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Gamma-conotoxin PnVIIA (PnMEKL-011)

 O27A_CONPE              Reviewed;          80 AA.
P56711; Q9BPA8;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
23-MAR-2010, sequence version 2.
10-OCT-2018, entry version 70.
RecName: Full=Gamma-conotoxin PnVIIA;
AltName: Full=PnMEKL-011;
Flags: Precursor;
Conus pennaceus (Feathered cone) (Conus episcopus).
Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Gastropoda;
Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Darioconus.
NCBI_TaxID=37335;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=11158371; DOI=10.1093/oxfordjournals.molbev.a003786;
Conticello S.G., Gilad Y., Avidan N., Ben-Asher E., Levy Z.,
Fainzilber M.;
"Mechanisms for evolving hypervariability: the case of conopeptides.";
Mol. Biol. Evol. 18:120-131(2001).
[2]
PROTEIN SEQUENCE OF 46-77, FUNCTION, HYDROXYLATION AT PRO-76,
GAMMA-CARBOXYGLUTAMATION AT GLU-59 AND GLU-71, MASS SPECTROMETRY, AND
TOXIN TARGET.
TISSUE=Venom;
PubMed=9484216; DOI=10.1021/bi971571f;
Fainzilber M., Nakamura T., Lodder J.C., Zlotkin E., Kits K.S.,
Burlingame A.L.;
"Gamma-conotoxin-PnVIIA, a gamma-carboxyglutamate-containing peptide
agonist of neuronal pacemaker cation currents.";
Biochemistry 37:1470-1477(1998).
-!- FUNCTION: Gamma-conotoxins may act on voltage-gated non-specific
cation pacemaker channels (HCN). Triggers depolarization and
firing of action potential bursts in the caudodorsal neurons of
lymnaea. This effect is due to activation or enhancement of a slow
inward cation current that may underlie endogenous bursting
activity of these neurons. {ECO:0000269|PubMed:9484216}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Expressed by the venom duct.
-!- DOMAIN: The presence of a 'disulfide through disulfide knot'
structurally defines this protein as a knottin. {ECO:0000250}.
-!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
-!- PTM: Contains 3 disulfide bonds.
-!- MASS SPECTROMETRY: Mass=3718.4; Method=Electrospray; Range=46-77;
Evidence={ECO:0000269|PubMed:9484216};
-!- SIMILARITY: Belongs to the conotoxin O2 superfamily.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AF215029; AAG60457.1; -; mRNA.
SMR; P56711; -.
ConoServer; 1636; PnVIIA.
ConoServer; 716; PnVIIA precursor.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
InterPro; IPR004214; Conotoxin.
Pfam; PF02950; Conotoxin; 1.
1: Evidence at protein level;
Cleavage on pair of basic residues; Direct protein sequencing;
Disulfide bond; Gamma-carboxyglutamic acid; Hydroxylation;
Ion channel impairing toxin; Knottin; Neurotoxin; Secreted; Signal;
Toxin.
SIGNAL 1 19 {ECO:0000255}.
PROPEP 20 43
/FTId=PRO_0000392707.
PEPTIDE 46 77 Gamma-conotoxin PnVIIA.
/FTId=PRO_0000044877.
PROPEP 78 80
/FTId=PRO_0000392708.
MOD_RES 59 59 4-carboxyglutamate.
{ECO:0000269|PubMed:9484216}.
MOD_RES 71 71 4-carboxyglutamate.
{ECO:0000269|PubMed:9484216}.
MOD_RES 76 76 4-hydroxyproline.
{ECO:0000269|PubMed:9484216}.
DISULFID 47 61 {ECO:0000250}.
DISULFID 54 65 {ECO:0000250}.
DISULFID 60 70 {ECO:0000250}.
SEQUENCE 80 AA; 9189 MW; 758ACDD9692E18D7 CRC64;
MEKLTILLLV AAVLMSTQAQ NQEQRQQAKI NFLSKRKPSA ERWRRDCTSW FGRCTVNSEC
CSNSCDQTYC ELYAFPSFGA


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Kits Elisa; taq POLYMERASE

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Pathways :
WP1224: EBV LMP1 signaling
WP1225: estrogen signalling
WP152: FGF signaling pathway
WP1654: gamma-Hexachlorocyclohexane degradation
WP1722: Th1/Th2
WP1836: Interferon gamma signaling
WP1886: Post-translational modification: gamma carboxylation and hypusine formation
WP1993: angiogenesis overview
WP2006: Squamous cell TarBase
WP2152: BDNF
WP2199: Seed Development
WP2292: Chemokine signaling pathway
WP262: EBV LMP1 signaling
WP32: Translation Factors
WP537: Translation Factors
WP542: Electron Transport Chain
WP758: EBV LMP1 signaling
WP760: estrogen signalling
WP866: EBV LMP1 signaling
WP868: estrogen signalling

