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Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (Protein SITPEC)

 ECSIT_MOUSE             Reviewed;         435 AA.
Q9QZH6; Q91V53;
26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
26-JUN-2007, sequence version 2.
16-OCT-2019, entry version 114.
RecName: Full=Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial;
AltName: Full=Protein SITPEC;
Flags: Precursor;
Name=Ecsit; Synonyms=Sitpec;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH TRAF6 AND MAP3K1,
FUNCTION, ALTERNATIVE SPLICING, AND TISSUE SPECIFICITY.
TISSUE=Liver;
PubMed=10465784; DOI=10.1101/gad.13.16.2059;
Kopp E., Medzhitov R., Carothers J., Xiao C., Douglas I.,
Janeway C.A., Ghosh S.;
"ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1
signal transduction pathway.";
Genes Dev. 13:2059-2071(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Czech II, and FVB/N; TISSUE=Mammary tumor;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH SMAD1 AND SMAD4,
ALTERNATIVE SPLICING, AND TISSUE SPECIFICITY.
PubMed=14633973; DOI=10.1101/gad.1145603;
Xiao C., Shim J.-H., Klueppel M., Zhang S.S.-M., Dong C.,
Flavell R.A., Fu X.-Y., Wrana J.L., Hogan B.L.M., Ghosh S.;
"Ecsit is required for Bmp signaling and mesoderm formation during
mouse embryogenesis.";
Genes Dev. 17:2933-2949(2003).
[4]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brown adipose tissue, Heart, Kidney, Liver, Spleen, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[5]
INTERACTION WITH TRIM59.
PubMed=22588174; DOI=10.1016/j.bbrc.2012.05.028;
Kondo T., Watanabe M., Hatakeyama S.;
"TRIM59 interacts with ECSIT and negatively regulates NF-kappaB and
IRF-3/7-mediated signal pathways.";
Biochem. Biophys. Res. Commun. 422:501-507(2012).
-!- FUNCTION: Adapter protein of the Toll-like and IL-1 receptor
signaling pathway that is involved in the activation of NF-kappa-B
via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in
the BMP signaling pathway. Required for normal embryonic
development. {ECO:0000269|PubMed:10465784,
ECO:0000269|PubMed:14633973}.
-!- FUNCTION: Required for efficient assembly of mitochondrial
NADH:ubiquinone oxidoreductase. {ECO:0000250}.
-!- SUBUNIT: Interacts with NDUFAF1 (By similarity). Interacts with
ACAD9 (By similarity). Part of the mitochondrial complex I
assembly (MCIA) complex. The complex comprises at least TMEM126B,
NDUFAF1, ECSIT, and ACAD9 (By similarity). Interacts with MAP3K1,
SMAD4 and TRAF6. Interacts with SMAD1 only after BMP4-treatment.
Interacts with TRIM59 (PubMed:22588174).
{ECO:0000250|UniProtKB:Q5XIC2, ECO:0000250|UniProtKB:Q9BQ95,
ECO:0000269|PubMed:10465784, ECO:0000269|PubMed:14633973,
ECO:0000269|PubMed:22588174}.
-!- INTERACTION:
Q9Y4K3:TRAF6 (xeno); NbExp=2; IntAct=EBI-527020, EBI-359276;
P70196:Traf6; NbExp=5; IntAct=EBI-527020, EBI-448028;
P62991:Ubc; NbExp=2; IntAct=EBI-527020, EBI-413074;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14633973}.
Nucleus {ECO:0000269|PubMed:14633973}. Mitochondrion
{ECO:0000250}.
-!- TISSUE SPECIFICITY: Detected in heart, brain, lung, liver,
skeletal muscle, kidney and testis. Detected in embryonic mesoderm
and epiblast, and in extraembryonic ectoderm.
{ECO:0000269|PubMed:10465784, ECO:0000269|PubMed:14633973}.
-!- SIMILARITY: Belongs to the ECSIT family. {ECO:0000305}.
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EMBL; AF182510; AAF01219.1; -; mRNA.
EMBL; BC004583; AAH04583.1; -; mRNA.
EMBL; BC016424; AAH16424.1; -; mRNA.
CCDS; CCDS22920.1; -.
