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Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)

 GRB2_RAT                Reviewed;         217 AA.
P62994; P29354; Q14450; Q5BKA7; Q63057; Q63059;
31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
31-AUG-2004, sequence version 1.
08-MAY-2019, entry version 147.
RecName: Full=Growth factor receptor-bound protein 2;
AltName: Full=Adapter protein GRB2;
AltName: Full=Protein Ash;
AltName: Full=SH2/SH3 adapter GRB2;
Name=Grb2; Synonyms=Ash;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
STRAIN=Fischer 344; TISSUE=Brain;
PubMed=1384039; DOI=10.1073/pnas.89.19.9015;
Matuoka K., Yamakawa A., Shibata M., Takenawa T.;
"Cloning of ASH, a ubiquitous protein composed of one Src homology
region (SH) 2 and two SH3 domains, from human and rat cDNA
libraries.";
Proc. Natl. Acad. Sci. U.S.A. 89:9015-9019(1992).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), AND FUNCTION.
STRAIN=Wistar; TISSUE=Brain;
PubMed=7775428; DOI=10.1074/jbc.270.23.13733;
Watanabe K., Fukuchi T., Hosoya H., Shirasawa T., Matsuoka K.,
Miki H., Takenawa T.;
"Splicing isoforms of rat Ash/Grb2. Isolation and characterization of
the cDNA and genomic DNA clones and implications for the physiological
roles of the isoforms.";
J. Biol. Chem. 270:13733-13739(1995).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Thymus;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
PROTEIN SEQUENCE OF 11-21; 77-86; 101-109; 125-136; 143-149 AND
208-215, AND IDENTIFICATION BY MASS SPECTROMETRY.
STRAIN=Sprague-Dawley; TISSUE=Hippocampus, and Spinal cord;
Lubec G., Afjehi-Sadat L., Chen W.-Q.;
Submitted (APR-2007) to UniProtKB.
[5]
INTERACTION WITH CSF1R.
PubMed=8262059;
van der Geer P., Hunter T.;
"Mutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase
binding site, abrogates signal transduction by the murine CSF-1
receptor expressed in Rat-2 fibroblasts.";
EMBO J. 12:5161-5172(1993).
[6]
INTERACTION WITH IRS1.
PubMed=8388384;
Tobe K., Matuoka K., Tamemoto H., Ueki K., Kaburagi Y., Asai S.,
Noguchi T., Matsuda M., Tanaka S., Hattori S., Fukui Y., Akanuma Y.,
Yazaki Y., Takenawa T., Kadowaki T.;
"Insulin stimulates association of insulin receptor substrate-1 with
the protein abundant Src homology/growth factor receptor-bound protein
2.";
J. Biol. Chem. 268:11167-11171(1993).
-!- FUNCTION: Adapter protein that provides a critical link between
cell surface growth factor receptors and the Ras signaling
pathway. {ECO:0000250, ECO:0000269|PubMed:7775428}.
-!- SUBUNIT: Associates (via SH2 domain) with activated EGF and PDGF
receptors (tyrosine phosphorylated). Interacts with PDGFRA
(tyrosine phosphorylated); the interaction may be indirect.
Interacts with IRS4 (when Tyr-phosphorylated). Also associates to
other cellular Tyr-phosphorylated proteins such as SIT1, SHC and
LNK; probably via the concerted action of both its SH2 and SH3
domains. It also seems to interact with RAS in the signaling
pathway leading to DNA synthesis. Interacts with SOS1. Forms a
complex with MUC1 and SOS1, through interaction of the SH3 domains
with SOS1 and the SH2 domain with phosphorylated MUC1. Interacts
with phosphorylated MET. Interacts with phosphorylated TOM1L1.
Interacts with the phosphorylated C-terminus of SH2B2. Interacts
with phosphorylated SIT1, LAX1, LAT, LAT2 and LIME1 upon TCR
and/or BCR activation. Interacts with NISCH, PTPNS1 and REPS2.
Interacts with syntrophin SNTA1. Interacts (via SH3 domains) with
REPS1. Interacts (via SH3 domains) with PIK3C2B. Interacts with
CBL and CBLB. Interacts with AJUBA and CLNK. Interacts (via SH2
domain) with TEK/TIE2 (tyrosine phosphorylated). Interacts with
SHB, INPP5D/SHIP1, SKAP1 and SKAP2. Interacts with PTPN11.
