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Geranial dehydrogenase (GaDH) (EC 1.2.1.86) (Geraniol oxidation pathway protein B)

 GEOB_CASDE              Reviewed;         478 AA.
H1ZV37;
05-SEP-2012, integrated into UniProtKB/Swiss-Prot.
21-MAR-2012, sequence version 1.
25-MAY-2022, entry version 24.
RecName: Full=Geranial dehydrogenase;
Short=GaDH;
EC=1.2.1.86;
AltName: Full=Geraniol oxidation pathway protein B;
Name=geoB;
Castellaniella defragrans (Alcaligenes defragrans).
Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
Alcaligenaceae; Castellaniella.
NCBI_TaxID=75697;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-18, FUNCTION,
CATALYTIC ACTIVITY, SUBSTRATE SPECIFICITY, INDUCTION, GENE NAME, AND
PATHWAY.
STRAIN=DSM 12143 / 65Phen;
PubMed=22286981; DOI=10.1128/aem.07226-11;
Luddeke F., Wulfing A., Timke M., Germer F., Weber J., Dikfidan A.,
Rahnfeld T., Linder D., Meyerdierks A., Harder J.;
"Geraniol and geranial dehydrogenases induced in anaerobic monoterpene
degradation by Castellaniella defragrans.";
Appl. Environ. Microbiol. 78:2128-2136(2012).
-!- FUNCTION: Catalyzes the NAD(+)-dependent oxidation of geranial to
geranic acid. Is involved in the anaerobic degradation of the
monoterpene beta-myrcene. Seems to be specific for the trans-isomer
geranial, since it does not act on the cis-isomer neral.
{ECO:0000269|PubMed:22286981}.
-!- CATALYTIC ACTIVITY:
Reaction=(2E)-geranial + H2O + NAD(+) = geranate + 2 H(+) + NADH;
Xref=Rhea:RHEA:34351, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
ChEBI:CHEBI:16980, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
ChEBI:CHEBI:67260; EC=1.2.1.86;
Evidence={ECO:0000269|PubMed:22286981};
-!- PATHWAY: Terpene metabolism; monoterpene degradation.
{ECO:0000269|PubMed:22286981}.
-!- INDUCTION: By the monoterpene phellandrene, but not by acetate.
{ECO:0000269|PubMed:22286981}.
-!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
{ECO:0000305}.
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EMBL; FR669447; CCF55023.1; -; Genomic_DNA.
AlphaFoldDB; H1ZV37; -.
SMR; H1ZV37; -.
UniPathway; UPA00137; -.
GO; GO:0034832; F:geranial dehydrogenase activity; IDA:UniProtKB.
GO; GO:0051287; F:NAD binding; IDA:UniProtKB.
GO; GO:0071310; P:cellular response to organic substance; IDA:UniProtKB.
GO; GO:0043694; P:monoterpene catabolic process; TAS:UniProtKB.
GO; GO:0016098; P:monoterpenoid metabolic process; IDA:UniProtKB.
Gene3D; 3.40.309.10; -; 1.
Gene3D; 3.40.605.10; -; 1.
InterPro; IPR016161; Ald_DH/histidinol_DH.
InterPro; IPR016163; Ald_DH_C.
InterPro; IPR029510; Ald_DH_CS_GLU.
InterPro; IPR016162; Ald_DH_N.
InterPro; IPR015590; Aldehyde_DH_dom.
Pfam; PF00171; Aldedh; 1.
SUPFAM; SSF53720; SSF53720; 1.
PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
1: Evidence at protein level;
Direct protein sequencing; NAD; Oxidoreductase.
INIT_MET 1
/note="Removed"
/evidence="ECO:0000269|PubMed:22286981"
CHAIN 2..478
/note="Geranial dehydrogenase"
/id="PRO_0000418649"
NP_BIND 230..235
/note="NAD"
/evidence="ECO:0000250"
ACT_SITE 252
/note="Proton acceptor"
/evidence="ECO:0000255|PROSITE-ProRule:PRU10007"
ACT_SITE 286
/note="Nucleophile"
/evidence="ECO:0000255|PROSITE-ProRule:PRU10007"
SITE 155
/note="Transition state stabilizer"
/evidence="ECO:0000250"
SEQUENCE 478 AA; 50637 MW; 3890AAA65A4C87C8 CRC64;
MTIDHQHIFV GGQWIAPKST QRSNILNAST EELVGSVPKC NNEDMDRAVA AAREAMRSLA
WAGLDGKGRA QHLRRFADAV ERRGQQLARS VSLQNGMPIN VADQLESAFV VSLLRYYASL
AENLVEEEAR PSPTGSTTLV RRDPVGVVGA IIPWNFPVAL SIFKIAPALA AGCAVVVKPS
SGTVLDSYVL AEAAAEAGLP PGVINWVPGD RGIGSHLVSH PGVDKVAFTG STSAGRIIAE
ACARLLRPVT LELGGKSAAI VLEDADLDAL IRSLPMSSVL NNGQACFSCT RILAPAGRYD
EVVDAIAGAV SAYSVGDALD RATVVGPMAS AAHRDSVQRY IELGTGEARL VVGGGRTSQD
RGWFVQPTVF ADVDNRSRIA REEIFGPVLS IIRYEGEDEA VEIANDSEYG LGGTVWSTDH
DHAVTIARRM ETGTVGINGY MPDLNAPFGG VKSSGMGREL GPESIGAYQR YKSVYLLG


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