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Fn14

 Q6SIX7_XENLA            Unreviewed;       120 AA.
Q6SIX7;
05-JUL-2004, integrated into UniProtKB/TrEMBL.
05-JUL-2004, sequence version 1.
16-JAN-2019, entry version 63.
SubName: Full=Fn14 {ECO:0000313|EMBL:AAR21225.1};
Name=tnfrsf12a {ECO:0000313|Xenbase:XB-GENE-921794};
Synonyms=Fn14 {ECO:0000313|EMBL:AAR21225.1};
Xenopus laevis (African clawed frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
Xenopus.
NCBI_TaxID=8355 {ECO:0000313|EMBL:AAR21225.1};
[1] {ECO:0000313|EMBL:AAR21225.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Heart {ECO:0000313|EMBL:AAR21225.1};
PubMed=16526941; DOI=10.1042/BJ20051362;
Brown S.A., Hanscom H.N., Vu H., Brew S.A., Winkles J.A.;
"TWEAK binding to the Fn14 cysteine-rich domain depends on charged
residues located in both the A1 and D2 modules.";
Biochem. J. 397:297-304(2006).
[2] {ECO:0000213|PDB:2KN0}
STRUCTURE BY NMR OF 23-72, AND DISULFIDE BONDS.
PubMed=23438059; DOI=10.1111/febs.12206;
Pellegrini M., Willen L., Perroud M., Krushinskie D., Strauch K.,
Cuervo H., Day E.S., Schneider P., Zheng T.S.;
"Structure of the extracellular domains of human and Xenopus Fn14:
implications in the evolution of TWEAK and Fn14 interactions.";
FEBS J. 280:1818-1829(2013).
[3] {ECO:0000313|EMBL:AAR21225.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Heart {ECO:0000313|EMBL:AAR21225.1};
Banno H., Chua N.-H.;
Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
-!- INTERACTION:
O43508:TNFSF12 (xeno); NbExp=2; IntAct=EBI-8445678, EBI-6932080;
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EMBL; AY458020; AAR21225.1; -; mRNA.
RefSeq; NP_001083640.1; NM_001090171.1.
UniGene; Xl.34690; -.
PDB; 2KN0; NMR; -; A=23-72.
PDBsum; 2KN0; -.
ProteinModelPortal; Q6SIX7; -.
SMR; Q6SIX7; -.
IntAct; Q6SIX7; 1.
MINT; Q6SIX7; -.
GeneID; 399035; -.
KEGG; xla:399035; -.
CTD; 399035; -.
Xenbase; XB-GENE-921794; tnfrsf12a.
HOVERGEN; HBG031553; -.
KO; K05149; -.
OrthoDB; 1502512at2759; -.
EvolutionaryTrace; Q6SIX7; -.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
CDD; cd13413; TNFRSF12A; 1.
InterPro; IPR022316; TNFR_12.
PANTHER; PTHR32037; PTHR32037; 1.
Pfam; PF12191; stn_TNFRSF12A; 1.
PRINTS; PR01962; TNFACTORR12.
ProDom; PD336131; TNFR_12; 1.
1: Evidence at protein level;
3D-structure {ECO:0000213|PDB:2KN0};
Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
SIGNAL 1 21 {ECO:0000256|SAM:SignalP}.
CHAIN 22 120 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5004279701.
TRANSMEM 69 93 Helical. {ECO:0000256|SAM:Phobius}.
DISULFID 27 40 {ECO:0000213|PDB:2KN0}.
DISULFID 43 58 {ECO:0000213|PDB:2KN0}.
DISULFID 46 55 {ECO:0000213|PDB:2KN0}.
SEQUENCE 120 AA; 13295 MW; F5B5D0BBAA3F7B4F CRC64;
MTPRNLLRTF VPLLLLVLSS AASQGECPEG RAYSQDLGKC MECSVCKNSE KSDFCQNCPS
KTEQPDFPWI WVIGFSAGGV FLIIVILSLT VYLTHCRRKS KFTTPIEETG SHSAEALLIH


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Kits Elisa; taq POLYMERASE

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Related Genes :
[TNFRSF12A FN14] Tumor necrosis factor receptor superfamily member 12A (Fibroblast growth factor-inducible immediate-early response protein 14) (FGF-inducible 14) (Tweak-receptor) (TweakR) (CD antigen CD266)
[Tnfrsf12a Fgfrp2 Fn14] Tumor necrosis factor receptor superfamily member 12A (Fibroblast growth factor-inducible immediate-early response protein 14) (FGF-inducible 14) (Fibroblast growth factor-regulated protein 2) (Tweak-receptor) (TweakR) (CD antigen CD266)
[TNFSF12 APO3L DR3LG UNQ181/PRO207] Tumor necrosis factor ligand superfamily member 12 (APO3 ligand) (TNF-related weak inducer of apoptosis) (TWEAK) [Cleaved into: Tumor necrosis factor ligand superfamily member 12, membrane form; Tumor necrosis factor ligand superfamily member 12, secreted form]
[Tnfsf12] Tumor necrosis factor ligand superfamily member 12 (TNF-related weak inducer of apoptosis) (TWEAK) [Cleaved into: Tumor necrosis factor ligand superfamily member 12, membrane form; Tumor necrosis factor ligand superfamily member 12, secreted form]
[tnfrsf12a Fn14] Fn14
[TNFRSF12A BOS_22618] Fn14 (TNF receptor superfamily member 12A) (Tumor necrosis factor receptor superfamily, member 12A-like)
[Tnfrsf12a] Tumor necrosis factor receptor superfamily, member 12a (Type 1 transmembrane protein FN14)
[tsf 8FN_14] Elongation factor Ts (EF-Ts)
[Fn14] Fn14 protein
[TNFRSF12A] Fibroblast growth factor-inducible 14
[] Fn14
[Tweak] Tumor necrosis factor superfamily member 12
[13FN_14] Cytidine and deoxycytidylate deaminase family protein (EC 3.5.4.-)
[] TWEAK
[TWEAK] Tumor necrosis factor-like weak inducer of apoptosis
[] Tumor necrosis factor receptor superfamily member 12a
[] Tumor necrosis factor superfamily member 12
[6FN_14] Uncharacterized protein
[3FN_14] GntR family transcriptional regulator
[] Capsid protein (Fragment)

Bibliography :
[30700754] Human skeletal muscle macrophages increase following cycle training and are associated with adaptations that may facilitate growth.
[30648117] Fn14 Deficiency Ameliorates Anti-dsDNA IgG-Induced Glomerular Damage in SCID Mice.
[30576385] Tumor necrosis factor-like weak inducer of apoptosis induces inflammation in Graves' orbital fibroblasts.
[30497391] The interaction of personal, contextual, and study characteristics and their effect on recruitment and participation of pregnant women in research: a qualitative study in Lebanon.
[30414907] TWEAK/Fn14 Interaction Confers Aggressive Properties to Cutaneous Squamous Cell Carcinoma.
[30344680] TWEAK promotes endothelial progenitor cell vasculogenesis to alleviate acute myocardial infarction via the Fn14-NF-κB signaling pathway.
[30260627] The Structure in Solution of Fibronectin Type III Domain 14 Reveals Its Synergistic Heparin Binding Site.
[30257485] Association between Serum Phospholipid Fatty Acid Levels and Adiposity among Lebanese Adults: A Cross-Sectional Study.
[30218067] Autophagy differentially regulates TNF receptor Fn14 by distinct mammalian Atg8 proteins.
[30180286] Antibody-Drug Conjugates with Pyrrole-Based KSP Inhibitors as the Payload Class.
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