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Glutathione hydrolase proenzyme 1 (EC 3.4.19.13) (Gamma-glutamyltransferase 1) (Gamma-glutamyltranspeptidase 1) (EC 2.3.2.2) [Cleaved into: Glutathione hydrolase 1 heavy chain; Glutathione hydrolase 1 light chain]

 GGT1_SCHPO              Reviewed;         630 AA.
Q9US04;
25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
26-FEB-2020, entry version 122.
RecName: Full=Glutathione hydrolase proenzyme 1;
EC=3.4.19.13;
AltName: Full=Gamma-glutamyltransferase 1;
AltName: Full=Gamma-glutamyltranspeptidase 1;
EC=2.3.2.2;
Contains:
RecName: Full=Glutathione hydrolase 1 heavy chain;
Contains:
RecName: Full=Glutathione hydrolase 1 light chain;
Flags: Precursor;
Name=ggt1; ORFNames=SPAC664.09;
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
Schizosaccharomyces.
NCBI_TaxID=284812;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
PubMed=15052323; DOI=10.1139/w03-106;
Park H.-J., Lim H.-W., Kim K., Kim I.-H., Park E.-H., Lim C.-J.;
"Characterization and regulation of the gamma-glutamyl transpeptidase gene
from the fission yeast Schizosaccharomyces pombe.";
Can. J. Microbiol. 50:61-66(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=972 / ATCC 24843;
PubMed=11859360; DOI=10.1038/nature724;
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
[3]
INDUCTION.
PubMed=15765057; DOI=10.1007/s12275-016-5562-5;
Kim H.-G., Park H.-J., Kang H.-J., Lim H.-W., Kim K., Park E.-H., Ahn K.,
Lim C.-J.;
"The Schizosaccharomyces pombe gene encoding gamma-glutamyl transpeptidase
I is regulated by non-fermentable carbon sources and nitrogen starvation.";
J. Microbiol. 43:44-48(2005).
[4]
SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
PubMed=16823372; DOI=10.1038/nbt1222;
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
Yoshida M.;
"ORFeome cloning and global analysis of protein localization in the fission
yeast Schizosaccharomyces pombe.";
Nat. Biotechnol. 24:841-847(2006).
-!- FUNCTION: Catalyzes the transfer of the gamma-glutamyl moiety of
glutathione (GSH) and other gamma-glutamyl compounds to amino acids and
peptides. Major GSH-degrading enzyme, catalyzing the hydrolytic release
of L-glutamate from GSH. {ECO:0000269|PubMed:15052323}.
-!- CATALYTIC ACTIVITY:
Reaction=an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] =
5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide];
Xref=Rhea:RHEA:23904, Rhea:RHEA-COMP:9780, Rhea:RHEA-COMP:9795,
ChEBI:CHEBI:77644, ChEBI:CHEBI:78597, ChEBI:CHEBI:78599,
ChEBI:CHEBI:78608; EC=2.3.2.2;
-!- CATALYTIC ACTIVITY:
Reaction=glutathione + H2O = L-cysteinylglycine + L-glutamate;
Xref=Rhea:RHEA:28807, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985,
ChEBI:CHEBI:57925, ChEBI:CHEBI:61694; EC=3.4.19.13;
-!- CATALYTIC ACTIVITY:
Reaction=an S-substituted glutathione + H2O = an S-substitued L-
cysteinylglycine + L-glutamate; Xref=Rhea:RHEA:59468,
ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:90779,
ChEBI:CHEBI:143103; EC=3.4.19.13;
-!- PATHWAY: Sulfur metabolism; glutathione metabolism.
-!- SUBUNIT: Heterodimer composed of the light and heavy chains. The active
site is located in the light chain (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
Single-pass type II membrane protein {ECO:0000305}.
-!- INDUCTION: Induced upon nitrogen starvation. Also induced by non-
fermentable carbon sources such as glycerol, acetate and ethanol in a
pap1-independent manner. {ECO:0000269|PubMed:15765057}.
-!- PTM: Cleaved by autocatalysis into a large and a small subunit.
{ECO:0000250}.
-!- SIMILARITY: Belongs to the gamma-glutamyltransferase family.
{ECO:0000305}.
---------------------------------------------------------------------------
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EMBL; AF535133; AAN01227.1; -; Genomic_DNA.
