GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1)

 GARE1_HUMAN             Reviewed;         876 AA.
Q9H706; Q0VAG3; Q0VAG4; Q8ND03; Q9BSF5;
06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
06-FEB-2007, sequence version 2.
17-JUN-2020, entry version 142.
RecName: Full=GRB2-associated and regulator of MAPK protein 1;
AltName: Full=GRB2-associated and regulator of MAPK1;
Name=GAREM1; Synonyms=C18orf11, FAM59A, GAREM;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
TISSUE=Colon;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Testis;
PubMed=17974005; DOI=10.1186/1471-2164-8-399;
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
Wiemann S., Schupp I.;
"The full-ORF clone resource of the German cDNA consortium.";
BMC Genomics 8:399-399(2007).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
TISSUE=Lung;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
FUNCTION, INTERACTION WITH EGFR; GRB2 AND PTPN11, ALTERNATIVE SPLICING
(ISOFORMS 1 AND 2), PHOSPHORYLATION AT TYR-453 AND TYR-105, MUTAGENESIS OF
TYR-105 AND TYR-453, AND TISSUE SPECIFICITY.
PubMed=19509291; DOI=10.1074/jbc.m109.021139;
Tashiro K., Tsunematsu T., Okubo H., Ohta T., Sano E., Yamauchi E.,
Taniguchi H., Konishi H.;
"GAREM, a novel adaptor protein for growth factor receptor-bound protein 2,
contributes to cellular transformation through the activation of
extracellular signal-regulated kinase signaling.";
J. Biol. Chem. 284:20206-20214(2009).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-610 AND SER-614, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=23186163; DOI=10.1021/pr300630k;
Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
Mohammed S.;
"Toward a comprehensive characterization of a human cancer cell
phosphoproteome.";
J. Proteome Res. 12:260-271(2013).
[6]
STRUCTURE BY NMR OF 2-165.
RIKEN structural genomics initiative (RSGI);
"Solution structure of the SAM_PNT-domain of the hypothetical protein
LOC64762.";
Submitted (OCT-2006) to the PDB data bank.
-!- FUNCTION: [Isoform 1]: Acts as an adapter protein that plays a role in
intracellular signaling cascades triggered either by the cell surface
activated epidermal growth factor receptor and/or cytoplasmic protein
tyrosine kinases. Promotes activation of the MAPK/ERK signaling
pathway. Plays a role in the regulation of cell proliferation.
{ECO:0000269|PubMed:19509291}.
-!- SUBUNIT: Isoform 1 interacts with EGFR. Isoform 1 interacts (via
proline-rich domain and phosphorylated at Tyr-105 and Tyr-453) with
GRB2 (via SH3 domains); the interaction occurs upon EGF stimulation.
Isoform 1 interacts (phosphorylated at Tyr-453) with PTPN11; the
interaction increases MAPK/ERK activity and does not affect the
GRB2/SOS complex formation. Isoform 2 does not interact with GRB2.
{ECO:0000269|PubMed:19509291}.
-!- INTERACTION:
Q9H706; O75791: GRAP2; NbExp=4; IntAct=EBI-3440103, EBI-740418;
Q9H706; P62993: GRB2; NbExp=11; IntAct=EBI-3440103, EBI-401755;
Q9H706; O43639: NCK2; NbExp=3; IntAct=EBI-3440103, EBI-713635;
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=1;
IsoId=Q9H706-1; Sequence=Displayed;
Name=2; Synonyms=GAREM(S);
IsoId=Q9H706-2; Sequence=VSP_023047;
Name=3;
IsoId=Q9H706-3; Sequence=VSP_023048;
-!- TISSUE SPECIFICITY: Isoform 1 is ubiquitously expressed.
{ECO:0000269|PubMed:19509291}.
-!- PTM: On EGF stimulation, phosphorylated on Tyr-105 and Tyr-453.
{ECO:0000269|PubMed:19509291}.
-!- SIMILARITY: Belongs to the GAREM family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=CAD39149.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; AK025263; BAB15094.1; -; mRNA.
EMBL; AL834491; CAD39149.1; ALT_INIT; mRNA.
