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FAST kinase domain-containing protein 4 (Cell cycle progression restoration protein 2) (Cell cycle progression protein 2) (Protein TBRG4) (Transforming growth factor beta regulator 4)

 FAKD4_HUMAN             Reviewed;         631 AA.
Q969Z0; A4D2L2; A4D2L3; D3DVL5; D3DVL6; O14710; Q53GI8; Q8NDM4; Q9BUC6;
Q9Y2F6;
23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
12-AUG-2020, entry version 154.
RecName: Full=FAST kinase domain-containing protein 4 {ECO:0000303|PubMed:20869947};
AltName: Full=Cell cycle progression restoration protein 2;
Short=Cell cycle progression protein 2;
AltName: Full=Protein TBRG4;
AltName: Full=Transforming growth factor beta regulator 4 {ECO:0000312|HGNC:HGNC:17443};
Flags: Precursor;
Name=TBRG4 {ECO:0000312|HGNC:HGNC:17443};
Synonyms=CPR2 {ECO:0000303|PubMed:9383053},
FASTKD4 {ECO:0000303|PubMed:20869947}, KIAA0948;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Brain;
PubMed=10231032; DOI=10.1093/dnares/6.1.63;
Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N.,
Tanaka A., Kotani H., Nomura N., Ohara O.;
"Prediction of the coding sequences of unidentified human genes. XIII. The
complete sequences of 100 new cDNA clones from brain which code for large
proteins in vitro.";
DNA Res. 6:63-70(1999).
[2]
SEQUENCE REVISION.
Ohara O., Nagase T., Kikuno R.;
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Kidney;
Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
Tanaka A., Yokoyama S.;
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS SER-22 AND
LEU-57.
TISSUE=Mammary cancer;
PubMed=17974005; DOI=10.1186/1471-2164-8-399;
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
Wiemann S., Schupp I.;
"The full-ORF clone resource of the German cDNA consortium.";
BMC Genomics 8:399-399(2007).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=12690205; DOI=10.1126/science.1083423;
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
Adams M.D., Tsui L.-C.;
"Human chromosome 7: DNA sequence and biology.";
Science 300:767-772(2003).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Lung, and Uterus;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8]
NUCLEOTIDE SEQUENCE [MRNA] OF 172-615 (ISOFORM 1), AND FUNCTION.
TISSUE=Hepatoma;
PubMed=9383053;
Edwards M.C., Liegeois N., Horecka J., DePinho R.A., Sprague G.F. Jr.,
Tyers M., Elledge S.J.;
"Human CPR (cell cycle progression restoration) genes impart a Far-
phenotype on yeast cells.";
Genetics 147:1063-1076(1997).
[9]
TISSUE SPECIFICITY.
TISSUE=Lung;
PubMed=12759187; DOI=10.1016/s0167-4781(03)00051-4;
Rival-Gervier S., Thepot D., Jolivet G., Houdebine L.-M.;
"Pig whey acidic protein gene is surrounded by two ubiquitously expressed
genes.";
Biochim. Biophys. Acta 1627:7-14(2003).
[10]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
Greff Z., Keri G., Stemmann O., Mann M.;
"Kinase-selective enrichment enables quantitative phosphoproteomics of the
kinome across the cell cycle.";
Mol. Cell 31:438-448(2008).
[11]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19608861; DOI=10.1126/science.1175371;
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C.,
Olsen J.V., Mann M.;
"Lysine acetylation targets protein complexes and co-regulates major
cellular functions.";
Science 325:834-840(2009).
[12]
SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
PubMed=20869947; DOI=10.1016/j.bbrc.2010.09.075;
Simarro M., Gimenez-Cassina A., Kedersha N., Lazaro J.B., Adelmant G.O.,
Marto J.A., Rhee K., Tisdale S., Danial N., Benarafa C., Orduna A.,
Anderson P.;
"Fast kinase domain-containing protein 3 is a mitochondrial protein
essential for cellular respiration.";
Biochem. Biophys. Res. Commun. 401:440-446(2010).
[13]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21269460; DOI=10.1186/1752-0509-5-17;
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
Bennett K.L., Superti-Furga G., Colinge J.;
"Initial characterization of the human central proteome.";
BMC Syst. Biol. 5:17-17(2011).
