ5; Q96LZ7: RMDN2; NbExp=3; IntAct=EBI-1052304, EBI-2806908;
Q8NBQ5; Q5QGT7: RTP2; NbExp=3; IntAct=EBI-1052304, EBI-10244780;
Q8NBQ5; Q96IW7: SEC22A; NbExp=3; IntAct=EBI-1052304, EBI-8652744;
Q8NBQ5; O75396: SEC22B; NbExp=3; IntAct=EBI-1052304, EBI-1058865;
Q8NBQ5; P05121: SERPINE1; NbExp=3; IntAct=EBI-1052304, EBI-953978;
Q8NBQ5; Q6FHJ7: SFRP4; NbExp=3; IntAct=EBI-1052304, EBI-2854879;
Q8NBQ5; O95562: SFT2D2; NbExp=3; IntAct=EBI-1052304, EBI-4402330;
Q8NBQ5; A0A1P0AYU5: SFXN3; NbExp=3; IntAct=EBI-1052304, EBI-14193895;
Q8NBQ5; Q96BI1: SLC22A18; NbExp=3; IntAct=EBI-1052304, EBI-11721845;
Q8NBQ5; Q96AG3: SLC25A46; NbExp=3; IntAct=EBI-1052304, EBI-10281975;
Q8NBQ5; Q8IWU4: SLC30A8; NbExp=3; IntAct=EBI-1052304, EBI-10262251;
Q8NBQ5; P0DN84: STRIT1; NbExp=3; IntAct=EBI-1052304, EBI-12200293;
Q8NBQ5; Q13190: STX5; NbExp=3; IntAct=EBI-1052304, EBI-714206;
Q8NBQ5; O15400: STX7; NbExp=3; IntAct=EBI-1052304, EBI-3221827;
Q8NBQ5; Q8N2H4: SYS1; NbExp=3; IntAct=EBI-1052304, EBI-13075176;
Q8NBQ5; A0PK00: TMEM120B; NbExp=3; IntAct=EBI-1052304, EBI-10171534;
Q8NBQ5; Q5BJH2-2: TMEM128; NbExp=3; IntAct=EBI-1052304, EBI-10694905;
Q8NBQ5; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-1052304, EBI-8638294;
Q8NBQ5; Q9NRX6: TMEM167B; NbExp=3; IntAct=EBI-1052304, EBI-17684533;
Q8NBQ5; Q969S6: TMEM203; NbExp=3; IntAct=EBI-1052304, EBI-12274070;
Q8NBQ5; Q9NWH2: TMEM242; NbExp=3; IntAct=EBI-1052304, EBI-10315004;
Q8NBQ5; Q69YG0: TMEM42; NbExp=3; IntAct=EBI-1052304, EBI-12038591;
Q8NBQ5; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-1052304, EBI-2852148;
Q8NBQ5; Q6PI78: TMEM65; NbExp=3; IntAct=EBI-1052304, EBI-6656213;
Q8NBQ5; Q9Y320: TMX2; NbExp=3; IntAct=EBI-1052304, EBI-6447886;
Q8NBQ5; Q6ZUI0: TPRG1; NbExp=3; IntAct=EBI-1052304, EBI-17249488;
Q8NBQ5; P49638: TTPA; NbExp=3; IntAct=EBI-1052304, EBI-10210710;
Q8NBQ5; Q9NYZ1: TVP23B; NbExp=3; IntAct=EBI-1052304, EBI-11343401;
Q8NBQ5; Q53HI1: UNC50; NbExp=3; IntAct=EBI-1052304, EBI-7601760;
Q8NBQ5; Q9P0L0: VAPA; NbExp=3; IntAct=EBI-1052304, EBI-1059156;
Q8NBQ5; O95070: YIF1A; NbExp=3; IntAct=EBI-1052304, EBI-2799703;
Q8NBQ5; Q96EC8: YIPF6; NbExp=3; IntAct=EBI-1052304, EBI-751210;
Q8NBQ5; Q6UX98: ZDHHC24; NbExp=3; IntAct=EBI-1052304, EBI-10254561;
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum
{ECO:0000250|UniProtKB:Q9EQ06}. Lipid droplet
{ECO:0000250|UniProtKB:Q9EQ06}. Note=Redistributed from the endoplasmic
reticulum to lipids droplets in the cell upon induction of lipids
droplet formation. {ECO:0000250|UniProtKB:Q9EQ06}.
