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Glycogen synthase kinase 3 beta

 H0VQQ9_CAVPO            Unreviewed;       423 AA.
H0VQQ9;
22-FEB-2012, integrated into UniProtKB/TrEMBL.
22-NOV-2017, sequence version 2.
17-JUN-2020, entry version 57.
SubName: Full=Glycogen synthase kinase 3 beta {ECO:0000313|Ensembl:ENSCPOP00000012892};
Name=GSK3B {ECO:0000313|Ensembl:ENSCPOP00000012892};
Cavia porcellus (Guinea pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
Cavia.
NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000012892, ECO:0000313|Proteomes:UP000005447};
[1] {ECO:0000313|Ensembl:ENSCPOP00000012892, ECO:0000313|Proteomes:UP000005447}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012892,
ECO:0000313|Proteomes:UP000005447};
PubMed=21993624; DOI=10.1038/nature10530;
Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
"A high-resolution map of human evolutionary constraint using 29 mammals.";
Nature 478:476-482(2011).
[2] {ECO:0000313|Ensembl:ENSCPOP00000012892}
IDENTIFICATION.
STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000012892};
Ensembl;
Submitted (JAN-2012) to UniProtKB.
-!- SIMILARITY: Belongs to the protein kinase superfamily.
{ECO:0000256|RuleBase:RU000304}.
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EMBL; AAKN02035617; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAKN02035618; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAKN02035619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAKN02035620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAKN02035621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAKN02035622; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAKN02035623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAKN02035624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_003469272.1; XM_003469224.3.
STRING; 10141.ENSCPOP00000012892; -.
Ensembl; ENSCPOT00000014453; ENSCPOP00000012892; ENSCPOG00000014311.
GeneID; 100714392; -.
CTD; 2932; -.
eggNOG; KOG0658; Eukaryota.
eggNOG; COG0515; LUCA.
GeneTree; ENSGT00520000055635; -.
HOGENOM; CLU_000288_181_20_1; -.
InParanoid; H0VQQ9; -.
OrthoDB; 990896at2759; -.
TreeFam; TF101104; -.
Proteomes; UP000005447; Unassembled WGS sequence.
Bgee; ENSCPOG00000014311; Expressed in brain and 2 other tissues.
GO; GO:0030877; C:beta-catenin destruction complex; IEA:Ensembl.
GO; GO:0005813; C:centrosome; IEA:Ensembl.
GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0008013; F:beta-catenin binding; IEA:Ensembl.
GO; GO:0034452; F:dynactin binding; IEA:Ensembl.
GO; GO:0051059; F:NF-kappaB binding; IEA:Ensembl.
GO; GO:0002039; F:p53 binding; IEA:Ensembl.
GO; GO:0002020; F:protease binding; IEA:Ensembl.
GO; GO:0034236; F:protein kinase A catalytic subunit binding; IEA:Ensembl.
GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO; GO:0001085; F:RNA polymerase II transcription factor binding; IEA:Ensembl.
GO; GO:0050321; F:tau-protein kinase activity; IEA:Ensembl.
GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
GO; GO:0001837; P:epithelial to mesenchymal transition; IEA:Ensembl.
GO; GO:0006983; P:ER overload response; IEA:Ensembl.
GO; GO:0005977; P:glycogen metabolic process; IEA:Ensembl.
GO; GO:0021766; P:hippocampus development; IEA:Ensembl.
GO; GO:0035556; P:intracellular signal transduction; IEA:Ensembl.
GO; GO:0070885; P:negative regulation of calcineurin-NFAT signaling cascade; IEA:Ensembl.
GO; GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
GO; GO:1901215; P:negative regulation of neuron death; IEA:Ensembl.
GO; GO:0032091; P:negative regulation of protein binding; IEA:Ensembl.
GO; GO:0031333; P:negative regulation of protein-containing complex assembly; IEA:Ensembl.
GO; GO:0031175; P:neuron projection development; IEA:Ensembl.
GO; GO:0018105; P:peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:0018107; P:peptidyl-threonine phosphorylation; IEA:Ensembl.
GO; GO:0001954; P:positive regulation of cell-matrix adhesion; IEA:Ensembl.
GO; GO:0043547; P:positive regulation of GTPase activity; IEA:Ensembl.
GO; GO:0010822; P:positive regulation of mitochondrion organization; IEA:Ensembl.
GO; GO:1901216; P:positive regulation of neuron death; IEA:Ensembl.
GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO; GO:0046827; P:positive regulation of protein export from nucleus; IEA:Ensembl.
GO; GO:1904781; P:positive regulation of protein localization to centrosome; IEA:Ensembl.
GO; GO:0031334; P:positive regulation of protein-containing complex assembly; IEA:Ensembl.
GO; GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
GO; GO:0150101; P:regulation of microtubule anchoring at centrosome; IEA:Ensembl.
GO; GO:2000300; P:regulation of synaptic vesicle exocytosis; IEA:Ensembl.
GO; GO:0071109; P:superior temporal gyrus development; IEA:Ensembl.
CDD; cd14137; STKc_GSK3; 1.
InterPro; IPR033573; GSK3B.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
InterPro; IPR039192; STKc_GSK3.
PANTHER; PTHR24057:SF8; PTHR24057:SF8; 1.
Pfam; PF00069; Pkinase; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
3: Inferred from homology;
ATP-binding {ECO:0000256|RuleBase:RU000304};
Kinase {ECO:0000256|RuleBase:RU000304};
Nucleotide-binding {ECO:0000256|RuleBase:RU000304};
Reference proteome {ECO:0000313|Proteomes:UP000005447};
Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU000304};
Transferase {ECO:0000256|RuleBase:RU000304}.
DOMAIN 56..343
/note="Protein kinase"
/evidence="ECO:0000259|PROSITE:PS50011"
REGION 1..53
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 390..423
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1..25
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
ACT_SITE 181
/note="Proton acceptor"
/evidence="ECO:0000256|PIRSR:PIRSR633573-1"
SEQUENCE 423 AA; 47087 MW; DFC1A4A90C377AEC CRC64;
MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR PQEVSYTDTK
VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI MRKLDHCNIV RLRYFFYSSG
EKKDEVYLNL VLDYVPETVY RVARHYSRAK QTLPVIYVKL YMYQLFRSLA YIHSFGICHR
DIKPQNLLLD PDTAVLKLCD FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV
WSAGCVLAEL LLGQPIFPGD SGVDQLVEHY QGEKVLGTPT REQIREMNPN YTEFKFPQIK
AHPWTKVFRP RTPPEAIALC SRLLEYTPTA RLTPLEACAH SFFDELRDPN VKLPNGRDTP
ALFNFTTQEL SSNPPLATIL IPPHARIQAA ASTPTNATAA SDANAGDRGQ TNNAASAAAS
NST


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U2298r CLIA kit FA,Factor A,Glycogen synthase kinase-3 beta,GSK-3 beta,Gsk3b,Rat,Rattus norvegicus,Serine_threonine-protein kinase GSK3B 96T
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U2298m CLIA Glycogen synthase kinase-3 beta,GSK-3 beta,Gsk3b,Mouse,Mus musculus,Serine_threonine-protein kinase GSK3B 96T
E2298r FA,Factor A,Glycogen synthase kinase-3 beta,GSK-3 beta,Gsk3b,Rat,Rattus norvegicus,Serine_threonine-protein kinase GSK3B
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bs-0023P Peptides: GSK-3 Beta(NT) (Glycogen Synthase Kinase-3 Beta) Protein Length:12-25 amino acids. 200ug lyophilized
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Pathways :
WP32: Translation Factors
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP668: Octadecanoid Pathway
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP1722: Th1/Th2
WP3: Keap1-Nrf2 Pathway
WP626: Abscisic Acid Biosynthesis
WP1045: TGF-beta Receptor Signaling Pathway
WP1493: Carbon assimilation C4 pathway
WP2208: Cardiolipin Biosynthesis
WP448: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP1832: Integrin alphaIIb beta3 signaling
WP1226: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP1571: EBV LMP1 signaling
WP2218: sGC
WP495: Glucocorticoid & Mineralcorticoid Metabolism
WP485: Alpha6-Beta4 Integrin Signaling Pathway
WP1269: Fatty Acid Beta Oxidation
WP187: Fatty Acid Beta Oxidation 2
WP763: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP1058: Senescence and Autophagy
WP1941: Peroxisomal beta-oxidation of tetracosanoyl-CoA
WP368: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP825: Fatty Acid Beta Oxidation
WP1106: Keap1-Nrf2

Related Genes :
[GSK3B] Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)
[Gsk3b] Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)
[Gsk3b] Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Factor A) (FA) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)
[GSK3B] Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)
[GSK3B] Glycogen synthase kinase 3 beta variant 2 (Glycogen synthase kinase-3 beta isoform 1)
[NIN KIAA1565] Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein)
[gsk3b Xgsk-3] Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Xgsk-3 protein)
[GSK3B] Glycogen synthase kinase 3 beta (Glycogen synthase kinase-3 beta isoform 1)
[GSK3A] Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1)
[Gsk3a] Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1)
[Gsk3a] Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Factor A) (FA) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1)
[GSK3B] Glycogen synthase kinase 3 beta (Glycogen synthase kinase-3 beta isoform 1)
[gsk-3 sgg-1 Y18D10A.5] Glycogen synthase kinase-3 (EC 2.7.11.26)
[GSK3B] Glycogen synthase kinase 3 beta
[GSK3B] Glycogen synthase kinase 3 beta
[GSK3B] Glycogen synthase kinase 3 beta
[GSK3B] Glycogen synthase kinase 3 beta
[GSK3B] Glycogen synthase kinase 3 beta
[GSK3B] Glycogen synthase kinase 3 beta
[gskA gsk3 DDB_G0272110] Glycogen synthase kinase-3 (GSK-3) (EC 2.7.11.26)
[Gsk3b] Glycogen synthase kinase-3 beta
[] Glycogen synthase kinase 3 beta
[GSK3B] Glycogen synthase kinase 3 beta
[Gsk3b] Glycogen synthase kinase-3 beta
[GSK3B] Glycogen synthase kinase 3 beta
[GSK3B] Glycogen synthase kinase 3 beta
[GSK3B] Glycogen synthase kinase 3 beta
[GSK3B] Glycogen synthase kinase 3 beta
[GSK3A] Glycogen synthase kinase 3 beta
[GSK3B] Glycogen synthase kinase 3 beta

Bibliography :
[32630830] KLF4 Acts as a wt-CFTR Suppressor through an AKT-Mediated Pathway.
[32606150] Increased Expression of p-GSK3β Predicts Poor Survival in T -III/IV Stage OSCC Patients.
[32581790] Shenmai Injection Protects Against Doxorubicin-Induced Cardiotoxicity Maintaining Mitochondrial Homeostasis.
[32576205] Phosphoproteomics of short-term hedgehog signaling in human medulloblastoma cells.
[32567157] Neuroprotective effects of astaxanthin against oxygen and glucose deprivation damage via the PI3K/Akt/GSK3β/Nrf2 signalling pathway in vitro.
[32531122] N-glycosylated IgG in patients with kidney transplants increases calcium/calmodulin kinase IV in podocytes and causes injury.
[32518634] Lithium and coronaviral infections. A scoping review.
[32515311] PTML Modeling for Alzheimer's Disease: Design and Prediction of Virtual Multi-Target Inhibitors of GSK3B, HDAC1, and HDAC6.
[32492398] Toxoplasma gondii Chinese I genotype Wh6 strain infection induces tau phosphorylation via activating GSK3β and causes hippocampal neuron apoptosis.
[32456135] Amelioration of BPSD-Like Phenotype and Cognitive Decline in SAMP8 Mice Model Accompanied by Molecular Changes after Treatment with I-Imidazoline Receptor Ligand MCR5.