EMBL; CU329670; CAB65810.1; -; Genomic_DNA.
PIR; T50239; T50239.
RefSeq; NP_593457.1; NM_001018890.2.
SMR; Q9US04; -.
STRING; 4896.SPAC664.09.1; -.
MEROPS; T03.011; -.
iPTMnet; Q9US04; -.
MaxQB; Q9US04; -.
PaxDb; Q9US04; -.
PRIDE; Q9US04; -.
EnsemblFungi; SPAC664.09.1; SPAC664.09.1:pep; SPAC664.09.
GeneID; 2543536; -.
KEGG; spo:SPAC664.09; -.
EuPathDB; FungiDB:SPAC664.09; -.
PomBase; SPAC664.09; ggt1.
HOGENOM; CLU_014813_4_1_1; -.
InParanoid; Q9US04; -.
KO; K18592; -.
OMA; KATKNMF; -.
PhylomeDB; Q9US04; -.
Reactome; R-SPO-174403; Glutathione synthesis and recycling.
Reactome; R-SPO-2142691; Synthesis of Leukotrienes (LT) and Eoxins (EX).
Reactome; R-SPO-5423646; Aflatoxin activation and detoxification.
UniPathway; UPA00204; -.
PRO; PR:Q9US04; -.
Proteomes; UP000002485; Chromosome I.
GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0000324; C:fungal-type vacuole; IBA:GO_Central.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0036374; F:glutathione hydrolase activity; EXP:PomBase.
GO; GO:0102953; F:hypoglycin A gamma-glutamyl transpeptidase activity; IEA:UniProtKB-EC.
GO; GO:0103068; F:leukotriene C4 gamma-glutamyl transferase activity; IEA:UniProtKB-EC.
GO; GO:0000048; F:peptidyltransferase activity; IBA:GO_Central.
GO; GO:1990748; P:cellular detoxification; NAS:PomBase.
GO; GO:0006751; P:glutathione catabolic process; IBA:GO_Central.
InterPro; IPR000101; GGT_peptidase.
InterPro; IPR029055; Ntn_hydrolases_N.
PANTHER; PTHR11686; PTHR11686; 1.
SUPFAM; SSF56235; SSF56235; 1.
TIGRFAMs; TIGR00066; g_glut_trans; 1.
2: Evidence at transcript level;
Acyltransferase; Endoplasmic reticulum; Glycoprotein; Hydrolase; Membrane;
Protease; Reference proteome; Signal-anchor; Transferase; Transmembrane;
Transmembrane helix.
CHAIN 1..440
/note="Glutathione hydrolase 1 heavy chain"
/evidence="ECO:0000250"
/id="PRO_0000247898"
CHAIN 441..630
/note="Glutathione hydrolase 1 light chain"
/evidence="ECO:0000250"
/id="PRO_0000247899"
TOPO_DOM 1..49
/note="Cytoplasmic"
/evidence="ECO:0000255"
TRANSMEM 50..70
/note="Helical; Signal-anchor for type II membrane protein"
/evidence="ECO:0000255"
TOPO_DOM 71..630
/note="Lumenal"
/evidence="ECO:0000255"
REGION 511..512
/note="Glutamate binding"
/evidence="ECO:0000250"
REGION 532..533
/note="Glutamate binding"
/evidence="ECO:0000250"
ACT_SITE 441
/note="Nucleophile"
/evidence="ECO:0000250"
BINDING 165
/note="Glutamate"
/evidence="ECO:0000250"
BINDING 459
/note="Glutamate"
/evidence="ECO:0000250"
BINDING 461
/note="Glutamate"
/evidence="ECO:0000250"
BINDING 483
/note="Glutamate"
/evidence="ECO:0000250"
CARBOHYD 156
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 180
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 315
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 397
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 417
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 612
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
SEQUENCE 630 AA; 68722 MW; E85E83D21AC24B20 CRC64;
MGINTSSAQS SGAASIARSS VNVKSGNRHL SSNKKSATSA LEERASRPSI LVTFLVLAGT
ILSLYIWPIL SPDLFFANQR CSFKYKNKGS QRVVVEGKNG VVATEEETCS QIGVGILKAG
GNAVDAAIAS GICIGAVNSF SSGIGGGGFM LIRHPNGTAH SLNFRETAPA GASKNMFHGN
STLSQVGGLS VAVPGEIAGY ERAWKMYGSL PWHKLFEPTI RLMRDGMPMP KELASRIRRP
EFSYFKTHPD WSKIFAPEGV FLHVGEKFYR PALASTLEEI AKFGPEVFYT GKIAERLVKF
VQQQGGILTM EDMANFSVVV EEPIYGNFYD REVITCGSPC SGEALILGLN VLSKVDLSEG
