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G protein pathway suppressor 2 (GPS-2)

 GPS2_MOUSE              Reviewed;         327 AA.
Q921N8;
25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
13-NOV-2019, entry version 116.
RecName: Full=G protein pathway suppressor 2 {ECO:0000303|PubMed:22424771};
Short=GPS-2 {ECO:0000303|PubMed:22424771};
Name=Gps2 {ECO:0000303|PubMed:22424771, ECO:0000312|MGI:MGI:1891751};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH RFX4.
PubMed=18218630; DOI=10.1074/jbc.m708209200;
Zhang D., Harry G.J., Blackshear P.J., Zeldin D.C.;
"G-protein pathway suppressor 2 (GPS2) interacts with the regulatory
factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-
activator.";
J. Biol. Chem. 283:8580-8590(2008).
[5]
FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH UBE2N; TRAF1;
TRAF2 AND TRAF6.
PubMed=22424771; DOI=10.1016/j.molcel.2012.01.025;
Cardamone M.D., Krones A., Tanasa B., Taylor H., Ricci L., Ohgi K.A.,
Glass C.K., Rosenfeld M.G., Perissi V.;
"A protective strategy against hyperinflammatory responses requiring
the nontranscriptional actions of GPS2.";
Mol. Cell 46:91-104(2012).
[6]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=22666460; DOI=10.1371/journal.pone.0038130;
Liu X.F., Bera T.K., Kahue C., Escobar T., Fei Z., Raciti G.A.,
Pastan I.;
"ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA
regulate adipogenesis in 3T3-L1 cells.";
PLoS ONE 7:E38130-E38130(2012).
[7]
FUNCTION.
PubMed=24953653; DOI=10.1016/j.celrep.2014.05.041;
Cardamone M.D., Tanasa B., Chan M., Cederquist C.T., Andricovich J.,
Rosenfeld M.G., Perissi V.;
"GPS2/KDM4A pioneering activity regulates promoter-specific
recruitment of PPARgamma.";
Cell Rep. 8:163-176(2014).
[8]
METHYLATION [LARGE SCALE ANALYSIS] AT ARG-312 AND ARG-323, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, and Embryo;
PubMed=24129315; DOI=10.1074/mcp.o113.027870;
Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V.,
Aguiar M., Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C.,
Vemulapalli V., Bedford M.T., Comb M.J.;
"Immunoaffinity enrichment and mass spectrometry analysis of protein
methylation.";
Mol. Cell. Proteomics 13:372-387(2014).
[9]
FUNCTION, DISRUPTION PHENOTYPE, IDENTIFICATION IN THE N-COR COMPLEX,
AND INTERACTION WITH PPARG.
PubMed=25519902; DOI=10.1074/jbc.m114.598797;
Guo C., Li Y., Gow C.H., Wong M., Zha J., Yan C., Liu H., Wang Y.,
Burris T.P., Zhang J.;
"The optimal corepressor function of nuclear receptor corepressor
(NCoR) for peroxisome proliferator-activated receptor gamma requires G
protein pathway suppressor 2.";
J. Biol. Chem. 290:3666-3679(2015).
[10]
SUBCELLULAR LOCATION, INTERACTION WITH TBL1X, METHYLATION AT ARG-312
AND ARG-323, SUMOYLATION AT LYS-45 AND LYS-71, UBIQUITINATION, AND
MUTAGENESIS OF LYS-45; 52-LYS-LYS-53; LYS-71; LYS-254; LYS-300;
ARG-312; ARG-323 AND LYS-327.
PubMed=26070566; DOI=10.1074/jbc.m115.637660;
Huang J., Cardamone M.D., Johnson H.E., Neault M., Chan M.,
Floyd Z.E., Mallette F.A., Perissi V.;
"Exchange factor TBL1 and arginine methyltransferase PRMT6 cooperate
in protecting G protein pathway suppressor 2 (GPS2) from proteasomal
degradation.";
J. Biol. Chem. 290:19044-19054(2015).
[11]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=27270589; DOI=10.1038/nm.4114;
Fan R., Toubal A., Goni S., Drareni K., Huang Z., Alzaid F.,
Ballaire R., Ancel P., Liang N., Damdimopoulos A., Hainault I.,
Soprani A., Aron-Wisnewsky J., Foufelle F., Lawrence T., Gautier J.F.,
Venteclef N., Treuter E.;
"Loss of the co-repressor GPS2 sensitizes macrophage activation upon
metabolic stress induced by obesity and type 2 diabetes.";
Nat. Med. 22:780-791(2016).