-!- TISSUE SPECIFICITY: Present at high level in steroidogenic cells such
as syncytiotrophoblasts, sebaceous gland, Leydig cells, and granulosa
cells of the dominant follicle and corpus luteum. In lung, it is
detected in the ciliated epithelium and in acini of adult trachea, in
bronchioles, but not in alveoli. In the eye, it is detected in the
nonpigmented epithelium of the ciliary body and, at lower level, in the
inner nuclear layer of the retina (at protein level). Widely expressed.
Highly expressed in retina, pancreas, kidney, liver, lung, adrenal,
small intestine, ovary and heart. {ECO:0000269|PubMed:10800688,
ECO:0000269|PubMed:11165019, ECO:0000269|PubMed:12697717,
ECO:0000269|PubMed:9888557}.
-!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
family. 17-beta-HSD 3 subfamily. {ECO:0000305}.
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EMBL; AF126780; AAF06939.1; -; mRNA.
EMBL; AF273056; AAM44459.1; -; mRNA.
EMBL; AY358553; AAQ88917.1; -; mRNA.
EMBL; AK075348; BAC11560.1; -; mRNA.
EMBL; AC108516; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC008650; AAH08650.1; -; mRNA.
EMBL; BC014327; AAH14327.1; -; mRNA.
EMBL; BC016367; AAH16367.1; -; mRNA.
EMBL; BC021673; AAH21673.1; -; mRNA.
EMBL; BC036001; AAH36001.1; -; mRNA.
CCDS; CCDS3619.1; -.
RefSeq; NP_057329.3; NM_016245.4.
PDB; 1YB1; X-ray; 1.95 A; A/B=28-275.
PDBsum; 1YB1; -.
SMR; Q8NBQ5; -.
BioGRID; 119349; 83.
IntAct; Q8NBQ5; 71.
MINT; Q8NBQ5; -.
STRING; 9606.ENSP00000351035; -.
DrugBank; DB02854; Aetiocholanolone.
iPTMnet; Q8NBQ5; -.
PhosphoSitePlus; Q8NBQ5; -.
SwissPalm; Q8NBQ5; -.
BioMuta; HSD17B11; -.
DMDM; 296439374; -.
EPD; Q8NBQ5; -.
jPOST; Q8NBQ5; -.
MassIVE; Q8NBQ5; -.
MaxQB; Q8NBQ5; -.
PaxDb; Q8NBQ5; -.
PeptideAtlas; Q8NBQ5; -.
PRIDE; Q8NBQ5; -.
ProteomicsDB; 72809; -.
Antibodypedia; 14449; 191 antibodies.
DNASU; 51170; -.
Ensembl; ENST00000358290; ENSP00000351035; ENSG00000198189.
GeneID; 51170; -.
KEGG; hsa:51170; -.
UCSC; uc003hqp.3; human.
CTD; 51170; -.
DisGeNET; 51170; -.
GeneCards; HSD17B11; -.
HGNC; HGNC:22960; HSD17B11.
HPA; ENSG00000198189; Tissue enhanced (blood, intestine).
MIM; 612831; gene.
neXtProt; NX_Q8NBQ5; -.
PharmGKB; PA162391655; -.
VEuPathDB; HostDB:ENSG00000198189.10; -.
eggNOG; KOG1201; Eukaryota.
HOGENOM; CLU_010194_2_5_1; -.
InParanoid; Q8NBQ5; -.
OrthoDB; 1373099at2759; -.
PhylomeDB; Q8NBQ5; -.
TreeFam; TF312837; -.
PathwayCommons; Q8NBQ5; -.
Reactome; R-HSA-193144; Estrogen biosynthesis.
BioGRID-ORCS; 51170; 11 hits in 995 CRISPR screens.
ChiTaRS; HSD17B11; human.
EvolutionaryTrace; Q8NBQ5; -.
GeneWiki; HSD17B11; -.
GenomeRNAi; 51170; -.