EMBL; BC005074; AAH05074.1; -; mRNA.
EMBL; BC121067; AAI21068.1; -; mRNA.
EMBL; BC121068; AAI21069.1; -; mRNA.
CCDS; CCDS11905.1; -. [Q9H706-3]
CCDS; CCDS56057.1; -. [Q9H706-1]
RefSeq; NP_001229338.1; NM_001242409.1. [Q9H706-1]
RefSeq; NP_073588.1; NM_022751.2. [Q9H706-3]
PDB; 2DKZ; NMR; -; A=801-871.
PDBsum; 2DKZ; -.
SMR; Q9H706; -.
BioGRID; 122275; 9.
IntAct; Q9H706; 22.
STRING; 9606.ENSP00000269209; -.
iPTMnet; Q9H706; -.
PhosphoSitePlus; Q9H706; -.
BioMuta; GAREM1; -.
DMDM; 125991851; -.
jPOST; Q9H706; -.
MassIVE; Q9H706; -.
MaxQB; Q9H706; -.
PaxDb; Q9H706; -.
PeptideAtlas; Q9H706; -.
PRIDE; Q9H706; -.
ProteomicsDB; 81068; -. [Q9H706-1]
ProteomicsDB; 81069; -. [Q9H706-2]
ProteomicsDB; 81070; -. [Q9H706-3]
Antibodypedia; 41891; 108 antibodies.
Ensembl; ENST00000269209; ENSP00000269209; ENSG00000141441. [Q9H706-1]
Ensembl; ENST00000399218; ENSP00000382165; ENSG00000141441. [Q9H706-3]
GeneID; 64762; -.
KEGG; hsa:64762; -.
UCSC; uc002kxk.3; human. [Q9H706-1]
CTD; 64762; -.
DisGeNET; 64762; -.
EuPathDB; HostDB:ENSG00000141441.15; -.
GeneCards; GAREM1; -.
HGNC; HGNC:26136; GAREM1.
HPA; ENSG00000141441; Tissue enhanced (pancreas).
MIM; 617998; gene.
neXtProt; NX_Q9H706; -.
OpenTargets; ENSG00000141441; -.
PharmGKB; PA134888032; -.
eggNOG; ENOG410II0U; Eukaryota.
eggNOG; ENOG410XSPW; LUCA.
GeneTree; ENSGT00530000063834; -.
HOGENOM; CLU_014784_0_0_1; -.
InParanoid; Q9H706; -.
OMA; HMAMPRF; -.
OrthoDB; 288834at2759; -.
PhylomeDB; Q9H706; -.
TreeFam; TF329726; -.
BioGRID-ORCS; 64762; 16 hits in 781 CRISPR screens.
ChiTaRS; GAREM1; human.
EvolutionaryTrace; Q9H706; -.
GenomeRNAi; 64762; -.
Pharos; Q9H706; Tbio.
PRO; PR:Q9H706; -.
Proteomes; UP000005640; Chromosome 18.
RNAct; Q9H706; protein.
Bgee; ENSG00000141441; Expressed in frontal cortex and 217 other tissues.
ExpressionAtlas; Q9H706; baseline and differential.
Genevisible; Q9H706; HS.
GO; GO:0005886; C:plasma membrane; NAS:UniProtKB.
GO; GO:0070064; F:proline-rich region binding; IDA:UniProtKB.
GO; GO:0071364; P:cellular response to epidermal growth factor stimulus; IDA:UniProtKB.
GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IDA:UniProtKB.
GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
GO; GO:0008284; P:positive regulation of cell population proliferation; IDA:UniProtKB.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:UniProtKB.
Gene3D; 1.10.150.50; -; 1.
InterPro; IPR025946; CABIT_dom.
InterPro; IPR013761; SAM/pointed_sf.
Pfam; PF12736; CABIT; 1.
SUPFAM; SSF47769; SSF47769; 1.
1: Evidence at protein level;
3D-structure; Alternative splicing; Mitogen; Phosphoprotein; Polymorphism;
Reference proteome.
