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Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM) (AP lyase MutM) (EC 4.2.99.18)

 FPG_PARXL               Reviewed;         276 AA.
Q145W8;
15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
22-AUG-2006, sequence version 1.
16-JAN-2019, entry version 86.
RecName: Full=Formamidopyrimidine-DNA glycosylase {ECO:0000255|HAMAP-Rule:MF_00103};
Short=Fapy-DNA glycosylase {ECO:0000255|HAMAP-Rule:MF_00103};
EC=3.2.2.23 {ECO:0000255|HAMAP-Rule:MF_00103};
AltName: Full=DNA-(apurinic or apyrimidinic site) lyase MutM {ECO:0000255|HAMAP-Rule:MF_00103};
Short=AP lyase MutM {ECO:0000255|HAMAP-Rule:MF_00103};
EC=4.2.99.18 {ECO:0000255|HAMAP-Rule:MF_00103};
Name=mutM {ECO:0000255|HAMAP-Rule:MF_00103};
Synonyms=fpg {ECO:0000255|HAMAP-Rule:MF_00103};
OrderedLocusNames=Bxeno_A0333; ORFNames=Bxe_A4129;
Paraburkholderia xenovorans (strain LB400).
Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
Burkholderiaceae; Paraburkholderia.
NCBI_TaxID=266265;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=LB400;
PubMed=17030797; DOI=10.1073/pnas.0606924103;
Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
Tiedje J.M.;
"Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
genome shaped for versatility.";
Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
-!- FUNCTION: Involved in base excision repair of DNA damaged by
oxidation or by mutagenic agents. Acts as DNA glycosylase that
recognizes and removes damaged bases. Has a preference for
oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has
AP (apurinic/apyrimidinic) lyase activity and introduces nicks in
the DNA strand. Cleaves the DNA backbone by beta-delta elimination
to generate a single-strand break at the site of the removed base
with both 3'- and 5'-phosphates. {ECO:0000255|HAMAP-
Rule:MF_00103}.
-!- CATALYTIC ACTIVITY:
Reaction=Hydrolysis of DNA containing ring-opened 7-methylguanine
residues, releasing 2,6-diamino-4-hydroxy-5-(N-
methyl)formamidopyrimidine.; EC=3.2.2.23;
Evidence={ECO:0000255|HAMAP-Rule:MF_00103};
-!- CATALYTIC ACTIVITY:
Reaction=The C-O-P bond 3' to the apurinic or apyrimidinic site in
DNA is broken by a beta-elimination reaction, leaving a 3'-
terminal unsaturated sugar and a product with a terminal 5'-
phosphate.; EC=4.2.99.18; Evidence={ECO:0000255|HAMAP-
Rule:MF_00103};
-!- COFACTOR:
Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Evidence={ECO:0000255|HAMAP-Rule:MF_00103};
Note=Binds 1 zinc ion per subunit. {ECO:0000255|HAMAP-
Rule:MF_00103};
-!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00103}.
-!- SIMILARITY: Belongs to the FPG family. {ECO:0000255|HAMAP-
Rule:MF_00103}.
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EMBL; CP000270; ABE28871.1; -; Genomic_DNA.
RefSeq; WP_011486702.1; NZ_CP008760.1.
ProteinModelPortal; Q145W8; -.
SMR; Q145W8; -.
STRING; 266265.Bxe_A4129; -.
EnsemblBacteria; ABE28871; ABE28871; Bxe_A4129.
GeneID; 4003433; -.
KEGG; bxb:DR64_1805; -.
KEGG; bxe:Bxe_A4129; -.
PATRIC; fig|266265.5.peg.353; -.
eggNOG; ENOG4105ERD; Bacteria.
eggNOG; COG0266; LUCA.
HOGENOM; HOG000020881; -.
KO; K10563; -.
OMA; GVHLRMT; -.
OrthoDB; 1162346at2; -.
BioCyc; BXEN266265:BXE_RS01670-MONOMER; -.
Proteomes; UP000001817; Chromosome 1.
GO; GO:0140078; F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity; IEA:UniProtKB-EC.
GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
GO; GO:0008534; F:oxidized purine nucleobase lesion DNA N-glycosylase activity; IEA:UniProtKB-UniRule.
GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
GO; GO:0006284; P:base-excision repair; IEA:InterPro.
GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
Gene3D; 3.20.190.10; -; 1.