Interacts with PRNP. Interacts with RALGPS1. Interacts also with
HCST. Interacts with KDR. Interacts with FLT1 (tyrosine-
phosphorylated). Interacts with GAPT and PTPRE. Interacts (via SH2
domain) with KIF26A. Interacts (via SH3 2) with GAB2. Interacts
with ADAM15. Interacts with THEMIS2. Interacts (via SH2 domain)
with AXL (phosphorylated). Interacts (via SH2 domain) with KIT
(phosphorylated). Interacts with PTPRJ and BCR. Interacts with
PTPN23. Interacts with FLT4 (tyrosine phosphorylated). Interacts
with EPHB1 and SHC1; activates the MAPK/ERK cascade to regulate
cell migration. Part of a complex including TNK2, GRB2 and one
receptor tyrosine kinase (RTK) such as AXL and PDGFRL, in which
GRB2 promotes RTK recruitment by TNK2. Interacts with ERBB4.
Interacts with NTRK1 (phosphorylated upon ligand-binding).
Interacts with PTK2/FAK1 (tyrosine phosphorylated). Interacts with
PTK2B/PYK2 (tyrosine phosphorylated). Interacts with SCIMP.
Interacts (via SH3 domains) with GAREM1 (via proline-rich domain
and tyrosine phosphorylated); the interaction occurs upon EGF
stimulation. Interacts with DAB2. Interacts with TESPA1. Interacts
with THEMIS. Interacts with PLCG1, LAT and THEMIS upon TCR
activation in thymocytes; the association is weaker in the absence
of TESPA1. Interacts with CD28. Interacts with RAB13; may recruit
RAB13 to the leading edge of migrating endothelial cells where it
can activate RHOA. Interacts with ASAP3 (phosphorylated form) (By
similarity). Interacts (via SH2 domain) with CSF1R and IRS1
(tyrosine phosphorylated) (PubMed:8262059, PubMed:8388384).
Interacts (via SH2 domain) with PTPRH (phosphorylated form) (By
similarity). Interacts with PTPRO (phosphorylated form) (By
similarity). Interacts with PTPRB (phosphorylated form) (By
similarity). Interacts (via SH3 domain 2) with PRR14 (via proline-
rich region) (By similarity). Interacts with ST5 (By similarity).
{ECO:0000250|UniProtKB:P62993, ECO:0000250|UniProtKB:Q60631,
ECO:0000269|PubMed:8262059, ECO:0000269|PubMed:8388384}.
-!- INTERACTION:
P21575:Dnm1; NbExp=3; IntAct=EBI-401775, EBI-80070;
P35739:Ntrk1; NbExp=6; IntAct=EBI-401775, EBI-976667;
P18545:PDE6G (xeno); NbExp=2; IntAct=EBI-401775, EBI-2622029;
P18031:PTPN1 (xeno); NbExp=3; IntAct=EBI-401775, EBI-968788;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm
{ECO:0000250}. Endosome {ECO:0000250}. Golgi apparatus
{ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Comment=Additional isoforms seem to exist.;
Name=1; Synonyms=Ash-L;
IsoId=P62994-1, P29354-1;
Sequence=Displayed;
Name=2; Synonyms=Ash-M;
IsoId=P62994-2, P29354-3;
Sequence=VSP_001840;
Name=3; Synonyms=Ash-S;
IsoId=P62994-3, P29354-4;
Sequence=VSP_001838;
-!- TISSUE SPECIFICITY: Wide tissue distribution.
{ECO:0000269|PubMed:1384039}.
-!- DOMAIN: The SH3 domains mediate interaction with RALGPS1 and SHB.
{ECO:0000250}.
-!- SIMILARITY: Belongs to the GRB2/sem-5/DRK family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; X62853; CAA44665.1; -; mRNA.
EMBL; D49846; BAA08645.1; -; mRNA.
EMBL; D49847; BAA08646.1; -; mRNA.
EMBL; BC091144; AAH91144.1; -; mRNA.
PIR; S26050; S26050.
RefSeq; NP_110473.2; NM_030846.2. [P62994-1]
SMR; P62994; -.
BioGrid; 249501; 12.
CORUM; P62994; -.
IntAct; P62994; 15.
MINT; P62994; -.
STRING; 10116.ENSRNOP00000005347; -.
iPTMnet; P62994; -.
PhosphoSitePlus; P62994; -.
SwissPalm; P62994; -.
jPOST; P62994; -.
PaxDb; P62994; -.
PRIDE; P62994; -.
Ensembl; ENSRNOT00000005347; ENSRNOP00000005347; ENSRNOG00000003990. [P62994-1]
GeneID; 81504; -.
