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Exosome complex component Csl4

 A0A075G549_9ARCH        Unreviewed;       185 AA.
A0A075G549;
29-OCT-2014, integrated into UniProtKB/TrEMBL.
29-OCT-2014, sequence version 1.
07-NOV-2018, entry version 9.
RecName: Full=Exosome complex component Csl4 {ECO:0000256|HAMAP-Rule:MF_00975};
Name=CSL4 {ECO:0000313|EMBL:AIE96931.1};
Synonyms=csl4 {ECO:0000256|HAMAP-Rule:MF_00975},
EXOSC1 {ECO:0000313|EMBL:AIE96931.1};
uncultured marine thaumarchaeote AD1000_88_E07.
Archaea; Thaumarchaeota; environmental samples.
NCBI_TaxID=1455946 {ECO:0000313|EMBL:AIE96931.1};
[1] {ECO:0000313|EMBL:AIE96931.1}
NUCLEOTIDE SEQUENCE.
PubMed=24923324; DOI=10.1093/gbe/evu127;
Deschamps P., Zivanovic Y., Moreira D., Rodriguez-Valera F.,
Lopez-Garcia P.;
"Pangenome evidence for extensive interdomain horizontal transfer
affecting lineage core and shell genes in uncultured planktonic
thaumarchaeota and euryarchaeota.";
Genome Biol. Evol. 6:1549-1563(2014).
-!- FUNCTION: Non-catalytic component of the exosome, which is a
complex involved in RNA degradation. Increases the RNA binding and
the efficiency of RNA degradation. Helpful for the interaction of
the exosome with A-poor RNAs. {ECO:0000256|HAMAP-Rule:MF_00975}.
-!- SUBUNIT: Component of the archaeal exosome complex. Forms a trimer
of Rrp4 and/or Csl4 subunits. The trimer associates with an
hexameric ring-like arrangement composed of 3 Rrp41-Rrp42
heterodimers. Interacts with DnaG. {ECO:0000256|HAMAP-
Rule:MF_00975}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00975}.
-!- SIMILARITY: Belongs to the CSL4 family. {ECO:0000256|HAMAP-
Rule:MF_00975}.
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EMBL; KF900493; AIE96931.1; -; Genomic_DNA.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
GO; GO:0006401; P:RNA catabolic process; IEA:UniProtKB-UniRule.
GO; GO:0006396; P:RNA processing; IEA:InterPro.
HAMAP; MF_00975; Exosome_Csl4; 1.
InterPro; IPR039771; Csl4.
InterPro; IPR025721; Exosome_cplx_N_dom.
InterPro; IPR030850; Exosome_Csl4_arc.
InterPro; IPR012340; NA-bd_OB-fold.
PANTHER; PTHR12686; PTHR12686; 1.
Pfam; PF14382; ECR1_N; 1.
SUPFAM; SSF50249; SSF50249; 1.
3: Inferred from homology;
Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00975};
Exosome {ECO:0000256|HAMAP-Rule:MF_00975};
Metal-binding {ECO:0000256|HAMAP-Rule:MF_00975};
Zinc {ECO:0000256|HAMAP-Rule:MF_00975}.
DOMAIN 7 40 ECR1_N. {ECO:0000259|Pfam:PF14382}.
METAL 142 142 Zinc. {ECO:0000256|HAMAP-Rule:MF_00975}.
METAL 145 145 Zinc. {ECO:0000256|HAMAP-Rule:MF_00975}.
METAL 158 158 Zinc. {ECO:0000256|HAMAP-Rule:MF_00975}.
METAL 161 161 Zinc. {ECO:0000256|HAMAP-Rule:MF_00975}.
SEQUENCE 185 AA; 20483 MW; F9B0F99DF344B941 CRC64;
MTEELKLPGD KIAMIEEFLP GDNTFEDGHS IRSASVGTVE LNKSEQLVSI QKKKSISIPN
IGDIIIGTVE ASLGSMIAVS IEYVNNIRTA SNVECICSIR HLRKKNAALV KDIVKLKILN
HVNGTIHAGI DEHDLGVLFT KCRKCFGVVV KVRDAVKCSE CGWIDDRKLS SDFEKADFLK
FDEHK