HAMAP; MF_00103; Fapy_DNA_glycosyl; 1.
InterPro; IPR015886; DNA_glyclase/AP_lyase_DNA-bd.
InterPro; IPR015887; DNA_glyclase_Znf_dom_DNA_BS.
InterPro; IPR020629; Formamido-pyr_DNA_Glyclase.
InterPro; IPR012319; FPG_cat.
InterPro; IPR035937; MutM-like_N-ter.
InterPro; IPR010979; Ribosomal_S13-like_H2TH.
InterPro; IPR000214; Znf_DNA_glyclase/AP_lyase.
InterPro; IPR010663; Znf_FPG/IleRS.
Pfam; PF01149; Fapy_DNA_glyco; 1.
Pfam; PF06831; H2TH; 1.
Pfam; PF06827; zf-FPG_IleRS; 1.
SMART; SM00898; Fapy_DNA_glyco; 1.
SMART; SM01232; H2TH; 1.
SUPFAM; SSF46946; SSF46946; 1.
SUPFAM; SSF81624; SSF81624; 1.
TIGRFAMs; TIGR00577; fpg; 1.
PROSITE; PS51068; FPG_CAT; 1.
PROSITE; PS01242; ZF_FPG_1; 1.
PROSITE; PS51066; ZF_FPG_2; 1.
3: Inferred from homology;
Complete proteome; DNA damage; DNA repair; DNA-binding; Glycosidase;
Hydrolase; Lyase; Metal-binding; Multifunctional enzyme;
Reference proteome; Zinc; Zinc-finger.
INIT_MET 1 1 Removed. {ECO:0000250}.
CHAIN 2 276 Formamidopyrimidine-DNA glycosylase.
/FTId=PRO_1000008689.
ZN_FING 242 276 FPG-type. {ECO:0000255|HAMAP-
Rule:MF_00103}.
ACT_SITE 2 2 Schiff-base intermediate with DNA.
{ECO:0000255|HAMAP-Rule:MF_00103}.
ACT_SITE 3 3 Proton donor. {ECO:0000255|HAMAP-
Rule:MF_00103}.
ACT_SITE 58 58 Proton donor; for beta-elimination
activity. {ECO:0000255|HAMAP-
Rule:MF_00103}.
ACT_SITE 266 266 Proton donor; for delta-elimination
activity. {ECO:0000255|HAMAP-
Rule:MF_00103}.
BINDING 94 94 DNA. {ECO:0000255|HAMAP-Rule:MF_00103}.
BINDING 112 112 DNA. {ECO:0000255|HAMAP-Rule:MF_00103}.
BINDING 157 157 DNA. {ECO:0000255|HAMAP-Rule:MF_00103}.
SEQUENCE 276 AA; 30808 MW; 6051EEF13F678AFA CRC64;
MPELPEVEVT RRGIEPYVSG RKVERVEVRT PALRWPIPAD LAKTLRGRVV RKVERRGKYL
LFEIDAGWFI VHLGMTGTLR VLRHVPHPPA AAKHDHVDWI FDEFILRYRD PRRFGAVLWH
PREAGDVLEH PLLAGLGVEP FSPAFSGALM HRLTRGRKVS VKQALLAGEI VVGVGNIYAS
ESLFRAGIRP ATAAGRVSLV RYDLLADAVR VTLAAAIEKG GSTLRDFVGS NGESGYFQLD
YFVYDRAGLP CRVCGTPIKQ IVQGQRSTYF CPTCQR


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EIAAB26876 DNA glycosylase_AP lyase Neil1,DNA-(apurinic or apyrimidinic site) lyase Neil1,Endonuclease 8-like 1,Endonuclease VIII-like 1,Mouse,Mus musculus,NEH1,Nei homolog 1,Nei1,Neil1,Nei-like protein 1
EIAAB26878 DNA glycosylase_AP lyase Neil2,DNA-(apurinic or apyrimidinic site) lyase Neil2,Endonuclease 8-like 2,Endonuclease VIII-like 2,Gm1212,Mouse,Mus musculus,NEH2,Nei homolog 2,Neil2,Nei-like protein 2
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EIAAB26877 DNA glycosylase_AP lyase Neil1,DNA-(apurinic or apyrimidinic site) lyase Neil1,Endonuclease 8-like 1,Endonuclease VIII-like 1,FPG1,Homo sapiens,Human,NEH1,Nei homolog 1,NEIL1,Nei-like protein 1
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Pathways :
WP1625: Base excision repair
WP1030: Selenium metabolism Selenoproteins
WP108: Selenium metabolism/Selenoproteins
WP1149: Selenium metabolism Selenoproteins
WP1293: Selenium metabolism Selenoproteins
WP1358: Selenium metabolism Selenoproteins
WP1640: Cysteine and methionine metabolism
WP1700: Selenoamino acid metabolism
WP1705: Sulfur metabolism
WP1718: Vitamin B6 metabolism
WP28: Selenium Metabolism and Selenoproteins
WP390: Serine-isocitrate lyase pathway
WP668: Octadecanoid Pathway

Related Genes :
[mutM fpg b3635 JW3610] Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM) (AP lyase MutM) (EC 4.2.99.18)