[12]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=28039360; DOI=10.1074/jbc.m116.755132;
Lentucci C., Belkina A.C., Cederquist C.T., Chan M., Johnson H.E.,
Prasad S., Lopacinski A., Nikolajczyk B.S., Monti S.,
Snyder-Cappione J., Tanasa B., Cardamone M.D., Perissi V.;
"Inhibition of Ubc13-mediated ubiquitination by GPS2 regulates
multiple stages of B Cell development.";
J. Biol. Chem. 292:2754-2772(2017).
[13]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=28123943; DOI=10.1016/j.molmet.2016.10.007;
Cederquist C.T., Lentucci C., Martinez-Calejman C., Hayashi V.,
Orofino J., Guertin D., Fried S.K., Lee M.J., Cardamone M.D.,
Perissi V.;
"Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT
ubiquitination and activation in adipose tissue.";
Mol. Metab. 6:125-137(2017).
[14]
FUNCTION, SUBCELLULAR LOCATION, SUMOYLATION AT LYS-45 AND LYS-71, AND
MUTAGENESIS OF LYS-45 AND LYS-71.
PubMed=29499132; DOI=10.1016/j.molcel.2018.01.037;
Cardamone M.D., Tanasa B., Cederquist C.T., Huang J., Mahdaviani K.,
Li W., Rosenfeld M.G., Liesa M., Perissi V.;
"Mitochondrial retrograde signaling in mammals is mediated by the
transcriptional cofactor GPS2 via direct mitochondria-to-nucleus
translocation.";
Mol. Cell 69:757-772(2018).
-!- FUNCTION: Key regulator of inflammation, lipid metabolism and
mitochondrion homeostasis that acts by inhibiting the activity of
the ubiquitin-conjugating enzyme UBE2N/Ubc13, thereby inhibiting
'Lys-63'-linked ubiquitination (PubMed:22424771, PubMed:24953653,
PubMed:28039360, PubMed:28123943, PubMed:29499132). In the
nucleus, can both acts as a corepressor and coactivator of
transcription, depending on the context (PubMed:18218630,
PubMed:24953653, PubMed:25519902, PubMed:27270589,
PubMed:28039360). Acts as a transcription coactivator in
adipocytes by promoting the recruitment of PPARG to promoters:
acts by inhibiting the activity of the ubiquitin-conjugating
enzyme UBE2N/Ubc13, leading to stabilization of KDM4A and
subsequent histone H3 'Lys-9' (H3K9) demethylation
(PubMed:22666460, PubMed:24953653). Promotes cholesterol efflux by
acting as a transcription coactivator (By similarity). Acts as a
regulator of B-cell development by inhibiting UBE2N/Ubc13, thereby
restricting the activation of Toll-like receptors (TLRs) and B-
cell antigen receptors (BCRs) signaling pathways
(PubMed:28039360). Acts as a key mediator of mitochondrial stress
response: in response to mitochondrial depolarization, relocates
from the mitochondria to the nucleus following desumoylation and
specifically promotes expression of nuclear-encoded mitochondrial
genes (PubMed:29499132). Promotes transcription of nuclear-encoded
mitochondrial genes by inhibiting UBE2N/Ubc13 (PubMed:29499132).
Can also act as a corepressor as part of the N-Cor repressor
complex by repressing active PPARG (PubMed:25519902). Plays an
anti-inflammatory role in macrophages and is required for insulin
sensitivity by acting as a corepressor (PubMed:27270589). Plays an
anti-inflammatory role during the hepatic acute phase response by
interacting with sumoylated NR1H2 and NR5A2 proteins, thereby
preventing N-Cor corepressor complex dissociation (By similarity).
