GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]

 GHR_SAIBB               Reviewed;         632 AA.
Q95ML5;
10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
16-JAN-2019, entry version 91.
RecName: Full=Growth hormone receptor;
Short=GH receptor;
AltName: Full=Somatotropin receptor;
Contains:
RecName: Full=Growth hormone-binding protein;
Short=GH-binding protein;
Short=GHBP;
AltName: Full=Serum-binding protein;
Flags: Precursor;
Name=GHR;
Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Platyrrhini; Cebidae; Saimiriinae; Saimiri.
NCBI_TaxID=39432;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=11371582; DOI=10.1093/oxfordjournals.molbev.a003895;
Liu J.-C., Makova K.D., Adkins R.M., Gibson S., Li W.-H.;
"Episodic evolution of growth hormone in primates and emergence of the
species specificity of human growth hormone receptor.";
Mol. Biol. Evol. 18:945-953(2001).
-!- FUNCTION: Receptor for pituitary gland growth hormone involved in
regulating postnatal body growth. On ligand binding, couples to,
and activates the JAK2/STAT5 pathway (By similarity).
{ECO:0000250}.
-!- FUNCTION: The soluble form (GHBP) acts as a reservoir of growth
hormone in plasma and may be a modulator/inhibitor of GH
signaling.
-!- SUBUNIT: On growth hormone (GH) binding, forms homodimers and
binds JAK2 via a box 1-containing domain. Binding to SOCS3
inhibits JAK2 activation, binding to CIS and SOCS2 inhibits STAT5
activation. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass
type I membrane protein {ECO:0000250}. Note=On growth hormone
binding, GHR is ubiquitinated, internalized, down-regulated and
transported into a degradative or non-degradative pathway.
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Growth hormone-binding protein: Secreted
{ECO:0000250}. Note=Complexed to a substantial fraction of
circulating GH. {ECO:0000250}.
-!- DOMAIN: The WSXWS motif appears to be necessary for proper protein
folding and thereby efficient intracellular transport and cell-
surface receptor binding.
-!- DOMAIN: The box 1 motif is required for JAK interaction and/or
activation.
-!- DOMAIN: The extracellular domain is the ligand-binding domain
representing the growth hormone-binding protein (GHBP).
-!- DOMAIN: The ubiquitination-dependent endocytosis motif (UbE) is
required for recruitment of the ubiquitin conjugation system on to
the receptor and for its internalization. {ECO:0000250}.
-!- PTM: On GH binding, phosphorylated on tyrosine residues in the
cytoplasmic domain by JAK2. {ECO:0000250}.
-!- PTM: On ligand binding, ubiquitinated on lysine residues in the
cytoplasmic domain. This ubiquitination is not sufficient for GHR
internalization (By similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 1
subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AF339061; AAK62288.1; -; mRNA.