Related Genes :
[] Gamma-conotoxin PnVIIA (PnMEKL-011)
[] Epsilon-conotoxin TxVA (Conotoxin TxMRCL-011) (Epsilon-conotoxin TxIX)
[] Alpha-conotoxin GID
[] Mu-conotoxin GVIIJ (Conotoxin muO-GVIIJ) (MuO'section sign'-GVIIJ)
[] Alpha-conotoxin BuIA (Conotoxin Bu1.3)
[] Epsilon-conotoxin TxVA (Epsilon-TxIX) (Tx-012) (Tx5.2) (tx5a)
[] Alpha-conotoxin TxID (Alpha-conotoxin TxIC) (Fragment)
[] Alpha-conotoxin PeIA (Fragment)
[tbg tub4 G17A4.160 NCU03954] Tubulin gamma chain (Gamma-tubulin)
[] Kappa-conotoxin PVIIA (CGX-1051) (Fin-popping peptide)
[] Alpha-conotoxin TxIA (Conotoxin tx1a)
[puuC aldH b1300 JW1293] NADP/NAD-dependent aldehyde dehydrogenase PuuC (ALDH) (EC 1.2.1.5) (3-hydroxypropionaldehyde dehydrogenase) (Gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase) (Gamma-Glu-gamma-aminobutyraldehyde dehydrogenase)
[] Rho-conotoxin TIA (Rho-TIA)
[] Mu-conotoxin cal12a (Conotoxin Cal 12.1.1a) (Conotoxin CalTx 12.1.1A)
[] Mu-conotoxin GIIIA (G3.9) (Geographutoxin I) (GTx-I) (Myotoxin I)
[met-6 B13C5.220 NCU00892] Folylpolyglutamate synthase (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase) (FPGS) (Tetrahydrofolylpolyglutamate synthase) (Tetrahydrofolate synthase)
[gshAB gshF SAG1821] Glutathione biosynthesis bifunctional protein GshAB (Gamma-GCS-GS) (GCS-GS) [Includes: Glutamate--cysteine ligase (EC 6.3.2.2) (Gamma-ECS) (GCS) (Gamma-glutamylcysteine synthetase); Glutathione synthetase (EC 6.3.2.3) (GSH synthetase) (GS) (GSH-S) (GSHase) (Glutathione synthase)]
[nef] Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]
[fbiB STIB_41980] Coenzyme F420:L-glutamate ligase (EC 6.3.2.31) (EC 6.3.2.34) (Coenzyme F420-0:L-glutamate ligase) (Coenzyme F420-1:gamma-L-glutamate ligase)
[] Alpha-conotoxin RVIIIA (AlphaS-conotoxin RVIIIA)
[arg-6 orn-2 NCU00567] Protein arg-6, mitochondrial [Cleaved into: N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) (N-acetyl-glutamate semialdehyde dehydrogenase) (NAGSA dehydrogenase); Acetylglutamate kinase (EC 2.7.2.8) (N-acetyl-L-glutamate 5-phosphotransferase) (NAG kinase) (AGK)]
[ALDH18A1 GSAS P5CS PYCS] Delta-1-pyrroline-5-carboxylate synthase (P5CS) (Aldehyde dehydrogenase family 18 member A1) [Includes: Glutamate 5-kinase (GK) (EC 2.7.2.11) (Gamma-glutamyl kinase); Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase)]
[Cgamma] Gamma conglutin 1 (Conglutin gamma 32) (allergen Lup a gamma-conglutin) [Cleaved into: Gamma conglutin 1 beta subunit (Gamma conglutin 1 17 kDa subunit) (Gamma conglutin 1 small subunit); Gamma conglutin 1 alpha subunit (Gamma conglutin 1 29 kDa subunit) (Gamma conglutin 1 large subunit)]
[APP A4 AD1] Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]
[Lamc1 Lamb-2 Lamc-1] Laminin subunit gamma-1 (Laminin B2 chain) (Laminin-1 subunit gamma) (Laminin-10 subunit gamma) (Laminin-11 subunit gamma) (Laminin-2 subunit gamma) (Laminin-3 subunit gamma) (Laminin-4 subunit gamma) (Laminin-6 subunit gamma) (Laminin-7 subunit gamma) (Laminin-8 subunit gamma) (Laminin-9 subunit gamma) (S-laminin subunit gamma) (S-LAM gamma)
[App] Amyloid-beta A4 protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) (Amyloid precursor protein) (Amyloid-beta precursor protein) (Amyloidogenic glycoprotein) (AG) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (APP-C99) (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (APP-C59) (Amyloid intracellular domain 59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (APP-C57) (Amyloid intracellular domain 57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AID(50)) (Gamma-CTF(50)); C31]
[APP] Amyloid-beta A4 protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) (Amyloid precursor protein) (Amyloid-beta precursor protein) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Gamma-CTF(50)); C31]
[APP QccE-15949] Amyloid-beta A4 protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) (Amyloid precursor protein) (Amyloid-beta precursor protein) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Gamma-CTF(50)); C31]
[APP] Amyloid-beta A4 protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) (Amyloid precursor protein) (Amyloid-beta precursor protein) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Gamma-CTF(50)); C31]
[APP] Amyloid-beta A4 protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) (Amyloid precursor protein) (Amyloid-beta precursor protein) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Gamma-CTF(50)); C31]

Bibliography :
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