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Glycogen synthase kinase 3 beta

 F7GCK3_ORNAN            Unreviewed;       247 AA.
F7GCK3;
27-JUL-2011, integrated into UniProtKB/TrEMBL.
27-JUL-2011, sequence version 1.
17-JUN-2020, entry version 60.
SubName: Full=Glycogen synthase kinase 3 beta {ECO:0000313|Ensembl:ENSOANP00000002674};
Name=GSK3B {ECO:0000313|Ensembl:ENSOANP00000002674};
Ornithorhynchus anatinus (Duckbill platypus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Monotremata; Ornithorhynchidae; Ornithorhynchus.
NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000002674, ECO:0000313|Proteomes:UP000002279};
[1] {ECO:0000313|Ensembl:ENSOANP00000002674}
IDENTIFICATION.
STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000002674};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
-!- SIMILARITY: Belongs to the protein kinase superfamily.
{ECO:0000256|RuleBase:RU000304}.
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STRING; 9258.ENSOANP00000002674; -.
Ensembl; ENSOANT00000002675; ENSOANP00000002674; ENSOANG00000001670.
eggNOG; KOG0658; Eukaryota.
eggNOG; COG0515; LUCA.
GeneTree; ENSGT00520000055635; -.
HOGENOM; CLU_000288_181_20_1; -.
InParanoid; F7GCK3; -.
OMA; VMRTVDH; -.
TreeFam; TF101104; -.
Proteomes; UP000002279; Unplaced.
Bgee; ENSOANG00000001670; Expressed in testis and 6 other tissues.
GO; GO:0030424; C:axon; IBA:GO_Central.
GO; GO:0030877; C:beta-catenin destruction complex; IBA:GO_Central.
GO; GO:0005813; C:centrosome; IEA:Ensembl.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005829; C:cytosol; IBA:GO_Central.
GO; GO:0098978; C:glutamatergic synapse; IBA:GO_Central.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0008013; F:beta-catenin binding; IBA:GO_Central.
GO; GO:0034452; F:dynactin binding; IEA:Ensembl.
GO; GO:0051059; F:NF-kappaB binding; IEA:Ensembl.
GO; GO:0002039; F:p53 binding; IEA:Ensembl.
GO; GO:0002020; F:protease binding; IEA:Ensembl.
GO; GO:0034236; F:protein kinase A catalytic subunit binding; IEA:Ensembl.
GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
GO; GO:0001085; F:RNA polymerase II transcription factor binding; IEA:Ensembl.
GO; GO:0050321; F:tau-protein kinase activity; IBA:GO_Central.
GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
GO; GO:0001837; P:epithelial to mesenchymal transition; IEA:Ensembl.
GO; GO:0006983; P:ER overload response; IEA:Ensembl.
GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IBA:GO_Central.
GO; GO:0005977; P:glycogen metabolic process; IEA:Ensembl.
GO; GO:0021766; P:hippocampus development; IEA:Ensembl.
GO; GO:0008286; P:insulin receptor signaling pathway; IBA:GO_Central.
GO; GO:0035556; P:intracellular signal transduction; IEA:Ensembl.
GO; GO:0070885; P:negative regulation of calcineurin-NFAT signaling cascade; IEA:Ensembl.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IBA:GO_Central.
GO; GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
GO; GO:1901215; P:negative regulation of neuron death; IEA:Ensembl.
GO; GO:0032091; P:negative regulation of protein binding; IEA:Ensembl.
GO; GO:0031333; P:negative regulation of protein-containing complex assembly; IEA:Ensembl.
GO; GO:0031175; P:neuron projection development; IEA:Ensembl.
GO; GO:0018105; P:peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:0018107; P:peptidyl-threonine phosphorylation; IEA:Ensembl.
GO; GO:0001954; P:positive regulation of cell-matrix adhesion; IEA:Ensembl.
GO; GO:0043547; P:positive regulation of GTPase activity; IEA:Ensembl.
GO; GO:0010822; P:positive regulation of mitochondrion organization; IEA:Ensembl.
GO; GO:1901216; P:positive regulation of neuron death; IEA:Ensembl.
GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO; GO:0046827; P:positive regulation of protein export from nucleus; IEA:Ensembl.
GO; GO:1904781; P:positive regulation of protein localization to centrosome; IEA:Ensembl.
GO; GO:0031334; P:positive regulation of protein-containing complex assembly; IEA:Ensembl.
GO; GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
GO; GO:0150101; P:regulation of microtubule anchoring at centrosome; IEA:Ensembl.
GO; GO:0070507; P:regulation of microtubule cytoskeleton organization; IBA:GO_Central.
GO; GO:0010975; P:regulation of neuron projection development; IBA:GO_Central.
GO; GO:2000300; P:regulation of synaptic vesicle exocytosis; IEA:Ensembl.
GO; GO:0007165; P:signal transduction; IBA:GO_Central.
GO; GO:0071109; P:superior temporal gyrus development; IEA:Ensembl.
CDD; cd14137; STKc_GSK3; 1.
InterPro; IPR033573; GSK3B.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
InterPro; IPR039192; STKc_GSK3.
PANTHER; PTHR24057:SF8; PTHR24057:SF8; 1.
Pfam; PF00069; Pkinase; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
3: Inferred from homology;
ATP-binding {ECO:0000256|RuleBase:RU000304};
Kinase {ECO:0000256|RuleBase:RU000304};
Nucleotide-binding {ECO:0000256|RuleBase:RU000304};
Reference proteome {ECO:0000313|Proteomes:UP000002279};
Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU000304};
Transferase {ECO:0000256|RuleBase:RU000304}.
DOMAIN 26..247
/note="Protein kinase"
/evidence="ECO:0000259|PROSITE:PS50011"
REGION 1..23
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
ACT_SITE 151
/note="Proton acceptor"
/evidence="ECO:0000256|PIRSR:PIRSR633573-1"
SEQUENCE 247 AA; 27852 MW; 8F4CE8FF8ED1D6A7 CRC64;
DKDGSKVTTV VATPGQGPDR PQEVSYTDTK VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD
KRFKNRELQI MRKLDHCNIV RLRYFFYSSG EKKDEVYLNL VLDYVPETVY RVARHYSRAK
QTLPVIYVKL YMYQLFRSLA YIHSFGICHR DIKPQNLLLD PDTAVLKLCD FGSAKQLVRG
EPNVSYICSR YYRAPELIFG ATDYTSSIDV WSAGCVLAEL LLGQPIFPGD SGVDQLVEII
KVCASPS