In the cytosol, also plays a non-transcriptional role by
regulating insulin signaling and pro-inflammatory pathways
(PubMed:22424771, PubMed:28123943). In the cytoplasm, acts as a
negative regulator of inflammation by inhibiting the
proinflammatory TNF-alpha pathway; acts by repressing UBE2N/Ubc13
activity (PubMed:22424771). In the cytoplasm of adipocytes,
restricts the activation of insulin signaling via inhibition of
UBE2N/Ubc13-mediated ubiquitination of AKT (PubMed:28123943). Able
to suppress G-protein- and mitogen-activated protein kinase-
mediated signal transduction (By similarity).
{ECO:0000250|UniProtKB:Q13227, ECO:0000269|PubMed:18218630,
ECO:0000269|PubMed:22424771, ECO:0000269|PubMed:22666460,
ECO:0000269|PubMed:24953653, ECO:0000269|PubMed:25519902,
ECO:0000269|PubMed:27270589, ECO:0000269|PubMed:28039360,
ECO:0000269|PubMed:28123943, ECO:0000269|PubMed:29499132}.
-!- SUBUNIT: Component of the N-Cor repressor complex, at least
composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2
(PubMed:25519902). Interacts (when sumoylated at Lys-71) with
TBL1X; leading to protect GPS2 from degradation by the proteasome
(PubMed:26070566). Interacts with UBE2N; leading to inhibit
UBE2N/Ubc13 activity (PubMed:22424771). Interacts with TRAF1
(PubMed:22424771). Interacts with TRAF2 (PubMed:22424771).
Interacts with TRAF6 (PubMed:22424771). Interacts with PPARG (when
in the liganded conformation) (PubMed:25519902). Interacts with
(sumoylated) NR1H2; interaction with sumoylated NR1H2 and NR5A2
onto hepatic acute phase protein promoters prevents N-Cor
corepressor complex dissociation (By similarity). Interacts with
(sumoylated) NR5A2; interaction with sumoylated NR1H2 and NR5A2
onto hepatic acute phase protein promoters prevents N-Cor
corepressor complex dissociation (By similarity). Interacts with
NR1H3 (By similarity). Interacts with RFX4 (PubMed:18218630).
Interacts with ANKRD26 (By similarity).
{ECO:0000250|UniProtKB:Q13227, ECO:0000269|PubMed:18218630,
ECO:0000269|PubMed:22424771, ECO:0000269|PubMed:25519902,
ECO:0000269|PubMed:26070566}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18218630,
ECO:0000269|PubMed:22424771, ECO:0000269|PubMed:22666460,
ECO:0000269|PubMed:26070566, ECO:0000269|PubMed:29499132}.
Mitochondrion {ECO:0000269|PubMed:29499132}. Cytoplasm, cytosol
{ECO:0000269|PubMed:22424771}. Note=Sumoylation regulates the
subcellular location (PubMed:29499132). Relocates from the
mitochondria to the nucleus following desumoylation, leading to
mediate mitochondrial stress response (PubMed:29499132).
{ECO:0000250|UniProtKB:Q13227, ECO:0000269|PubMed:29499132}.
-!- PTM: Sumoylation regulates its subcellular location
(PubMed:26070566, PubMed:29499132). Sumoylation at Lys-45 and Lys-
71 regulates the shuttling between the cytoplasm and the nucleus
(By similarity). Sumoylation at Lys-71 is required for interaction
with TBL1X (PubMed:26070566). Sumoylated at Lys-45 and Lys-71 in
mitochondrion (PubMed:29499132). Desumoylation by SENP1 leads to
relocation from the mitochondria to the nucleus (PubMed:29499132).
{ECO:0000250|UniProtKB:Q13227, ECO:0000269|PubMed:26070566,
ECO:0000269|PubMed:29499132}.
-!- PTM: Ubiquitinated at the C-terminus by SIAH2; leading to its
degradation by the proteasome. Interaction with TBL1X and
methylation at Arg-323 protect GPS2 against ubiquitination and
degradation. {ECO:0000269|PubMed:26070566}.
-!- PTM: Methylated at Arg-312 and Arg-323 by PRMT6. Methylation at
Arg-323 protects from degradation by the proteasome.
{ECO:0000269|PubMed:26070566}.
-!- DISRUPTION PHENOTYPE: Embryonic lethality (PubMed:25519902).
