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G1/S-specific cyclin-D1

 CCND1_CHICK             Reviewed;         292 AA.
P55169;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 1.
05-JUN-2019, entry version 97.
RecName: Full=G1/S-specific cyclin-D1;
Name=CCND1;
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Li H., Lahti J.M., Kidd V.J.;
Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Essential for the control of the cell cycle at the G1/S
(start) transition. Interacts with the CDK4 and CDK6 protein
kinases. May play a role in transcriptional regulation (By
similarity). {ECO:0000250}.
-!- PTM: Phosphorylation at Thr-283 by MAP kinases is required for
ubiquitination and degradation following DNA damage. It probably
plays an essential role for recognition by the FBXO31 component of
SCF (SKP1-cullin-F-box) protein ligase complex (By similarity).
{ECO:0000250}.
-!- PTM: Following DNA damage it is ubiquitinated by some SCF (SKP1-
cullin-F-box) protein ligase complex containing FBXO31.
Ubiquitination leads to its degradation and G1 arrest (By
similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the cyclin family. Cyclin D subfamily.
{ECO:0000305}.
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EMBL; U40844; AAA83271.1; -; mRNA.
RefSeq; NP_990712.1; NM_205381.1.
SMR; P55169; -.
STRING; 9031.ENSGALP00000012203; -.
PaxDb; P55169; -.
GeneID; 396341; -.
KEGG; gga:396341; -.
CTD; 595; -.
eggNOG; KOG0656; Eukaryota.
eggNOG; ENOG410XRKC; LUCA.
HOGENOM; HOG000008182; -.
InParanoid; P55169; -.
KO; K04503; -.
OrthoDB; 1234739at2759; -.
PhylomeDB; P55169; -.
PRO; PR:P55169; -.
Proteomes; UP000000539; Unplaced.
GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; ISS:UniProtKB.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0017053; C:transcriptional repressor complex; ISS:UniProtKB.
GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
GO; GO:0003714; F:transcription corepressor activity; ISS:UniProtKB.
GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
GO; GO:0000082; P:G1/S transition of mitotic cell cycle; ISS:UniProtKB.
GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
GO; GO:0031571; P:mitotic G1 DNA damage checkpoint; ISS:UniProtKB.
GO; GO:0071157; P:negative regulation of cell cycle arrest; ISS:UniProtKB.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
GO; GO:0045737; P:positive regulation of cyclin-dependent protein serine/threonine kinase activity; ISS:UniProtKB.
GO; GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; IBA:GO_Central.
GO; GO:0010971; P:positive regulation of G2/M transition of mitotic cell cycle; ISS:UniProtKB.
GO; GO:0001934; P:positive regulation of protein phosphorylation; ISS:UniProtKB.
GO; GO:0006468; P:protein phosphorylation; IEA:GOC.
GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
GO; GO:0070141; P:response to UV-A; ISS:UniProtKB.
CDD; cd00043; CYCLIN; 1.
InterPro; IPR039361; Cyclin.
InterPro; IPR013763; Cyclin-like.
InterPro; IPR036915; Cyclin-like_sf.
InterPro; IPR004367; Cyclin_C-dom.
InterPro; IPR015451; Cyclin_D.
InterPro; IPR006671; Cyclin_N.
PANTHER; PTHR10177; PTHR10177; 1.
PANTHER; PTHR10177:SF67; PTHR10177:SF67; 1.
Pfam; PF02984; Cyclin_C; 1.
Pfam; PF00134; Cyclin_N; 1.
PIRSF; PIRSF001771; Cyclin_A_B_D_E; 1.
SMART; SM00385; CYCLIN; 1.
SMART; SM01332; Cyclin_C; 1.
SUPFAM; SSF47954; SSF47954; 2.
PROSITE; PS00292; CYCLINS; 1.
2: Evidence at transcript level;
Cell cycle; Cell division; Complete proteome; Cyclin; Phosphoprotein;
Reference proteome; Transcription; Transcription regulation;
Ubl conjugation.
CHAIN 1 292 G1/S-specific cyclin-D1.
/FTId=PRO_0000080434.
MOD_RES 283 283 Phosphothreonine. {ECO:0000250}.
SEQUENCE 292 AA; 33264 MW; 7B543029DB45A67D CRC64;
MEHQLQCCEV ETIRRAYLDA NLLNDRVLQT MLKAEETCSP SVSYFKCVQK EILPYMRKIV
ATWMLEVCEE QKCEEEVFPL AMNYLDRFLS FEPLKKSRLQ LLGATCMFVA SKMKETIPLT
AEKLCIYTDN SIRPDELLQM ELLLVNKLKW NLAAMTPHDF IEHFLTKMPL AEDTKQIIRK
HAQTFVALCA TDVKFISNPP SMIAAGSVVA AVQGLHLGNT NTFLSYQCLT HFLSQVIKCD
PDCLRACQEQ IESLLESSLR QAQQHNVSSE TKTVEDEADL SCTPTDVRDV NI


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