RefSeq; NP_001240826.1; NM_001253897.1.
RefSeq; NP_001240827.1; NM_001253898.1.
RefSeq; NP_036159.1; NM_012029.2.
RefSeq; XP_006510433.1; XM_006510370.3.
RefSeq; XP_011240840.1; XM_011242538.2.
SMR; Q9QZH6; -.
BioGrid; 205076; 5.
CORUM; Q9QZH6; -.
DIP; DIP-33901N; -.
IntAct; Q9QZH6; 16.
STRING; 10090.ENSMUSP00000137424; -.
iPTMnet; Q9QZH6; -.
PhosphoSitePlus; Q9QZH6; -.
EPD; Q9QZH6; -.
jPOST; Q9QZH6; -.
MaxQB; Q9QZH6; -.
PaxDb; Q9QZH6; -.
PeptideAtlas; Q9QZH6; -.
PRIDE; Q9QZH6; -.
GeneID; 26940; -.
KEGG; mmu:26940; -.
UCSC; uc009ons.2; mouse.
CTD; 51295; -.
MGI; MGI:1349469; Ecsit.
eggNOG; KOG3941; Eukaryota.
eggNOG; ENOG41100I6; LUCA.
HOGENOM; HOG000112324; -.
InParanoid; Q9QZH6; -.
KO; K04405; -.
OrthoDB; 995360at2759; -.
PhylomeDB; Q9QZH6; -.
TreeFam; TF314943; -.
Reactome; R-MMU-166058; MyD88:MAL(TIRAP) cascade initiated on plasma membrane.
Reactome; R-MMU-6799198; Complex I biogenesis.
Reactome; R-MMU-975138; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
Reactome; R-MMU-975871; MyD88 cascade initiated on plasma membrane.
ChiTaRS; Ecsit; mouse.
PRO; PR:Q9QZH6; -.
Proteomes; UP000000589; Unplaced.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005829; C:cytosol; ISO:MGI.
GO; GO:0005739; C:mitochondrion; IDA:MGI.
GO; GO:0005654; C:nucleoplasm; ISO:MGI.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0005667; C:transcription factor complex; IDA:MGI.
GO; GO:0003682; F:chromatin binding; IDA:MGI.
GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:MGI.
GO; GO:0016651; F:oxidoreductase activity, acting on NAD(P)H; ISS:UniProtKB.
GO; GO:0030509; P:BMP signaling pathway; IDA:MGI.
GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO; GO:0001707; P:mesoderm formation; IMP:MGI.
GO; GO:0051341; P:regulation of oxidoreductase activity; ISS:UniProtKB.
GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:MGI.
GO; GO:0007178; P:transmembrane receptor protein serine/threonine kinase signaling pathway; IDA:MGI.
InterPro; IPR029342; ECIST_C.
InterPro; IPR010418; ECSIT.
PANTHER; PTHR13113; PTHR13113; 1.
Pfam; PF06239; ECSIT; 1.
Pfam; PF14784; ECSIT_C; 1.
SMART; SM01284; ECSIT_Cterm; 1.
1: Evidence at protein level;
Complete proteome; Cytoplasm; Immunity; Innate immunity;
Mitochondrion; Nucleus; Reference proteome; Transit peptide.
TRANSIT 1 48 Mitochondrion. {ECO:0000255}.
CHAIN 49 435 Evolutionarily conserved signaling
intermediate in Toll pathway,
mitochondrial.
/FTId=PRO_0000291987.
CONFLICT 75 75 L -> S (in Ref. 1; AAF01219).
{ECO:0000305}.