Embryonic fibroblast cells show reduced corepressor function of
the N-CoR complex for PPARG, leading to constitutive activation of
PPARG target genes and spontaneous adipogenesis of the cells
(PubMed:25519902). Conditional knockout mice lacking Gps2 in B-
cells show developmental defects at multiple stages of B-cell
differentiation, caused by of aberrant activation of 'Lys-63'-
linked ubiquitination events and altered gene expression programs
downstream of the misregulated signaling pathways
(PubMed:28039360). Conditional knockout mice lacking Gps2 in
macrophages show inappropriate corepressor complex function,
leading to enhancer activation, pro-inflammatory gene expression
and hypersensitivity toward metabolic-stress signals
(PubMed:27270589). Conditional knockout mice lacking Gps2 in
adipose tissues show obesity associated with constitutive insulin
signaling, increased lipid deposition in the white adipose tissue
and improved systemic insulin sensitivity (PubMed:28123943).
Conditional knockout mice lacking Gps2 in adipose tissues display
reduced mitochondrial content in brown adipose tissue
(PubMed:29499132). {ECO:0000269|PubMed:25519902,
ECO:0000269|PubMed:27270589, ECO:0000269|PubMed:28039360,
ECO:0000269|PubMed:28123943, ECO:0000269|PubMed:29499132}.
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EMBL; AL596185; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH466596; EDL12472.1; -; Genomic_DNA.
EMBL; CH466596; EDL12474.1; -; Genomic_DNA.
EMBL; BC011317; AAH11317.1; -; mRNA.
EMBL; BC138879; AAI38880.1; -; mRNA.
EMBL; BC138880; AAI38881.1; -; mRNA.
CCDS; CCDS24922.1; -.
RefSeq; NP_062700.2; NM_019726.3.
RefSeq; XP_006533850.1; XM_006533787.2.
SMR; Q921N8; -.
CORUM; Q921N8; -.
STRING; 10090.ENSMUSP00000054072; -.
iPTMnet; Q921N8; -.
PhosphoSitePlus; Q921N8; -.
EPD; Q921N8; -.
MaxQB; Q921N8; -.
PaxDb; Q921N8; -.
PeptideAtlas; Q921N8; -.
PRIDE; Q921N8; -.
Ensembl; ENSMUST00000057884; ENSMUSP00000054072; ENSMUSG00000023170.
Ensembl; ENSMUST00000072581; ENSMUSP00000072389; ENSMUSG00000023170.
Ensembl; ENSMUST00000116358; ENSMUSP00000112062; ENSMUSG00000023170.
GeneID; 56310; -.
KEGG; mmu:56310; -.
UCSC; uc007jsp.1; mouse.
CTD; 2874; -.
MGI; MGI:1891751; Gps2.
eggNOG; ENOG410IH6X; Eukaryota.
eggNOG; ENOG4110MFH; LUCA.
GeneTree; ENSGT00390000004049; -.
HOGENOM; HOG000112796; -.
InParanoid; Q921N8; -.
KO; K15307; -.
OMA; IPTRHYQ; -.
OrthoDB; 1206280at2759; -.
PhylomeDB; Q921N8; -.
TreeFam; TF329067; -.
Reactome; R-MMU-9029569; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux.
ChiTaRS; Gps2; mouse.
PRO; PR:Q921N8; -.
Proteomes; UP000000589; Chromosome 11.
Bgee; ENSMUSG00000023170; Expressed in 250 organ(s), highest expression level in bone marrow.
ExpressionAtlas; Q921N8; baseline and differential.
GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO; GO:0005829; C:cytosol; ISO:MGI.
GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0017053; C:transcriptional repressor complex; IDA:UniProtKB.
GO; GO:0030332; F:cyclin binding; ISO:MGI.
GO; GO:0003713; F:transcription coactivator activity; IDA:UniProtKB.
GO; GO:0003714; F:transcription corepressor activity; IDA:UniProtKB.
GO; GO:0030183; P:B cell differentiation; IMP:UniProtKB.
GO; GO:0050859; P:negative regulation of B cell receptor signaling pathway; IMP:UniProtKB.
GO; GO:0045599; P:negative regulation of fat cell differentiation; IMP:UniProtKB.
GO; GO:0050728; P:negative regulation of inflammatory response; IDA:UniProtKB.