TSILGCEMTD IGVHHLIETM KWMSAGRTVL ADPTFYNNTD HVEQLLSLEY ADEIRNNISN
ERTFDFTHYK AEYDFPNDHG TTHLSVIDKD NMAVGLTASI NLMFGSQLLE PETGIILNDH
MDDFASPGIV NAFGLSPSPY NFIAPGKRPQ SSAVPTILVY NGEVEMVLGG SGGSRIVTAV
LDTIIKKYKW GKSLLESVES PRFHHQLMPN IVYIDETVEI EVLRALEKFG HIVDLIPVQY
PFSEIQAVFR TNGTLYGLSD SRKQAVAAAY


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Pathways :
WP1654: gamma-Hexachlorocyclohexane degradation
WP542: Electron Transport Chain
WP889: metapathway biotransformation
WP100: Glutathione metabolism
WP196: Glutathione Biosynthesis
WP1006: metapathway biotransformation
WP164: Glutathione metabolism
WP678: Arachidonate Epoxygenase / Epoxide Hydrolase
WP1116: Arachidonate Epoxygenase Epoxide Hydrolase
WP2248: anthocyanin biosynthesis
WP1212: metapathway biotransformation
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP1656: Glutathione metabolism
WP1250: Arachidonate Epoxygenase Epoxide Hydrolase
WP2349: vitamin B3 (niacin), NAD and NADP biosynthesis pathway
WP1286: metapathway biotransformation
WP469: Glutathione metabolism
WP1124: metapathway biotransformation
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP730: Glutathione and one carbon metabolism
WP1285: Arachidonate Epoxygenase Epoxide Hydrolase
WP882: Arachidonate Epoxygenase Epoxide Hydrolase
WP1000: Arachidonate Epoxygenase Epoxide Hydrolase
WP392: Glutathione-Glutaredoxin Redox Reaction
WP1039: Glutathione metabolism

Related Genes :
[Ggt1 Ggt] Glutathione hydrolase 1 proenzyme (EC 3.4.19.13) (Gamma-glutamyltransferase 1) (Gamma-glutamyltranspeptidase 1) (GGT 1) (EC 2.3.2.2) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) (CD antigen CD224) [Cleaved into: Glutathione hydrolase 1 heavy chain; Glutathione hydrolase 1 light chain]
[ECM38 CIS2 YLR299W] Glutathione hydrolase proenzyme (EC 3.4.19.13) (CIK1 suppressor protein 2) (Extracellular mutant protein 38) (Gamma-glutamyltransferase) (EC 2.3.2.2) (Gamma-glutamyltranspeptidase) (Gamma-GT) [Cleaved into: Glutathione hydrolase heavy chain; Glutathione hydrolase light chain]
[ggt b3447 JW3412] Glutathione hydrolase proenzyme (EC 3.4.19.13) (Gamma-glutamyltranspeptidase proenzyme) (GGT) (EC 2.3.2.2) [Cleaved into: Glutathione hydrolase large chain; Glutathione hydrolase small chain]
[] Botulinum neurotoxin type C (BoNT/C) (Bontoxilysin-C1) (BoNT/C1) (Botulinum neurotoxin type C1) [Cleaved into: Botulinum neurotoxin C light chain (LC) (EC 3.4.24.69); Botulinum neurotoxin C heavy chain (HC)]
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM (Precursor membrane protein); Peptide pr (Peptide precursor); Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[ustH AFLA_095030] Glutathione hydrolase (EC 3.4.19.13) (Gamma-glutamyltransferase ustH) (EC 2.3.2.2) (Ustiloxin B biosynthesis protein H)
[hchA A8C65_13880 A9R57_25255 AKG99_20940 AMK83_16550 B7C53_22525 B9M99_11580 B9T59_01945 BJJ90_15205 BMT49_12710 BON65_01250 BON66_15955 BON86_06490 BON95_14610 BUE81_10670 BvCms12BK_01457 BvCms28BK_04168 BvCmsHHP001_02632 BvCmsKKP061_00566 BvCmsKSP045_04450 BvCmsKSP058_03204 BvCmsKSP067_02879 BvCmsNSP006_03750 BvCmsNSP007_03329 BvCmsNSP047_03567 BvCmsSINP011_04162 BW690_17225 BZL69_29425 C2U48_24800 C5715_19445 C5N07_21380 C6669_19295 C7B06_02290 C7B07_03930 C9Z23_21970 C9Z37_00915 C9Z43_06360 C9Z78_05610 CDC27_10055 CDL37_00765 CI694_25210 COD46_23180 