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Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)

 ESR2_MOUSE              Reviewed;         530 AA.
O08537; B2RUC6; E9QKX7; O35635; O70519; Q8BG65; Q91Z86;
15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
21-MAR-2012, sequence version 3.
26-FEB-2020, entry version 193.
RecName: Full=Estrogen receptor beta;
Short=ER-beta;
AltName: Full=Nuclear receptor subfamily 3 group A member 2;
Name=Esr2; Synonyms=Estrb, Nr3a2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
STRAIN=C57BL/6J; TISSUE=Ovary;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of the
mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 46-530, AND MUTAGENESIS.
STRAIN=129/Sv; TISSUE=Ovary;
PubMed=9058381; DOI=10.1210/mend.11.3.9902;
Tremblay G.B., Tremblay A., Copeland N.G., Gilbert D.J., Jenkins N.A.,
Labrie F., Giguere V.;
"Cloning, chromosomal localization, and functional analysis of the murine
estrogen receptor beta.";
Mol. Endocrinol. 11:353-365(1997).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 46-530, AND CHARACTERIZATION.
TISSUE=Ovary;
PubMed=9280064; DOI=10.1210/mend.11.10.9989;
Pettersson K., Grandien K., Kuiper G.G.J.M., Gustafsson J.-A.;
"Mouse estrogen receptor beta forms estrogen response element-binding
heterodimers with estrogen receptor alpha.";
Mol. Endocrinol. 11:1486-1496(1997).
[6]
NUCLEOTIDE SEQUENCE [MRNA] OF 46-530 (ISOFORM 2), AND INDUCTION.
STRAIN=ddY; TISSUE=Calvaria;
PubMed=11878304; DOI=10.1359/jbmr.2002.17.3.394;
Dang Z.C., van Bezooijen R.L., Karperien M., Papapoulos S.E., Lowik C.W.;
"Exposure of KS483 cells to estrogen enhances osteogenesis and inhibits
adipogenesis.";
J. Bone Miner. Res. 17:394-405(2002).
[7]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-60.
TISSUE=Ovary;
Leygue E., Lu B., Dotzlaw H., Glor C., Watson P.H., Murphy L.C.;
Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
[8]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-60.
TISSUE=Ovary;
Rosenfeld C.S., Lubahn D.B.;
Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
[9]
INTERACTION WITH NCOA3.
PubMed=9192892; DOI=10.1038/42652;
Torchia J., Rose D.W., Inostroza J., Kamei Y., Westin S., Glass C.K.,
Rosenfeld M.G.;
"The transcriptional co-activator p/CIP binds CBP and mediates nuclear-
receptor function.";
Nature 387:677-684(1997).
[10]
TISSUE SPECIFICITY.
PubMed=9607809; DOI=10.1210/endo.139.6.6028;
Rosenfeld C.S., Ganjam V.K., Taylor J.A., Yuan X., Stiehr J.R., Hardy M.P.,
Lubahn D.B.;
"Transcription and translation of estrogen receptor-beta in the male
reproductive tract of estrogen receptor-alpha knock-out and wild-type
mice.";
Endocrinology 139:2982-2987(1998).
[11]
ALTERNATIVE SPLICING (ISOFORMS 1; 2; 3; 4 AND 5).
TISSUE=Ovary;
PubMed=9685228; DOI=10.1016/s0303-7207(98)00050-1;
Lu B., Leygue E., Dotzlaw H., Murphy L.J., Murphy L.C., Watson P.H.;
"Estrogen receptor-beta mRNA variants in human and murine tissues.";
Mol. Cell. Endocrinol. 138:199-203(1998).
[12]
PHOSPHORYLATION AT SER-87 AND SER-105.
PubMed=10230404; DOI=10.1016/s1097-2765(00)80479-7;
Tremblay A., Tremblay G.B., Labrie F., Giguere V.;
"Ligand-independent recruitment of SRC-1 to estrogen receptor beta through
phosphorylation of activation function AF-1.";
Mol. Cell 3:513-519(1999).