[fpg1 mutM Rv2924c MTCY338.13c] Formamidopyrimidine-DNA glycosylase 1 (Fapy-DNA glycosylase 1) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM 1) (AP lyase MutM 1) (EC 4.2.99.18)
[FPG1 FPG2 At1g52500 F6D8.28] Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (EC 4.2.99.18) (DNA-(apurinic or apyrimidinic site) lyase FPG1) (Formamidopyrimidine-DNA glycosylase 1) (AtFPG-1) (Formamidopyrimidine-DNA glycosylase 2) (AtFPG-2) (Protein MutM homolog 1) (AtMMH-1) (Protein MutM homolog 2) (AtMMH-2)
[mutM fpg] Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM) (AP lyase MutM) (EC 4.2.99.18)
[mutM fpg ytaE BSU29080] Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM) (AP lyase MutM) (EC 4.2.99.18)
[OGG1 MMH MUTM OGH1] N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (AP lyase) (EC 4.2.99.18)]
[mutM coaE fpg BN756_01377] Multifunctional fusion protein [Includes: Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM) (AP lyase MutM) (EC 4.2.99.18); Dephospho-CoA kinase (EC 2.7.1.24) (Dephosphocoenzyme A kinase)]
[coaE fpg mutM BHW12_00885] Multifunctional fusion protein [Includes: Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM) (AP lyase MutM) (EC 4.2.99.18); Dephospho-CoA kinase (EC 2.7.1.24) (Dephosphocoenzyme A kinase)]
[fpg mutM MSMEG_2419 MSMEI_2358] Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM) (AP lyase MutM) (EC 4.2.99.18)
[nei coaE fpg mutM IWT126_01258] Multifunctional fusion protein [Includes: Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM) (AP lyase MutM) (EC 4.2.99.18); Dephospho-CoA kinase (EC 2.7.1.24) (Dephosphocoenzyme A kinase)]
[nei coaE fpg mutM IWT30_00335] Multifunctional fusion protein [Includes: Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM) (AP lyase MutM) (EC 4.2.99.18); Dephospho-CoA kinase (EC 2.7.1.24) (Dephosphocoenzyme A kinase)]
[nei coaE fpg mutM IWT140_00256] Multifunctional fusion protein [Includes: Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM) (AP lyase MutM) (EC 4.2.99.18); Dephospho-CoA kinase (EC 2.7.1.24) (Dephosphocoenzyme A kinase)]
[nei coaE fpg mutM IWT25_01109] Multifunctional fusion protein [Includes: Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM) (AP lyase MutM) (EC 4.2.99.18); Dephospho-CoA kinase (EC 2.7.1.24) (Dephosphocoenzyme A kinase)]
[nei coaE fpg mutM IWT5_00868] Multifunctional fusion protein [Includes: Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM) (AP lyase MutM) (EC 4.2.99.18); Dephospho-CoA kinase (EC 2.7.1.24) (Dephosphocoenzyme A kinase)]
[mutM coaE fpg Selsp_1096 SELSPUOL_01150] Multifunctional fusion protein [Includes: Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM) (AP lyase MutM) (EC 4.2.99.18); Dephospho-CoA kinase (EC 2.7.1.24) (Dephosphocoenzyme A kinase)]
[coaE fpg mutM HMPREF1153_1130] Multifunctional fusion protein [Includes: Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM) (AP lyase MutM) (EC 4.2.99.18); Dephospho-CoA kinase (EC 2.7.1.24) (Dephosphocoenzyme A kinase)]
[coaE fpg mutM FC17_GL001869] Multifunctional fusion protein [Includes: Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM) (AP lyase MutM) (EC 4.2.99.18); Dephospho-CoA kinase (EC 2.7.1.24) (Dephosphocoenzyme A kinase)]
[mutM coaE fpg FC82_GL000215] Multifunctional fusion protein [Includes: Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM) (AP lyase MutM) (EC 4.2.99.18); Dephospho-CoA kinase (EC 2.7.1.24) (Dephosphocoenzyme A kinase)]