CQP61_17160 CRD98_26150 D2188_01360 D9D20_21030 D9D43_06110 D9H68_20750 D9H70_25730 D9I87_15275 DEN89_24995 DEO04_05510 DL800_09215 DQE83_22775 DTL43_21780 DU321_04440 DXT73_20690 E2134_24005 E2135_17195 E2855_02503 E2863_02392 E5P22_21380 E5S46_06650 EC95NR1_00961 ED648_25045 ELT20_21515 ELV08_24970 EPT01_11070 EQ825_23250 ERS085379_01273 ERS085386_05041 ExPECSC038_01920 EXX71_02385 EXX78_21815 EYD11_09165 F7F11_20115 F7F29_22635 FNJ83_13175 FQ915_04255 FQR64_09390 FWK02_18105 HmCmsJML079_02678 HMPREF3040_01583 HW43_13705 NCTC10082_04431 NCTC10418_03071 NCTC10767_03558 NCTC11022_01867 NCTC11126_04427 NCTC11181_05650 NCTC12950_02263 NCTC8985_00529 NCTC9111_05933 NCTC9703_00277 PGD_01271 PU06_24500 SAMEA3472043_00447 SAMEA3472055_03589 SAMEA3472056_01268 SAMEA3472070_00654 SAMEA3472080_04213 SAMEA3472090_03376 SAMEA3472110_00060 SAMEA3472112_00448 SAMEA3752372_00752 UN91_23615 WQ89_10695] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.124) (Maillard deglycase)
[] Genome polyprotein [Cleaved into: Leader protein; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Rho) (Virion protein 4); Capsid protein VP2 (Beta) (P1B) (Virion protein 2); Capsid protein VP3 (Gamma) (P1C) (Virion protein 3); Capsid protein VP1 (Alpha) (P1D) (Virion protein 1); Protein 2A (P2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.4.13); Protein 3A (P3A); VPg (Protein 3B) (P3B) (Viral protein genome-linked); Protease 3C (P3C) (EC 3.4.19.12) (EC 3.4.22.28) (Picornain 3C) (p22); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[F2] Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]
[Prdx6 Aop2 Ltw4 Prdx5] Peroxiredoxin-6 (EC 1.11.1.15) (1-Cys peroxiredoxin) (1-Cys PRX) (Acidic calcium-independent phospholipase A2) (aiPLA2) (EC 3.1.1.4) (Antioxidant protein 2) (Non-selenium glutathione peroxidase) (NSGPx)
[1a] Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) (Leader protein); Non-structural protein 2 (nsp2) (p65 homolog); Non-structural protein 3 (nsp3) (EC 3.4.19.12) (EC 3.4.22.69) (PL2-PRO) (Papain-like proteinase) (PL-PRO) (SARS coronavirus main proteinase); Non-structural protein 4 (nsp4); 3C-like proteinase (3CL-PRO) (3CLp) (EC 3.4.22.-) (nsp5); Non-structural protein 6 (nsp6); Non-structural protein 7 (nsp7); Non-structural protein 8 (nsp8); Non-structural protein 9 (nsp9); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL); Non-structural protein 11 (nsp11)]
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[gag-pol] Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide 1 (SP1) (p2); Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.16) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2) (p66 RT); p51 RT; p15; Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[] Genome polyprotein [Cleaved into: Leader protein (L); Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Rho) (Virion protein 4); Capsid protein VP2 (Beta) (P1B) (Virion protein 2); Capsid protein VP3 (Gamma) (P1C) (Virion protein 3); Capsid protein VP1 (Alpha) (P1D) (Virion protein 1); Protein 2A (P2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.4.13); Protein 3A (P3A); VPg (P3B) (Protein 3B); Protease 3C (P3C) (EC 3.4.22.28) (Picornain 3C) (p22); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[F13A1 F13A] Coagulation factor XIII A chain (Coagulation factor XIIIa) (EC 2.3.2.13) (Protein-glutamine gamma-glutamyltransferase A chain) (Transglutaminase A chain)
