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Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)

 ESR1_TAEGU              Reviewed;         587 AA.
Q91250;
15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
26-FEB-2020, entry version 133.
RecName: Full=Estrogen receptor;
Short=ER;
AltName: Full=ER-alpha;
AltName: Full=Estradiol receptor;
AltName: Full=Nuclear receptor subfamily 3 group A member 1;
Name=ESR1; Synonyms=ESR, NR3A1;
Taeniopygia guttata (Zebra finch) (Poephila guttata).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
Estrildinae; Taeniopygia.
NCBI_TaxID=59729;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Hypothalamus;
PubMed=9010328; DOI=10.1016/s0960-0760(96)00096-9;
Jacobs E.C., Arnold A.P., Campagnoni A.T.;
"Zebra finch estrogen receptor cDNA: cloning and mRNA expression.";
J. Steroid Biochem. Mol. Biol. 59:135-145(1996).
-!- FUNCTION: The steroid hormones and their receptors are involved in the
regulation of eukaryotic gene expression and affect cellular
proliferation and differentiation in target tissues.
-!- SUBUNIT: Binds DNA as a homodimer. Can form a heterodimer with ER-beta
(By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- DOMAIN: Composed of three domains: a modulating N-terminal domain, a
DNA-binding domain and a C-terminal ligand-binding domain. The
modulating domain, also known as A/B or AF-1 domain has a ligand-
independent transactivation function. The C-terminus contains a ligand-
dependent transactivation domain, also known as E/F or AF-2 domain
which overlaps with the ligand binding domain. AF-1 and AF-2 activate
transcription independently and synergistically and act in a
promoter- and cell-specific manner (By similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
subfamily. {ECO:0000305}.
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EMBL; L79911; AAB81108.1; -; mRNA.
RefSeq; NP_001070169.1; NM_001076701.1.
SMR; Q91250; -.
PRIDE; Q91250; -.
GeneID; 751998; -.
KEGG; tgu:751998; -.
CTD; 2099; -.
eggNOG; KOG3575; Eukaryota.
eggNOG; ENOG410XRZC; LUCA.
InParanoid; Q91250; -.
KO; K08550; -.
OrthoDB; 487299at2759; -.
Proteomes; UP000007754; Unplaced.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
GO; GO:0030284; F:estrogen receptor activity; ISS:AgBase.
GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
GO; GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0048747; P:muscle fiber development; IMP:AgBase.
GO; GO:0010628; P:positive regulation of gene expression; ISS:AgBase.
Gene3D; 1.10.565.10; -; 1.
Gene3D; 3.30.50.10; -; 1.
InterPro; IPR035500; NHR-like_dom_sf.
InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
InterPro; IPR001723; Nuclear_hrmn_rcpt.
InterPro; IPR024178; Oest_rcpt/oest-rel_rcp.
InterPro; IPR001292; Oestr_rcpt.
InterPro; IPR024736; Oestrogen-typ_rcpt_final_C_dom.
InterPro; IPR001628; Znf_hrmn_rcpt.
InterPro; IPR013088; Znf_NHR/GATA.
Pfam; PF12743; ESR1_C; 1.
Pfam; PF00104; Hormone_recep; 1.
Pfam; PF02159; Oest_recep; 1.
Pfam; PF00105; zf-C4; 1.
PIRSF; PIRSF500101; ER-a; 1.
PIRSF; PIRSF002527; ER-like_NR; 1.
PRINTS; PR00543; OESTROGENR.
PRINTS; PR00398; STRDHORMONER.
PRINTS; PR00047; STROIDFINGER.
SMART; SM00430; HOLI; 1.
SMART; SM00399; ZnF_C4; 1.
SUPFAM; SSF48508; SSF48508; 1.
PROSITE; PS51843; NR_LBD; 1.
PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
2: Evidence at transcript level;
DNA-binding; Lipid-binding; Metal-binding; Nucleus; Receptor;
Reference proteome; Steroid-binding; Transcription;
Transcription regulation; Zinc; Zinc-finger.
CHAIN 1..587
/note="Estrogen receptor"
/id="PRO_0000053636"
DOMAIN 303..539
/note="NR LBD"
/evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
DNA_BIND 177..242
/note="Nuclear receptor"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
ZN_FING 177..197
/note="NR C4-type"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
ZN_FING 213..237
/note="NR C4-type"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
REGION 1..176
/note="Modulating (transactivation AF-1)"
REGION 243..302
/note="Hinge"
REGION 303..587
/note="Transactivation AF-2"
/evidence="ECO:0000250"
SEQUENCE 587 AA; 66553 MW; 2B254168A7A910AB CRC64;
MTLHTKTSGV TLLHQIQGTE LETLSRPQLK IPLERSLSDM YVETNKTGVF NYPEGATYDF
GTTAPVYSST TLSYAPTSES FGSSSLAGFH SLNSVPPSPV VFLQTAPHWS PFIHHHSQQV
PYYLENDQGS FGMREAAPPA FYRPNSDNRR HSIRERMSSA NEKGSLSMES TKETRYCAVC
NDYASGYHYG VWSCEGCKAF FKRSIQGHND YMCPATNQCT IDKNRRKSCQ ACRLRKCYEV
GMMKGGIRKD RRGGRVMKQK RQREEQDSRN GEASSTELRA PTLWASPLVV KHNKKNSPAL
SLTAEQMVSA LLEAEPPLVY SEYDPNRPFN EASMMTLLTN LADRELVHMI NWAKRVPGFV
DLTLHDQVHL LECAWLEILM IGLVWRSMEH PGKLLFAPNL LLDRNQGKCV EGMVEIFDML
LATAARFRMM NLQGEEFVCL KSIILLNSGV YTFLSSTLKS LEEKDYIHRV LDKITDTLIH
LMAKSGLSLQ QQHRRLAQLL LILSHIRHMS NKGMEHLYNM KCKNVVPLYD LLLEMLDAHR
LHAPAARSAA PMEEENRSQL TTASASSHSL QSFYINSKEE ENMQNTL