[13]
GLYCOSYLATION AT SER-61, AND PHOSPHORYLATION AT SER-61.
PubMed=10995228; DOI=10.1021/bi000755i;
Cheng X., Cole R.N., Zaia J., Hart G.W.;
"Alternative O-glycosylation/O-phosphorylation of the murine estrogen
receptor beta.";
Biochemistry 39:11609-11620(2000).
[14]
INTERACTION WITH NCOA6.
PubMed=10788465; DOI=10.1074/jbc.275.18.13510;
Zhu Y.-J., Kan L., Qi C., Kanwar Y.S., Yeldandi A.V., Rao M.S., Reddy J.K.;
"Isolation and characterization of peroxisome proliferator-activated
receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR.";
J. Biol. Chem. 275:13510-13516(2000).
[15]
INTERACTION WITH RBM39.
PubMed=11704680; DOI=10.1074/jbc.m110417200;
Jung D.-J., Na S.-Y., Na D.S., Lee J.W.;
"Molecular cloning and characterization of CAPER, a novel coactivator of
activating protein-1 and estrogen receptors.";
J. Biol. Chem. 277:1229-1234(2002).
-!- FUNCTION: Nuclear hormone receptor. Binds estrogens with an affinity
similar to that of ESR1 (ER-alpha), and activates expression of
reporter genes containing estrogen response elements (ERE) in an
estrogen-dependent manner. May play a role in ovarian follicular growth
and maturation. {ECO:0000250|UniProtKB:Q92731}.
-!- SUBUNIT: Binds DNA as a homodimer. Can form a heterodimer with ESR1.
Interacts with NCOA1, NCOA3, NCOA5 and NCOA6 coactivators, leading to a
strong increase of transcription of target genes. Interacts with PELP1,
UBE1C and AKAP13. Interacts with DNTTIP2 (By similarity). Interacts
with CCDC62 in the presence of estradiol/E2; this interaction seems to
enhance the transcription of target genes. Interacts with DNAAF4.
Interacts with PRMT2. Interacts with CCAR2 (via N-terminus) in a
ligand-independent manner (By similarity). Interacts with RBM39, in the
presence of estradiol (E2) (PubMed:11704680).
{ECO:0000250|UniProtKB:Q62986, ECO:0000250|UniProtKB:Q92731,
ECO:0000269|PubMed:11704680}.
-!- INTERACTION:
P01101:Fos; NbExp=2; IntAct=EBI-2526214, EBI-4288185;
-!- SUBCELLULAR LOCATION: Nucleus.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=5;
Comment=Additional isoforms seem to exist.;
Name=1; Synonyms=Beta-1;
IsoId=O08537-1; Sequence=Displayed;
Name=2; Synonyms=Beta-2;
IsoId=O08537-2; Sequence=VSP_003693;
Name=3; Synonyms=Beta-5A;
IsoId=O08537-4; Sequence=VSP_003696;
Name=4;
IsoId=O08537-6; Sequence=VSP_042429, VSP_042430;
Name=5;
IsoId=O08537-7; Sequence=VSP_042431, VSP_042432;
-!- TISSUE SPECIFICITY: Expressed in prostate, ovary, Leydig cells and in
epithelium of the efferent ductules and of the initial segment of the
epididymis. {ECO:0000269|PubMed:9607809}.
-!- INDUCTION: Isoforms 1 and 2 are down-regulated by 17-beta-estradiol.
{ECO:0000269|PubMed:11878304}.
-!- DOMAIN: Composed of three domains: a modulating N-terminal domain, a
DNA-binding domain and a C-terminal ligand-binding domain.
-!- PTM: Phosphorylation at Ser-87 and Ser-105 recruits NCOA1.
{ECO:0000269|PubMed:10230404, ECO:0000269|PubMed:10995228}.
-!- MISCELLANEOUS: [Isoform 3]: Corresponds to exons 5 and 6 deletion.
{ECO:0000305|PubMed:9685228}.