[14]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22814378; DOI=10.1073/pnas.1210303109;
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
"N-terminal acetylome analyses and functional insights of the N-terminal
acetyltransferase NatB.";
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
[15]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-553, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma, and Erythroleukemia;
PubMed=23186163; DOI=10.1021/pr300630k;
Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
Mohammed S.;
"Toward a comprehensive characterization of a human cancer cell
phosphoproteome.";
J. Proteome Res. 12:260-271(2013).
[16]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=25944712; DOI=10.1002/pmic.201400617;
Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
"N-terminome analysis of the human mitochondrial proteome.";
Proteomics 15:2519-2524(2015).
[17]
SUBCELLULAR LOCATION, FUNCTION, DOMAIN, AND MUTAGENESIS OF ASP-531.
PubMed=28335001; DOI=10.1093/nar/gkx164;
Boehm E., Zaganelli S., Maundrell K., Jourdain A.A., Thore S.,
Martinou J.C.;
"FASTKD1 and FASTKD4 have opposite effects on expression of specific
mitochondrial RNAs, depending upon their endonuclease-like RAP domain.";
Nucleic Acids Res. 45:6135-6146(2017).
-!- FUNCTION: Plays a role in processing of mitochondrial RNA precursors
and in stabilization of a subset of mature mitochondrial RNA species,
such as MT-CO1, MT-CO2, MT-CYB, MT-CO3, MT-ND3, MT-ND5 and MT-ATP8/6.
May play a role in cell cycle progression (PubMed:9383053).
{ECO:0000269|PubMed:28335001, ECO:0000269|PubMed:9383053}.
-!- INTERACTION:
Q969Z0; Q6RW13: AGTRAP; NbExp=3; IntAct=EBI-702328, EBI-741181;
Q969Z0; Q6RW13-2: AGTRAP; NbExp=3; IntAct=EBI-702328, EBI-11522760;
Q969Z0; Q8TD16-2: BICD2; NbExp=3; IntAct=EBI-702328, EBI-11975051;
Q969Z0; Q8WZ55: BSND; NbExp=3; IntAct=EBI-702328, EBI-7996695;
Q969Z0; Q13137: CALCOCO2; NbExp=3; IntAct=EBI-702328, EBI-739580;
Q969Z0; Q86X02: CDR2L; NbExp=3; IntAct=EBI-702328, EBI-11063830;
Q969Z0; Q8IZR5-2: CMTM4; NbExp=3; IntAct=EBI-702328, EBI-17278014;
Q969Z0; Q96DZ9-2: CMTM5; NbExp=3; IntAct=EBI-702328, EBI-11522780;
Q969Z0; Q9NRY5: FAM114A2; NbExp=4; IntAct=EBI-702328, EBI-10973142;
Q969Z0; Q8IZU0: FAM9B; NbExp=3; IntAct=EBI-702328, EBI-10175124;
Q969Z0; Q96D09: GPRASP2; NbExp=3; IntAct=EBI-702328, EBI-473189;
Q969Z0; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-702328, EBI-18053395;
Q969Z0; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-702328, EBI-3044087;
Q969Z0; Q9H400: LIME1; NbExp=3; IntAct=EBI-702328, EBI-2830566;
Q969Z0; Q969L2: MAL2; NbExp=3; IntAct=EBI-702328, EBI-944295;
Q969Z0; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-702328, EBI-16439278;
Q969Z0; Q04118: PRB3; NbExp=3; IntAct=EBI-702328, EBI-13360404;
Q969Z0; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-702328, EBI-10192441;
Q969Z0; O15126: SCAMP1; NbExp=3; IntAct=EBI-702328, EBI-954338;
Q969Z0; Q8WV19: SFT2D1; NbExp=3; IntAct=EBI-702328, EBI-2854842;
Q969Z0; B7ZLI8: STK19; NbExp=3; IntAct=EBI-702328, EBI-10176124;
Q969Z0; Q9UBB9: TFIP11; NbExp=3; IntAct=EBI-702328, EBI-1105213;
Q969Z0; Q8WW34-2: TMEM239; NbExp=3; IntAct=EBI-702328, EBI-11528917;
Q969Z0; Q9UBN6: TNFRSF10D; NbExp=3; IntAct=EBI-702328, EBI-1044859;
-!- SUBCELLULAR LOCATION: Mitochondrion matrix
{ECO:0000269|PubMed:20869947, ECO:0000269|PubMed:28335001}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q969Z0-1; Sequence=Displayed;
Name=2;
IsoId=Q969Z0-2; Sequence=VSP_022460;
-!- TISSUE SPECIFICITY: Ubiquitously expressed (PubMed:12759187).