CHAIN 1..876
/note="GRB2-associated and regulator of MAPK protein 1"
/id="PRO_0000277647"
DOMAIN 811..876
/note="SAM"
REGION 12..320
/note="CABIT"
REGION 498..550
/note="Necessary for interaction with GRB2"
/evidence="ECO:0000269|PubMed:19509291"
COMPBIAS 512..566
/note="Pro-rich"
MOD_RES 105
/note="Phosphotyrosine"
/evidence="ECO:0000269|PubMed:19509291"
MOD_RES 453
/note="Phosphotyrosine"
/evidence="ECO:0000269|PubMed:19509291"
MOD_RES 610
/note="Phosphoserine"
/evidence="ECO:0000244|PubMed:23186163"
MOD_RES 614
/note="Phosphoserine"
/evidence="ECO:0000244|PubMed:23186163"
VAR_SEQ 495..563
/note="Missing (in isoform 2)"
/evidence="ECO:0000303|PubMed:15489334"
/id="VSP_023047"
VAR_SEQ 579
/note="Missing (in isoform 3)"
/evidence="ECO:0000303|PubMed:14702039"
/id="VSP_023048"
VARIANT 243
/note="T -> N (in dbSNP:rs671138)"
/id="VAR_030580"
VARIANT 291
/note="K -> R (in dbSNP:rs3744921)"
/id="VAR_030581"
VARIANT 490
/note="A -> V (in dbSNP:rs16962974)"
/id="VAR_030582"
VARIANT 580
/note="V -> I (in dbSNP:rs3891458)"
/id="VAR_030583"
VARIANT 720
/note="T -> M (in dbSNP:rs2276374)"
/id="VAR_030584"
MUTAGEN 105
/note="Y->F: Does not abolish phosphorylation upon EGF
stimulation. Reduces interaction with GRB2. Abolishes
phosphorylation, interaction with GRB2 and ERK activation
upon EGF stimulation; when associated with F-453."
/evidence="ECO:0000269|PubMed:19509291"
MUTAGEN 453
/note="Y->F: Does not abolish phosphorylation upon EGF
stimulation. Abolishes interaction with PTPN11. Abolishes
phosphorylation upon EGF stimulation; when associated with
F-105."
/evidence="ECO:0000269|PubMed:19509291"
HELIX 813..819
/evidence="ECO:0000244|PDB:2DKZ"
HELIX 820..822
/evidence="ECO:0000244|PDB:2DKZ"
HELIX 827..834
/evidence="ECO:0000244|PDB:2DKZ"
TURN 835..837
/evidence="ECO:0000244|PDB:2DKZ"
HELIX 840..845
/evidence="ECO:0000244|PDB:2DKZ"
HELIX 848..853
/evidence="ECO:0000244|PDB:2DKZ"
HELIX 859..870
/evidence="ECO:0000244|PDB:2DKZ"
SEQUENCE 876 AA; 97186 MW; 668EBABC9CDE4CDF CRC64;
MDPAPSLGCS LKDVKWSSVA VPLDLLVSTY RLPQIARLDN GECVEGLREN DYLLIHSCRQ
WTTITAHSLE EGHYVIGPKI EIPVHYAGQF KLLEQDRDIK EPVQYFNSVE EVAKAFPERV
YVMEDITFNV KVASGECNED TEVYNITLCT GDELTLMGQA EILYAKTFKE KSRLNTIFKK
IGKLNSISKL GKGKMPCLIC MNHRTNESIS LPFQCKGRFS TRSPLELQMQ EGEHTIRNIV
EKTRLPVNVT VPSPPPRNPY DLHFIREGHR YKFVNIQTKT VVVCCVLRNN KILPMHFPLH
LTVPKFSLPE HLVKGESWPE TLVHHWLGIC QEQFDIDEYS RAVRDVKTDW NEECKSPKKG
RCSGHNHVPN SLSYARDELT QSFHRLSVCV YGNNLHGNSE VNLHGCRDLG GDWAPFPHDI
LPYQDSGDSG SDYLFPEASE ESAGIPGKSE LPYEELWLEE GKPSHQPLTR SLSEKNRCDQ
FRGSVRSKCA TSPLPIPGTL GAAVKSSDTA LPPPPVPPKS EAVREECRLL NAPPVPPRSA
KPLSTSPSIP PRTVKPARQQ TRSPSPTLSY YSSGLHNISV TKTDTNPSES TPVSCYPCNR
VKTDSVDLKS PFGSPSAEAV SSRLSWPNHY SGASESQTRS DFLLDPSRSY SYPRQKTPGT
PKRNCPAPFD FDGCELLASP TSPVTAEFSS SVSGCPKSAS YSLESTDVKS LAAGVTKQST
SCPALPPRAP KLVEEKVASE TSPLPLKIDG AEEDPKSGSP DLSEDQYFVK KGMQDIFSAS
YPFSSPLHLQ LAPRSCGDGS PWQPPADLSG LSIEEVSKSL RFIGLSEDVI SFFVTEKIDG
NLLVQLTEEI LSEDFKLSKL QVKKIMQFIN GWRPKI


Related products :

Catalog number Product name Quantity
E0946p Human ELISA Kit FOR GRB2-associated and regulator of MAPK protein-like 96T