GO; GO:0046329; P:negative regulation of JNK cascade; IMP:UniProtKB.
GO; GO:1900045; P:negative regulation of protein K63-linked ubiquitination; IDA:UniProtKB.
GO; GO:0034122; P:negative regulation of toll-like receptor signaling pathway; IMP:UniProtKB.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:UniProtKB.
GO; GO:0010804; P:negative regulation of tumor necrosis factor-mediated signaling pathway; IMP:UniProtKB.
GO; GO:0010875; P:positive regulation of cholesterol efflux; ISS:UniProtKB.
GO; GO:0035360; P:positive regulation of peroxisome proliferator activated receptor signaling pathway; IDA:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:UniProtKB.
GO; GO:0045598; P:regulation of fat cell differentiation; IDA:UniProtKB.
GO; GO:0019216; P:regulation of lipid metabolic process; IDA:UniProtKB.
GO; GO:0098780; P:response to mitochondrial depolarisation; IDA:UniProtKB.
InterPro; IPR026094; GPS2.
PANTHER; PTHR22654; PTHR22654; 1.
Pfam; PF15991; G_path_suppress; 1.
1: Evidence at protein level;
Activator; Coiled coil; Complete proteome; Cytoplasm; Isopeptide bond;
Methylation; Mitochondrion; Nucleus; Reference proteome; Repressor;
Transcription; Transcription regulation; Ubl conjugation.
CHAIN 1 327 G protein pathway suppressor 2.
/FTId=PRO_0000441803.
REGION 61 94 interaction with SUMO.
{ECO:0000250|UniProtKB:Q13227}.
COILED 14 109 {ECO:0000255}.
MOD_RES 312 312 Asymmetric dimethylarginine.
{ECO:0000244|PubMed:24129315,
ECO:0000269|PubMed:26070566}.
MOD_RES 323 323 Asymmetric dimethylarginine; alternate.
{ECO:0000244|PubMed:24129315,
ECO:0000269|PubMed:26070566}.
MOD_RES 323 323 Omega-N-methylarginine; alternate.
{ECO:0000250|UniProtKB:Q13227}.
CROSSLNK 45 45 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO1).
{ECO:0000269|PubMed:26070566,
ECO:0000269|PubMed:29499132}.
CROSSLNK 71 71 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO1).
{ECO:0000269|PubMed:26070566,
ECO:0000269|PubMed:29499132}.
MUTAGEN 45 45 K->R: Decreased stability of the protein,
probably due inability to interact with
TBL1X; when associated with R-71.
Abolishes sumoylation; when associated
with R-71. {ECO:0000269|PubMed:29499132}.
MUTAGEN 52 53 KK->AA: Does not affect localization to
the nucleus.
{ECO:0000269|PubMed:26070566}.
MUTAGEN 71 71 K->R: Decreased stability of the protein,
probably due inability to interact with
TBL1X; when associated with R-45.
Abolishes sumoylation; when associated
with R-45. {ECO:0000269|PubMed:26070566,
ECO:0000269|PubMed:29499132}.
MUTAGEN 254 254 K->A: Increased stability due to impaired
ubiquitination; when associated with A-
300 and A-327.
{ECO:0000269|PubMed:26070566}.
MUTAGEN 300 300 K->A: Increased stability due to impaired
ubiquitination; when associated with A-
254 and A-327.
{ECO:0000269|PubMed:26070566}.
MUTAGEN 312 312 R->A: Abolished methylation; when
associated with A-323.
{ECO:0000269|PubMed:26070566}.
MUTAGEN 323 323 R->A: Promotes ubiquitination and
degradation by the proteasome. Abolished
methylation; when associated with A-312.
{ECO:0000269|PubMed:26070566}.
MUTAGEN 327 327 K->A: Increased stability due to impaired
ubiquitination; when associated with A-
254 and A-300.
{ECO:0000269|PubMed:26070566}.