[PCS1 ARA8 CAD1 At5g44070 MRH10.11 MRH10_18] Glutathione gamma-glutamylcysteinyltransferase 1 (EC 2.3.2.15) (Cadmium tolerance protein) (Phytochelatin synthase 1) (AtPCS1)
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[gag-pol] Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide 1 (SP1) (p2); Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.16) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2) (p66 RT); p51 RT; p15; Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[TGM3] Protein-glutamine gamma-glutamyltransferase E (EC 2.3.2.13) (Transglutaminase E) (TG(E)) (TGE) (TGase E) (Transglutaminase-3) (TGase-3) [Cleaved into: Protein-glutamine gamma-glutamyltransferase E 50 kDa catalytic chain; Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain]
[Tgm3 Tgase3] Protein-glutamine gamma-glutamyltransferase E (EC 2.3.2.13) (Transglutaminase E) (TG(E)) (TGE) (TGase E) (Transglutaminase-3) (TGase-3) [Cleaved into: Protein-glutamine gamma-glutamyltransferase E 50 kDa catalytic chain; Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion protein 4); Capsid protein VP2 (P1B) (Virion protein 2); Capsid protein VP3 (P1C) (Virion protein 3); Capsid protein VP1 (P1D) (Virion protein 1); P2; Protease 2A (P2A) (EC 3.4.22.29) (Picornain 2A) (Protein 2A); Protein 2B (P2B); Protein 2C (P2C) (EC 3.6.1.15); P3; Protein 3AB; Protein 3A (P3A); Viral protein genome-linked (VPg) (Protein 3B) (P3B); Protein 3CD (EC 3.4.22.28); Protease 3C (EC 3.4.22.28) (Picornain 3C) (P3C); RNA-directed RNA polymerase (RdRp) (EC 2.7.7.48) (3D polymerase) (3Dpol) (Protein 3D) (3D)]
[gag-pol] Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide 1 (SP1) (p2); Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.16) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2) (p66 RT); p51 RT; p15; Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[hchA A9819_11910 ACN81_03425 AML35_08765 AW059_23935 BANRA_00208 BANRA_00433 BANRA_02614 BHF46_18455 BMT91_24760 BON76_21885 BvCmsC61A_00149 BvCmsKSNP120_04693 BvCmsKSP026_03873 BvCmsKSP076_04891 C7B08_25495 C9Z39_20510 CR538_10415 D3Y67_22910 D9G42_11130 D9I97_22010 D9J11_25195 DJ503_24045 DP258_02540 E3B71_05970 EC3234A_36c00010 EC382_21100 ECTO6_01955 EHH55_07135 FORC82_1921 FV293_07100 NCTC8500_02249 NCTC9117_02637 NCTC9969_02156 SAMEA3472108_01151 SAMEA3484427_04795 SAMEA3484429_02051 SAMEA3752557_05476 SAMEA3752559_04333] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.124) (Maillard deglycase)
[CRY2 PHH1 SEL20 At1g04400 F19P19.14] Cryptochrome-2 (Atcry2) (Blue light photoreceptor) (Protein PHR homolog 1) (AtPHH1) (Protein SUPPRESSOR OF elf3 20)
[Klk1b3 Klk-3 Klk3 Ngfg] Kallikrein 1-related peptidase b3 (EC 3.4.21.35) (7S nerve growth factor gamma chain) (Gamma-NGF) (Glandular kallikrein K3) (mGK-3) (Tissue kallikrein-3) [Cleaved into: Nerve growth factor gamma chain 1; Nerve growth factor gamma chain 2]
[ctxA toxA VC_1457] Cholera enterotoxin subunit A (Cholera enterotoxin, A chain) [Cleaved into: Cholera enterotoxin subunit A1 (EC 2.4.2.-) (Cholera enterotoxin A1 chain) (Cholera enterotoxin alpha chain) (NAD(+)--diphthamide ADP-ribosyltransferase); Cholera enterotoxin subunit A2 (Cholera enterotoxin A2 chain) (Cholera enterotoxin gamma chain)]

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