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G protein-coupled receptor 50 (GPR50 isoform 1)

 A0A2I3SNR6_PANTR        Unreviewed;       628 AA.
A0A2I3SNR6; A0A2J8JL73;
28-FEB-2018, integrated into UniProtKB/TrEMBL.
28-FEB-2018, sequence version 1.
17-JUN-2020, entry version 15.
SubName: Full=G protein-coupled receptor 50 {ECO:0000313|Ensembl:ENSPTRP00000078605};
Name=GPR50 {ECO:0000313|Ensembl:ENSPTRP00000078605,
ECO:0000313|VGNC:VGNC:12389};
Pan troglodytes (Chimpanzee).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Pan.
NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000078605, ECO:0000313|Proteomes:UP000002277};
[1] {ECO:0000313|Ensembl:ENSPTRP00000078605, ECO:0000313|Proteomes:UP000002277}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16136131; DOI=10.1038/nature04072;
Chimpanzee sequencing and analysis consortium;
"Initial sequence of the chimpanzee genome and comparison with the human
genome.";
Nature 437:69-87(2005).
[2] {ECO:0000313|Ensembl:ENSPTRP00000078605}
IDENTIFICATION.
Ensembl;
Submitted (JAN-2018) to UniProtKB.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000256|RuleBase:RU000688}.
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EMBL; AACZ04044066; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_016799921.1; XM_016944432.1.
Ensembl; ENSPTRT00000097486; ENSPTRP00000078605; ENSPTRG00000028172.
GeneID; 736267; -.
KEGG; ptr:736267; -.
CTD; 9248; -.
VGNC; VGNC:12389; GPR50.
GeneTree; ENSGT00940000160515; -.
KO; K04287; -.
OrthoDB; 907115at2759; -.
Proteomes; UP000002277; Chromosome X.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0008502; F:melatonin receptor activity; IEA:InterPro.
GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR002280; Mel_rcpt_1X.
InterPro; IPR000025; Melatonin_rcpt.
PANTHER; PTHR24228:SF56; PTHR24228:SF56; 1.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR01151; MELATONIN1XR.
PRINTS; PR00857; MELATONINR.
SMART; SM01381; 7TM_GPCR_Srsx; 1.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
3: Inferred from homology;
G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
Membrane {ECO:0000256|RuleBase:RU000688};
Receptor {ECO:0000256|RuleBase:RU000688};
Reference proteome {ECO:0000313|Proteomes:UP000002277};
Transducer {ECO:0000256|RuleBase:RU000688};
Transmembrane {ECO:0000256|RuleBase:RU000688}.
SEQUENCE 628 AA; 68606 MW; D834A4F4468CF719 CRC64;
MGPTLAVPTP YGCIGCKLPQ PDYPLALIIF MFCAMVITIV VDLIGNSMVI LAVTKNKKLR
NSGNIFVVSL SVADMLVAIY PYPLMLHAMS IGGWDLSQLQ CQMVGFITGL SVVGSIFNIV
AIAINRYCYI CHSLQYERIF SVRNTCIYLV ITWIMTVLAV LPNMYIGTIE YDPRTYTCIF
NYLNNPVFTV TIVCIHFVLP LLIVGFCYLR IWTKVLAARD PAGQNPDNQL AEVRNFLTMF
VIFLLFAVCW CPINVLTVLV AVSPKEMAGK IPNWLYLAAY FIAYFNSCLN AVIYGLLNEN
FRREYWTIFH AMRHPIIFFS GLISDIREMQ EARTLARARA HARDQAREQA LEQDRAHACP
AVEETPMNVR NVPLPGDAAA GHPDRASGHP KPHSRSSSAY RKSASTHHKS VFSHSKAASG
HLKPVCGHSK PASGHPKSAT VYPKPASVHF KGDSVHFKPA SVHFKGDSVH FKPDSVHFKP
ASSNPKPITG QHVSAGSHSK SAFSAATSHP KPATGHIKPA TSHAEPTTAD YPKPATTSHP
KPAAADHPEL STSHCPEIPA IAHPVSDDSD LPESASSPAA GPTKPAASQL ESDTIADLPD
PTVVTTNTND YHDVVVIDVE DDPDEMAV


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WP1438: Influenza A virus infection
WP2199: Seed Development
WP581: EPO Receptor Signaling
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[RXFP2 GPR106 GREAT LGR8] Relaxin receptor 2 (G-protein coupled receptor 106) (G-protein coupled receptor affecting testicular descent) (Leucine-rich repeat-containing G-protein coupled receptor 8) (Relaxin family peptide receptor 2)
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[ADGRL2 KIAA0786 LEC1 LPHH1 LPHN2] Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin homolog 1) (Latrophilin-2) (Lectomedin-1)
[Adgrl1 Kiaa0821 Lec2 Lphn1] Adhesion G protein-coupled receptor L1 (Calcium-independent alpha-latrotoxin receptor 1) (CIRL-1) (Latrophilin-1) (Lectomedin-2)
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[Gper1 Cmkrl2 Gper Gpr30] G-protein coupled estrogen receptor 1 (Chemoattractant receptor-like 2) (G protein-coupled estrogen receptor 1) (G-protein coupled receptor 30) (Membrane estrogen receptor) (mER)
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Bibliography :