SEQUENCE 327 AA; 36738 MW; 3008661CE6579F4B CRC64;
MPALLERPKL SNAMARALHR HIMMERERKR QEEEEVDKMM EQKMKEEQER RKKKEMEERM
SLEETKEQIL KLQEKLSALQ EEKHQLFLQL KKVLHEEEKR RRKEQSDLTT LTSAAYQQSL
TVHTGTHLLS MQGSPGGHNR PGTLMAADRA KQMFGPQVLT TRHYVGSAAA FAGTPEHGQF
QGSPGGAYGT AQPPPHYGPT QPAYSPSQQL RAPSAFPAVQ YLSQPQPQPY AVHGHFQPTQ
TGFLQPGSTL SLQKQMEHAN QQTSFSDSSS LRPMHPQALH PAPGLLASPQ LPVQIQAAGK
SGFATTSQPG PRLPFIQHSQ NPRFYHK


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WP2272: Pathogenic Escherichia coli infection
WP2292: Chemokine signaling pathway
WP1493: Carbon assimilation C4 pathway
WP1144: B Cell Receptor Signaling Pathway
WP2169: Lithiums effects on cAMP pathway
WP902: FAS pathway and Stress induction of HSP regulation
WP1271: Toll-like receptor signaling pathway
WP998: MAPK signaling pathway
WP1375: Polyol pathway
WP35: G Protein Signaling Pathways
WP1663: Homologous recombination
WP44: IL-5 Signaling Pathway
WP1971: Integrated Cancer pathway
WP571: FAS pathway and Stress induction of HSP regulation
WP1: Statin Pathway
WP780: T Cell Receptor Signaling Pathway
WP1092: IL-9 Signaling Pathway
WP867: Alpha6-Beta4 Integrin Signaling Pathway
WP1171: IL-4 signaling Pathway
WP231: TNF alpha Signaling Pathway

Related Genes :
[GPS1 COPS1 CSN1] COP9 signalosome complex subunit 1 (SGN1) (Signalosome subunit 1) (G protein pathway suppressor 1) (GPS-1) (JAB1-containing signalosome subunit 1) (Protein MFH)
[CRY2 PHH1 SEL20 At1g04400 F19P19.14] Cryptochrome-2 (Atcry2) (Blue light photoreceptor) (Protein PHR homolog 1) (AtPHH1) (Protein SUPPRESSOR OF elf3 20)
[Plaat3 H-rev107 Hrasls3 Hrev107 Pla2g16] Phospholipase A and acyltransferase 3 (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (Adipose-specific phospholipase A2) (AdPLA) (Group XVI phospholipase A2) (H-rev 107 protein homolog) (HRAS-like suppressor 3) (HRSL3)
[Cdkn2a] Tumor suppressor ARF (Alternative reading frame) (ARF) (Cyclin-dependent kinase inhibitor 2A) (p19ARF)
[STEAP3 TSAP6] Metalloreductase STEAP3 (EC 1.16.1.-) (Dudulin-2) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde)
[Steap3 Tsap6] Metalloreductase STEAP3 (EC 1.16.1.-) (Dudulin-2) (Protein nm1054) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6)
[Gps1 Cops1 Csn1] COP9 signalosome complex subunit 1 (SGN1) (Signalosome subunit 1) (G protein pathway suppressor 1) (GPS-1) (JAB1-containing signalosome subunit 1)
[SCL1 PRC2 PRS2 YGL011C] Proteasome subunit alpha type-1 (EC 3.4.25.1) (Macropain subunit C7-alpha) (Multicatalytic endopeptidase complex C7) (Proteasome component C7-alpha) (Proteasome component Y8) (Proteinase YSCE subunit 7) (SCL1 suppressor protein)
[NPRL2 TUSC4] GATOR complex protein NPRL2 (Gene 21 protein) (G21 protein) (Nitrogen permease regulator 2-like protein) (NPR2-like protein) (Tumor suppressor candidate 4)
[ksr-1 F13B9.5] Kinase suppressor of Ras A (EC 2.7.11.1)
[SOG1 NAC008 At1g25580 F14G11.2 F2J7.1] SUPPRESSOR OF GAMMA RESPONSE 1 (NAC domain-containing protein 8) (ANAC008) (Protein SOG1) (SUPPRESSOR OF GAMMA RADIATION 1)
[PLAAT3 HRASLS3 HREV107 PLA2G16] Phospholipase A and acyltransferase 3 (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (Adipose-specific phospholipase A2) (AdPLA) (Group XVI phospholipase A1/A2) (H-rev 107 protein homolog) (H-REV107) (HREV107-1) (HRAS-like suppressor 1) (HRAS-like suppressor 3) (HRSL3) (HREV107-3) (Renal carcinoma antigen NY-REN-65)
[smu-2 Y49F6B.4] Smu-2 suppressor of mec-8 and unc-52 protein (RED homolog) (Suppressor of Mec and Unc defects 2)
[gld-1 T23G11.3] Female germline-specific tumor suppressor gld-1 (Defective in germ line development protein 1)
[SPA1 At2g46340/At2g46350 F11C10.3/F11C10.4] Protein SUPPRESSOR OF PHYA-105 1 (EC 2.7.-.-)
[STM1 MPT4 STO1 YLR150W L9634.1] Suppressor protein STM1 (3BP1) (GU4 nucleic-binding protein 2) (G4p2 protein) (POP2 multicopy suppressor protein 4) (Ribosomal subunits association factor) (AF) (TOM1 suppressor protein 1) (Triplex-binding protein 1)
[ksr-2 F58D5.4] Kinase suppressor of Ras B
[TRIM13 LEU5 RFP2 RNF77] E3 ubiquitin-protein ligase TRIM13 (EC 2.3.2.27) (B-cell chronic lymphocytic leukemia tumor suppressor Leu5) (Leukemia-associated protein 5) (Putative tumor suppressor RFP2) (RING finger protein 77) (RING-type E3 ubiquitin transferase TRIM13) (Ret finger protein 2) (Tripartite motif-containing protein 13)
[TGFB2] Transforming growth factor beta-2 proprotein (Cetermin) (Glioblastoma-derived T-cell suppressor factor) (G-TSF) [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-2 (TGF-beta-2)]
[SCPL24 BRS1 At4g30610 F17I23.50] Serine carboxypeptidase 24 (EC 3.4.16.6) (Bri1 suppressor 1) (Carboxypeptidase D) (Serine carboxypeptidase II) [Cleaved into: Serine carboxypeptidase 24 chain A (Serine carboxypeptidase II chain A); Serine carboxypeptidase 24 chain B (Serine carboxypeptidase II chain B)]
[SGT1 YOR057W YOR29-08] Protein SGT1 (Suppressor of G2 allele of SKP1)
[sorf-2 F52C9.1] Suppressor of organelle fusion 2 (WD repeat-containing protein 81 homolog sorf-2)
[CLPR1 NCLPP5 SVR2 At1g49970 F2J10.14] ATP-dependent Clp protease proteolytic subunit-related protein 1, chloroplastic (ClpR1) (Protein SUPPRESSOR OF VARIEGATION 2) (nClpP5)
[EXT2] Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Multiple exostoses protein 2) (Putative tumor suppressor protein EXT2)
[CD82 KAI1 SAR2 ST6 TSPAN27] CD82 antigen (C33 antigen) (IA4) (Inducible membrane protein R2) (Metastasis suppressor Kangai-1) (Suppressor of tumorigenicity 6 protein) (Tetraspanin-27) (Tspan-27) (CD antigen CD82)
[LATS2 KPM] Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)
[SKD1 VPS4 At2g27600 F10A12.27 F15K20] Protein SUPPRESSOR OF K(+) TRANSPORT GROWTH DEFECT 1 (AtSKD1) (EC 3.6.4.6) (Protein VACUOLAR PROTEIN SORTING 4)
[smu-1 CC4.3] Smu-1 suppressor of mec-8 and unc-52 protein (Smu1) (Suppressor of Mec and Unc defects 1)
[Lats2] Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm)
[Plaat3 H-rev107 Hrasls3 Hrev107 Pla2g16] Phospholipase A and acyltransferase 3 (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (Group XVI phospholipase A2) (H-rev 107 protein homolog) (HRAS-like suppressor 3) (HRSL3)

Bibliography :
[30153049] G protein pathway suppressor 2 (GPS2) links inflammation and cholesterol efflux by controlling lipopolysaccharide-induced ATP-binding cassette transporter A1 expression in macrophages.
[19917673] Differential arginine methylation of the G-protein pathway suppressor GPS-2 recognized by tumor-specific T cells in melanoma.