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Ethylene-responsive transcription factor WRI1 (Protein ACTIVATOR OF SPORAMIN::LUC 1) (Protein WRINKLED 1)

 WRI1_ARATH              Reviewed;         430 AA.
Q6X5Y6; Q2V3P6; Q6J9N7; Q9M2V3; Q9M2V4;
21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 1.
08-MAY-2019, entry version 108.
RecName: Full=Ethylene-responsive transcription factor WRI1;
AltName: Full=Protein ACTIVATOR OF SPORAMIN::LUC 1;
AltName: Full=Protein WRINKLED 1;
Name=WRI1; Synonyms=ASML1; OrderedLocusNames=At3g54320;
ORFNames=T12E18.10, T12E18.20;
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, AND TISSUE
SPECIFICITY.
STRAIN=cv. Col-2;
PubMed=15500472; DOI=10.1111/j.1365-313X.2004.02235.x;
Cernac A., Benning C.;
"WRINKLED1 encodes an AP2/EREB domain protein involved in the control
of storage compound biosynthesis in Arabidopsis.";
Plant J. 40:575-585(2004).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY,
AND INDUCTION.
STRAIN=cv. Columbia;
PubMed=15753106; DOI=10.1093/pcp/pci072;
Masaki T., Mitsui N., Tsukagoshi H., Nishii T., Morikami A.,
Nakamura K.;
"ACTIVATOR of Spomin::LUC1/WRINKLED1 of Arabidopsis thaliana
transactivates sugar-inducible promoters.";
Plant Cell Physiol. 46:547-556(2005).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Pan Y., Gong W., Liu D., Fu Q., Mei W.-Q., Song W.-Q., Ma L.-G.,
Luo J.-C., Deng X.-W., Zhu Y.-X.;
"Molecular cloning, expression, phylogenetic and functional
characterization of the Arabidopsis AP2/EREBP transcription factor
family.";
Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=11130713; DOI=10.1038/35048706;
Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M.,
Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B.,
Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P.,
De Simone V., Choisne N., Artiguenave F., Robert C., Brottier P.,
Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F.,
Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V.,
Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S.,
Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G.,
Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B.,
Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G.,
Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J.,
Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D.,
Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
Monfort A., Argiriou A., Flores M., Liguori R., Vitale D.,
Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W.,
Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J.,
Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P.,
Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S.,
Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V.,
Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C.,
Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E.,
Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y.,
Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A.,
Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
Watanabe A., Yamada M., Yasuda M., Tabata S.;
"Sequence and analysis of chromosome 3 of the plant Arabidopsis
thaliana.";
Nature 408:820-822(2000).
[5]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
PubMed=27862469; DOI=10.1111/tpj.13415;
Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
Town C.D.;
"Araport11: a complete reannotation of the Arabidopsis thaliana
reference genome.";
Plant J. 89:789-804(2017).
[6]
FUNCTION.
PubMed=9733529; DOI=10.1104/pp.118.1.91;
Focks N., Benning C.;
"wrinkled1: A novel, low-seed-oil mutant of Arabidopsis with a
deficiency in the seed-specific regulation of carbohydrate
metabolism.";
Plant Physiol. 118:91-101(1998).
[7]
FUNCTION.
PubMed=12084821; DOI=10.1105/tpc.000877;
Ruuska S.A., Girke T., Benning C., Ohlrogge J.B.;
"Contrapuntal networks of gene expression during Arabidopsis seed
filling.";
Plant Cell 14:1191-1206(2002).
[8]
FUNCTION.
PubMed=16553903; DOI=10.1111/j.1365-313X.2006.02682.x;
Baud S., Graham I.A.;
"A spatiotemporal analysis of enzymatic activities associated with
carbon metabolism in wild-type and mutant embryos of Arabidopsis using
in situ histochemistry.";
Plant J. 46:155-169(2006).
[9]
FUNCTION.
PubMed=16632590; DOI=10.1104/pp.106.079574;
Cernac A., Andre C., Hoffmann-Benning S., Benning C.;
"WRI1 is required for seed germination and seedling establishment.";
Plant Physiol. 141:745-757(2006).
[10]
GENE FAMILY, AND NOMENCLATURE.
PubMed=16407444; DOI=10.1104/pp.105.073783;
Nakano T., Suzuki K., Fujimura T., Shinshi H.;
"Genome-wide analysis of the ERF gene family in Arabidopsis and
rice.";
Plant Physiol. 140:411-432(2006).
[11]
ACTIVITY REGULATION, MUTAGENESIS OF LYS-2; LYS-3; THR-70 AND SER-166,
UBIQUITINATION, INTERACTION WITH KIN10 AND KIN11, PHOSPHORYLATION AT
THR-70 AND SER-166, AND IDENTIFICATION BY MASS SPECTROMETRY.
PubMed=28314829; DOI=10.1105/tpc.17.00019;
Zhai Z., Liu H., Shanklin J.;
"Phosphorylation of WRINKLED1 by KIN10 results in its proteasomal
degradation, providing a link between energy homeostasis and lipid
biosynthesis.";
Plant Cell 29:871-889(2017).
-!- FUNCTION: May be involved in the regulation of gene expression by
stress factors and by components of stress signal transduction
pathways (By similarity). Transcriptional activator involved in
the activation of a subset of sugar-responsive genes and the
control of carbon flow from sucrose import to oil accumulation in
developing seeds. Binds to the GCC-box pathogenesis-related
promoter element. Promotes sugar uptake and seed oil accumulation
by glycolysis. Required for embryo development, seed germination
and, indirectly, for seedling establishment. Negative regulator of
the ABA-mediated germination inhibition. {ECO:0000250,
ECO:0000269|PubMed:12084821, ECO:0000269|PubMed:15500472,
ECO:0000269|PubMed:15753106, ECO:0000269|PubMed:16553903,
ECO:0000269|PubMed:16632590, ECO:0000269|PubMed:9733529}.