Pharos; Q8NBQ5; Tbio.
PRO; PR:Q8NBQ5; -.
Proteomes; UP000005640; Chromosome 4.
RNAct; Q8NBQ5; protein.
Bgee; ENSG00000198189; Expressed in colonic mucosa and 238 other tissues.
ExpressionAtlas; Q8NBQ5; baseline and differential.
Genevisible; Q8NBQ5; HS.
GO; GO:0005737; C:cytoplasm; IDA:HGNC-UCL.
GO; GO:0005829; C:cytosol; TAS:Reactome.
GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO; GO:0005811; C:lipid droplet; IDA:UniProtKB.
GO; GO:0044594; F:17-beta-hydroxysteroid dehydrogenase (NAD+) activity; IEA:RHEA.
GO; GO:0072582; F:17-beta-hydroxysteroid dehydrogenase (NADP+) activity; IEA:RHEA.
GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
GO; GO:0016229; F:steroid dehydrogenase activity; IDA:HGNC-UCL.
GO; GO:0006710; P:androgen catabolic process; IDA:HGNC-UCL.
GO; GO:0006703; P:estrogen biosynthetic process; TAS:Reactome.
InterPro; IPR036291; NAD(P)-bd_dom_sf.
InterPro; IPR002347; SDR_fam.
Pfam; PF00106; adh_short; 1.
PRINTS; PR00081; GDHRDH.
PRINTS; PR00080; SDRFAMILY.
SUPFAM; SSF51735; SSF51735; 1.
1: Evidence at protein level;
3D-structure; Endoplasmic reticulum; Lipid biosynthesis; Lipid droplet;
Lipid metabolism; NADP; Oxidoreductase; Reference proteome; Signal;
Steroid biosynthesis.
SIGNAL 1..19
/evidence="ECO:0000255"
CHAIN 20..300
/note="Estradiol 17-beta-dehydrogenase 11"
/id="PRO_0000031970"
NP_BIND 40..64
/note="NADP"
/evidence="ECO:0000250"
ACT_SITE 185
/note="Proton acceptor"
/evidence="ECO:0000250"
BINDING 172
/note="Substrate"
/evidence="ECO:0000250"
CONFLICT 23
/note="V -> E (in Ref. 6; AAH08650)"
/evidence="ECO:0000305"
CONFLICT 38
/note="I -> T (in Ref. 4; BAC11560)"
/evidence="ECO:0000305"
CONFLICT 106
/note="K -> N (in Ref. 6; AAH08650)"
/evidence="ECO:0000305"
CONFLICT 107
/note="V -> C (in Ref. 6; AAH08650)"
/evidence="ECO:0000305"
CONFLICT 228
/note="N -> K (in Ref. 6; AAH08650)"
/evidence="ECO:0000305"
CONFLICT 229
/note="P -> M (in Ref. 6; AAH08650)"
/evidence="ECO:0000305"
CONFLICT 263
/note="I -> N (in Ref. 6; AAH08650)"
/evidence="ECO:0000305"
CONFLICT 264
/note="A -> C (in Ref. 6; AAH08650)"
/evidence="ECO:0000305"
CONFLICT 265
/note="F -> I (in Ref. 6; AAH08650)"
/evidence="ECO:0000305"
CONFLICT 283
/note="Q -> R (in Ref. 1; AAF06939, 2; AAM44459, 3;
AAQ88917, 4; BAC11560 and 6; AAH08650/AAH14327/AAH16367/
AAH21673/AAH36001)"
/evidence="ECO:0000305"
STRAND 38..42
/evidence="ECO:0007744|PDB:1YB1"
TURN 43..45
/evidence="ECO:0007744|PDB:1YB1"
HELIX 47..58
/evidence="ECO:0007744|PDB:1YB1"
STRAND 62..68
/evidence="ECO:0007744|PDB:1YB1"
HELIX 70..82
/evidence="ECO:0007744|PDB:1YB1"
STRAND 87..91
/evidence="ECO:0007744|PDB:1YB1"
HELIX 97..110
/evidence="ECO:0007744|PDB:1YB1"
STRAND 115..119
/evidence="ECO:0007744|PDB:1YB1"
HELIX 130..132
/evidence="ECO:0007744|PDB:1YB1"
HELIX 133..144
/evidence="ECO:0007744|PDB:1YB1"
HELIX 146..161
/evidence="ECO:0007744|PDB:1YB1"
STRAND 165..170
/evidence="ECO:0007744|PDB:1YB1"
HELIX 179..205
/evidence="ECO:0007744|PDB:1YB1"
STRAND 211..218
/evidence="ECO:0007744|PDB:1YB1"
HELIX 220..223
/evidence="ECO:0007744|PDB:1YB1"
HELIX 230..233
/evidence="ECO:0007744|PDB:1YB1"
