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Gastrin [Cleaved into: Big gastrin (Gastrin-34) (G34); Gastrin]

 GAST_RAT                Reviewed;         104 AA.
P04563;
13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
01-NOV-1990, sequence version 2.
16-JAN-2019, entry version 139.
RecName: Full=Gastrin;
Contains:
RecName: Full=Big gastrin;
AltName: Full=Gastrin-34;
Short=G34;
Contains:
RecName: Full=Gastrin;
Flags: Precursor;
Name=Gast; Synonyms=Gas;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Gastric antrum;
PubMed=3453895; DOI=10.1210/mend-1-4-306;
Fuller P.J., Stone D.L., Brand S.J.;
"Molecular cloning and sequencing of a rat preprogastrin complementary
deoxyribonucleic acid.";
Mol. Endocrinol. 1:306-311(1987).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 56-92.
PubMed=6897117; DOI=10.1016/0196-9781(82)90172-3;
Schaffer M.H., Agarwal K.L., Noyes B.E.;
"Rat gastrin's amino acid sequence determined from the nucleotide
sequence of the mRNA.";
Peptides 3:693-696(1982).
[3]
PROTEOLYTIC PROCESSING, PHOSPHORYLATION AT SER-96, SULFATION AT TYR-87
AND TYR-103, AND AMIDATION AT PHE-92.
PubMed=1701434;
Varro A., Nemeth J., Bridson J., Lee C., Moore S., Dockray G.J.;
"Processing of the gastrin precursor. Modulation of phosphorylated,
sulfated, and amidated products.";
J. Biol. Chem. 265:21476-21481(1990).
-!- FUNCTION: Gastrin stimulates the stomach mucosa to produce and
secrete hydrochloric acid and the pancreas to secrete its
digestive enzymes. It also stimulates smooth muscle contraction
and increases blood circulation and water secretion in the stomach
and intestine.
-!- SUBCELLULAR LOCATION: Secreted.
-!- PTM: Sulfation on Tyr-87 enhances proteolytic processing, and
blocks peptide degradation. Levels of sulfation differ between
proteolytically-cleaved gastrins and between tissues (By
similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
{ECO:0000305}.
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EMBL; M38653; AAA41919.1; -; mRNA.
EMBL; M25459; AAA41195.1; -; mRNA.
PIR; A40910; A40910.
RefSeq; NP_036981.1; NM_012849.1.
RefSeq; XP_017452526.1; XM_017597037.1.
UniGene; Rn.9754; -.
STRING; 10116.ENSRNOP00000019863; -.
iPTMnet; P04563; -.
PhosphoSitePlus; P04563; -.
PaxDb; P04563; -.
PRIDE; P04563; -.
Ensembl; ENSRNOT00000019863; ENSRNOP00000019863; ENSRNOG00000014740.
GeneID; 25320; -.
KEGG; rno:25320; -.
UCSC; RGD:2662; rat.
CTD; 2520; -.
RGD; 2662; Gast.
eggNOG; ENOG410J1ZA; Eukaryota.
eggNOG; ENOG4111D7Y; LUCA.
GeneTree; ENSGT00390000014792; -.
HOGENOM; HOG000073533; -.
HOVERGEN; HBG097593; -.
InParanoid; P04563; -.
KO; K13768; -.
OMA; KKQGPWM; -.
OrthoDB; 1589970at2759; -.
PhylomeDB; P04563; -.
TreeFam; TF336994; -.
Reactome; R-RNO-416476; G alpha (q) signalling events.
Reactome; R-RNO-881907; Gastrin-CREB signalling pathway via PKC and MAPK.
PRO; PR:P04563; -.
Proteomes; UP000002494; Chromosome 10.
Bgee; ENSRNOG00000014740; Expressed in 4 organ(s), highest expression level in colon.
Genevisible; P04563; RN.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0005179; F:hormone activity; IDA:RGD.
GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:RGD.
GO; GO:0032094; P:response to food; IBA:GO_Central.
GO; GO:0007165; P:signal transduction; IDA:RGD.
InterPro; IPR039236; GAST.
InterPro; IPR001651; Gastrin/CCK.
InterPro; IPR013152; Gastrin/cholecystokinin_CS.
PANTHER; PTHR19309; PTHR19309; 1.
Pfam; PF00918; Gastrin; 1.
PROSITE; PS00259; GASTRIN; 1.
1: Evidence at protein level;
Amidation; Cleavage on pair of basic residues; Complete proteome;
Hormone; Phosphoprotein; Reference proteome; Secreted; Signal;
Sulfation.
SIGNAL 1 21 {ECO:0000305}.
PROPEP 22 58
/FTId=PRO_0000010648.
PEPTIDE 59 92 Big gastrin.
/FTId=PRO_0000010649.
PEPTIDE 76 92 Gastrin.
/FTId=PRO_0000010650.
PROPEP 96 104
/FTId=PRO_0000010651.
MOD_RES 87 87 Sulfotyrosine.
{ECO:0000269|PubMed:1701434}.
MOD_RES 92 92 Phenylalanine amide.
{ECO:0000269|PubMed:1701434}.
MOD_RES 96 96 Phosphoserine.
{ECO:0000269|PubMed:1701434}.
MOD_RES 103 103 Sulfotyrosine.
{ECO:0000269|PubMed:1701434}.
SEQUENCE 104 AA; 11832 MW; 973FD06276BF1E21 CRC64;
MPRLCVCMLV LVLALATFSE ASWKPRSQLQ DASSGPRTNG ALEQHQLEKL GPASHHRRQL
GPQGPQHFIA DLSKKQRPPM EEEEEAYGWM DFGRRSAEEE DQYN