-!- ACTIVITY REGULATION: Down-regulated by KIN10 that controls its
protein stability under a phosphorylation-dependent manner.
{ECO:0000269|PubMed:28314829}.
-!- SUBUNIT: Interacts with KIN10 and KIN11.
{ECO:0000269|PubMed:28314829}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=1;
IsoId=Q6X5Y6-1; Sequence=Displayed;
Name=2;
IsoId=Q6X5Y6-2; Sequence=VSP_027415, VSP_027416;
Name=3;
IsoId=Q6X5Y6-3; Sequence=VSP_027417;
Note=Derived from EST data. No experimental confirmation
available.;
-!- TISSUE SPECIFICITY: Mostly expressed in siliques, especially in
seeds. Also detected in roots and flowers, and, to a lower extent,
in leaves stems and seedlings. {ECO:0000269|PubMed:15500472,
ECO:0000269|PubMed:15753106}.
-!- INDUCTION: Transiantly in leaves by sucrose, but not by abscisic
acid (ABA). {ECO:0000269|PubMed:15753106}.
-!- PTM: Ubiquitinated. {ECO:0000269|PubMed:28314829}.
-!- PTM: The phosphorylation at Thr-70 and Ser-166 by KIN10
facilitates its degradation via the proteasomal pathway.
{ECO:0000269|PubMed:28314829}.
-!- SIMILARITY: Belongs to the AP2/ERF transcription factor family.
AP2 subfamily. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=CAB81797.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Sequence=CAB81798.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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EMBL; AY254038; AAP80382.1; -; mRNA.
EMBL; AY885245; AAX11223.1; -; mRNA.
EMBL; AY560888; AAT44955.1; -; mRNA.
EMBL; AL132971; CAB81797.1; ALT_SEQ; Genomic_DNA.
EMBL; AL132971; CAB81798.1; ALT_SEQ; Genomic_DNA.
EMBL; CP002686; AEE79213.1; -; Genomic_DNA.
EMBL; CP002686; AEE79215.1; -; Genomic_DNA.
PIR; T47591; T47591.
PIR; T47592; T47592.
RefSeq; NP_001030857.1; NM_001035780.3. [Q6X5Y6-1]
RefSeq; NP_191000.3; NM_115292.4. [Q6X5Y6-3]
SMR; Q6X5Y6; -.
BioGrid; 9916; 6.
STRING; 3702.AT3G54320.1; -.
PaxDb; Q6X5Y6; -.
EnsemblPlants; AT3G54320.1; AT3G54320.1; AT3G54320. [Q6X5Y6-3]
EnsemblPlants; AT3G54320.3; AT3G54320.3; AT3G54320. [Q6X5Y6-1]
GeneID; 824599; -.
Gramene; AT3G54320.1; AT3G54320.1; AT3G54320. [Q6X5Y6-3]
Gramene; AT3G54320.3; AT3G54320.3; AT3G54320. [Q6X5Y6-1]
KEGG; ath:AT3G54320; -.
Araport; AT3G54320; -.
TAIR; locus:2096144; AT3G54320.
eggNOG; ENOG410IKV6; Eukaryota.
eggNOG; ENOG410Y9IH; LUCA.
HOGENOM; HOG000238389; -.
InParanoid; Q6X5Y6; -.
OrthoDB; 934258at2759; -.
PhylomeDB; Q6X5Y6; -.
PRO; PR:Q6X5Y6; -.
Proteomes; UP000006548; Chromosome 3.
ExpressionAtlas; Q6X5Y6; baseline and differential.
Genevisible; Q6X5Y6; AT.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0003677; F:DNA binding; IDA:TAIR.
GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
GO; GO:0019900; F:kinase binding; IPI:UniProtKB.
GO; GO:0009873; P:ethylene-activated signaling pathway; IEA:UniProtKB-KW.
GO; GO:0008610; P:lipid biosynthetic process; IMP:TAIR.
GO; GO:0006629; P:lipid metabolic process; IMP:TAIR.
GO; GO:1901959; P:positive regulation of cutin biosynthetic process; IGI:TAIR.
GO; GO:0006109; P:regulation of carbohydrate metabolic process; IMP:TAIR.
GO; GO:0006110; P:regulation of glycolytic process; IMP:TAIR.
GO; GO:0009744; P:response to sucrose; IEP:TAIR.
GO; GO:0019432; P:triglyceride biosynthetic process; IMP:TAIR.
CDD; cd00018; AP2; 2.
Gene3D; 3.30.730.10; -; 2.
InterPro; IPR001471; AP2/ERF_dom.
InterPro; IPR036955; AP2/ERF_dom_sf.
InterPro; IPR016177; DNA-bd_dom_sf.
Pfam; PF00847; AP2; 2.
PRINTS; PR00367; ETHRSPELEMNT.
SMART; SM00380; AP2; 2.
SUPFAM; SSF54171; SSF54171; 2.
PROSITE; PS51032; AP2_ERF; 2.
1: Evidence at protein level;
Activator; Alternative splicing; Complete proteome; DNA-binding;
Ethylene signaling pathway; Nucleus; Phosphoprotein;
Reference proteome; Repeat; Transcription; Transcription regulation;
Ubl conjugation.
CHAIN 1