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Pathways :
WP32: Translation Factors
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP668: Octadecanoid Pathway
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP1722: Th1/Th2
WP3: Keap1-Nrf2 Pathway
WP626: Abscisic Acid Biosynthesis
WP1045: TGF-beta Receptor Signaling Pathway
WP1493: Carbon assimilation C4 pathway
WP2208: Cardiolipin Biosynthesis
WP448: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP1832: Integrin alphaIIb beta3 signaling
WP1226: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP1571: EBV LMP1 signaling
WP2218: sGC
WP495: Glucocorticoid & Mineralcorticoid Metabolism
WP485: Alpha6-Beta4 Integrin Signaling Pathway
WP1269: Fatty Acid Beta Oxidation
WP187: Fatty Acid Beta Oxidation 2
WP763: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP1058: Senescence and Autophagy
WP1941: Peroxisomal beta-oxidation of tetracosanoyl-CoA
WP368: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP825: Fatty Acid Beta Oxidation
WP1106: Keap1-Nrf2

Related Genes :
[GSK3B] Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)
[Gsk3b] Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)
[Gsk3b] Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Factor A) (FA) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)
[GSK3B] Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)
[GSK3B] Glycogen synthase kinase 3 beta variant 2 (Glycogen synthase kinase-3 beta isoform 1)
[NIN KIAA1565] Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein)
[gsk3b Xgsk-3] Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Xgsk-3 protein)
[GSK3B] Glycogen synthase kinase 3 beta (Glycogen synthase kinase-3 beta isoform 1)
[GSK3A] Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1)
[Gsk3a] Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1)
[Gsk3a] Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Factor A) (FA) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1)
[GSK3B] Glycogen synthase kinase 3 beta (Glycogen synthase kinase-3 beta isoform 1)
[gsk-3 sgg-1 Y18D10A.5] Glycogen synthase kinase-3 (EC 2.7.11.26)
[GSK3B] Glycogen synthase kinase 3 beta
[GSK3B] Glycogen synthase kinase 3 beta
[GSK3B] Glycogen synthase kinase 3 beta
[GSK3B] Glycogen synthase kinase 3 beta
[GSK3B] Glycogen synthase kinase 3 beta
[GSK3B] Glycogen synthase kinase 3 beta
[gskA gsk3 DDB_G0272110] Glycogen synthase kinase-3 (GSK-3) (EC 2.7.11.26)
[Gsk3b] Glycogen synthase kinase-3 beta
[] Glycogen synthase kinase 3 beta
[GSK3B] Glycogen synthase kinase 3 beta
[Gsk3b] Glycogen synthase kinase-3 beta
[GSK3B] Glycogen synthase kinase 3 beta
[GSK3B] Glycogen synthase kinase 3 beta
[GSK3B] Glycogen synthase kinase 3 beta
[GSK3B] Glycogen synthase kinase 3 beta
[GSK3A] Glycogen synthase kinase 3 beta
[GSK3B] Glycogen synthase kinase 3 beta

Bibliography :
[32630830] KLF4 Acts as a wt-CFTR Suppressor through an AKT-Mediated Pathway.
[32606150] Increased Expression of p-GSK3β Predicts Poor Survival in T -III/IV Stage OSCC Patients.
[32581790] Shenmai Injection Protects Against Doxorubicin-Induced Cardiotoxicity Maintaining Mitochondrial Homeostasis.
[32576205] Phosphoproteomics of short-term hedgehog signaling in human medulloblastoma cells.
[32567157] Neuroprotective effects of astaxanthin against oxygen and glucose deprivation damage via the PI3K/Akt/GSK3β/Nrf2 signalling pathway in vitro.
[32531122] N-glycosylated IgG in patients with kidney transplants increases calcium/calmodulin kinase IV in podocytes and causes injury.
[32518634] Lithium and coronaviral infections. A scoping review.
[32515311] PTML Modeling for Alzheimer's Disease: Design and Prediction of Virtual Multi-Target Inhibitors of GSK3B, HDAC1, and HDAC6.
[32492398] Toxoplasma gondii Chinese I genotype Wh6 strain infection induces tau phosphorylation via activating GSK3β and causes hippocampal neuron apoptosis.
[32456135] Amelioration of BPSD-Like Phenotype and Cognitive Decline in SAMP8 Mice Model Accompanied by Molecular Changes after Treatment with I-Imidazoline Receptor Ligand MCR5.