-!- MISCELLANEOUS: [Isoform 4]: Corresponds to exon 5 deletion
(PubMed:9685228). May be produced at very low levels due to a premature
stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No
experimental confirmation available. {ECO:0000305|PubMed:9685228}.
-!- MISCELLANEOUS: [Isoform 5]: Corresponds to exon 6 deletion
(PubMed:9685228). May be produced at very low levels due to a premature
stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No
experimental confirmation available. {ECO:0000305|PubMed:9685228}.
-!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
subfamily. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAC17919.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Sequence=AAI41076.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Sequence=AAI45330.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Sequence=AAL15175.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Sequence=BAC35719.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Sequence=BAC35770.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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EMBL; AK054290; BAC35719.1; ALT_INIT; mRNA.
EMBL; AK054413; BAC35770.1; ALT_INIT; mRNA.
EMBL; AC164121; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC141075; AAI41076.1; ALT_INIT; mRNA.
EMBL; BC145329; AAI45330.1; ALT_INIT; mRNA.
EMBL; U81451; AAB51132.1; -; mRNA.
EMBL; AJ000220; CAA03949.1; -; Genomic_DNA.
EMBL; AY054413; AAL15175.1; ALT_INIT; mRNA.
EMBL; AF067422; AAC17919.1; ALT_INIT; mRNA.
EMBL; AF063853; AAC16656.1; -; mRNA.
RefSeq; NP_034287.3; NM_010157.3.
RefSeq; NP_997590.1; NM_207707.1.
SMR; O08537; -.
BioGrid; 199522; 3.
IntAct; O08537; 2.
STRING; 10090.ENSMUSP00000098849; -.
BindingDB; O08537; -.
ChEMBL; CHEMBL2995; -.
DrugCentral; O08537; -.
GuidetoPHARMACOLOGY; 621; -.
GlyConnect; 146; -.
iPTMnet; O08537; -.
PhosphoSitePlus; O08537; -.
UniCarbKB; O08537; -.
PaxDb; O08537; -.
PRIDE; O08537; -.
Ensembl; ENSMUST00000101291; ENSMUSP00000098849; ENSMUSG00000021055. [O08537-2]
Ensembl; ENSMUST00000110421; ENSMUSP00000106051; ENSMUSG00000021055. [O08537-1]
Ensembl; ENSMUST00000133564; ENSMUSP00000138637; ENSMUSG00000021055. [O08537-6]
GeneID; 13983; -.
KEGG; mmu:13983; -.
UCSC; uc007nxu.1; mouse. [O08537-2]
UCSC; uc007nxv.1; mouse. [O08537-1]
CTD; 2100; -.
MGI; MGI:109392; Esr2.
eggNOG; KOG3575; Eukaryota.
eggNOG; ENOG410XRZC; LUCA.
GeneTree; ENSGT00940000156116; -.
InParanoid; O08537; -.
KO; K08551; -.
OMA; GMMKCGS; -.
OrthoDB; 487299at2759; -.
TreeFam; TF323751; -.
Reactome; R-MMU-1257604; PIP3 activates AKT signaling.
Reactome; R-MMU-383280; Nuclear Receptor transcription pathway.
Reactome; R-MMU-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
Reactome; R-MMU-8939211; ESR-mediated signaling.
Reactome; R-MMU-9009391; Extra-nuclear estrogen signaling.
ChiTaRS; Esr2; mouse.
PRO; PR:O08537; -.
Proteomes; UP000000589; Chromosome 12.
RNAct; O08537; protein.
ExpressionAtlas; O08537; baseline and differential.
GO; GO:0005929; C:cilium; ISO:MGI.
GO; GO:0005737; C:cytoplasm; IDA:MGI.
GO; GO:0005739; C:mitochondrion; ISO:MGI.
GO; GO:0043005; C:neuron projection; ISO:MGI.
GO; GO:0043025; C:neuronal cell body; ISO:MGI.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0043204; C:perikaryon; ISO:MGI.
GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:MGI.
GO; GO:0005886; C:plasma membrane; ISO:MGI.
GO; GO:0032993; C:protein-DNA complex; ISO:MGI.
GO; GO:0003677; F:DNA binding; IDA:MGI.
GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
GO; GO:0008144; F:drug binding; ISO:MGI.
GO; GO:0019899; F:enzyme binding; ISO:MGI.
GO; GO:1903924; F:estradiol binding; ISO:MGI.
GO; GO:0030284; F:estrogen receptor activity; ISO:MGI.
GO; GO:0034056; F:estrogen response element binding; ISO:MGI.
GO; GO:0042562; F:hormone binding; ISO:MGI.
GO; GO:0042802; F:identical protein binding; ISO:MGI.
GO; GO:0004879; F:nuclear receptor activity; ISO:MGI.
GO; GO:0042975; F:peroxisome proliferator activated receptor binding; ISO:MGI.
GO; GO:1990841; F:promoter-specific chromatin binding; ISO:MGI.
GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
GO; GO:0043565; F:sequence-specific DNA binding; ISO:MGI.
GO; GO:0005496; F:steroid binding; ISS:UniProtKB.
GO; GO:1990239; F:steroid hormone binding; ISO:MGI.
GO; GO:0003707; F:steroid hormone receptor activity; ISO:MGI.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0001662; P:behavioral fear response; ISO:MGI.
GO; GO:0007420; P:brain development; IMP:MGI.
GO; GO:0071392; P:cellular response to estradiol stimulus; ISO:MGI.
GO; GO:0060743; P:epithelial cell maturation involved in prostate gland development; IMP:MGI.
GO; GO:0044849; P:estrous cycle; ISO:MGI.
GO; GO:0008628; P:hormone-mediated apoptotic signaling pathway; IMP:MGI.
GO; GO:0030520; P:intracellular estrogen receptor signaling pathway; IMP:MGI.
GO; GO:0030518; P:intracellular steroid hormone receptor signaling pathway; ISO:MGI.
GO; GO:0007611; P:learning or memory; ISO:MGI.
GO; GO:0060766; P:negative regulation of androgen receptor signaling pathway; IMP:MGI.
GO; GO:0048521; P:negative regulation of behavior; ISO:MGI.
GO; GO:0060548; P:negative regulation of cell death; ISO:MGI.
GO; GO:0008285; P:negative regulation of cell population proliferation; IGI:MGI.
GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IMP:MGI.
GO; GO:2000252; P:negative regulation of feeding behavior; ISO:MGI.
GO; GO:1901215; P:negative regulation of neuron death; ISO:MGI.
GO; GO:2000378; P:negative regulation of reactive oxygen species metabolic process; ISO:MGI.
GO; GO:0048662; P:negative regulation of smooth muscle cell proliferation; ISO:MGI.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:MGI.
GO; GO:0001764; P:neuron migration; IMP:MGI.
GO; GO:0001541; P:ovarian follicle development; IMP:MGI.
GO; GO:0043065; P:positive regulation of apoptotic process; ISO:MGI.
GO; GO:0097755; P:positive regulation of blood vessel diameter; ISO:MGI.
GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; ISS:UniProtKB.
GO; GO:0045742; P:positive regulation of epidermal growth factor receptor signaling pathway; ISO:MGI.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISO:MGI.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0060740; P:prostate gland epithelium morphogenesis; IMP:MGI.
GO; GO:0042127; P:regulation of cell population proliferation; IMP:MGI.
GO; GO:0043523; P:regulation of neuron apoptotic process; ISO:MGI.
GO; GO:0033574; P:response to testosterone; ISO:MGI.
GO; GO:0060011; P:Sertoli cell proliferation; ISO:MGI.
GO; GO:0060065; P:uterus development; IGI:MGI.
GO; GO:0060068; P:vagina development; IGI:MGI.
Gene3D; 1.10.565.10; -; 1.
Gene3D; 3.30.50.10; -; 1.