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WP1963: The effect of Glucocorticoids on target gene expression
WP352: T Cell Receptor Signaling Pathway
WP794: B Cell Receptor Signaling Pathway
WP1249: EPO Receptor Signaling
WP926: TGF-beta Receptor Signaling Pathway
WP1130: T Cell Receptor Signaling Pathway
WP258: TGF-beta Receptor Signaling Pathway
WP1161: TGF-beta Receptor Signaling Pathway
WP2140: MaxYvesSuperCombo
WP407: Kit Receptor Signaling Pathway
WP1014: Androgen receptor signaling pathway
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1309: Toll-like receptor signaling pathway
WP733: Serotonin Receptor 2 and STAT3 Signaling
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WP285: B Cell Receptor Signaling Pathway
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WP2272: Pathogenic Escherichia coli infection
WP480: T Cell Receptor Signaling Pathway
WP878: EPO Receptor Signaling
WP1067: Toll-like receptor signaling pathway
WP1336: EPO Receptor Signaling
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Related Genes :
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[Esr1 Esr Estr Estra Nr3a1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[Esr1 Esr Estr Nr3a1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) (Fragment)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[ESR2 ESTRB NR3A2] Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
[Esr2 Erbeta Nr3a2] Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
[Esr2 Estrb Nr3a2] Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) (Fragment)
[ESRRA ERR1 ESRL1 NR3B1] Steroid hormone receptor ERR1 (Estrogen receptor-like 1) (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1)
[Esrra Err1 Estrra Nr3b1] Steroid hormone receptor ERR1 (Estrogen receptor-like 1) (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1)
[Esrra Nr3b1] Steroid hormone receptor ERR1 (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[Esrrb Err-2 Err2 Nr3b2] Steroid hormone receptor ERR2 (Estrogen receptor-like 2) (Estrogen-related receptor beta) (ERR-beta) (Nuclear receptor subfamily 3 group B member 2)
[ESRRB ERRB2 ESRL2 NR3B2] Steroid hormone receptor ERR2 (ERR beta-2) (Estrogen receptor-like 2) (Estrogen-related receptor beta) (ERR-beta) (Nuclear receptor subfamily 3 group B member 2)
[Esrrg Err3 Kiaa0832 Nr3b3] Estrogen-related receptor gamma (Estrogen receptor-related protein 3) (Nuclear receptor subfamily 3 group B member 3)
[Esrrb Err2 Esrl2 Nr3b2] Steroid hormone receptor ERR2 (Estrogen receptor-like 2) (Estrogen-related receptor beta) (ERR-beta) (Nuclear receptor subfamily 3 group B member 2)
[NR5A2 B1F CPF FTF] Nuclear receptor subfamily 5 group A member 2 (Alpha-1-fetoprotein transcription factor) (B1-binding factor) (hB1F) (CYP7A promoter-binding factor) (Hepatocytic transcription factor) (Liver receptor homolog 1) (LRH-1)
[AR DHTR NR3C4] Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4)
[NR1D2] Nuclear receptor subfamily 1 group D member 2 (Orphan nuclear hormone receptor BD73) (Rev-erb alpha-related receptor) (RVR) (Rev-erb-beta) (V-erbA-related protein 1-related) (EAR-1R)
[THRA EAR7 ERBA1 NR1A1 THRA1 THRA2] Thyroid hormone receptor alpha (Nuclear receptor subfamily 1 group A member 1) (V-erbA-related protein 7) (EAR-7) (c-erbA-1) (c-erbA-alpha)
[RARA NR1B1] Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1)
[NR3C1 GRL] Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1)
[Rara Nr1b1] Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1)
[ftz-f1 NR5A3 CG4059] Nuclear hormone receptor FTZ-F1 (FTZ-F1 alpha) (Nuclear receptor subfamily 5 group A member 3)

Bibliography :
[31855806] PARP-1 expression as a prognostic factor in Desmoid-type fibromatosis.
[28087261] DNA aptamer probes for detection of estrogen receptor α positive carcinomas.
[26573009] Macromolecular Modelling and Docking Simulations for the Discovery of Selective GPER Ligands.
[25943116] Estrogen-Induced Cholestasis Leads to Repressed CYP2D6 Expression in CYP2D6-Humanized Mice.
[25769926] Estradiol inhibits Th17 cell differentiation through inhibition of RORγT transcription by recruiting the ERα/REA complex to estrogen response elements of the RORγT promoter.
[25675114] Estrogen and Estrogen Receptor-α-Mediated Transrepression of Bile Salt Export Pump.
[23592396] Estrogen receptor α induction by mitoxantrone increases Abcg2 expression in placental trophoblast cells.
[23064813] Expression of MAGE-A11 in breast cancer tissues and its effects on the proliferation of breast cancer cells.
[22158945] S100A7 enhances mammary tumorigenesis through upregulation of inflammatory pathways.
[20667977] Biological and biochemical consequences of global deletion of exon 3 from the ER alpha gene.