RefSeq; NP_001289860.1; NM_001302931.1.
ProteinModelPortal; Q95ML5; -.
SMR; Q95ML5; -.
GeneID; 101042350; -.
CTD; 2690; -.
HOVERGEN; HBG005836; -.
OrthoDB; 346239at2759; -.
Proteomes; UP000233220; Whole Genome Shotgun Assembly.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
CDD; cd00063; FN3; 1.
Gene3D; 2.60.40.10; -; 2.
InterPro; IPR003961; FN3_dom.
InterPro; IPR036116; FN3_sf.
InterPro; IPR025871; GHBP.
InterPro; IPR015152; Growth/epo_recpt_lig-bind.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003528; Long_hematopoietin_rcpt_CS.
Pfam; PF09067; EpoR_lig-bind; 1.
Pfam; PF00041; fn3; 1.
Pfam; PF12772; GHBP; 1.
SUPFAM; SSF49265; SSF49265; 2.
PROSITE; PS50853; FN3; 1.
PROSITE; PS01352; HEMATOPO_REC_L_F1; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Disulfide bond; Endocytosis;
Glycoprotein; Membrane; Phosphoprotein; Receptor; Reference proteome;
Secreted; Signal; Transmembrane; Transmembrane helix; Ubl conjugation.
SIGNAL 1 18 {ECO:0000255}.
CHAIN 19 632 Growth hormone receptor.
/FTId=PRO_0000010971.
CHAIN 19 256 Growth hormone-binding protein.
{ECO:0000250}.
/FTId=PRO_0000010972.
TOPO_DOM 19 264 Extracellular. {ECO:0000255}.
TRANSMEM 265 288 Helical. {ECO:0000255}.
TOPO_DOM 289 632 Cytoplasmic. {ECO:0000255}.
DOMAIN 151 254 Fibronectin type-III.
{ECO:0000255|PROSITE-ProRule:PRU00316}.
REGION 294 379 Required for JAK2 binding. {ECO:0000250}.
MOTIF 240 244 WSXWS motif.
MOTIF 297 305 Box 1 motif.
MOTIF 340 349 UbE motif.
SITE 345 345 Required for endocytosis and down-
regulation. {ECO:0000250}.
MOD_RES 341 341 Phosphoserine.
{ECO:0000250|UniProtKB:P10912}.
CARBOHYD 46 46 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 115 115 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 156 156 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 161 161 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 200 200 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 56 66 {ECO:0000250}.
DISULFID 101 112 {ECO:0000250}.
DISULFID 126 140 {ECO:0000250}.
SEQUENCE 632 AA; 70884 MW; 440E17AF6277EDA3 CRC64;
MDLWQLLLTL ALAGSSDAFS GRETTAAVLS RVSQSLLSVN PGLKTNSSKE PKFTKCRSPE
LETFSCRWTD AVHHGLKSPG PIQLFYTRRN TQEGTQEWKE CPDYVSAGEN SCYFNSSFTS
IWIPYCIKLT SNGGTVDEKC FSVDQIVQPD PPIALNWTLL NISLTGVHAD IQVRWEAPPN
ADIQKGWMVL EYELQYKEVN ETQWKMMDPI LSTSVPLYSL RVDKEYEVRV RSRQRKSENY
GEFSEVLYVK LPQMSQFTCE EDFYYPWLLI IIFGISGLTV MLFVFLFSKQ QRIKMLILPP
VPVPKIKGID PDLLKEGKLE EVNTILAIHD SYKPEFHSDD SWVEFIELDI EDPDEKTEGL
DTDRLLSSDH EKSRSNLGVK DGDSGRTSCY EPDMLETDFN ANDIHDGTSE VVQPQRLKGE
ADLLCLDQKN QNNSPYHDAC PAIHQPSVIQ AEKNKPQPLL IDGAESTHQA AHIQLSNPSS
LANIDFYAQV SDITPAGSVV LSPGQKNNGG MSQWDMHPEV VSLCQANFIM DNAYFCEADA
KKCIPVTPHI KVESHTEPSF NQEDIYITTE SLTTTARRPG TAEHVPGSEM PVPDYTSIHI
VQSPQGLILN ATALPLPDKE FLSSCGYVAQ TN


