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GRB2 isoform 3 (GRB2 isoform 4) (GRB2 isoform 6) (Growth factor receptor-bound protein 2)

 G2HGD2_PANTR            Unreviewed;       217 AA.
G2HGD2; A0A2J8KBE0;
16-NOV-2011, integrated into UniProtKB/TrEMBL.
16-NOV-2011, sequence version 1.
03-JUL-2019, entry version 69.
SubName: Full=GRB2 isoform 3 {ECO:0000313|EMBL:PNI32343.1};
SubName: Full=GRB2 isoform 4 {ECO:0000313|EMBL:PNI32344.1};
SubName: Full=GRB2 isoform 6 {ECO:0000313|EMBL:PNI32346.1};
SubName: Full=Growth factor receptor-bound protein 2 {ECO:0000313|EMBL:BAK62790.1, ECO:0000313|Ensembl:ENSPTRP00000016382};
Name=GRB2 {ECO:0000313|EMBL:JAA03233.1,
ECO:0000313|Ensembl:ENSPTRP00000016382, ECO:0000313|VGNC:VGNC:14183};
ORFNames=CK820_G0039891 {ECO:0000313|EMBL:PNI32343.1};
Pan troglodytes (Chimpanzee).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pan.
NCBI_TaxID=9598 {ECO:0000313|EMBL:BAK62790.1};
[1] {ECO:0000313|Ensembl:ENSPTRP00000016382, ECO:0000313|Proteomes:UP000002277}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16136131; DOI=10.1038/nature04072;
Chimpanzee sequencing and analysis consortium;
"Initial sequence of the chimpanzee genome and comparison with the
human genome.";
Nature 437:69-87(2005).
[2] {ECO:0000313|EMBL:BAK62790.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Testis {ECO:0000313|EMBL:BAK62790.1};
PubMed=21484476; DOI=10.1007/s10142-011-0220-9;
Kim R.N., Kim D.W., Choi S.H., Chae S.H., Nam S.H., Kim D.W., Kim A.,
Kang A., Park K.H., Lee Y.S., Hirai M., Suzuki Y., Sugano S.,
Hashimoto K., Kim D.S., Park H.S.;
"Major chimpanzee-specific structural changes in sperm development-
associated genes.";
Funct. Integr. Genomics 11:507-517(2011).
[3] {ECO:0000313|Ensembl:ENSPTRP00000016382}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2012) to UniProtKB.
[4] {ECO:0000313|EMBL:JAA03233.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA03233.1},
Skeletal muscle {ECO:0000313|EMBL:JAA40077.1},
Skin {ECO:0000313|EMBL:JAA30201.1}, and
Smooth vascular {ECO:0000313|EMBL:JAA16033.1};
Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
"De novo assembly of the reference chimpanzee transcriptome from
NextGen mRNA sequences.";
Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
[5] {ECO:0000313|EMBL:PNI32343.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI32343.1};
TISSUE=Blood {ECO:0000313|EMBL:PNI32343.1};
Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R.,
Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C.,
Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V.,
Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S.,
Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I.,
Haussler D., Eichler E.;
"High-resolution comparative analysis of great ape genomes.";
Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
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EMBL; AACZ04070071; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AACZ04070072; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AK305796; BAK62790.1; -; mRNA.
EMBL; GABC01008105; JAA03233.1; -; mRNA.
EMBL; GABC01008104; JAA03234.1; -; mRNA.
EMBL; GABF01006112; JAA16033.1; -; mRNA.
EMBL; GABF01006111; JAA16034.1; -; mRNA.
EMBL; GABF01006110; JAA16035.1; -; mRNA.
EMBL; GABF01006109; JAA16036.1; -; mRNA.
EMBL; GABF01006108; JAA16037.1; -; mRNA.
EMBL; GABF01006107; JAA16038.1; -; mRNA.
EMBL; GABD01002899; JAA30201.1; -; mRNA.
EMBL; GABD01002898; JAA30202.1; -; mRNA.
EMBL; GABD01002897; JAA30203.1; -; mRNA.