5479 Grb2-associated and regulator of ERK_MAPK 0.1 mg
5479 Grb2-associated and regulator of ERK_MAPK 0.5 mg
18-783-78613 GOAT ANTI HUMAN Grb2 - Adapter protein GRB2; SH2_SH3 adapter GRB2; Protein Ash Polyclonal 0.1 mg
20-272-192013 GRB2 - Mouse monoclonal [R11] to GRB2; Adapter protein GRB2; SH2_SH3 adapter GRB2; Protein Ash Monoclonal 1 ml
20-272-192014 GRB2 - Mouse monoclonal [R13] to GRB2; Adapter protein GRB2; SH2_SH3 adapter GRB2; Protein Ash Monoclonal 1 ml
DL-Grb2-Hu Human Growth Factor Receptor Bound Protein 2 (Grb2) ELISA Kit 96T
18-003-42928 GRB2-associated-binding protein 1 - GRB2-associated binder 1 Polyclonal 0.1 mg Protein A
A0039 GRB2 Primary Antibody, GRB2, Species: Human Recombinant Protein Source: Rabbit Polyclonal 100ug
11-554-C025 Rabbit Polyclonal to Grb2 Antigen Grb2 Antigen Grb2 0.025 mg
11-554-C100 Rabbit Polyclonal to Grb2 Antigen Grb2 Antigen Grb2 0.1 mg
EIAAB47168 AFP regulator 1,Afr1,Alpha-fetoprotein regulator 1,Raf,Rat,Rattus norvegicus,Regulator of AFP,Zhx2,Zinc finger and homeodomain protein 2,Zinc fingers and homeoboxes protein 2
EIAAB47170 AFP regulator 1,Afr1,Alpha-fetoprotein regulator 1,Mouse,Mus musculus,Raf,Regulator of AFP,Zhx2,Zinc finger and homeodomain protein 2,Zinc fingers and homeoboxes protein 2
EIAAB47169 AFP regulator 1,AFR1,Alpha-fetoprotein regulator 1,Homo sapiens,Human,KIAA0854,RAF,Regulator of AFP,ZHX2,Zinc finger and homeodomain protein 2,Zinc fingers and homeoboxes protein 2
15-288-22538F Growth factor receptor-bound protein 2 - Adapter protein GRB2; SH2_SH3 adapter GRB2; Protein Ash Polyclonal 0.1 mg
15-288-22538F Growth factor receptor-bound protein 2 - Adapter protein GRB2; SH2_SH3 adapter GRB2; Protein Ash Polyclonal 0.05 mg
A0039 GRB2 Polyclonal Antibody, Reactivity: H M R, Gene ID: 2885, Synonyms: GRB2 100ug
A0039 GRB2 Polyclonal Antibody, Reactivity: H M R, Gene ID: 2885, Synonyms: GRB2 200ug
18-003-43259 Zinc fingers and homeoboxes protein 2 - Zinc finger and homeodomain protein 2; Alpha-fetoprotein regulator 1; AFP regulator 1; Regulator of AFP Polyclonal 0.1 mg Protein A
10-288-22538F Growth factor receptor-bound protein 2 - Adapter protein GRB2; SH2_SH3 adapter GRB2; Protein Ash 0.1 mg
10-288-22538F Growth factor receptor-bound protein 2 - Adapter protein GRB2; SH2_SH3 adapter GRB2; Protein Ash 0.05 mg
EIAAB34563 G(z)GAP,Gz-GAP,Gz-selective GTPase-activating protein,Homo sapiens,Human,Regulator of G-protein signaling 20,Regulator of G-protein signaling Z1,Regulator of Gz-selective protein signaling 1,RGS20,RGS
LF-PA42788 Anti-GRB2, Rabbit Polyclonal to GRB2, Isotype , Host Rabbit 50
LF-PA42722 Anti-GRB2, Goat Polyclonal to GRB2, Isotype , Host Goat 50
LF-PA42975 Anti-GRB2, Rabbit Polyclonal to GRB2, Isotype , Host Rabbit 50
Pathways :
WP2292: Chemokine signaling pathway
WP493: MAPK signaling pathway
WP382: MAPK signaling pathway
WP1337: MAPK signaling pathway
WP880: MAPK signaling pathway
WP358: MAPK signaling pathway
WP769: MAPK signaling pathway
WP998: MAPK signaling pathway
WP1114: MAPK signaling pathway
WP402: ERK1 - ERK2 MAPK cascade
WP849: IL-5 Signaling Pathway