KEGG; rno:81504; -.
CTD; 2885; -.
RGD; 619758; Grb2.
eggNOG; KOG3601; Eukaryota.
eggNOG; ENOG410XR1G; LUCA.
GeneTree; ENSGT00940000155738; -.
HOGENOM; HOG000251625; -.
InParanoid; P62994; -.
KO; K04364; -.
OMA; HWWHGEI; -.
OrthoDB; 1091250at2759; -.
PhylomeDB; P62994; -.
TreeFam; TF354288; -.
Reactome; R-RNO-109704; PI3K Cascade.
Reactome; R-RNO-112412; SOS-mediated signalling.
Reactome; R-RNO-1250347; SHC1 events in ERBB4 signaling.
Reactome; R-RNO-1257604; PIP3 activates AKT signaling.
Reactome; R-RNO-1295596; Spry regulation of FGF signaling.
Reactome; R-RNO-1433557; Signaling by SCF-KIT.
Reactome; R-RNO-1433559; Regulation of KIT signaling.
Reactome; R-RNO-167044; Signalling to RAS.
Reactome; R-RNO-179812; GRB2 events in EGFR signaling.
Reactome; R-RNO-180292; GAB1 signalosome.
Reactome; R-RNO-180336; SHC1 events in EGFR signaling.
Reactome; R-RNO-182971; EGFR downregulation.
Reactome; R-RNO-186763; Downstream signal transduction.
Reactome; R-RNO-1963640; GRB2 events in ERBB2 signaling.
Reactome; R-RNO-1963642; PI3K events in ERBB2 signaling.
Reactome; R-RNO-2029482; Regulation of actin dynamics for phagocytic cup formation.
Reactome; R-RNO-210993; Tie2 Signaling.
Reactome; R-RNO-2179392; EGFR Transactivation by Gastrin.
Reactome; R-RNO-2424491; DAP12 signaling.
Reactome; R-RNO-2428933; SHC-related events triggered by IGF1R.
Reactome; R-RNO-2730905; Role of LAT2/NTAL/LAB on calcium mobilization.
Reactome; R-RNO-2871796; FCERI mediated MAPK activation.
Reactome; R-RNO-2871809; FCERI mediated Ca+2 mobilization.
Reactome; R-RNO-354194; GRB2:SOS provides linkage to MAPK signaling for Integrins.
Reactome; R-RNO-375165; NCAM signaling for neurite out-growth.
Reactome; R-RNO-388841; Costimulation by the CD28 family.
Reactome; R-RNO-389359; CD28 dependent Vav1 pathway.
Reactome; R-RNO-391160; Signal regulatory protein family interactions.
Reactome; R-RNO-5654688; SHC-mediated cascade:FGFR1.
Reactome; R-RNO-5654689; PI-3K cascade:FGFR1.
Reactome; R-RNO-5654693; FRS-mediated FGFR1 signaling.
Reactome; R-RNO-5654695; PI-3K cascade:FGFR2.
Reactome; R-RNO-5654699; SHC-mediated cascade:FGFR2.
Reactome; R-RNO-5654700; FRS-mediated FGFR2 signaling.
Reactome; R-RNO-5654704; SHC-mediated cascade:FGFR3.
Reactome; R-RNO-5654706; FRS-mediated FGFR3 signaling.
Reactome; R-RNO-5654710; PI-3K cascade:FGFR3.
Reactome; R-RNO-5654712; FRS-mediated FGFR4 signaling.
Reactome; R-RNO-5654719; SHC-mediated cascade:FGFR4.
Reactome; R-RNO-5654720; PI-3K cascade:FGFR4.
Reactome; R-RNO-5654726; Negative regulation of FGFR1 signaling.
Reactome; R-RNO-5654727; Negative regulation of FGFR2 signaling.
Reactome; R-RNO-5654732; Negative regulation of FGFR3 signaling.
Reactome; R-RNO-5654733; Negative regulation of FGFR4 signaling.
Reactome; R-RNO-5663213; RHO GTPases Activate WASPs and WAVEs.
Reactome; R-RNO-5673001; RAF/MAP kinase cascade.
Reactome; R-RNO-6807004; Negative regulation of MET activity.
Reactome; R-RNO-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
Reactome; R-RNO-74749; Signal attenuation.
Reactome; R-RNO-74751; Insulin receptor signalling cascade.
Reactome; R-RNO-8851805; MET activates RAS signaling.
Reactome; R-RNO-8851907; MET activates PI3K/AKT signaling.