HELIX 239..251
/evidence="ECO:0007744|PDB:1YB1"
STRAND 255..259
/evidence="ECO:0007744|PDB:1YB1"
HELIX 265..270
/evidence="ECO:0007744|PDB:1YB1"
SEQUENCE 300 AA; 32936 MW; 51DE633A205EBE86 CRC64;
MKFLLDILLL LPLLIVCSLE SFVKLFIPKR RKSVTGEIVL ITGAGHGIGR LTAYEFAKLK
SKLVLWDINK HGLEETAAKC KGLGAKVHTF VVDCSNREDI YSSAKKVKAE IGDVSILVNN
AGVVYTSDLF ATQDPQIEKT FEVNVLAHFW TTKAFLPAMT KNNHGHIVTV ASAAGHVSVP
FLLAYCSSKF AAVGFHKTLT DELAALQITG VKTTCLCPNF VNTGFIKNPS TSLGPTLEPE
EVVNRLMHGI LTEQKMIFIP SSIAFLTTLE RILPERFLAV LKQKISVKFD AVIGYKMKAQ


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Pathways :
WP1614: 1- and 2-Methylnaphthalene degradation
WP1566: Citrate cycle (TCA cycle)
WP1626: Benzoate degradation via CoA ligation
WP1628: beta-Alanine metabolism
WP1655: Geraniol degradation
WP305: Glucocorticoid Metabolism
WP1673: Naphthalene and anthracene degradation
WP1654: gamma-Hexachlorocyclohexane degradation
WP495: Glucocorticoid & Mineralcorticoid Metabolism
WP1665: Limonene and pinene degradation
WP1633: Bisphenol A degradation
WP237: Glucocorticoid & Mineralcorticoid Metabolism
WP1647: Fatty acid biosynthesis
WP1634: Butanoate metabolism
WP1680: Oxidative phosphorylation
WP668: Octadecanoid Pathway
WP542: Electron Transport Chain
WP1621: Arginine and proline metabolism
WP1627: Benzoate degradation via hydroxylation
WP1716: Valine, leucine and isoleucine biosynthesis
WP1581: Histidine metabolism
WP1615: 3-Chloroacrylic acid degradation
WP214: Pyruvate Dehydrogenase Pathway
WP1671: Methane metabolism
WP312: Pentose Phosphate Pathway

Related Genes :
[HSD17B11 DHRS8 PAN1B SDR16C2 PSEC0029 UNQ207/PRO233] Estradiol 17-beta-dehydrogenase 11 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 11) (17-beta-HSD 11) (17bHSD11) (17betaHSD11) (17-beta-hydroxysteroid dehydrogenase XI) (17-beta-HSD XI) (17betaHSDXI) (Cutaneous T-cell lymphoma-associated antigen HD-CL-03) (CTCL-associated antigen HD-CL-03) (Dehydrogenase/reductase SDR family member 8) (Retinal short-chain dehydrogenase/reductase 2) (retSDR2) (Short chain dehydrogenase/reductase family 16C member 2)
[Hsd17b11 Dhrs8 Pan1b] Estradiol 17-beta-dehydrogenase 11 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 11) (17-beta-HSD 11) (17bHSD11) (17betaHSD11) (17-beta-hydroxysteroid dehydrogenase XI) (17-beta-HSD XI) (17betaHSDXI) (Dehydrogenase/reductase SDR family member 8)
[HSD17B10 ERAB HADH2 MRPP2 SCHAD SDR5C1 XH98G2] 3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-estradiol 17-dehydrogenase) (EC 1.1.1.62) (2-methyl-3-hydroxybutyryl-CoA dehydrogenase) (MHBD) (3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))) (EC 1.1.1.239) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (3alpha(or 20beta)-hydroxysteroid dehydrogenase) (EC 1.1.1.53) (7-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.159) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Short chain dehydrogenase/reductase family 5C member 1) (Short-chain type dehydrogenase/reductase XH98G2) (Type II HADH)