Related products :

Catalog number Product name Quantity
10-663-45107 Growth Hormone Binding Protein (GHBP) Human - GH receptor; Somatotropin receptor N_A 0.1 mg
10-663-45107 Growth Hormone Binding Protein (GHBP) Human - GH receptor; Somatotropin receptor N_A 1 mg
10-663-45107 Growth Hormone Binding Protein (GHBP) Human - GH receptor; Somatotropin receptor N_A 0.2 mg
29-653 GHRHR is a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in its gene have been associated with isol 0.05 mg
18-003-42687 Thyroid receptor-interacting protein 13 - Thyroid hormone receptor interactor 13; Trip-13; Human papillomavirus type 16 E1 protein-binding protein; HPV16 E1 protein-binding protein; 16E1-BP Polyclonal 0.1 mg Protein A
18-003-43213 Thyroid receptor-interacting protein 13 - Thyroid hormone receptor interactor 13; Trip-13; Human papillomavirus type 16 E1 protein-binding protein; HPV16 E1 protein-binding protein; 16E1-BP Polyclonal 0.1 mg Protein A
10-288-22014F Thyroid receptor-interacting protein 13 - Thyroid hormone receptor interactor 13; Trip-13; Human papillomavirus type 16 E1 protein-binding protein; HPV16 E1 protein-binding protein; 16E1-BP 0.1 mg
10-288-22014F Thyroid receptor-interacting protein 13 - Thyroid hormone receptor interactor 13; Trip-13; Human papillomavirus type 16 E1 protein-binding protein; HPV16 E1 protein-binding protein; 16E1-BP 0.05 mg
PA1030X Growth Hormone Binding Protein (GHBP) 0.2 mg
PA1030 Growth Hormone Binding Protein (GHBP) 0.1 mg
PA1030XC Growth Hormone Binding Protein (GHBP) 1 mg
orb80352 Ovine Growth Hormone Binding protein Growth Hormone Binding Protein Ovine Recombinant produced in E.coli is a single, non-glycosylated, polypeptide chain containing 237 amino acids and having a molecu 100
orb80353 Bovine Growth Hormone Binding protein Growth Hormone Binding Protein Bovine Recombinant produced in E.coli is a single, non-glycosylated, polypeptide chain containing 237 amino acids and having a mole 100
orb80351 Human Growth Hormone Binding protein Growth Hormone Binding Protein Human Recombinant produced in E.coli is a single, non-glycosylated, polypeptide chain containing 237 amino acids and having a molecu 100
orb80354 Rabbit Growth Hormone Binding protein Growth Hormone Binding Protein Rabbit Recombinant produced in E.coli is a single, non-glycosylated, polypeptide chain containing 248 amino acids and having a mole 100
cyt-238 Recombinant Human Growth Hormone Binding Protein GHBP 1mg
E02G0014 Rat Growth Hormone Binding Protein ELISA, GHBP
cyt-238 Recombinant Human Growth Hormone Binding Protein GHBP 20
E02G0014 Rat Growth Hormone Binding Protein ELISA, GHBP 96 Tests/kit
cyt-238 Recombinant Human Growth Hormone Binding Protein GHBP 5
E12530877 Mouse Growth Hormone Binding Protein(GHBP) ELISA Kit 1
E06G0014 Goat Growth Hormone Binding Protein ELISA, GHBP
SL0804Hu Human Growth Hormone Binding Protein,GHBP ELISA Kit 96T
E13831861 Chicken Growth Hormone Binding Protein(GHBP) ELISA Kit
E11G0014 Bovine Growth Hormone Binding Protein ELISA, GHBP

Kits Elisa; taq POLYMERASE

Search in Google:

google

Share this page:
share on twitter rss feedsfacebookgoogle gentaur



Quick order!
Enter catalog number :


Gentaur; yes we can

Pathways :
WP2292: Chemokine signaling pathway
WP1531: Vitamin D synthesis
WP474: Endochondral Ossification
WP1616: ABC transporters
WP1869: Neuroransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
WP2272: Pathogenic Escherichia coli infection
WP590: Cardiovascular Signaling
WP731: Sterol regulatory element binding protein related
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP2355: Corticotropin-releasing hormone
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP1065: Endochondral Ossification
WP1181: Endochondral Ossification
WP1270: Endochondral Ossification
WP1308: Endochondral Ossification

Related Genes :
[GHR] Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]
[Ghr] Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]
[GHR] Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]
[GHR] Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]
[Ghr] Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]
[GHR] Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]
[GHR] Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]
[GHR] Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]
[GHR] Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]
[GHR] Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]
[GHR] Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]
[GHR] Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]
[GH1] Somatotropin (Growth hormone) (GH) (GH-N) (Growth hormone 1) (Pituitary growth hormone)
[GHR] Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]
[GHR] Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]
[GHR] Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]
[GHR] Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]
[GH2] Growth hormone variant (GH-V) (Growth hormone 2) (Placenta-specific growth hormone)
[GHSR] Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor)
[Ghsr] Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor)
[Ghsr] Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor)
[GHSR] Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor)
[MED1 ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2] Mediator of RNA polymerase II transcription subunit 1 (Activator-recruited cofactor 205 kDa component) (ARC205) (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) (Vitamin D receptor-interacting protein complex component DRIP205) (p53 regulatory protein RB18A)
[Med1 Crsp210 Drip205 Pbp Pparbp Trap220 Trip2] Mediator of RNA polymerase II transcription subunit 1 (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2)
[PTH1R PTHR PTHR1] Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor)
[GHRL MTLRP UNQ524/PRO1066] Appetite-regulating hormone (Growth hormone secretagogue) (Growth hormone-releasing peptide) (Motilin-related peptide) (Protein M46) [Cleaved into: Ghrelin-27; Ghrelin-28 (Ghrelin); Obestatin]
[PDGFRB PDGFR PDGFR1] Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
[PDGFRA PDGFR2 RHEPDGFRA] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
[GHRH GHRF] Somatoliberin (Growth hormone-releasing factor) (GRF) (Growth hormone-releasing hormone) (GHRH) (Somatocrinin) (Somatorelin) (Sermorelin)
[Igf1r] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]

Bibliography :
?>