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FOS protein (V-fos FBJ murine osteosarcoma viral oncogene homolog, isoform CRA_a) (cDNA FLJ76842, highly similar to Homo sapiens v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS), mRNA)

 Q6FG41_HUMAN            Unreviewed;       380 AA.
Q6FG41;
10-MAY-2005, integrated into UniProtKB/TrEMBL.
10-MAY-2005, sequence version 1.
13-FEB-2019, entry version 137.
SubName: Full=FOS protein {ECO:0000313|EMBL:CAG47063.1};
SubName: Full=V-fos FBJ murine osteosarcoma viral oncogene homolog, isoform CRA_a {ECO:0000313|EMBL:EAW81227.1};
SubName: Full=cDNA FLJ76842, highly similar to Homo sapiens v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS), mRNA {ECO:0000313|EMBL:BAF84015.1};
Name=FOS {ECO:0000313|EMBL:CAG47063.1};
ORFNames=hCG_22355 {ECO:0000313|EMBL:EAW81227.1};
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606 {ECO:0000313|EMBL:CAG47063.1};
[1] {ECO:0000313|EMBL:EAW81227.1}
NUCLEOTIDE SEQUENCE.
PubMed=11181995; DOI=10.1126/science.1058040;
Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G.,
Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D.,
Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q.,
Kodira C.D., Zheng X.H., Chen L., Skupski M., Subramanian G.,
Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S.,
Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J.,
Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R.,
Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A.,
Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K.,
Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V.,
Brandon R., Cargill M., Chandramouliswaran I., Charlab R.,
Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K.,
Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z.,
Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A.,
Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V.,
Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B.,
Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J.,
Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C.,
Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L.,
Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S.,
Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A.,
Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D.,
Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L.,
Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N.,
Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S.,
Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F.,
Kline L., Koduru S., Love A., Mann F., May D., McCawley S.,
McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K.,
Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M.,
Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C.,
Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N.,
Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M.,
Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F.,
Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A.,
Mi H., Lazareva B., Hatton T., Narechania A., Diemer K.,
Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R.,
Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J.,
Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H.,
Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D.,
Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A.,
Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S.,
Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L.,
Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W.,
McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M.,
Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J.,
Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E.,
Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.;
"The sequence of the human genome.";
Science 291:1304-1351(2001).
[2] {ECO:0000313|EMBL:CAG47063.1}
NUCLEOTIDE SEQUENCE.
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S.,
Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W.,
Korn B., Zuo D., Hu Y., LaBaer J.;
"Cloning of human full open reading frames in Gateway(TM) system entry
vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|EMBL:EAW81227.1}
NUCLEOTIDE SEQUENCE.
Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|EMBL:BAF84015.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Tongue {ECO:0000313|EMBL:BAF84015.1};
Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K.,
Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y.,
Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M.,
Kisu Y., Nishikawa T., Sugano S., Nomura N., Isogai T.;
"NEDO human cDNA sequencing project.";
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
-!- INTERACTION:
P29972:AQP1; NbExp=3; IntAct=EBI-10198738, EBI-745213;
Q8N6T3:ARFGAP1; NbExp=3; IntAct=EBI-10198738, EBI-716933;
P15336:ATF2; NbExp=3; IntAct=EBI-10198738, EBI-1170906;
Q9BU64:CENPO; NbExp=3; IntAct=EBI-10198738, EBI-745954;
Q02930-3:CREB5; NbExp=3; IntAct=EBI-10198738, EBI-10192698;
Q8WWE8:CYTH4; NbExp=3; IntAct=EBI-10198738, EBI-10277443;
Q53Y01:GNG11; NbExp=3; IntAct=EBI-10198738, EBI-10243023;
P17275:JUNB; NbExp=4; IntAct=EBI-10198738, EBI-748062;
Q8TAP4:LMO3; NbExp=3; IntAct=EBI-10198738, EBI-742259;
Q9P127:LUZP4; NbExp=3; IntAct=EBI-10198738, EBI-10198848;
P54646:PRKAA2; NbExp=3; IntAct=EBI-10198738, EBI-1383852;
P62195:PSMC5; NbExp=3; IntAct=EBI-10198738, EBI-357745;
P22415:USF1; NbExp=3; IntAct=EBI-10198738, EBI-1054489;
Q15853:USF2; NbExp=3; IntAct=EBI-10198738, EBI-1055994;
-----------------------------------------------------------------------
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EMBL; AK291326; BAF84015.1; -; mRNA.
EMBL; CR541785; CAG46584.1; -; mRNA.
EMBL; CR542267; CAG47063.1; -; mRNA.
EMBL; CH471061; EAW81227.1; -; Genomic_DNA.
EMBL; CH471061; EAW81228.1; -; Genomic_DNA.
RefSeq; NP_005243.1; NM_005252.3.
UniGene; Hs.25647; -.
IntAct; Q6FG41; 14.
DNASU; 2353; -.
GeneID; 2353; -.
KEGG; hsa:2353; -.
UCSC; uc001xrn.4; human.
CTD; 2353; -.
EuPathDB; HostDB:ENSG00000170345.9; -.
PharmGKB; PA28212; -.
eggNOG; KOG1414; Eukaryota.
eggNOG; ENOG4111CH5; LUCA.
HOVERGEN; HBG005743; -.
KO; K04379; -.
OMA; SPDLQWM; -.
OrthoDB; 741011at2759; -.
ChiTaRS; FOS; human.
GenomeRNAi; 2353; -.
Bgee; ENSG00000170345; Expressed in 237 organ(s), highest expression level in mucosa of stomach.
GO; GO:0016020; C:membrane; IEA:Ensembl.
GO; GO:0043005; C:neuron projection; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IDA:HPA.
GO; GO:0005667; C:transcription factor complex; IEA:Ensembl.
GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
GO; GO:0007568; P:aging; IEA:Ensembl.
GO; GO:0071277; P:cellular response to calcium ion; IEA:Ensembl.
GO; GO:0031668; P:cellular response to extracellular stimulus; IEA:Ensembl.
GO; GO:0032870; P:cellular response to hormone stimulus; IEA:Ensembl.
GO; GO:0001661; P:conditioned taste aversion; IEA:Ensembl.
GO; GO:0007565; P:female pregnancy; IEA:Ensembl.
GO; GO:0007399; P:nervous system development; IEA:Ensembl.
GO; GO:1901216; P:positive regulation of neuron death; IEA:Ensembl.
GO; GO:0045672; P:positive regulation of osteoclast differentiation; IEA:Ensembl.
GO; GO:1902895; P:positive regulation of pri-miRNA transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0051591; P:response to cAMP; IEA:Ensembl.
GO; GO:0009409; P:response to cold; IEA:Ensembl.
GO; GO:0051412; P:response to corticosterone; IEA:Ensembl.
GO; GO:0034097; P:response to cytokine; IEA:Ensembl.
GO; GO:0009629; P:response to gravity; IEA:Ensembl.
GO; GO:0035902; P:response to immobilization stress; IEA:Ensembl.
GO; GO:0009416; P:response to light stimulus; IEA:Ensembl.
GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
GO; GO:0035994; P:response to muscle stretch; IEA:Ensembl.
GO; GO:0032570; P:response to progesterone; IEA:Ensembl.
GO; GO:0009636; P:response to toxic substance; IEA:Ensembl.
GO; GO:0035914; P:skeletal muscle cell differentiation; IEA:Ensembl.
GO; GO:0030431; P:sleep; IEA:Ensembl.
GO; GO:0006366; P:transcription by RNA polymerase II; IEA:Ensembl.
InterPro; IPR000837; AP-1.
InterPro; IPR004827; bZIP.
InterPro; IPR029816; c-Fos/v-Fos.
PANTHER; PTHR23351; PTHR23351; 1.
PANTHER; PTHR23351:SF4; PTHR23351:SF4; 1.
Pfam; PF00170; bZIP_1; 1.
PRINTS; PR00042; LEUZIPPRFOS.
SMART; SM00338; BRLZ; 1.
PROSITE; PS50217; BZIP; 1.
PROSITE; PS00036; BZIP_BASIC; 1.
1: Evidence at protein level;
Coiled coil {ECO:0000256|SAM:Coils};
DNA-binding {ECO:0000256|SAAS:SAAS00843640}.
DOMAIN 137 200 BZIP. {ECO:0000259|PROSITE:PS50217}.
COILED 135 196 {ECO:0000256|SAM:Coils}.
NON_TER 380 380 {ECO:0000313|EMBL:CAG46584.1}.
SEQUENCE 380 AA; 40695 MW; 9E3B2969347C90C8 CRC64;
MMFSGFNADY EASSSRCSSA SPAGDSLSYY HSPADSFSSM GSPVNAQDFC TDLAVSSANF
IPTVTAISTS PDLQWLVQPA LVSSVAPSQT RAPHPFGVPA PSAGAYSRAG VVKTMTGGRA
QSIGRRGKVE QLSPEEEEKR RIRRERNKMA AAKCRNRRRE LTDTLQAETD QLEDEKSALQ
TEIANLLKEK EKLEFILAAH RPACKIPDDL GFPEEMSVAS LDLTGGLPEV ATPESEEAFT
LPLLNDPEPK PSVEPVKSIS SMELKTEPFD DFLFPASSRP SGSETARSVP DMDLSGSFYA
ADWEPLHSGS LGMGPMATEL EPLCTPVVTC TPSCTAYTSS FVFTYPEADS FPSCAAAHRK
GSSSNEPSSD SLSSPTLLAL