[coaE fpg mutM FD14_GL000336] Multifunctional fusion protein [Includes: Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM) (AP lyase MutM) (EC 4.2.99.18); Dephospho-CoA kinase (EC 2.7.1.24) (Dephosphocoenzyme A kinase)]
[mutM coaE fpg FD04_GL000887] Multifunctional fusion protein [Includes: Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM) (AP lyase MutM) (EC 4.2.99.18); Dephospho-CoA kinase (EC 2.7.1.24) (Dephosphocoenzyme A kinase)]
[coaE fpg mutM FC96_GL000135] Multifunctional fusion protein [Includes: Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM) (AP lyase MutM) (EC 4.2.99.18); Dephospho-CoA kinase (EC 2.7.1.24) (Dephosphocoenzyme A kinase)]
[mutM coaE fpg DDW71_02325] Multifunctional fusion protein [Includes: Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM) (AP lyase MutM) (EC 4.2.99.18); Dephospho-CoA kinase (EC 2.7.1.24) (Dephosphocoenzyme A kinase)]
[mutM coaE fpg BN602_00990] Multifunctional fusion protein [Includes: Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM) (AP lyase MutM) (EC 4.2.99.18); Dephospho-CoA kinase (EC 2.7.1.24) (Dephosphocoenzyme A kinase)]
[mutM coaE fpg BN609_01411] Multifunctional fusion protein [Includes: Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM) (AP lyase MutM) (EC 4.2.99.18); Dephospho-CoA kinase (EC 2.7.1.24) (Dephosphocoenzyme A kinase)]
[mutM coaE fpg DCR62_05615] Multifunctional fusion protein [Includes: Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM) (AP lyase MutM) (EC 4.2.99.18); Dephospho-CoA kinase (EC 2.7.1.24) (Dephosphocoenzyme A kinase)]
[Ogg1] N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (AP lyase) (EC 4.2.99.18)]
[mutM fpg PA0357] Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM) (AP lyase MutM) (EC 4.2.99.18)
[NEIL1] Endonuclease 8-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (Endonuclease VIII-like 1) (FPG1) (Nei homolog 1) (NEH1) (Nei-like protein 1)
[mutM fpg TTHA1806] Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM) (AP lyase MutM) (EC 4.2.99.18)
[mutM coaE fpg BWX94_00856] Multifunctional fusion protein [Includes: Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM) (AP lyase MutM) (EC 4.2.99.18); Dephospho-CoA kinase (EC 2.7.1.24) (Dephosphocoenzyme A kinase)]

Bibliography :
[19223326] KsgA, a 16S rRNA adenine methyltransferase, has a novel DNA glycosylase/AP lyase activity to prevent mutations in Escherichia coli.
[11978483] Involvement of mammalian OGG1(MMH) in excision of the 8-hydroxyguanine residue in DNA.
[11960995] Escherichia coli apurinic-apyrimidinic endonucleases enhance the turnover of the adenine glycosylase MutY with G:A substrates.
[11892789] Repair of oxidative DNA damage: mechanisms and functions.
[11554297] Multiple DNA glycosylases for repair of 8-oxoguanine and their potential in vivo functions.
[11554290] Mammalian Ogg1/Mmh gene plays a major role in repair of the 8-hydroxyguanine lesion in DNA.
[11182542] The Drosophila S3 multifunctional DNA repair/ribosomal protein protects Fanconi anemia cells against oxidative DNA damaging agents.
[10921868] Crystal structure of a repair enzyme of oxidatively damaged DNA, MutM (Fpg), from an extreme thermophile, Thermus thermophilus HB8.
[11121482] Adenine excisional repair function of MYH protein on the adenine:8-hydroxyguanine base pair in double-stranded DNA.
[10329432] Human MMH (OGG1) type 1a protein is a major enzyme for repair of 8-hydroxyguanine lesions in human cells.
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