WP2261: Signaling Pathways in Glioblastoma
WP10: IL-9 Signaling Pathway
WP1112: EPO Receptor Signaling
WP8: IL-9 Signaling Pathway
WP895: IL-7 Signaling Pathway
WP1363: p38 MAPK Signaling Pathway
WP285: B Cell Receptor Signaling Pathway
WP1993: angiogenesis overview
WP481: Insulin Signaling
WP1284: EPO Receptor Signaling
WP297: IL-7 Signaling Pathway
WP1069: Integrin-mediated cell adhesion
WP856: IL-9 Signaling Pathway
WP1330: estrogen signalling

Related Genes :
[GAREM1 C18orf11 FAM59A GAREM] GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1)
[GRB2 ASH] Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
[Garem1 Fam59a Garem Gm944 Kiaa4238] GRB2-associated and regulator of MAPK protein (GRB2-associated and regulator of MAPK1)
[Grb2] Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
[Grb2 Ash] Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
[Mapk1 Erk2 Mapk Prkm1] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[GRB2] Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
[GAB1] GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
[MED28 EG1 FKSG20] Mediator of RNA polymerase II transcription subunit 28 (Endothelial-derived protein 1) (Mediator complex subunit 28) (Merlin and Grb2-interacting cytoskeletal protein) (Magicin) (Tumor angiogenesis marker EG-1)
[Themis] Protein THEMIS (Grb2-associating protein) (Gasp) (Protein thylex) (Thymocyte-expressed molecule involved in selection)
[SGIP1] SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein)
[GRAP] GRB2-related adapter protein
[SH3GL2 CNSA2 SH3D2A] Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2)
[Sgip1] SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein)
[Sgip1] SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein)
[Sh3gl2 Sh3d2a Sh3p4] Endophilin-A1 (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2) (SH3p4)
[Mapk1 Erk2 Mapk Prkm1] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[MAPK1 ERK2 PRKM1 PRKM2] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[MAPK1 ERK2 PRKM1] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[Mapk3 Erk1 Prkm3] Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (MNK1) (Microtubule-associated protein 2 kinase) (p44-ERK1)
[SGIP1] SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein)
[FLT4 VEGFR3] Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4)
[FLT1 FLT FRT VEGFR1] Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor)
[Csf1r Csfmr Fms] Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115)
[Mertk Mer] Tyrosine-protein kinase Mer (EC 2.7.10.1) (Proto-oncogene c-Mer) (Receptor tyrosine kinase MerTK)
[Khdrbs1] KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68)
[PTPRJ DEP1] Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (Density-enhanced phosphatase 1) (DEP-1) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (CD antigen CD148)
[PTPN11 PTP2C SHPTP2] Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
[KDR FLK1 VEGFR2] Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)
[Flt1 Flt-1 Vegfr1] Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase receptor FLT)

Bibliography :
No related Items