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G protein-coupled receptor 50

 K7GLF5_PIG              Unreviewed;       613 AA.
K7GLF5;
09-JAN-2013, integrated into UniProtKB/TrEMBL.
09-JAN-2013, sequence version 1.
17-JUN-2020, entry version 41.
SubName: Full=G protein-coupled receptor 50 {ECO:0000313|Ensembl:ENSSSCP00000028684};
Name=GPR50 {ECO:0000313|Ensembl:ENSSSCP00000028684,
ECO:0000313|VGNC:VGNC:88633};
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000028684, ECO:0000313|Proteomes:UP000008227};
[1] {ECO:0000313|Ensembl:ENSSSCP00000028684, ECO:0000313|Proteomes:UP000008227}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000028684,
ECO:0000313|Proteomes:UP000008227};
Porcine genome sequencing project;
Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSSSCP00000028684}
IDENTIFICATION.
Ensembl;
Submitted (NOV-2012) to UniProtKB.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000256|RuleBase:RU000688}.
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EMBL; AEMK02000122; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 9823.ENSSSCP00000028684; -.
PaxDb; K7GLF5; -.
PRIDE; K7GLF5; -.
Ensembl; ENSSSCT00000035039; ENSSSCP00000028684; ENSSSCG00000023462.
VGNC; VGNC:88633; GPR50.
eggNOG; ENOG410IHFY; Eukaryota.
eggNOG; ENOG4111ZZV; LUCA.
GeneTree; ENSGT00940000160515; -.
InParanoid; K7GLF5; -.
OMA; VGFCYMR; -.
OrthoDB; 907115at2759; -.
TreeFam; TF331693; -.
Proteomes; UP000008227; Chromosome X.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0008502; F:melatonin receptor activity; IEA:InterPro.
GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR002280; Mel_rcpt_1X.
InterPro; IPR000025; Melatonin_rcpt.
PANTHER; PTHR24228:SF56; PTHR24228:SF56; 1.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR01151; MELATONIN1XR.
PRINTS; PR00857; MELATONINR.
SMART; SM01381; 7TM_GPCR_Srsx; 1.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
3: Inferred from homology;
G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
Membrane {ECO:0000256|SAM:Phobius};
Receptor {ECO:0000256|RuleBase:RU000688};
Reference proteome {ECO:0000313|Proteomes:UP000008227};
Transducer {ECO:0000256|RuleBase:RU000688};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
TRANSMEM 27..53
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 65..83
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 103..124
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 145..166
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 186..209
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 236..262
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
TRANSMEM 274..297
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
DOMAIN 45..294
/note="G_PROTEIN_RECEP_F1_2"
/evidence="ECO:0000259|PROSITE:PS50262"
REGION 343..443
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 463..613
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 343..361
/note="Polyampholyte"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 463..496
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 497..513
/note="Pro-rich"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 524..538
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 558..575
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 613 AA; 66481 MW; A5E8551F3AF1E699 CRC64;
MGPTLAVPTP YGCIGCKLPQ PDYPPALIVF MFCAMVITIV VDLIGNSMVI LAVSKNKKLR
NSGNIFVVSL SVADVLVAVY PYPLMLHAMA VGGWDLSQLQ CQMVGFITGL SVVGSIFNIV
AIAINRYCYI CHSLQYERIF SVRNTCIYLA VTWTMTVMAV LPNMYIGTIE YDPRTYTCIF
NYLNNPIFAV TIVCIHFVLP LVVVGFCYVR IWTKVLAARD PAGQNPDNQL AEVRNFLTMF
VIFLLFAVCW CPINVLTVLV AVSPKEMAGK IPNWLYLAAY FIAYFNSCLN AVIYGLLNEN
FRREYWTIFH AMRHPILFIS GLITDAREMR EARALARARA RARDRARQQA REQDRARVEE
VPMSVRNVPL PGDAAAGQPE LASGHPKPAS SHSRSASAHR KSASGHHKSV FSHSKPASGH
SKPASGPSKP ASGHPKSATV YPKPASVHFK PASVHFKADS VHFKSSSSHP KSVTGHHIPS
GSHSKTAFSP DTSRPKPTSG PTKPAPTHPE PTTADFPEPV ATSHPEPTIS SQPELAASCH
PETTAPGHLE CDVTGLPEPA SSPSTESSES AASSPEPATA AAPVDPIEGT TASSDYHEIE
VLDVEADSDE MAL


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WP1714: Tyrosine metabolism
WP26: Signal Transduction of S1P Receptor
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WP1183: Toll-like receptor signaling pathway
WP1888: Post-translational protein modification
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Bibliography :
[32595514] Inhibition of Adenosine Pathway Alters Atrial Electrophysiology and Prevents Atrial Fibrillation.
[32592811] Transcriptomic analysis of hookworm Ancylostoma ceylanicum life cycle stages reveals changes in G-protein coupled receptor diversity associated with the onset of parasitism.
[32584181] Assessment of luteinizing hormone receptor expression in structural support tissues of canine hip and femorotibial joints.
[32575439] Immunoadsorption for Treatment of Patients with Suspected Alzheimer Dementia and Agonistic Autoantibodies against Alpha1a-Adrenoceptor-Rationale and Design of the IMAD Pilot Study.
[32545589] Molecular Identification, Characterization, and Expression Analysis of a Gonadotropin-Releasing Hormone Receptor (GnRH-R) in Pacific Abalone, .
[32533118] Genetics of kidney stone disease.
[32513839] Fentanyl but not Morphine Interacts with Non-Opioid Recombinant Human Neurotransmitter Receptors and Transporters.
[32494050] Advances in therapeutic peptides targeting G protein-coupled receptors.
[32483378] An allosteric modulator binds to a conformational hub in the β adrenergic receptor.
[32438771] A Reference Genome of Provides New Resources for Revealing Its Displacement by Pinewood Nematode.