EMBL; GABE01004662; JAA40077.1; -; mRNA.
EMBL; GABE01004661; JAA40078.1; -; mRNA.
EMBL; NBAG03000379; PNI32343.1; -; Genomic_DNA.
EMBL; NBAG03000379; PNI32344.1; -; Genomic_DNA.
EMBL; NBAG03000379; PNI32346.1; -; Genomic_DNA.
RefSeq; NP_001233546.1; NM_001246617.1.
SMR; G2HGD2; -.
STRING; 9598.ENSPTRP00000016382; -.
Ensembl; ENSPTRT00000017683; ENSPTRP00000016382; ENSPTRG00000009642.
GeneID; 737245; -.
KEGG; ptr:737245; -.
CTD; 2885; -.
VGNC; VGNC:14183; GRB2.
eggNOG; KOG3601; Eukaryota.
eggNOG; ENOG410XR1G; LUCA.
GeneTree; ENSGT00940000155738; -.
KO; K04364; -.
OMA; HWWHGEI; -.
OrthoDB; 1091250at2759; -.
TreeFam; TF354288; -.
Proteomes; UP000002277; Chromosome 17.
Bgee; ENSPTRG00000009642; Expressed in 6 organ(s), highest expression level in cerebellum.
GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
GO; GO:0008180; C:COP9 signalosome; IEA:Ensembl.
GO; GO:0005768; C:endosome; IEA:Ensembl.
GO; GO:0070436; C:Grb2-EGFR complex; IEA:Ensembl.
GO; GO:0005730; C:nucleolus; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0012506; C:vesicle membrane; IEA:Ensembl.
GO; GO:0046875; F:ephrin receptor binding; IEA:Ensembl.
GO; GO:0005154; F:epidermal growth factor receptor binding; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0043560; F:insulin receptor substrate binding; IEA:Ensembl.
GO; GO:0005168; F:neurotrophin TRKA receptor binding; IEA:Ensembl.
GO; GO:0001784; F:phosphotyrosine residue binding; IEA:Ensembl.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0019903; F:protein phosphatase binding; IEA:Ensembl.
GO; GO:0017124; F:SH3 domain binding; IEA:Ensembl.
GO; GO:0005070; F:SH3/SH2 adaptor activity; IEA:Ensembl.
GO; GO:0048646; P:anatomical structure formation involved in morphogenesis; IEA:Ensembl.
GO; GO:0060670; P:branching involved in labyrinthine layer morphogenesis; IEA:Ensembl.
GO; GO:0030154; P:cell differentiation; IEA:Ensembl.
GO; GO:0071479; P:cellular response to ionizing radiation; IEA:Ensembl.
GO; GO:0008286; P:insulin receptor signaling pathway; IEA:Ensembl.
GO; GO:0030838; P:positive regulation of actin filament polymerization; IEA:Ensembl.
GO; GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IEA:Ensembl.
GO; GO:0031623; P:receptor internalization; IEA:Ensembl.
GO; GO:0043408; P:regulation of MAPK cascade; IEA:Ensembl.
GO; GO:0042770; P:signal transduction in response to DNA damage; IEA:Ensembl.
CDD; cd11949; SH3_GRB2_C; 1.
CDD; cd11946; SH3_GRB2_N; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR030219; Grb2.
InterPro; IPR035643; GRB2_C_SH3.
InterPro; IPR035641; GRB2_N_SH3.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR036028; SH3-like_dom_sf.
InterPro; IPR001452; SH3_domain.
PANTHER; PTHR46037:SF4; PTHR46037:SF4; 1.
Pfam; PF00017; SH2; 1.
Pfam; PF00018; SH3_1; 2.
PRINTS; PR00401; SH2DOMAIN.
PRINTS; PR00452; SH3DOMAIN.
SMART; SM00252; SH2; 1.
SMART; SM00326; SH3; 2.
SUPFAM; SSF50044; SSF50044; 2.
SUPFAM; SSF55550; SSF55550; 1.
PROSITE; PS50001; SH2; 1.
PROSITE; PS50002; SH3; 2.