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Kits Elisa; taq POLYMERASE

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Pathways :
WP1663: Homologous recombination
WP1676: Non-homologous end-joining
WP2218: sGC
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP32: Translation Factors
WP1023: mRNA processing
WP1036: Homologous recombination
WP1049: G Protein Signaling Pathways
WP1097: Non-homologous end joining
WP1142: mRNA processing
WP1153: Homologous recombination
WP1165: G Protein Signaling Pathways
WP1201: Non-homologous end joining
WP1205: Homologous recombination
WP1208: Non-homologous end joining
WP1216: Homologous recombination
WP1222: Non-homologous end joining
WP1229: mRNA processing
WP123: mRNA processing
WP1234: Homologous recombination
WP1242: Non-homologous end joining
WP1258: Homologous recombination
WP1277: Non-homologous end joining
WP1296: Homologous recombination

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[ABL1 ABL JTK7] Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
[ABL2 ABLL ARG] Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG)
[Abl1 Abl] Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
[JUN] Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39)
[kay Fra CG15509] Transcription factor kayak, isoforms A/B/F (AP-1) (Fos-related antigen) (Dfos) (dFra)
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[fos-1 evl-5 F29G9.4] Transcription factor fos-1
[MYC BHLHE39] Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
[SRC SRC1] Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
[CSF1R FMS] Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115)
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Bibliography :
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