Expression detected in spleen, thymus, testis, ovary, colon, heart,
smooth muscle, kidney, brain, lung, liver and white adipose tissue with
highest expression in smooth muscle (PubMed:20869947).
{ECO:0000269|PubMed:12759187, ECO:0000269|PubMed:20869947}.
-!- DOMAIN: RAP domain is required for TBRG4 function in mRNA stability and
translation. {ECO:0000269|PubMed:28335001}.
-!- SIMILARITY: Belongs to the FAST kinase family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAB69312.1; Type=Frameshift; Evidence={ECO:0000305};
Sequence=BAA76792.2; Type=Erroneous initiation; Evidence={ECO:0000305};
---------------------------------------------------------------------------
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EMBL; AB023165; BAA76792.2; ALT_INIT; mRNA.
EMBL; AK222943; BAD96663.1; -; mRNA.
EMBL; AL833840; CAD38700.1; -; mRNA.
EMBL; CH236960; EAL23744.1; -; Genomic_DNA.
EMBL; CH236960; EAL23745.1; -; Genomic_DNA.
EMBL; CH471128; EAW61051.1; -; Genomic_DNA.
EMBL; CH471128; EAW61052.1; -; Genomic_DNA.
EMBL; CH471128; EAW61054.1; -; Genomic_DNA.
EMBL; CH471128; EAW61055.1; -; Genomic_DNA.
EMBL; BC002732; AAH02732.2; -; mRNA.
EMBL; BC014918; AAH14918.1; -; mRNA.
EMBL; BC017235; AAH17235.1; -; mRNA.
EMBL; AF011792; AAB69312.1; ALT_FRAME; mRNA.
CCDS; CCDS5501.1; -. [Q969Z0-1]
CCDS; CCDS5502.1; -. [Q969Z0-2]
RefSeq; NP_004740.2; NM_004749.3. [Q969Z0-1]
RefSeq; NP_112162.1; NM_030900.3. [Q969Z0-2]
RefSeq; NP_954573.1; NM_199122.2. [Q969Z0-2]
BioGRID; 114666; 55.
IntAct; Q969Z0; 60.
MINT; Q969Z0; -.
STRING; 9606.ENSP00000258770; -.
iPTMnet; Q969Z0; -.
MetOSite; Q969Z0; -.
PhosphoSitePlus; Q969Z0; -.
BioMuta; TBRG4; -.
DMDM; 74731072; -.
EPD; Q969Z0; -.
jPOST; Q969Z0; -.
MassIVE; Q969Z0; -.
MaxQB; Q969Z0; -.
PaxDb; Q969Z0; -.
PeptideAtlas; Q969Z0; -.
PRIDE; Q969Z0; -.
ProteomicsDB; 75880; -. [Q969Z0-1]
ProteomicsDB; 75881; -. [Q969Z0-2]
Antibodypedia; 13534; 172 antibodies.
DNASU; 9238; -.
Ensembl; ENST00000258770; ENSP00000258770; ENSG00000136270. [Q969Z0-1]
Ensembl; ENST00000361278; ENSP00000354992; ENSG00000136270. [Q969Z0-2]
Ensembl; ENST00000395655; ENSP00000379016; ENSG00000136270. [Q969Z0-2]
Ensembl; ENST00000494076; ENSP00000420597; ENSG00000136270. [Q969Z0-1]
GeneID; 9238; -.
KEGG; hsa:9238; -.
UCSC; uc003tmv.5; human. [Q969Z0-1]
CTD; 9238; -.
DisGeNET; 9238; -.
EuPathDB; HostDB:ENSG00000136270.13; -.
GeneCards; TBRG4; -.
HGNC; HGNC:17443; TBRG4.
HPA; ENSG00000136270; Low tissue specificity.
MIM; 611325; gene.
neXtProt; NX_Q969Z0; -.
OpenTargets; ENSG00000136270; -.
PharmGKB; PA134882196; -.
eggNOG; ENOG502QTRE; Eukaryota.
GeneTree; ENSGT00950000182779; -.
HOGENOM; CLU_029448_0_0_1; -.
InParanoid; Q969Z0; -.
