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G protein-coupled receptor 50

 F1Q1H9_CANLF            Unreviewed;       617 AA.
F1Q1H9;
03-MAY-2011, integrated into UniProtKB/TrEMBL.
11-DEC-2019, sequence version 3.
17-JUN-2020, entry version 46.
SubName: Full=G protein-coupled receptor 50 {ECO:0000313|Ensembl:ENSCAFP00000028239};
Name=GPR50 {ECO:0000313|Ensembl:ENSCAFP00000028239,
ECO:0000313|VGNC:VGNC:41437};
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000028239, ECO:0000313|Proteomes:UP000002254};
[1] {ECO:0000313|Ensembl:ENSCAFP00000028239, ECO:0000313|Proteomes:UP000002254}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000028239,
ECO:0000313|Proteomes:UP000002254};
PubMed=16341006; DOI=10.1038/nature04338;
Broad Sequencing Platform;
Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., Mauceli E.,
Xie X., Breen M., Wayne R.K., Ostrander E.A., Ponting C.P., Galibert F.,
Smith D.R., deJong P.J., Kirkness E.F., Alvarez P., Biagi T., Brockman W.,
Butler J., Chin C.-W., Cook A., Cuff J., Daly M.J., DeCaprio D., Gnerre S.,
Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A.,
Hitte C., Kim L., Koepfli K.-P., Parker H.G., Pollinger J.P.,
Searle S.M.J., Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P.,
Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B.,
Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A.,
Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M.,
Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S.,
Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L.,
Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C.,
Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G.,
Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N.,
Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A.,
Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A.,
Kanga B., Kells C., Khazanovich D., Kieu A.C., Kisner P., Kumar M.,
Lance K., Landers T., Lara M., Lee W., Leger J.-P., Lennon N., Leuper L.,
LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A.,
Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S.,
Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T.,
Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A.,
Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S.,
Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M.,
Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F.,
Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T.,
Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C.,
Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C.,
Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D.,
Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H.,
Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J.,
Zembek L., Zimmer A., Lander E.S.;
"Genome sequence, comparative analysis and haplotype structure of the
domestic dog.";
Nature 438:803-819(2005).
[2] {ECO:0000313|Ensembl:ENSCAFP00000028239}
IDENTIFICATION.
STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000028239};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000256|RuleBase:RU000688}.
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EMBL; AAEX03027047; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAEX03027048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 9612.ENSCAFP00000028239; -.
PaxDb; F1Q1H9; -.
Ensembl; ENSCAFT00000030392; ENSCAFP00000028239; ENSCAFG00000019143.
VGNC; VGNC:41437; GPR50.
eggNOG; ENOG410IHFY; Eukaryota.
eggNOG; ENOG4111ZZV; LUCA.
GeneTree; ENSGT00940000160515; -.
HOGENOM; CLU_468199_0_0_1; -.
InParanoid; F1Q1H9; -.
TreeFam; TF331693; -.
Proteomes; UP000002254; Chromosome X.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0008502; F:melatonin receptor activity; IEA:InterPro.
GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR002280; Mel_rcpt_1X.
InterPro; IPR000025; Melatonin_rcpt.
PANTHER; PTHR24228:SF56; PTHR24228:SF56; 1.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR01151; MELATONIN1XR.
PRINTS; PR00857; MELATONINR.
SMART; SM01381; 7TM_GPCR_Srsx; 1.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
3: Inferred from homology;
G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
Membrane {ECO:0000256|SAM:Phobius};
Receptor {ECO:0000256|RuleBase:RU000688};
Reference proteome {ECO:0000313|Proteomes:UP000002254};
Transducer {ECO:0000256|RuleBase:RU000688};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
TRANSMEM 27..53
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 65..83
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 103..124
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 145..166
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 186..209
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 236..262
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 274..297
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
DOMAIN 45..294
/note="G_PROTEIN_RECEP_F1_2"
/evidence="ECO:0000259|PROSITE:PS50262"
REGION 340..437
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 476..539
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 340..358
/note="Polyampholyte"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 399..423
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 617 AA; 67074 MW; 3505B641D4A57A1C CRC64;
MGPTLAVPTP YGCIGCKLPQ PDYPPALIIF MFCAMVITIV VDLIGNSMVI LAVTKNKKLR
NSGNIFVVSL SVADMLVAIY PYPLMLHAMA IGGWDLSQLQ CQMVGFITGL SVVGSIFNIV
AIAINRYCYI CHSLQYERIF SVRNTCIYLI ITWIMTVLAV LPNMYIGTIE YDPRTYTCIF
NYLNNPAFAV TIVCIHFVLP LLIVGFCYVR IWTKVLAARD PAGQNPDNQL AEVRNFLTMF
VIFLLFAVCW CPINVLTVLV AVSPKEMAGK IPNWLYLAAY FIAYFNSCLN AVIYGLLNEN
FRREYWTIFH AMRHPILFLS GLITDIRETR EARALARARA RARDQAREQA HEQEPARACP
AVEEMPMNAR NVPLPGDAAA GRPERASGHP KPASGHSRSA SAYRKSASSH HKSVFSHSKP
ASGHSKPASG HPKSATVYPK PASVHFKADS VHFKPASVHF KADSVHFKAA SNHPKPVTGH
HIPAGSHSKA VLSPATSPHK PTTGYIKPAA THPEPTTADN PEPAAASPPE PANAGHRELT
ASSCPETTAA GHVECDVADL PEPVCSPPSA SPEPAASPLE LAAAANLPDP TVTTTTTTDY
HKIVVIDVEA DSDEMDV


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