[Hsd17b10 Erab Hadh2] 3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-estradiol 17-dehydrogenase) (EC 1.1.1.62) (2-methyl-3-hydroxybutyryl-CoA dehydrogenase) (MHBD) (3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))) (EC 1.1.1.239) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (3alpha(or 20beta)-hydroxysteroid dehydrogenase) (EC 1.1.1.53) (7-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.159) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Short chain dehydrogenase/reductase family 5C member 1) (Short-chain type dehydrogenase/reductase XH98G2) (Type II HADH)
[HSD17B1 E17KSR EDH17B1 EDH17B2 EDHB17 SDR28C1] 17-beta-hydroxysteroid dehydrogenase type 1 (17-beta-HSD 1) (EC 1.1.1.51) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Estradiol 17-beta-dehydrogenase 1) (EC 1.1.1.62) (Placental 17-beta-hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 28C member 1)
[HSD17B8 FABGL HKE6 RING2 SDR30C1] Estradiol 17-beta-dehydrogenase 8 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 8) (17-beta-HSD 8) (3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit) (KAR alpha subunit) (3-oxoacyl-[acyl-carrier-protein] reductase) (EC 1.1.1.-) (Protein Ke6) (Ke-6) (Really interesting new gene 2 protein) (Short chain dehydrogenase/reductase family 30C member 1) (Testosterone 17-beta-dehydrogenase 8) (EC 1.1.1.239)
[Hsd17b10 Erab Hadh2] 3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-estradiol 17-dehydrogenase) (EC 1.1.1.62) (2-methyl-3-hydroxybutyryl-CoA dehydrogenase) (MHBD) (3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))) (EC 1.1.1.239) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (3alpha(or 20beta)-hydroxysteroid dehydrogenase) (EC 1.1.1.53) (7-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.159) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Short chain dehydrogenase/reductase family 5C member 1) (Short-chain type dehydrogenase/reductase XH98G2) (Type II HADH)
[HSD17B7 17HSD7 SDR37C1 UNQ2563/PRO6243] 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (17-beta-hydroxysteroid dehydrogenase 7) (17-beta-HSD 7) (3-keto-steroid reductase) (EC 1.1.1.270) (Dihydrotestosterone oxidoreductase) (EC 1.1.1.210) (Estradiol 17-beta-dehydrogenase 7) (EC 1.1.1.62) (Short chain dehydrogenase/reductase family 37C member 1)
[HSD17B14 DHRS10 SDR3 SDR47C1 UNQ502/PRO474] 17-beta-hydroxysteroid dehydrogenase 14 (17-beta-HSD 14) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase DHRS10) (Dehydrogenase/reductase SDR family member 10) (Retinal short-chain dehydrogenase/reductase retSDR3) (Short chain dehydrogenase/reductase family 47C member 1)
[HSD17B10 HADH2] 3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-estradiol 17-dehydrogenase) (EC 1.1.1.62) (2-methyl-3-hydroxybutyryl-CoA dehydrogenase) (MHBD) (3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))) (EC 1.1.1.239) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (3alpha(or 20beta)-hydroxysteroid dehydrogenase) (EC 1.1.1.53) (7-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.159) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Short chain dehydrogenase/reductase family 5C member 1) (Short-chain type dehydrogenase/reductase XH98G2) (Type II HADH)
