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Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)

 ESR1_CHICK              Reviewed;         589 AA.
P06212;
01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
01-JAN-1988, sequence version 1.
18-SEP-2019, entry version 152.
RecName: Full=Estrogen receptor;
Short=ER;
AltName: Full=ER-alpha;
AltName: Full=Estradiol receptor;
AltName: Full=Nuclear receptor subfamily 3 group A member 1;
Name=ESR1; Synonyms=ESR, NR3A1;
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3755102; DOI=10.1002/j.1460-2075.1986.tb04300.x;
Krust A., Green S., Argos P., Kumar V., Walter P., Bornert J.-M.,
Chambon P.;
"The chicken oestrogen receptor sequence: homology with v-erbA and the
human oestrogen and glucocorticoid receptors.";
EMBO J. 5:891-897(1986).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2901032; DOI=10.1210/mend-1-1-25;
Maxwell B.L., McDonnell D.P., Conneely O.M., Schulz T.Z., Greene G.L.,
O'Malley B.W.;
"Structural organization and regulation of the chicken estrogen
receptor.";
Mol. Endocrinol. 1:25-35(1987).
-!- FUNCTION: The steroid hormones and their receptors are involved in
the regulation of eukaryotic gene expression and affect cellular
proliferation and differentiation in target tissues.
-!- SUBUNIT: Binds DNA as a homodimer. Can form a heterodimer with ER-
beta.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- DOMAIN: Composed of three domains: a modulating N-terminal domain,
a DNA-binding domain and a C-terminal ligand-binding domain. The
modulating domain, also known as A/B or AF-1 domain has a ligand-
independent transactivation function. The C-terminus contains a
ligand-dependent transactivation domain, also known as E/F or AF-2
domain which overlaps with the ligand binding domain. AF-1 and AF-
2 activate transcription independently and synergistically and act
in a promoter- and cell-specific manner (By similarity).
{ECO:0000250}.
-!- MISCELLANEOUS: In the absence of ligand, steroid hormone receptors
are thought to be weakly associated with nuclear components;
hormone binding greatly increases receptor affinity. The hormone-
receptor complex appears to recognize discrete DNA sequences
upstream of transcriptional start sites.
-!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
subfamily. {ECO:0000305}.
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EMBL; X03805; CAA27433.1; -; mRNA.
PIR; A40914; QRCHE.
RefSeq; NP_990514.1; NM_205183.2.
SMR; P06212; -.
STRING; 9031.ENSGALP00000042556; -.
PaxDb; P06212; -.
PRIDE; P06212; -.
GeneID; 396099; -.
KEGG; gga:396099; -.
CTD; 2099; -.
eggNOG; KOG3575; Eukaryota.
eggNOG; ENOG410XRZC; LUCA.
HOGENOM; HOG000233468; -.
InParanoid; P06212; -.
KO; K08550; -.
OrthoDB; 487299at2759; -.
PhylomeDB; P06212; -.
PRO; PR:P06212; -.
Proteomes; UP000000539; Unplaced.
GO; GO:0005737; C:cytoplasm; IDA:AgBase.
GO; GO:0005634; C:nucleus; IDA:AgBase.
GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
GO; GO:0030284; F:estrogen receptor activity; IDA:AgBase.
GO; GO:0051879; F:Hsp90 protein binding; IPI:AgBase.
GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
GO; GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0010628; P:positive regulation of gene expression; IDA:AgBase.
Gene3D; 1.10.565.10; -; 1.
Gene3D; 3.30.50.10; -; 1.
InterPro; IPR035500; NHR-like_dom_sf.
InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
InterPro; IPR001723; Nuclear_hrmn_rcpt.
InterPro; IPR024178; Oest_rcpt/oest-rel_rcp.
InterPro; IPR001292; Oestr_rcpt.
InterPro; IPR024736; Oestrogen-typ_rcpt_final_C_dom.
InterPro; IPR001628; Znf_hrmn_rcpt.
InterPro; IPR013088; Znf_NHR/GATA.
Pfam; PF12743; ESR1_C; 1.
Pfam; PF00104; Hormone_recep; 1.
Pfam; PF02159; Oest_recep; 1.