OMA; CNLLMTF; -.
PhylomeDB; Q969Z0; -.
TreeFam; TF324885; -.
PathwayCommons; Q969Z0; -.
BioGRID-ORCS; 9238; 34 hits in 876 CRISPR screens.
ChiTaRS; TBRG4; human.
GeneWiki; TBRG4; -.
GenomeRNAi; 9238; -.
Pharos; Q969Z0; Tbio.
PRO; PR:Q969Z0; -.
Proteomes; UP000005640; Chromosome 7.
RNAct; Q969Z0; protein.
Bgee; ENSG00000136270; Expressed in stomach and 167 other tissues.
ExpressionAtlas; Q969Z0; baseline and differential.
Genevisible; Q969Z0; HS.
GO; GO:0005759; C:mitochondrial matrix; IDA:UniProtKB.
GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
GO; GO:0007050; P:cell cycle arrest; TAS:UniProtKB.
GO; GO:0090615; P:mitochondrial mRNA processing; IMP:UniProtKB.
GO; GO:0016071; P:mRNA metabolic process; IMP:UniProtKB.
GO; GO:0008284; P:positive regulation of cell population proliferation; TAS:UniProtKB.
GO; GO:0044528; P:regulation of mitochondrial mRNA stability; IMP:UniProtKB.
InterPro; IPR013579; FAST_2.
InterPro; IPR010622; FAST_Leu-rich.
InterPro; IPR013584; RAP.
Pfam; PF06743; FAST_1; 1.
Pfam; PF08368; FAST_2; 1.
Pfam; PF08373; RAP; 1.
SMART; SM00952; RAP; 1.
PROSITE; PS51286; RAP; 1.
1: Evidence at protein level;
Alternative splicing; Mitochondrion; Phosphoprotein; Polymorphism;
Reference proteome; Transit peptide.
TRANSIT 1..107
/note="Mitochondrion"
/evidence="ECO:0000255"
CHAIN 108..631
/note="FAST kinase domain-containing protein 4"
/id="PRO_0000273026"
DOMAIN 561..619
/note="RAP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00619"
MOD_RES 553
/note="Phosphoserine"
/evidence="ECO:0000244|PubMed:23186163"
VAR_SEQ 246..355
/note="Missing (in isoform 2)"
/evidence="ECO:0000303|PubMed:10231032, ECO:0000303|Ref.3"
/id="VSP_022460"
VARIANT 22
/note="A -> S (in dbSNP:rs2304694)"
/evidence="ECO:0000269|PubMed:17974005"
/id="VAR_030071"
VARIANT 57
/note="P -> L (in dbSNP:rs2304693)"
/evidence="ECO:0000269|PubMed:17974005"
/id="VAR_030072"
MUTAGEN 531
/note="D->A: Does not affect location in mitochondria;
fails to rescue the increased accumulation of the level of
mature MT-ND3, MT-CO3, MT-CYB or MT-ND5 mRNA in TBRG4-
deficient cells; does not abolish the accumulation of the
MT-ND5-CYB precursor RNA in a TBRG4-deficient cell line."
