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G protein-coupled receptor 50

 F7GTE4_MACMU            Unreviewed;       628 AA.
F7GTE4; G7NRZ0;
27-JUL-2011, integrated into UniProtKB/TrEMBL.
30-NOV-2016, sequence version 2.
22-APR-2020, entry version 52.
SubName: Full=G protein-coupled receptor 50 {ECO:0000313|Ensembl:ENSMMUP00000002171};
Name=GPR50 {ECO:0000313|Ensembl:ENSMMUP00000002171,
ECO:0000313|VGNC:VGNC:73138};
Macaca mulatta (Rhesus macaque).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000002171, ECO:0000313|Proteomes:UP000006718};
[1] {ECO:0000313|Ensembl:ENSMMUP00000002171, ECO:0000313|Proteomes:UP000006718}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000002171,
ECO:0000313|Proteomes:UP000006718};
PubMed=17431167; DOI=10.1126/science.1139247;
Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
Kuhn R.M., Smith K.E., Zwieg A.S.;
"Evolutionary and biomedical insights from the rhesus macaque genome.";
Science 316:222-234(2007).
[2] {ECO:0000313|Ensembl:ENSMMUP00000002171}
IDENTIFICATION.
STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000002171};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000256|RuleBase:RU000688}.
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RefSeq; XP_001092026.2; XM_001092026.2.
STRING; 9544.ENSMMUP00000002171; -.
Ensembl; ENSMMUT00000002295; ENSMMUP00000002171; ENSMMUG00000001620.
GeneID; 703817; -.
KEGG; mcc:703817; -.
CTD; 9248; -.
VGNC; VGNC:73138; GPR50.
eggNOG; ENOG410IHFY; Eukaryota.
eggNOG; ENOG4111ZZV; LUCA.
GeneTree; ENSGT00940000160515; -.
HOGENOM; CLU_468199_0_0_1; -.
InParanoid; F7GTE4; -.
KO; K04287; -.
OrthoDB; 907115at2759; -.
TreeFam; TF331693; -.
Proteomes; UP000006718; Chromosome X.
Bgee; ENSMMUG00000001620; Expressed in heart.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0008502; F:melatonin receptor activity; IEA:InterPro.
GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR002280; Mel_rcpt_1X.
InterPro; IPR000025; Melatonin_rcpt.
PANTHER; PTHR24228:SF56; PTHR24228:SF56; 1.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR01151; MELATONIN1XR.
PRINTS; PR00857; MELATONINR.
SMART; SM01381; 7TM_GPCR_Srsx; 1.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
3: Inferred from homology;
G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
Membrane {ECO:0000256|RuleBase:RU000688};
Receptor {ECO:0000256|RuleBase:RU000688};
Reference proteome {ECO:0000313|Proteomes:UP000006718};
Transducer {ECO:0000256|RuleBase:RU000688};
Transmembrane {ECO:0000256|RuleBase:RU000688}.
SEQUENCE 628 AA; 68571 MW; A5429053A97B1C85 CRC64;
MGPTLAVPTP YGCIGCKLPQ PDYPPALIIF MFCAMVITIV VDLIGNSMVI LAVTKSKKLR
NSGNIFVVSL SVADMLVAIY PYPLMLHAMS TGGWDLSQLQ CQMVGFITGL SVVSSIFNIV
AIAINRYCYI CHSLQYERIF SARNTCIYLV VTWIMTILAV LPNMYIGTIE YDPRTYTCIF
NYLNNPVFTV TIVCIHFVLP LLIVGFCYLR IWTKVLAARD PAGQNPDNQL AEVRNFLTMF
VIFLLFAVCW CPINVLTVLV AVSPKEMAGK IPNWLYLAAY FIAYFNSCLN AVIYGLLNEN
FRREYWTIFH AMRHPIIFFS GLISDIREMQ EAHALARARA HARDQACEQA LEQDCAHACP
AVEETLMNVR NVPLPGDAAA GHPDRASGHP KPHSRSSSAY RKSASTHHKS VFSHSKAASG
HLKPVSGHSK PASGHPKSAT VYPKPASVYF KADSVHFKPA SVHFKGDSVH FKPDSVHFKP
ASSHPKPITG HHVSTGSHSK SAFSAATSHP KPTTGHIKPA TSHAEPTTAD YPKPATTSHP
EPTAADHPEL SASHCPEIPA IAHPESDDSD LPASASSPAS GPTKPAASQL EPDTIADLPD
TTVVTTNTHD YHDVVVIDVE DDLNEMAV


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