Pfam; PF00105; zf-C4; 1.
PIRSF; PIRSF500101; ER-a; 1.
PIRSF; PIRSF002527; ER-like_NR; 1.
PRINTS; PR00543; OESTROGENR.
PRINTS; PR00398; STRDHORMONER.
PRINTS; PR00047; STROIDFINGER.
SMART; SM00430; HOLI; 1.
SMART; SM00399; ZnF_C4; 1.
SUPFAM; SSF48508; SSF48508; 1.
PROSITE; PS51843; NR_LBD; 1.
PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
2: Evidence at transcript level;
Complete proteome; DNA-binding; Lipid-binding; Metal-binding; Nucleus;
Receptor; Reference proteome; Steroid-binding; Transcription;
Transcription regulation; Zinc; Zinc-finger.
CHAIN 1 589 Estrogen receptor.
/FTId=PRO_0000053625.
DOMAIN 305 541 NR LBD. {ECO:0000255|PROSITE-
ProRule:PRU01189}.
DNA_BIND 179 244 Nuclear receptor. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
ZN_FING 179 199 NR C4-type. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
ZN_FING 215 239 NR C4-type. {ECO:0000255|PROSITE-
ProRule:PRU00407}.
REGION 1 178 Modulating (transactivation AF-1).
REGION 245 304 Hinge.
REGION 305 589 Transactivation AF-2. {ECO:0000250}.
CONFLICT 257 257 E -> R (in Ref. 2). {ECO:0000305}.
SEQUENCE 589 AA; 66746 MW; 1B092233C770A54B CRC64;
MTMTLHTKAS GVTLLHQIQG TELETLSRPQ LKIPLERSLS DMYVESNKTG VFNYPEGATY
DFGTTAPVYG STTLSYAPTS ESFGSSSLAG FHSLNNVPPS PVVFLQTAPQ LSPFIHHHSQ
QVPYYLENEQ GSFGMREAAP PAFYRPSSDN RRHSIRERMS STNEKGSLSM ESTKETRYCA
VCNDYASGYH YGVWSCEGCK AFFKRSIQGH NDYMCPATNQ CTIDKNRRKS CQACRLRKCY
EVGMMKGGIR KDRRGGEMMK QKRQREEQDS RNGEASSTEL RAPTLWTSPL VVKHNKKNSP
ALSLTAEQMV SALLEAEPPI VYSEYDPNRP FNEASMMTLL TNLADRELVH MINWAKRVPG
FVDLTLHDQV HLLECAWLEI LMIGLVWRSM EHPGKLLFAP NLLLDRNQGK CVEGMVEIFD
MLLATAARFR MMNLQGEEFV CLKSIILLNS GVYTFLSSTL KSLEERDYIH RVLDKITDTL
IHLMAKSGLS LQQQHRRLAQ LLLILSHIRH MSNKGMEHLY NMKCKNVVPL YDLLLEMLDA
HRLHAPAARS AAPMEEENRN QLTTAPASSH SLQSFYINSK EEESMQNTI


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WP566: canonical wnt - zebrafish
WP1963: The effect of Glucocorticoids on target gene expression
WP794: B Cell Receptor Signaling Pathway
WP1249: EPO Receptor Signaling
WP926: TGF-beta Receptor Signaling Pathway
WP1130: T Cell Receptor Signaling Pathway
WP352: T Cell Receptor Signaling Pathway
WP1161: TGF-beta Receptor Signaling Pathway
WP2140: MaxYvesSuperCombo
WP407: Kit Receptor Signaling Pathway
WP1014: Androgen receptor signaling pathway
WP258: TGF-beta Receptor Signaling Pathway
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1309: Toll-like receptor signaling pathway
WP733: Serotonin Receptor 2 and STAT3 Signaling
WP1449: Regulation of toll-like receptor signaling pathway
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP2272: Pathogenic Escherichia coli infection
WP480: T Cell Receptor Signaling Pathway
WP878: EPO Receptor Signaling
WP1067: Toll-like receptor signaling pathway
WP1336: EPO Receptor Signaling
WP285: B Cell Receptor Signaling Pathway
WP996: EPO Receptor Signaling
WP1345: T Cell Receptor Signaling Pathway

Related Genes :
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[Esr1 Esr Estr Estra Nr3a1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[Esr1 Esr Estr Nr3a1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) (Fragment)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[ESR2 ESTRB NR3A2] Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
[Esr2 Erbeta Nr3a2] Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