SEQUENCE 435 AA; 49799 MW; A2ABA68F1E2C6BF3 CRC64;
MSWVQVNLLV RSLSRGWGGL CRPALSGTPF AQVSLQALRG LHCSAATHKD EPWLVPRPPE
PQRKPIKVPA MHEDLFKPSG NRERDKASFL NAVRSFGAHN VRKRGHVDFI YLALRKMPEF
GVERDLSVYN LLLDVFPKEV FRPRNVIQRI FVHYPRQQEC GVAVLEQMER HGVMPSAETE
FLLIQIFGRK SYPMLKFLRM KLWFTRFKNI NPYPVPRDLP QDPLDLAKLG LRHMEPDLSA
KVTVYQMSLP SDSTGMEDPT QPHIVGIQSP DQQAALARHN PSRPVFVEGP FPLWLRNKCV
YYHILRADLP PPEEEKVEEI PEEWELYYPQ KLDLEYSRSG WDDYEFDVDE VTEGPVFAMC
MAGAHDQATL IKWIQGLQET NPTLAQIPVV FRLARSTGEL LTTSRLEGQS PPHSPPKGPE
EDDETIQAEQ QQGQS


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[Mavs Ips1 Visa] Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Virus-induced-signaling adapter) (VISA)
[TICAM1 PRVTIRB TRIF] TIR domain-containing adapter molecule 1 (TICAM-1) (Proline-rich, vinculin and TIR domain-containing protein B) (Putative NF-kappa-B-activating protein 502H) (Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta) (MyD88-3) (TIR domain-containing adapter protein inducing IFN-beta)
[TICAM2 TIRAP3 TIRP TRAM] TIR domain-containing adapter molecule 2 (TICAM-2) (Putative NF-kappa-B-activating protein 502) (TRIF-related adapter molecule) (Toll-like receptor adaptor protein 3) (Toll/interleukin-1 receptor domain-containing protein) (MyD88-4)
[MAVS IPS1 KIAA1271 VISA] Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)
[FXN FRDA X25] Frataxin, mitochondrial (EC 1.16.3.1) (Friedreich ataxia protein) (Fxn) [Cleaved into: Frataxin intermediate form (i-FXN); Frataxin(56-210) (m56-FXN); Frataxin(78-210) (d-FXN) (m78-FXN); Frataxin mature form (Frataxin(81-210)) (m81-FXN)]
[TOLLIP] Toll-interacting protein
[SEPTIN4 ARTS PNUTL2 SEP4 SEPT4 hucep-7] Septin-4 (Apoptosis-related protein in the TGF-beta signaling pathway) (ARTS) (Bradeion beta) (Brain protein H5) (CE5B3 beta) (Cell division control-related protein 2) (hCDCREL-2) (Cerebral protein 7) (Peanut-like protein 2)
[Ticam1 Trif] TIR domain-containing adapter molecule 1 (TICAM-1) (Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta) (TIR domain-containing adapter protein inducing IFN-beta)
[Ticam2 Tirp Tram] TIR domain-containing adapter molecule 2 (TICAM-2) (TRIF-related adapter molecule) (Toll/interleukin-1 receptor domain-containing protein)
[TLR2 TIL4] Toll-like receptor 2 (Toll/interleukin-1 receptor-like protein 4) (CD antigen CD282)
[TLR1 KIAA0012] Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281)
[TLR4] Toll-like receptor 4 (hToll) (CD antigen CD284)
[Tlr1] Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281)
[PAM16 MAGMAS TIM16 TIMM16 CGI-136] Mitochondrial import inner membrane translocase subunit TIM16 (Mitochondria-associated granulocyte macrophage CSF-signaling molecule) (Presequence translocated-associated motor subunit PAM16)
[TLR5 TIL3] Toll-like receptor 5 (Toll/interleukin-1 receptor-like protein 3)
[TLR6] Toll-like receptor 6 (CD antigen CD286)
[APEX1 APE APE1 APEX APX HAP1 REF1] DNA-(apurinic or apyrimidinic site) lyase (EC 3.1.-.-) (EC 4.2.99.18) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (APE-1) (REF-1) (Redox factor-1) [Cleaved into: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial]
[Apex1 Ape Apex Ref1] DNA-(apurinic or apyrimidinic site) lyase (EC 3.1.-.-) (EC 4.2.99.18) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (REF-1) (Redox factor-1) [Cleaved into: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial]
[Apex1 Ape Apex Ref1] DNA-(apurinic or apyrimidinic site) lyase (EC 3.1.-.-) (EC 4.2.99.18) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (REF-1) (Redox factor-1) [Cleaved into: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial]
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[APEX1 APE APEX BAP1 REF1] DNA-(apurinic or apyrimidinic site) lyase (EC 3.1.-.-) (EC 4.2.99.18) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (REF-1) (Redox factor-1) [Cleaved into: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial]
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Bibliography :