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Pathways :
WP1102: EBV LMP1 signaling
WP1122: Blood Clotting Cascade
WP1209: EBV LMP1 signaling
WP1224: EBV LMP1 signaling
WP1243: EBV LMP1 signaling
WP1278: EBV LMP1 signaling
WP1328: EBV LMP1 signaling
WP1571: EBV LMP1 signaling
WP1602: Nicotine Activity on Dopaminergic Neurons
WP1624: Bacterial secretion system
WP1692: Protein export
WP1713: Two-component system
WP2083: Nicotine Activity on Dopaminergic Neurons
WP2272: Pathogenic Escherichia coli infection
WP2361: Gastric cancer network 1
WP2411: Cancer prevention Q
WP2429: Cancer prevention Q
WP255: Blood Clotting Cascade
WP262: EBV LMP1 signaling
WP272: Blood Clotting Cascade
WP460: Blood Clotting Cascade
WP758: EBV LMP1 signaling
WP775: Blood Clotting Cascade
WP866: EBV LMP1 signaling
WP887: Blood Clotting Cascade

Related Genes :
[EXOSC1 CSL4 CGI-108] Exosome complex component CSL4 (Exosome component 1)
[CSL4 SKI4 YNL232W N1154] Exosome complex component CSL4 (CEP1 synthetic lethal protein 4)
[csl4 SPCC1840.11 SPCC965.01] Exosome complex component csl4
[Exosc1 Csl4] Exosome complex component CSL4 (Exosome component 1)
[csl4 SSO0292] Exosome complex component Csl4
[csl4 AF_0206] Exosome complex component Csl4
[RRP4 YHR069C] Exosome complex component RRP4 (Ribosomal RNA-processing protein 4)
[RRP40 YOL142W] Exosome complex component RRP40 (Ribosomal RNA-processing protein 40)
[RRP43 YCR035C YCR35C YCR522] Exosome complex component RRP43 (Ribosomal RNA-processing protein 43)
[SKI6 ECM20 RRP41 YGR195W G7587] Exosome complex component SKI6 (Extracellular mutant protein 20) (Ribosomal RNA-processing protein 41) (Superkiller protein 6)
[RRP42 YDL111C] Exosome complex component RRP42 (Ribosomal RNA-processing protein 42)
[RRP46 YGR095C] Exosome complex component RRP46 (Ribosomal RNA-processing protein 46)
[RRP45 YDR280W D9954.1] Exosome complex component RRP45 (Ribosomal RNA-processing protein 45)
[MTR3 YGR158C G6676] Exosome complex component MTR3 (mRNA transport regulator 3)
[CSL4 csl4 EXOSC1] Exosome complex component Csl4
[CSL4 csl4 EXOSC1] Exosome complex component Csl4
[CSL4 csl4 EXOSC1] Exosome complex component Csl4
[CSL4 csl4 EXOSC1] Exosome complex component Csl4
[ski6 rrp41 SPAC3G9.10c] Exosome complex component ski6 (Ribosomal RNA-processing protein 41)
[DIS3 RRP44 YOL021C O2197] Exosome complex exonuclease DIS3 (EC 3.1.13.-) (EC 3.1.26.-) (Chromosome disjunction protein 3) (Ribosomal RNA-processing protein 44)
[RRP6 UNC733 YOR001W] Exosome complex exonuclease RRP6 (EC 3.1.13.-) (Ribosomal RNA-processing protein 6)
[dis3 rrp44 SPBC26H8.10] Exosome complex exonuclease dis3 (EC 3.1.13.-) (EC 3.1.26.-) (Chromosome disjunction protein 3) (Mitotic control protein dis3) (Ribosomal RNA-processing protein 44)
[rrp6 SPAC1F3.01 SPAC3H8.11] Exosome complex exonuclease rrp6 (EC 3.1.13.-) (Ribosomal RNA-processing protein 6)
[CSL4 csl4 EXOSC1] Exosome complex component Csl4
[csl4 Mmah_1743] Exosome complex component Csl4
[CSL4 csl4 EXOSC1] Exosome complex component Csl4
[CSL4 csl4 EXOSC1] Exosome complex component Csl4
[CSL4 csl4 EXOSC1] Exosome complex component Csl4
[CSL4 csl4 EXOSC1] Exosome complex component Csl4
[CSL4 csl4 EXOSC1] Exosome complex component Csl4

Bibliography :
[27538750] cDNA-library testing identifies transforming genes cooperating with c-myc in mouse pre-B cells.
[27345150] Structure of a Cytoplasmic 11-Subunit RNA Exosome Complex.
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