[Esr2 Estrb Nr3a2] Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) (Fragment)
[ESRRA ERR1 ESRL1 NR3B1] Steroid hormone receptor ERR1 (Estrogen receptor-like 1) (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1)
[Esrra Err1 Estrra Nr3b1] Steroid hormone receptor ERR1 (Estrogen receptor-like 1) (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1)
[Esrra Nr3b1] Steroid hormone receptor ERR1 (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[Esrrb Err-2 Err2 Nr3b2] Steroid hormone receptor ERR2 (Estrogen receptor-like 2) (Estrogen-related receptor beta) (ERR-beta) (Nuclear receptor subfamily 3 group B member 2)
[ESRRB ERRB2 ESRL2 NR3B2] Steroid hormone receptor ERR2 (ERR beta-2) (Estrogen receptor-like 2) (Estrogen-related receptor beta) (ERR-beta) (Nuclear receptor subfamily 3 group B member 2)
[Esrrg Err3 Kiaa0832 Nr3b3] Estrogen-related receptor gamma (Estrogen receptor-related protein 3) (Nuclear receptor subfamily 3 group B member 3)
[Esrrb Err2 Esrl2 Nr3b2] Steroid hormone receptor ERR2 (Estrogen receptor-like 2) (Estrogen-related receptor beta) (ERR-beta) (Nuclear receptor subfamily 3 group B member 2)
[NR5A2 B1F CPF FTF] Nuclear receptor subfamily 5 group A member 2 (Alpha-1-fetoprotein transcription factor) (B1-binding factor) (hB1F) (CYP7A promoter-binding factor) (Hepatocytic transcription factor) (Liver receptor homolog 1) (LRH-1)
[NR1D2] Nuclear receptor subfamily 1 group D member 2 (Orphan nuclear hormone receptor BD73) (Rev-erb alpha-related receptor) (RVR) (Rev-erb-beta) (V-erbA-related protein 1-related) (EAR-1R)
[AR DHTR NR3C4] Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4)
[THRA EAR7 ERBA1 NR1A1 THRA1 THRA2] Thyroid hormone receptor alpha (Nuclear receptor subfamily 1 group A member 1) (V-erbA-related protein 7) (EAR-7) (c-erbA-1) (c-erbA-alpha)
[RARA NR1B1] Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1)
[NR3C1 GRL] Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1)
[Rara Nr1b1] Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1)
[ftz-f1 NR5A3 CG4059] Nuclear hormone receptor FTZ-F1 (FTZ-F1 alpha) (Nuclear receptor subfamily 5 group A member 3)

Bibliography :
[28087261] DNA aptamer probes for detection of estrogen receptor α positive carcinomas.
[26573009] Macromolecular Modelling and Docking Simulations for the Discovery of Selective GPER Ligands.
[25943116] Estrogen-Induced Cholestasis Leads to Repressed CYP2D6 Expression in CYP2D6-Humanized Mice.
[25769926] Estradiol inhibits Th17 cell differentiation through inhibition of RORγT transcription by recruiting the ERα/REA complex to estrogen response elements of the RORγT promoter.
[25675114] Estrogen and Estrogen Receptor-α-Mediated Transrepression of Bile Salt Export Pump.
[23592396] Estrogen receptor α induction by mitoxantrone increases Abcg2 expression in placental trophoblast cells.
[23064813] Expression of MAGE-A11 in breast cancer tissues and its effects on the proliferation of breast cancer cells.
[22158945] S100A7 enhances mammary tumorigenesis through upregulation of inflammatory pathways.
[20667977] Biological and biochemical consequences of global deletion of exon 3 from the ER alpha gene.
[20460386] Estrogen receptor beta signaling through phosphatase and tensin homolog/phosphoinositide 3-kinase/Akt/glycogen synthase kinase 3 down-regulates blood-brain barrier breast cancer resistance protein.