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Related Genes :
[CCKBR CCKRB] Gastrin/cholecystokinin type B receptor (CCK-B receptor) (CCK-BR) (Cholecystokinin-2 receptor) (CCK2-R)
[Grpr] Gastrin-releasing peptide receptor (GRP-R) (GRP-preferring bombesin receptor)
[GRPR] Gastrin-releasing peptide receptor (GRP-R) (GRP-preferring bombesin receptor)
[Grpr] Gastrin-releasing peptide receptor (GRP-R) (GRP-preferring bombesin receptor)
[nnrE nnrD CND01_00250] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[HADHA HADH] Trifunctional enzyme subunit alpha, mitochondrial (78 kDa gastrin-binding protein) (TP-alpha) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)]
[pyrG CND01_01800] CTP synthase (EC 6.3.4.2) (Cytidine 5'-triphosphate synthase) (Cytidine triphosphate synthetase) (CTP synthetase) (CTPS) (UTP--ammonia ligase)
[HADHA LCHYD-HAD] Trifunctional enzyme subunit alpha, mitochondrial (78 kDa gastrin-binding protein) (TP-alpha) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)]
[GAST] Gastrin/cholecystokinin-like peptide (Antral peptide)
[fumC CND01_02090] Fumarate hydratase class II (Fumarase C) (EC 4.2.1.2) (Aerobic fumarase) (Iron-independent fumarase)
[sucC CND01_02600] Succinate--CoA ligase [ADP-forming] subunit beta (EC 6.2.1.5) (Succinyl-CoA synthetase subunit beta) (SCS-beta)
[pepA CND01_01775] Probable cytosol aminopeptidase (EC 3.4.11.1) (Leucine aminopeptidase) (LAP) (EC 3.4.11.10) (Leucyl aminopeptidase)
[carA CND01_03275] Carbamoyl-phosphate synthase small chain (EC 6.3.5.5) (Carbamoyl-phosphate synthetase glutamine chain)
[psmB CND01_03115] Proteasome subunit beta (EC 3.4.25.1) (20S proteasome beta subunit) (Proteasome core protein PsmB)
[sucD CND01_02605] Succinate--CoA ligase [ADP-forming] subunit alpha (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)
[pyrE CND01_02070] Orotate phosphoribosyltransferase (OPRT) (OPRTase) (EC 2.4.2.10)
[Mapk7 Bmk1 Erk5] Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5)
[psmA CND01_00810] Proteasome subunit alpha (EC 3.4.25.1) (20S proteasome alpha subunit) (Proteasome core protein PsmA)
[nth CND01_04190] Endonuclease III (EC 4.2.99.18) (DNA-(apurinic or apyrimidinic site) lyase)
[MEP1B] Meprin A subunit beta (EC 3.4.24.63) (Endopeptidase-2) (Meprin B) (N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta) (PABA peptide hydrolase) (PPH beta)
[nnrE nnrD B5G34_08785] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[nnrE nnrD A3G34_09745] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[PRKD2 PKD2 HSPC187] Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2)
[MAPK7 BMK1 ERK5 PRKM7] Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5)
[ribBA B5G34_08185] Riboflavin biosynthesis protein RibBA [Includes: 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase) (EC 4.1.99.12); GTP cyclohydrolase-2 (EC 3.5.4.25) (GTP cyclohydrolase II)]
[ribBA A3G34_00170] Riboflavin biosynthesis protein RibBA [Includes: 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase) (EC 4.1.99.12); GTP cyclohydrolase-2 (EC 3.5.4.25) (GTP cyclohydrolase II)]
[lon HP9810_11g34] Lon protease (EC 3.4.21.53) (ATP-dependent protease La)
[ZNF148 ZBP89] Zinc finger protein 148 (Transcription factor ZBP-89) (Zinc finger DNA-binding protein 89)
[cytB CYTB] Cytochrome b (Fragment)
[Reg1 Reg] Lithostathine (Islet cells regeneration factor) (ICRF) (Islet of Langerhans regenerating protein) (REG) (Pancreatic stone protein) (PSP) (Pancreatic thread protein) (PTP)

Bibliography :
[17188424] Role of Annexin-II in GI cancers: interaction with gastrins/progastrins.
[11515585] Facile solid-phase synthesis of sulfated tyrosine-containing peptides: Part II. Total synthesis of human big gastrin-II and its C-terminal glycine-extended peptide (G34-Gly sulfate) by the solid-phase segment condensation approach.
[11251044] Measurement of secretory vesicle pH reveals intravesicular alkalinization by vesicular monoamine transporter type 2 resulting in inhibition of prohormone cleavage.
[10771309] Diminished prohormone convertase 3 expression (PC1/PC3) inhibits progastrin post-translational processing.
[9263920] Regulation by gastric acid of the processing of progastrin-derived peptides in rat antral mucosa.
[9192308] Amine precursor uptake and decarboxylation: significance for processing of the rat gastrin precursor.
[9041234] Gastrin biosynthesis in the antrum of patients with pernicious anemia.
[8853848] Stability of gastrin in the gastrointestinal lumen of suckling, weanling and adult pigs.
[7706472] Pathways of processing of the gastrin precursor in rat antral mucosa.
[8314507] Helicobacter pylori related hypergastrinaemia is the result of a selective increase in gastrin 17.
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