InterPro; IPR028355; ER-beta/gamma.
InterPro; IPR021064; Estrogen_rcpt_beta_N.
InterPro; IPR035500; NHR-like_dom_sf.
InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
InterPro; IPR001723; Nuclear_hrmn_rcpt.
InterPro; IPR024178; Oest_rcpt/oest-rel_rcp.
InterPro; IPR001628; Znf_hrmn_rcpt.
InterPro; IPR013088; Znf_NHR/GATA.
Pfam; PF12497; ERbeta_N; 1.
Pfam; PF00104; Hormone_recep; 1.
Pfam; PF00105; zf-C4; 1.
PIRSF; PIRSF500102; ER-b; 1.
PIRSF; PIRSF002527; ER-like_NR; 1.
PRINTS; PR00398; STRDHORMONER.
PRINTS; PR00047; STROIDFINGER.
SMART; SM00430; HOLI; 1.
SMART; SM00399; ZnF_C4; 1.
SUPFAM; SSF48508; SSF48508; 1.
PROSITE; PS51843; NR_LBD; 1.
PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
1: Evidence at protein level;
Activator; Alternative splicing; DNA-binding; Glycoprotein; Lipid-binding;
Metal-binding; Nucleus; Phosphoprotein; Receptor; Reference proteome;
Steroid-binding; Transcription; Transcription regulation; Zinc;
Zinc-finger.
CHAIN 1..530
/note="Estrogen receptor beta"
/id="PRO_0000053644"
DOMAIN 264..498
/note="NR LBD"
/evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
DNA_BIND 149..214
/note="Nuclear receptor"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
ZN_FING 149..169
/note="NR C4-type"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
ZN_FING 185..209
/note="NR C4-type"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
REGION 1..148
/note="Modulating"
MOD_RES 61
/note="Phosphoserine; alternate"
/evidence="ECO:0000269|PubMed:10995228"
MOD_RES 87
/note="Phosphoserine; by MAPK"
/evidence="ECO:0000269|PubMed:10230404"
MOD_RES 105
/note="Phosphoserine; by MAPK"
/evidence="ECO:0000269|PubMed:10230404"
CARBOHYD 61
/note="O-linked (GlcNAc) serine; alternate"
/evidence="ECO:0000269|PubMed:10995228"
/id="CAR_000201"
VAR_SEQ 319..409
/note="Missing (in isoform 3)"
/evidence="ECO:0000305"
/id="VSP_003696"
VAR_SEQ 319..343
/note="FVELSLLDQVRLLESCWMEVLMVGL -> MRGSAWKGFWKSLTCSWRRRHGS
VS (in isoform 4)"
/evidence="ECO:0000305"
/id="VSP_042429"
VAR_SEQ 344..530
/note="Missing (in isoform 4)"
/evidence="ECO:0000305"
/id="VSP_042430"
VAR_SEQ 364
/note="R -> RSSEDPHWHVAQTKSAVPR (in isoform 2)"
/evidence="ECO:0000303|PubMed:11878304,
ECO:0000303|PubMed:16141072"
/id="VSP_003693"
VAR_SEQ 365..377
/note="DEGKCVEGILEIF -> YVPLGYRKPGSRE (in isoform 5)"
/evidence="ECO:0000305"
/id="VSP_042431"
VAR_SEQ 378..530
/note="Missing (in isoform 5)"
/evidence="ECO:0000305"
/id="VSP_042432"
MUTAGEN 105
/note="S->A: Abolishes stimulatory effect of Ras."
/evidence="ECO:0000269|PubMed:9058381"
MUTAGEN 139
/note="S->A: No loss of the stimulatory effect of Ras."