/evidence="ECO:0000269|PubMed:28335001"
CONFLICT 365
/note="T -> A (in Ref. 3; BAD96663)"
/evidence="ECO:0000305"
CONFLICT 489
/note="V -> E (in Ref. 8; AAB69312)"
/evidence="ECO:0000305"
CONFLICT 524
/note="A -> S (in Ref. 8; AAB69312)"
/evidence="ECO:0000305"
SEQUENCE 631 AA; 70738 MW; 4EFC3AF5D5BBABD3 CRC64;
MAAHLVKRCT CLLREAARQA PAMAPVGRLR LAWVAHKTLT SSATSPISHL PGSLMEPVEK
ERASTPYIEK QVDHLIKKAT RPEELLELLG GSHDLDSNQA AMVLIRLSHL LSEKPEDKGL
LIQDAHFHQL LCLLNSQIAS VWHGTLSKLL GSLYALGIPK ASKELQSVEQ EVRWRMRKLK
YKHLAFLAES CATLSQEQHS QELLAELLTH LERRWTEIED SHTLVTVMMK VGHLSEPLMN
RLEDKCLELV EHFGPNELRK VLVMLAAQSR RSVPLLRAIS YHLVQKPFSL TKDVLLDVAY
AYGKLSFHQT QVSQRLATDL LSLMPSLTSG EVAHCAKSFA LLKWLSLPLF EAFAQHVLNR
AQDITLPHLC SVLLAFARLN FHPDQEDQFF SLVHEKLGSE LPGLEPALQV DLVWALCVLQ
QAREAELQAV LHPEFHIQFL GGKSQKDQNT FQKLLHINAT ALLEYPEYSG PLLPASAVAP
GPSALDRKVT PLQKELQETL KGLLGSADKG SLEVATQYGW VLDAEVLLDS DGEFLPVRDF
VAPHLAQPTG SQSPPPGSKR LAFLRWEFPN FNSRSKDLLG RFVLARRHIV AAGFLIVDVP
FYEWLELKSE WQKGAYLKDK MRKAVAEELA K


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CSB-EL004838CH Chicken Cell cycle progression protein 1(CCPG1) ELISA kit 96T
CSB-EL004838HU Human Cell cycle progression protein 1(CCPG1) ELISA kit 96T
CSB-EL004838CH Chicken Cell cycle progression protein 1(CCPG1) ELISA kit SpeciesChicken 96T
CSB-EL004838HU Human Cell cycle progression protein 1(CCPG1) ELISA kit SpeciesHuman 96T
CSB-EL004838MO Mouse Cell cycle progression protein 1(CCPG1) ELISA kit SpeciesMouse 96T
CCPG1_MOUSE ELISA Kit FOR Cell cycle progression protein 1; organism: Mouse; gene name: Ccpg1 96T
CCPG1_HUMAN ELISA Kit FOR Cell cycle progression protein 1; organism: Human; gene name: CCPG1 96T
29-826 CDC23 shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2_M transition. This protein is a component of anaphase-promoting comple 0.1 mg
29-827 CDC23 shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2_M transition. This protein is a component of anaphase-promoting comple 0.05 mg
22248 cell cycle progression 2 protein isoform 2 antibody Source Rabbit Polyconal Ab Species Human Application WB IHC IF 100ul
EIAAB05874 Carp1,CARP-1,Ccar1,Cell cycle and apoptosis regulatory protein 1,Cell division cycle and apoptosis regulator protein 1,Mouse,Mus musculus
27-427 GFI1 may be a transcription factor involved in regulating the expression of genes active in the S phase during cell cycle progression in T-cells. GFI1 may be involved in tumor progression. Defects in 0.05 mg
27-632 GFI1 may be a transcription factor involved in regulating the expression of genes active in the S phase during cell cycle progression in T-cells. GFI1 may be involved in tumor progression. Defects in 0.05 mg
EIAAB41608 Protein TBRG4,Rat,Rattus norvegicus,Tbrg4,Transforming growth factor beta regulator 4
Pathways :
WP1566: Citrate cycle (TCA cycle)
WP1689: Porphyrin and chlorophyll metabolism
WP210: Cytoplasmic Ribosomal Proteins
WP1493: Carbon assimilation C4 pathway
WP2218: sGC
WP1939: Unfolded Protein Response
WP2292: Chemokine signaling pathway
WP1371: G Protein Signaling Pathways
WP445: G1 to S cell cycle control
WP1663: Homologous recombination
WP232: G Protein Signaling Pathways
WP348: G1 to S cell cycle control
WP1393: Cell cycle
WP1673: Naphthalene and anthracene degradation
WP211: BMP signaling pathway
WP1616: ABC transporters
WP1714: Tyrosine metabolism
WP1892: Protein folding
WP1049: G Protein Signaling Pathways
WP413: G1 to S cell cycle control
WP1625: Base excision repair
WP1782: APC/C-mediated degradation of cell cycle proteins
WP1678: Nucleotide excision repair
WP813: G Protein Signaling Pathways
WP2203: TSLP Signaling Pathway

Related Genes :
[TBRG4 CPR2 FASTKD4 KIAA0948] FAST kinase domain-containing protein 4 (Cell cycle progression restoration protein 2) (Cell cycle progression protein 2) (Protein TBRG4) (Transforming growth factor beta regulator 4)
[CCPG1 CCP8 CPR8 KIAA1254] Cell cycle progression protein 1 (Cell cycle progression restoration protein 8)