2: Evidence at transcript level;
Complete proteome {ECO:0000313|Proteomes:UP000002277};
Receptor {ECO:0000313|EMBL:BAK62790.1};
Reference proteome {ECO:0000313|Proteomes:UP000002277};
SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192,
ECO:0000256|SAAS:SAAS01042643}.
DOMAIN 1 58 SH3. {ECO:0000259|PROSITE:PS50002}.
DOMAIN 60 152 SH2. {ECO:0000259|PROSITE:PS50001}.
DOMAIN 156 215 SH3. {ECO:0000259|PROSITE:PS50002}.
SEQUENCE 217 AA; 25206 MW; 83A4B0BA1B248DC4 CRC64;
MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW
FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL
WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQVPQQPTY VQALFDFDPQ EDGELGFRRG
DFIHVMDNSD PNWWKGACHG QTGMFPRNYV TPVNRNV


Related products :

Catalog number Product name Quantity
DL-Grb2-Hu Human Growth Factor Receptor Bound Protein 2 (Grb2) ELISA Kit 96T
15-288-22538F Growth factor receptor-bound protein 2 - Adapter protein GRB2; SH2_SH3 adapter GRB2; Protein Ash Polyclonal 0.05 mg
15-288-22538F Growth factor receptor-bound protein 2 - Adapter protein GRB2; SH2_SH3 adapter GRB2; Protein Ash Polyclonal 0.1 mg
10-288-22538F Growth factor receptor-bound protein 2 - Adapter protein GRB2; SH2_SH3 adapter GRB2; Protein Ash 0.05 mg
10-288-22538F Growth factor receptor-bound protein 2 - Adapter protein GRB2; SH2_SH3 adapter GRB2; Protein Ash 0.1 mg
CE35 Growth Factor Receptor-Bound Protein 2 GRB2 lmg
CE35 Growth Factor Receptor-Bound Protein 2 GRB2 500
GRD1 GRB2 Gene growth factor receptor-bound protein 2
E-EL-R0467 Rat GRB2 (Growth Factor Receptor Bound Protein 2) ELISA Kit 96T
201-20-2382 GRB2{growth factor receptor-bound protein 2}rabbit.pAb 0.2ml
pro-678 Recombinant Human Growth Factor Receptor-Bound Protein 2 GRB2 5
GRB2 GRB10 Gene growth factor receptor-bound protein 10
E92514Hu ELISA Kit for Growth Factor Receptor Bound Protein 2 (Grb2) 96T/Kit
CD19 Human Growth Factor Receptor-Bound Protein 2 GRB2 l0
E02G0247 Rat Growth Factor Receptor Bound Protein 2 Elisa Kit (Grb2) 96 Tests/kit
pro-678 Recombinant Human Growth Factor Receptor-Bound Protein 2 GRB2 25
E02G0247 Rat Growth Factor Receptor Bound Protein 2 ELISA , Grb2 96 Tests/kit
CSB-EL009889RA Rat Growth factor receptor-bound protein 2(GRB2) ELISA kit 96T
pro-678 Recombinant Human Growth Factor Receptor-Bound Protein 2 GRB2 1mg
C048 Human Growth Factor Receptor-Bound Protein 2 GRB2 50
E02G0247 Rat Growth Factor Receptor Bound Protein 2 ELISA , Grb2
228-10569-1 Recombinant Human Growth Factor Receptor-Bound Protein 2 (GRB2) 5
228-10569-2 Recombinant Human Growth Factor Receptor-Bound Protein 2 (GRB2) 25
228-10569-3 Recombinant Human Growth Factor Receptor-Bound Protein 2 (GRB2) 1 mg
CSB-EL009889HU Human Growth factor receptor-bound protein 2(GRB2) ELISA kit 96T
Pathways :
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP2292: Chemokine signaling pathway
WP1284: EPO Receptor Signaling
WP147: Kit Receptor Signaling Pathway
WP1011: T Cell Receptor Signaling Pathway
WP894: T Cell Receptor Signaling Pathway
WP1354: B Cell Receptor Signaling Pathway
WP908: B Cell Receptor Signaling Pathway
WP1965: VEGF-receptor Signal Transduction
WP274: B Cell Receptor Signaling Pathway
WP1025: B Cell Receptor Signaling Pathway
WP774: Kit Receptor Signaling Pathway
WP1112: EPO Receptor Signaling
WP1130: T Cell Receptor Signaling Pathway
WP1144: B Cell Receptor Signaling Pathway
WP1336: EPO Receptor Signaling
WP878: EPO Receptor Signaling
WP352: T Cell Receptor Signaling Pathway

Related Genes :
[Grb2] Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