[Hsd17b11 Dhrs8] Estradiol 17-beta-dehydrogenase 11 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 11) (17-beta-HSD 11) (17bHSD11) (17betaHSD11) (17-beta-hydroxysteroid dehydrogenase XI) (17-beta-HSD XI) (17betaHSDXI) (Dehydrogenase/reductase SDR family member 8)
[HSD17B6 RODH SDR9C6] 17-beta-hydroxysteroid dehydrogenase type 6 (17-beta-HSD 6) (17-beta-HSD6) (EC 1.1.1.105) (EC 1.1.1.209) (EC 1.1.1.239) (EC 1.1.1.53) (EC 1.1.1.62) (3-alpha->beta-hydroxysteroid epimerase) (3-alpha->beta-HSE) (Oxidative 3-alpha hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 6)
[HSD17B13 SCDR9 SDR16C3 HMFN0376 UNQ497/PRO1014] 17-beta-hydroxysteroid dehydrogenase 13 (17-beta-HSD 13) (EC 1.1.-.-) (Short chain dehydrogenase/reductase family 16C member 3) (Short-chain dehydrogenase/reductase 9)
[AKR1C3 DDH1 HSD17B5 KIAA0119 PGFS] Aldo-keto reductase family 1 member C3 (EC 1.1.1.-) (EC 1.1.1.210) (EC 1.1.1.53) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 5) (17-beta-HSD 5) (3-alpha-HSD type II, brain) (3-alpha-hydroxysteroid dehydrogenase type 2) (3-alpha-HSD type 2) (EC 1.1.1.357) (Chlordecone reductase homolog HAKRb) (Dihydrodiol dehydrogenase 3) (DD-3) (DD3) (Dihydrodiol dehydrogenase type I) (HA1753) (Prostaglandin F synthase) (PGFS) (EC 1.1.1.188) (Testosterone 17-beta-dehydrogenase 5) (EC 1.1.1.239) (EC 1.1.1.64)
[Dhrs11 Sdr24c1] Dehydrogenase/reductase SDR family member 11 (17-beta-hydroxysteroid dehydrogenase) (3-beta-hydroxysteroid 3-dehydrogenase) (EC 1.1.1.270) (Estradiol 17-beta-dehydrogenase) (EC 1.1.1.62) (Short-chain dehydrogenase/reductase family 24C member 1)
[HSD11B2 HSD11K SDR9C3] Corticosteroid 11-beta-dehydrogenase isozyme 2 (EC 1.1.1.-) (11-beta-hydroxysteroid dehydrogenase type 2) (11-DH2) (11-beta-HSD2) (11-beta-hydroxysteroid dehydrogenase type II) (11-HSD type II) (11-beta-HSD type II) (NAD-dependent 11-beta-hydroxysteroid dehydrogenase) (11-beta-HSD) (Short chain dehydrogenase/reductase family 9C member 3)
[Hsd17b8 H2-Ke6 Hke6] Estradiol 17-beta-dehydrogenase 8 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 8) (17-beta-HSD 8) (3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit) (KAR alpha subunit) (3-oxoacyl-[acyl-carrier-protein] reductase) (EC 1.1.1.-) (Protein Ke6) (Ke-6) (Testosterone 17-beta-dehydrogenase 8) (EC 1.1.1.239)
[HSD11B1 HSD11 HSD11L SDR26C1] Corticosteroid 11-beta-dehydrogenase isozyme 1 (EC 1.1.1.146) (11-beta-hydroxysteroid dehydrogenase 1) (11-DH) (11-beta-HSD1) (Short chain dehydrogenase/reductase family 26C member 1)
[Hsd17b7 17hsd7] 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (17-beta-hydroxysteroid dehydrogenase 7) (17-beta-HSD 7) (3-keto-steroid reductase) (EC 1.1.1.270) (Dihydrotestosterone oxidoreductase) (EC 1.1.1.210) (Estradiol 17-beta-dehydrogenase 7) (EC 1.1.1.62)
[AKR1C3] Aldo-keto reductase family 1 member C3 (EC 1.1.1.-) (EC 1.1.1.210) (EC 1.1.1.53) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase type 5) (17-beta-HSD 5) (3-alpha-HSD type II, brain) (3-alpha-hydroxysteroid dehydrogenase type 2) (3-alpha-HSD type 2) (EC 1.1.1.357) (Chlordecone reductase homolog HAKRb) (Dihydrodiol dehydrogenase 3) (DD-3) (DD3) (Dihydrodiol dehydrogenase type I) (HA1753) (Prostaglandin F synthase) (PGFS) (EC 1.1.1.188) (Testosterone 17-beta-dehydrogenase 5) (EC 1.1.1.239) (EC 1.1.1.64)
