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G protein-coupled receptor 50

 A0A3Q2I2D4_HORSE        Unreviewed;       591 AA.
A0A3Q2I2D4;
10-APR-2019, integrated into UniProtKB/TrEMBL.
10-APR-2019, sequence version 1.
11-DEC-2019, entry version 7.
SubName: Full=G protein-coupled receptor 50 {ECO:0000313|Ensembl:ENSECAP00000041279};
Name=GPR50 {ECO:0000313|Ensembl:ENSECAP00000041279,
ECO:0000313|VGNC:VGNC:58995};
Equus caballus (Horse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000041279, ECO:0000313|Proteomes:UP000002281};
[1] {ECO:0000313|Ensembl:ENSECAP00000041279, ECO:0000313|Proteomes:UP000002281}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000041279,
ECO:0000313|Proteomes:UP000002281};
PubMed=19892987; DOI=10.1126/science.1178158;
Broad Institute Genome Sequencing Platform;
Broad Institute Whole Genome Assembly Team;
Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
"Genome sequence, comparative analysis, and population genetics of the
domestic horse.";
Science 326:865-867(2009).
[2] {ECO:0000313|Ensembl:ENSECAP00000041279}
IDENTIFICATION.
STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000041279};
Ensembl;
Submitted (JAN-2019) to UniProtKB.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000256|RuleBase:RU000688}.
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Ensembl; ENSECAT00000048319; ENSECAP00000041279; ENSECAG00000022224.
VGNC; VGNC:58995; GPR50.
GeneTree; ENSGT00940000160515; -.
Proteomes; UP000002281; Chromosome X.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0008502; F:melatonin receptor activity; IEA:InterPro.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR002280; Mel_rcpt_1X.
InterPro; IPR000025; Melatonin_rcpt.
PANTHER; PTHR24228:SF56; PTHR24228:SF56; 1.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR01151; MELATONIN1XR.
PRINTS; PR00857; MELATONINR.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
3: Inferred from homology;
G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
Membrane {ECO:0000256|SAM:Phobius};
Receptor {ECO:0000256|RuleBase:RU000688};
Reference proteome {ECO:0000313|Proteomes:UP000002281};
Transducer {ECO:0000256|RuleBase:RU000688};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
TRANSMEM 21..39
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 59..80
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 101..122
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 142..165
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 192..218
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 230..253
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
DOMAIN 20..250
/note="G_PROTEIN_RECEP_F1_2"
/evidence="ECO:0000259|PROSITE:PS50262"
REGION 294..394
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 425..518
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 294..315
/note="Polyampholyte"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 341..366
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 447..475
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 486..500
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 591 AA; 64051 MW; 3FAC21EE6DBA9044 CRC64;
MPCLRRFCGP VCRINAMLGN IFVVSLSVAD MLVAFYPYPL MLHAMAIGGW DLSQFQCQMV
GFITGLSVVG SIFNIVAIAI NRYCYICHSL QYERVFSVRN TCIYLVVTWI MTILAVLPNM
YIGTIEYDPR TYTCIFNYLN NPVFAVTIVC IHFVLPLLIV GFCYVRIWTK VLAARHLAGQ
NPDNELAEVR NFLTMFVIFL LFAVCWCPIN VLTVLVAVSP KEMAGKIPSW LYLAAYFTAY
FNSCLNAVIY GLLNENFRRE YWTTFHAMRH PIQFISGLIT DVRETREAHA LARARAHARD
QAREQAHEQD RVHASPAVEE IPMNVRNVPL PGHAAAASDY PKSSSGHSRS ASAHCKSASG
HHKSVFSHSK PASGHPKPAS GHPKPASGHS KSATVNPKSA SVYFKADSVH FKPASVHFKA
DSAHFQPVSN HPKPVTGHHI PAGSHSKTAF SPATSCSKPT TGHTKLATSQ PEPTTADYPE
PAATSHSKPA ITSHSEPAIT SHSEPAAAGH PELSASCHPE TTAAGHLECD ITDLPESASS
SAPGSPEPAT SPLELAAATD LLDPTVVTTA TNGYRGAGVI DAEADSDEMA L


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