[GRB2 ASH] Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
[Grb2 Ash] Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
[GRB2] Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
[GAB1] GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
[GAREM1 C18orf11 FAM59A GAREM] GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1)
[Sgip1] SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein)
[SGIP1] SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein)
[Themis] Protein THEMIS (Grb2-associating protein) (Gasp) (Protein thylex) (Thymocyte-expressed molecule involved in selection)
[SH3GL2 CNSA2 SH3D2A] Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2)
[Sh3gl2 Sh3d2a Sh3p4] Endophilin-A1 (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2) (SH3p4)
[Sgip1] SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein)
[MED28 EG1 FKSG20] Mediator of RNA polymerase II transcription subunit 28 (Endothelial-derived protein 1) (Mediator complex subunit 28) (Merlin and Grb2-interacting cytoskeletal protein) (Magicin) (Tumor angiogenesis marker EG-1)
[NRG1 GGF HGL HRGA NDF SMDF] Pro-neuregulin-1, membrane-bound isoform (Pro-NRG1) [Cleaved into: Neuregulin-1 (Acetylcholine receptor-inducing activity) (ARIA) (Breast cancer cell differentiation factor p45) (Glial growth factor) (Heregulin) (HRG) (Neu differentiation factor) (Sensory and motor neuron-derived factor)]
[Garem1 Fam59a Garem Gm944 Kiaa4238] GRB2-associated and regulator of MAPK protein (GRB2-associated and regulator of MAPK1)
[Nrg1 Ndf] Pro-neuregulin-1, membrane-bound isoform (Pro-NRG1) [Cleaved into: Neuregulin-1 (Acetylcholine receptor-inducing activity) (ARIA) (Glial growth factor) (Heregulin) (HRG) (Neu differentiation factor) (Sensory and motor neuron-derived factor)]
[SH3GLB1 KIAA0491 CGI-61] Endophilin-B1 (Bax-interacting factor 1) (Bif-1) (SH3 domain-containing GRB2-like protein B1)
[FLT4 VEGFR3] Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4)
[Fgfr1 Flg] Fibroblast growth factor receptor 1 (FGFR-1) (bFGF-R-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (MFR) (Proto-oncogene c-Fgr) (CD antigen CD331)
[Kdr Flk-1 Flk1] Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase NYK) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)
[Pdgfrb Pdgfr Pdgfr1] Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
[Fgfr4 Fgfr-4 Mpk-11] Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (Protein-tyrosine kinase receptor MPK-11) (CD antigen CD334)
[KIT SCFR] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
[PDGFRA PDGFR2 RHEPDGFRA] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
[PDGFRB PDGFR PDGFR1] Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
[Pdgfra] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (Platelet-derived growth factor alpha receptor) (CD antigen CD140a)
[Kit Sl] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (CD antigen CD117)
[FGFR2 BEK KGFR KSAM] Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332)
[SGIP1] SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein)
[EGFR ERBB ERBB1 HER1] Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)

Bibliography :
[17329403] Angiotensin II type 2 receptor-dependent increases in nitric oxide synthase expression in the pulmonary endothelium is mediated via a G alpha i3/Ras/Raf/MAPK pathway.
[15316024] Tyrosine phosphoproteomics of fibroblast growth factor signaling: a role for insulin receptor substrate-4.
[11016645] Taxol mediates serine phosphorylation of the 66-kDa Shc isoform.
[9045692] Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein.