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Growth factor receptor bound protein 2

 G1KFH8_ANOCA            Unreviewed;       217 AA.
G1KFH8;
19-OCT-2011, integrated into UniProtKB/TrEMBL.
26-JUN-2013, sequence version 2.
03-JUL-2019, entry version 58.
SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSACAP00000006419};
Name=GRB2 {ECO:0000313|Ensembl:ENSACAP00000006419};
Anolis carolinensis (Green anole) (American chameleon).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
Toxicofera; Iguania; Dactyloidae; Anolis.
NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000006419, ECO:0000313|Proteomes:UP000001646};
[1] {ECO:0000313|Ensembl:ENSACAP00000006419, ECO:0000313|Proteomes:UP000001646}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000006419};
The Genome Sequencing Platform;
Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
Lander E.S., Lindblad-Toh K.;
"The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSACAP00000006419}
IDENTIFICATION.
Ensembl;
Submitted (SEP-2011) to UniProtKB.
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RefSeq; XP_003217257.1; XM_003217209.3.
STRING; 28377.ENSACAP00000006419; -.
Ensembl; ENSACAT00000006564; ENSACAP00000006419; ENSACAG00000006524.
GeneID; 100564375; -.
KEGG; acs:100564375; -.
CTD; 2885; -.
GeneTree; ENSGT00940000155738; -.
InParanoid; G1KFH8; -.
KO; K04364; -.
OrthoDB; 1091250at2759; -.
TreeFam; TF354288; -.
Proteomes; UP000001646; Chromosome 2.
Bgee; ENSACAG00000006524; Expressed in 4 organ(s), highest expression level in brain.
GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
GO; GO:0008180; C:COP9 signalosome; IEA:Ensembl.
GO; GO:0005768; C:endosome; IEA:Ensembl.
GO; GO:0070436; C:Grb2-EGFR complex; IEA:Ensembl.
GO; GO:0005730; C:nucleolus; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0012506; C:vesicle membrane; IEA:Ensembl.
GO; GO:0046875; F:ephrin receptor binding; IEA:Ensembl.
GO; GO:0005154; F:epidermal growth factor receptor binding; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0043560; F:insulin receptor substrate binding; IEA:Ensembl.
GO; GO:0005168; F:neurotrophin TRKA receptor binding; IEA:Ensembl.
GO; GO:0001784; F:phosphotyrosine residue binding; IEA:Ensembl.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0019903; F:protein phosphatase binding; IEA:Ensembl.
GO; GO:0017124; F:SH3 domain binding; IEA:Ensembl.
GO; GO:0005070; F:SH3/SH2 adaptor activity; IEA:Ensembl.
GO; GO:0048646; P:anatomical structure formation involved in morphogenesis; IEA:Ensembl.
GO; GO:0030154; P:cell differentiation; IEA:Ensembl.
GO; GO:0071479; P:cellular response to ionizing radiation; IEA:Ensembl.
GO; GO:0008286; P:insulin receptor signaling pathway; IEA:Ensembl.
GO; GO:0030838; P:positive regulation of actin filament polymerization; IEA:Ensembl.
GO; GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IEA:Ensembl.
GO; GO:0031623; P:receptor internalization; IEA:Ensembl.
GO; GO:0043408; P:regulation of MAPK cascade; IEA:Ensembl.
GO; GO:0042770; P:signal transduction in response to DNA damage; IEA:Ensembl.
CDD; cd11949; SH3_GRB2_C; 1.
CDD; cd11946; SH3_GRB2_N; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR030219; Grb2.
InterPro; IPR035643; GRB2_C_SH3.
InterPro; IPR035641; GRB2_N_SH3.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR036028; SH3-like_dom_sf.
InterPro; IPR001452; SH3_domain.
PANTHER; PTHR46037:SF4; PTHR46037:SF4; 1.
Pfam; PF00017; SH2; 1.
Pfam; PF00018; SH3_1; 2.
PRINTS; PR00401; SH2DOMAIN.
PRINTS; PR00452; SH3DOMAIN.
SMART; SM00252; SH2; 1.
SMART; SM00326; SH3; 2.
SUPFAM; SSF50044; SSF50044; 2.
SUPFAM; SSF55550; SSF55550; 1.
PROSITE; PS50001; SH2; 1.
PROSITE; PS50002; SH3; 2.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000001646};
Reference proteome {ECO:0000313|Proteomes:UP000001646};
SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192,
ECO:0000256|SAAS:SAAS01042643}.
DOMAIN 1 58 SH3. {ECO:0000259|PROSITE:PS50002}.
DOMAIN 60 152 SH2. {ECO:0000259|PROSITE:PS50001}.
DOMAIN 156 215 SH3. {ECO:0000259|PROSITE:PS50002}.
SEQUENCE 217 AA; 25163 MW; 4DF37E6B50067345 CRC64;
MEAVAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW
FFGKIPRAKA EEMLGKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL
WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQVPQQPTY VQALFDFDPQ EEGELGFRRG
DFIQVLDNSD PNWWKGACHG QTGMFPRNYV TPVNRNI


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Pathways :
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP1348: Androgen Receptor Signaling Pathway
WP1371: G Protein Signaling Pathways
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP2292: Chemokine signaling pathway
WP1345: T Cell Receptor Signaling Pathway
WP2272: Pathogenic Escherichia coli infection
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP1354: B Cell Receptor Signaling Pathway
WP474: Endochondral Ossification
WP2032: TSH signaling pathway
WP285: B Cell Receptor Signaling Pathway
WP106: Alanine and aspartate metabolism
WP1382: Delta-Notch Signaling Pathway
WP1438: Influenza A virus infection
WP1714: Tyrosine metabolism

Related Genes :

Bibliography :
[31320611] Grb2 binds to PTEN and regulates its nuclear translocation to maintain the genomic stability in DNA damage response.
[31312847] Gene expression in stress urinary incontinence: a systematic review.
[31245515] Outlining the Grb2 interactome data and its interacting partners in HEK293 cells in absence and presence of epidermal growth factor.
[31220469] LncRNA PCFL promotes cardiac fibrosis via miR-378/GRB2 pathway following myocardial infarction.
[31053155] SGIP1α functions as a selective endocytic adaptor for the internalization of synaptotagmin 1 at synapses.
[31028611] NMR assignment of free H, N and C-Grb2-SH2 domain.
[31002126] SGK2 promotes renal cancer progression via enhancing ERK 1/2 and AKT phosphorylation.
[30956905] Up-regulation of Grb2-associated binder 1 promotes hepatocyte growth factor-induced endothelial progenitor cell proliferation and migration.
[30936879] Gab2 and Gab3 Redundantly Suppress Colitis by Modulating Macrophage and CD8 T-Cell Activation.
[30923665] Structural and functional properties of Grb2 SH2 dimer in CD28 binding.