/evidence="ECO:0000269|PubMed:9058381"
CONFLICT 47
/note="T -> A (in Ref. 5; CAA03949)"
/evidence="ECO:0000305"
CONFLICT 142
/note="A -> T (in Ref. 5; CAA03949)"
/evidence="ECO:0000305"
CONFLICT 200
/note="S -> N (in Ref. 5; CAA03949)"
/evidence="ECO:0000305"
CONFLICT 378
/note="D -> G (in Ref. 1; AAB51132 and 6; AAL15175)"
/evidence="ECO:0000305"
CONFLICT 412
/note="P -> H (in Ref. 5; CAA03949)"
/evidence="ECO:0000305"
CONFLICT 445
/note="G -> R (in Ref. 5; CAA03949)"
/evidence="ECO:0000305"
CONFLICT 511
/note="E -> G (in Ref. 5; CAA03949)"
/evidence="ECO:0000305"
SEQUENCE 530 AA; 59070 MW; BEFA25F62650A8D4 CRC64;
MEIKNSPSSL TSPASYNCSQ SILPLEHGPI YIPSSYVESR HEYSAMTFYS PAVMNYSVPS
STGNLEGGPV RQTASPNVLW PTSGHLSPLA THCQSSLLYA EPQKSPWCEA RSLEHTLPVN
RETLKRKLGG SGCASPVTSP SAKRDAHFCA VCSDYASGYH YGVWSCEGCK AFFKRSIQGH
NDYICPATNQ CTIDKNRRKS CQACRLRKCY EVGMVKCGSR RERCGYRIVR RQRSASEQVH
CLNKAKRTSG HTPRVKELLL NSLSPEQLVL TLLEAEPPNV LVSRPSMPFT EASMMMSLTK
LADKELVHMI GWAKKIPGFV ELSLLDQVRL LESCWMEVLM VGLMWRSIDH PGKLIFAPDL
VLDRDEGKCV EGILEIFDML LATTARFREL KLQHKEYLCV KAMILLNSSM YPLATASQEA
ESSRKLTHLL NAVTDALVWV ISKSGISSQQ QSVRLANLLM LLSHVRHISN KGMEHLLSMK
CKNVVPVYDL LLEMLNAHTL RGYKSSISGS ECCSTEDSKS KEGSQNLQSQ


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WP926: TGF-beta Receptor Signaling Pathway
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WP258: TGF-beta Receptor Signaling Pathway
WP1367: TGF-beta Receptor Signaling Pathway
WP362: TGF-beta Receptor Signaling Pathway
WP1045: TGF-beta Receptor Signaling Pathway
WP1161: TGF-beta Receptor Signaling Pathway
WP1225: estrogen signalling
WP495: Glucocorticoid & Mineralcorticoid Metabolism
WP1004: Kit Receptor Signaling Pathway
WP1207: Fatty Acid Beta Oxidation
WP1449: Regulation of toll-like receptor signaling pathway
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WP368: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP68: Androgen Receptor Signaling Pathway
WP1107: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP1309: Toll-like receptor signaling pathway
WP25: Fatty Acid Beta Oxidation 3
WP113: TGF Beta Signaling Pathway
WP1336: EPO Receptor Signaling
WP1897: Regulation of beta-cell development
WP26: Signal Transduction of S1P Receptor
WP505: TGF Beta Signaling Pathway
WP1025: B Cell Receptor Signaling Pathway

Related Genes :
[ESR2 ESTRB NR3A2] Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
[Esr2 Erbeta Nr3a2] Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
[Esr2 Estrb Nr3a2] Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[Esrrb Err-2 Err2 Nr3b2] Steroid hormone receptor ERR2 (Estrogen receptor-like 2) (Estrogen-related receptor beta) (ERR-beta) (Nuclear receptor subfamily 3 group B member 2)
[ESRRB ERRB2 ESRL2 NR3B2] Steroid hormone receptor ERR2 (ERR beta-2) (Estrogen receptor-like 2) (Estrogen-related receptor beta) (ERR-beta) (Nuclear receptor subfamily 3 group B member 2)
[Esr1 Esr Estr Estra Nr3a1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[Esr1 Esr Estr Nr3a1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[Esrrb Err2 Esrl2 Nr3b2] Steroid hormone receptor ERR2 (Estrogen receptor-like 2) (Estrogen-related receptor beta) (ERR-beta) (Nuclear receptor subfamily 3 group B member 2)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) (Fragment)