Reactome; R-RNO-8853659; RET signaling.
Reactome; R-RNO-8856825; Cargo recognition for clathrin-mediated endocytosis.
Reactome; R-RNO-8856828; Clathrin-mediated endocytosis.
Reactome; R-RNO-8865999; MET activates PTPN11.
Reactome; R-RNO-8875555; MET activates RAP1 and RAC1.
Reactome; R-RNO-8875656; MET receptor recycling.
Reactome; R-RNO-8983432; Interleukin-15 signaling.
Reactome; R-RNO-9027284; Erythropoietin activates RAS.
Reactome; R-RNO-9028731; Activated NTRK2 signals through FRS2 and FRS3.
Reactome; R-RNO-912526; Interleukin receptor SHC signaling.
Reactome; R-RNO-912631; Regulation of signaling by CBL.
Reactome; R-RNO-983695; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
PRO; PR:P62994; -.
Proteomes; UP000002494; Chromosome 10.
Bgee; ENSRNOG00000003990; Expressed in 10 organ(s), highest expression level in spleen.
Genevisible; P62994; RN.
GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
GO; GO:0008180; C:COP9 signalosome; ISS:UniProtKB.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005829; C:cytosol; TAS:Reactome.
GO; GO:0005768; C:endosome; ISS:UniProtKB.
GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
GO; GO:0070436; C:Grb2-EGFR complex; IEA:Ensembl.
GO; GO:0005730; C:nucleolus; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0032991; C:protein-containing complex; IDA:RGD.
GO; GO:0012506; C:vesicle membrane; IEA:Ensembl.
GO; GO:0019899; F:enzyme binding; IPI:RGD.
GO; GO:0046875; F:ephrin receptor binding; IEA:Ensembl.
GO; GO:0005154; F:epidermal growth factor receptor binding; IPI:RGD.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0043560; F:insulin receptor substrate binding; IPI:RGD.
GO; GO:0005168; F:neurotrophin TRKA receptor binding; IEA:Ensembl.
GO; GO:0051219; F:phosphoprotein binding; IPI:RGD.
GO; GO:0001784; F:phosphotyrosine residue binding; IPI:RGD.
GO; GO:0019904; F:protein domain specific binding; IPI:RGD.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0019903; F:protein phosphatase binding; IEA:Ensembl.
GO; GO:0017124; F:SH3 domain binding; ISS:UniProtKB.
GO; GO:0005070; F:SH3/SH2 adaptor activity; IEA:Ensembl.
GO; GO:0007568; P:aging; IPI:RGD.
GO; GO:0048646; P:anatomical structure formation involved in morphogenesis; IEA:Ensembl.
GO; GO:0060670; P:branching involved in labyrinthine layer morphogenesis; IEA:Ensembl.
GO; GO:0030154; P:cell differentiation; IEA:Ensembl.
GO; GO:0071479; P:cellular response to ionizing radiation; IEA:Ensembl.
GO; GO:0008286; P:insulin receptor signaling pathway; IEA:Ensembl.
GO; GO:0030838; P:positive regulation of actin filament polymerization; IEA:Ensembl.
GO; GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IEA:Ensembl.
GO; GO:0051291; P:protein heterooligomerization; IDA:RGD.
GO; GO:0007265; P:Ras protein signal transduction; TAS:RGD.
GO; GO:0031623; P:receptor internalization; IEA:Ensembl.
GO; GO:0043408; P:regulation of MAPK cascade; IEA:Ensembl.
GO; GO:0042770; P:signal transduction in response to DNA damage; IEA:Ensembl.
CDD; cd11949; SH3_GRB2_C; 1.
CDD; cd11946; SH3_GRB2_N; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR030219; Grb2.
InterPro; IPR035643; GRB2_C_SH3.
InterPro; IPR035641; GRB2_N_SH3.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR036028; SH3-like_dom_sf.
InterPro; IPR001452; SH3_domain.
PANTHER; PTHR46037:SF4; PTHR46037:SF4; 1.
Pfam; PF00017; SH2; 1.
Pfam; PF00018; SH3_1; 2.
PRINTS; PR00401; SH2DOMAIN.
PRINTS; PR00452; SH3DOMAIN.
SMART; SM00252; SH2; 1.
SMART; SM00326; SH3; 2.
SUPFAM; SSF50044; SSF50044; 2.
SUPFAM; SSF55550; SSF55550; 1.
PROSITE; PS50001; SH2; 1.
PROSITE; PS50002; SH3; 2.