[CDK11A CDC2L2 CDC2L3 PITSLREB] Cyclin-dependent kinase 11A (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 2) (Cell division protein kinase 11A) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L2)
[cdc-48.2 C41C4.8] Transitional endoplasmic reticulum ATPase homolog 2 (EC 3.6.4.6) (Cell division cycle-related protein 48.2) (p97/CDC48 homolog 2)
[Ccpg1] Cell cycle progression protein 1
[Taf1 Ccg1] Transcription initiation factor TFIID subunit 1 (EC 2.3.1.48) (EC 2.7.11.1) (Cell cycle gene 1 protein) (TBP-associated factor 250 kDa) (p250) (Transcription initiation factor TFIID 250 kDa subunit) (TAF(II)250) (TAFII-250) (TAFII250)
[TGFB2] Transforming growth factor beta-2 proprotein (Cetermin) (Glioblastoma-derived T-cell suppressor factor) (G-TSF) [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-2 (TGF-beta-2)]
[CDK9 CDC2L4 TAK] Cyclin-dependent kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (C-2K) (Cell division cycle 2-like protein kinase 4) (Cell division protein kinase 9) (Serine/threonine-protein kinase PITALRE) (Tat-associated kinase complex catalytic subunit)
[CDK11B CDC2L1 CDK11 PITSLREA PK58] Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1)
[TAF1 BA2R CCG1 CCGS TAF2A] Transcription initiation factor TFIID subunit 1 (EC 2.3.1.48) (EC 2.7.11.1) (Cell cycle gene 1 protein) (TBP-associated factor 250 kDa) (p250) (Transcription initiation factor TFIID 250 kDa subunit) (TAF(II)250) (TAFII-250) (TAFII250)
[TGFBR1 ALK5 SKR4] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[Asun IntS13 Mat89Bb ovary2 CG6814] Protein asunder (Cell cycle regulator Mat89Bb) (Integrator complex subunit 13) (Maternal transcript 89Bb) (Set apart in position or space protein)
[cdc-48.1 C06A1.1] Transitional endoplasmic reticulum ATPase homolog 1 (EC 3.6.4.6) (Cell division cycle-related protein 48.1) (p97/CDC48 homolog 1)
[Cdk11b Cdc2l1 Cdk11] Cyclin-dependent kinase 11B (Cell division cycle 2-like protein kinase 1) (Cell division protein kinase 11) (Cyclin-dependent kinase 11) (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1)
[Tgfbr1] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[cdc-14 C17G10.4] Tyrosine-protein phosphatase cdc-14 (EC 3.1.3.48) (Cell division cycle-related protein 14)
[CHEK1 CHK1] Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Cell cycle checkpoint kinase) (Checkpoint kinase-1)
[CCAR1 CARP1 DIS] Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain)
[Cdc73] Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein homolog)
[Ccar1 Carp1] Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1)
[cdc-48.3 K04G2.3] ATPase family protein 2 homolog (EC 3.6.4.10) (Cell division cycle-related protein 48.3)
[CDC7 CDC7L1] Cell division cycle 7-related protein kinase (CDC7-related kinase) (HsCdc7) (huCdc7) (EC 2.7.11.1)
[mat-3 apc-8 cdc-23 pod-4 vex-2 F10C5.1] Cell division cycle protein 23 homolog (Anaphase-promoting complex subunit 8) (APC8) (Metaphase-to-anaphase transition defect protein 3)
[LTBP4] Latent-transforming growth factor beta-binding protein 4 (LTBP-4)
[TAF1 CCG1] Transcription initiation factor TFIID subunit 1 (EC 2.3.1.48) (EC 2.7.11.1) (Cell cycle gene 1 protein) (TBP-associated factor 250 kDa) (p250) (Transcription initiation factor TFIID 250 kDa subunit) (TAF(II)250) (TAFII-250) (TAFII250)
[MAP3K7 TAK1] Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
[Cdk1 Cdc2 Cdc2a Cdkn1] Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
[CDK13 CDC2L CDC2L5 CHED KIAA1791] Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller)
[Cdk7 Cak Cdkn7 Crk4 Mo15 Mpk-7] Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (P39 Mo15) (CDK-activating kinase) (CR4 protein kinase) (CRK4) (Cell division protein kinase 7) (Protein-tyrosine kinase MPK-7) (TFIIH basal transcription factor complex kinase subunit)
[CDC73 C1orf28 HRPT2] Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein)

Bibliography :
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