[Hsd17b7] 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (17-beta-hydroxysteroid dehydrogenase 7) (17-beta-HSD 7) (3-keto-steroid reductase) (EC 1.1.1.270) (Dihydrotestosterone oxidoreductase) (EC 1.1.1.210) (Estradiol 17-beta-dehydrogenase 7) (EC 1.1.1.62) (PRL receptor-associated protein) (PRAP)
[Hsd17b8] Estradiol 17-beta-dehydrogenase 8 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 8) (17-beta-HSD 8) (3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit) (KAR alpha subunit) (3-oxoacyl-[acyl-carrier-protein] reductase) (EC 1.1.1.-) (Testosterone 17-beta-dehydrogenase 8) (EC 1.1.1.239)
[HSD17B11 DHRS8] Estradiol 17-beta-dehydrogenase 11 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 11) (17-beta-HSD 11) (17bHSD11) (17betaHSD11) (17-beta-hydroxysteroid dehydrogenase XI) (17-beta-HSD XI) (17betaHSDXI) (Dehydrogenase/reductase SDR family member 8)
[SDR16C5 RDHE2] Epidermal retinol dehydrogenase 2 (EPHD-2) (RDH-E2) (EC 1.1.1.105) (Retinal short-chain dehydrogenase reductase 2) (retSDR2) (Short-chain dehydrogenase/reductase family 16C member 5)
[DHRS9 RDH15 SDR9C4 UNQ835/PRO1773] Dehydrogenase/reductase SDR family member 9 (EC 1.1.1.209) (EC 1.1.1.53) (3-alpha hydroxysteroid dehydrogenase) (3-alpha-HSD) (NADP-dependent retinol dehydrogenase/reductase) (RDH-E2) (RDHL) (Retinol dehydrogenase 15) (EC 1.1.1.105) (Short chain dehydrogenase/reductase family 9C member 4) (Short-chain dehydrogenase/reductase retSDR8) (Tracheobronchial epithelial cell-specific retinol dehydrogenase) (RDH-TBE)
[Hsd17b6 Gm182 Hsd17b9 Rdh8] 17-beta-hydroxysteroid dehydrogenase type 6 (17-beta-HSD 6) (17-beta-HSD6) (EC 1.1.1.105) (EC 1.1.1.209) (EC 1.1.1.239) (EC 1.1.1.53) (EC 1.1.1.62) (17-beta-HSD9) (3-alpha->beta-hydroxysteroid epimerase) (3-alpha->beta-HSE) (Oxidative 3-alpha hydroxysteroid dehydrogenase)
[HSD17B8 FABGL HKE6] Estradiol 17-beta-dehydrogenase 8 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 8) (17-beta-HSD 8) (3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit) (KAR alpha subunit) (3-oxoacyl-[acyl-carrier-protein] reductase) (EC 1.1.1.-) (Protein Ke6) (Ke-6) (Testosterone 17-beta-dehydrogenase 8) (EC 1.1.1.239)
[Akr1c21] Aldo-keto reductase family 1 member C21 (EC 1.1.1.-) (17-alpha-hydroxysteroid dehydrogenase) (17-alpha-HSD) (3(or 17)-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.209) (3-alpha-hydroxysteroid dehydrogenase) (Dihydrodiol dehydrogenase type 1) (DD1) (Dihydrodiol dehydrogenase type 3) (DD3)
[Hsd17b1 Edh17b1] 17-beta-hydroxysteroid dehydrogenase type 1 (17-beta-HSD 1) (EC 1.1.1.51) (Estradiol 17-beta-dehydrogenase 1) (EC 1.1.1.62)
[RDH5 HSD17B9 RDH1 SDR9C5] Retinol dehydrogenase 5 (EC 1.1.1.209) (EC 1.1.1.315) (EC 1.1.1.53) (11-cis retinol dehydrogenase) (11-cis RDH) (11-cis RoDH) (9-cis retinol dehydrogenase) (9cRDH) (Short chain dehydrogenase/reductase family 9C member 5)

Bibliography :