1: Evidence at protein level;
Acetylation; Alternative splicing; Complete proteome; Cytoplasm;
Direct protein sequencing; Endosome; Golgi apparatus; Nucleus;
Phosphoprotein; Reference proteome; Repeat; SH2 domain; SH3 domain.
CHAIN 1 217 Growth factor receptor-bound protein 2.
/FTId=PRO_0000088201.
DOMAIN 1 58 SH3 1. {ECO:0000255|PROSITE-
ProRule:PRU00192}.
DOMAIN 60 152 SH2. {ECO:0000255|PROSITE-
ProRule:PRU00191}.
DOMAIN 156 215 SH3 2. {ECO:0000255|PROSITE-
ProRule:PRU00192}.
MOD_RES 1 1 N-acetylmethionine.
{ECO:0000250|UniProtKB:P62993}.
MOD_RES 6 6 N6-acetyllysine.
{ECO:0000250|UniProtKB:P62993}.
MOD_RES 50 50 N6-acetyllysine.
{ECO:0000250|UniProtKB:P62993}.
MOD_RES 109 109 N6-acetyllysine.
{ECO:0000250|UniProtKB:P62993}.
MOD_RES 211 211 Phosphothreonine.
{ECO:0000250|UniProtKB:P62993}.
VAR_SEQ 60 217 Missing (in isoform 3).
{ECO:0000303|PubMed:7775428}.
/FTId=VSP_001838.
VAR_SEQ 157 170 Missing (in isoform 2).
{ECO:0000303|PubMed:7775428}.
/FTId=VSP_001840.
SEQUENCE 217 AA; 25206 MW; 83A4B0BA1B248DC4 CRC64;
MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW
FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL
WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQVPQQPTY VQALFDFDPQ EDGELGFRRG
DFIHVMDNSD PNWWKGACHG QTGMFPRNYV TPVNRNV


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Pathways :
WP2292: Chemokine signaling pathway
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP2272: Pathogenic Escherichia coli infection
WP1676: Non-homologous end-joining
WP1566: Citrate cycle (TCA cycle)
WP407: Kit Receptor Signaling Pathway
WP794: B Cell Receptor Signaling Pathway
WP1892: Protein folding
WP931: G Protein Signaling Pathways
WP1689: Porphyrin and chlorophyll metabolism
WP1624: Bacterial secretion system
WP1693: Purine metabolism
WP35: G Protein Signaling Pathways
WP1650: Fluorobenzoate degradation
WP2371: Parkinsons Disease Pathway
WP480: T Cell Receptor Signaling Pathway
WP1939: Unfolded Protein Response
WP1284: EPO Receptor Signaling

Related Genes :
[GRB2 ASH] Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
[Grb2 Ash] Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
[Grb2] Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
[GRB2] Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
[GAB1] GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
[NCK2 GRB4] Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
[SGIP1] SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein)
[NCK1 NCK] Cytoplasmic protein NCK1 (NCK adaptor protein 1) (Nck-1) (SH2/SH3 adaptor protein NCK-alpha)
[Nck2 Grb4] Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
[Sgip1] SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein)
[Sgip1] SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein)
[GAREM1 C18orf11 FAM59A GAREM] GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1)
[SH3GL2 CNSA2 SH3D2A] Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2)
[Sh3gl2 Sh3d2a Sh3p4] Endophilin-A1 (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2) (SH3p4)
[Grb7] Growth factor receptor-bound protein 7 (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein)
[BLNK BASH SLP65] B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65)
[SHB] SH2 domain-containing adapter protein B
[CD2AP] CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)
[Shb] SH2 domain-containing adapter protein B
[Blnk Bash Ly57 Slp65] B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Lymphocyte antigen 57) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65)
[Inpp5d 7a33 Ship Ship1] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship)
[SGIP1] SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein)
[FRS2] Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1)
[Frs2 Frs2a] Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (FRS2-alpha) (Suc1-associated neurotrophic factor target 1) (SNT-1)
[SH3GLB1 KIAA0491 CGI-61] Endophilin-B1 (Bax-interacting factor 1) (Bif-1) (SH3 domain-containing GRB2-like protein B1)
[KIT SCFR] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
[Themis] Protein THEMIS (Grb2-associating protein) (Gasp) (Protein thylex) (Thymocyte-expressed molecule involved in selection)
[CBLB RNF56 Nbla00127] E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B)
[SH2D2A SCAP TSAD VRAP] SH2 domain-containing protein 2A (SH2 domain-containing adapter protein) (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein)
[SHC1 SHC SHCA] SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)

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