[Esrrg Err3 Kiaa0832 Nr3b3] Estrogen-related receptor gamma (Estrogen receptor-related protein 3) (Nuclear receptor subfamily 3 group B member 3)
[ESRRA ERR1 ESRL1 NR3B1] Steroid hormone receptor ERR1 (Estrogen receptor-like 1) (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1)
[Nr1h2 Lxrb] Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear receptor subfamily 1 group H member 2) (Orphan nuclear receptor OR-1) (Ubiquitously-expressed nuclear receptor) (UR)
[NR1D2] Nuclear receptor subfamily 1 group D member 2 (Orphan nuclear hormone receptor BD73) (Rev-erb alpha-related receptor) (RVR) (Rev-erb-beta) (V-erbA-related protein 1-related) (EAR-1R)
[ESR1 ESR NR3A1] Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1) (Fragment)
[THRB ERBA2 NR1A2 THR1] Thyroid hormone receptor beta (Nuclear receptor subfamily 1 group A member 2) (c-erbA-2) (c-erbA-beta)
[Rxrb Nr2b2] Retinoic acid receptor RXR-beta (MHC class I regulatory element-binding protein H-2RIIBP) (Nuclear receptor subfamily 2 group B member 2) (Retinoid X receptor beta)
[Esrra Err1 Estrra Nr3b1] Steroid hormone receptor ERR1 (Estrogen receptor-like 1) (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1)
[Thrb Erba2 Nr1a2] Thyroid hormone receptor beta (Nuclear receptor subfamily 1 group A member 2) (c-erbA-2) (c-erbA-beta)
[Esrra Nr3b1] Steroid hormone receptor ERR1 (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1)
[Nr1d2] Nuclear receptor subfamily 1 group D member 2 (Orphan nuclear receptor RVR) (Rev-erb-beta)
[thrb nr1a2 trb si:ch211-264a6.2] Thyroid hormone receptor beta (TR-beta) (TRb) (Nuclear receptor subfamily 1 group A member 2) (Thyroid hormone receptor beta-1) (TRbeta1)
[rxrba nr2b2a rxrb rxre] Retinoic acid receptor RXR-beta-A (Nuclear receptor subfamily 2 group B member 2-A) (Retinoid X receptor beta-A)
[NR5A2 B1F CPF FTF] Nuclear receptor subfamily 5 group A member 2 (Alpha-1-fetoprotein transcription factor) (B1-binding factor) (hB1F) (CYP7A promoter-binding factor) (Hepatocytic transcription factor) (Liver receptor homolog 1) (LRH-1)

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[23117931] The androgen metabolite, 5α-androstane-3β,17β-diol, decreases cytokine-induced cyclooxygenase-2, vascular cell adhesion molecule-1 expression, and P-glycoprotein expression in male human brain microvascular endothelial cells.
[23064813] Expression of MAGE-A11 in breast cancer tissues and its effects on the proliferation of breast cancer cells.
[19132993] pS2 (TFF1) expression in prostate carcinoma: correlation with steroid receptor status.
[16481595] Molecular evidence that growth of dominant follicles involves a reduction in follicle-stimulating hormone dependence and an increase in luteinizing hormone dependence in cattle.
[16352672] Regulation of BCRP/ABCG2 expression by progesterone and 17beta-estradiol in human placental BeWo cells.
[14605098] Estrogen receptor functional activity changes during differentiation of mammary epithelial cells.
[12828421] Distribution of estrogen receptor beta mRNA-containing cells in ovariectomized and estrogen-treated female rat brain.
[12822488] [Studies on estrogenic activities of food additives with human breast cancer MCF-7 cells and mechanism of estrogenicity by BHA and OPP].
[11345900] Transcriptional activation of genes by 17 beta-estradiol through estrogen receptor-Sp1 interactions.