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H-2 class II histocompatibility antigen gamma chain (Ia antigen-associated invariant chain) (Ii) (Ii chain) (MHC class II-associated invariant chain) (CD antigen CD74) [Cleaved into: Class-II-associated invariant chain peptide (CLIP)]

 HG2A_MOUSE              Reviewed;         279 AA.
P04441; O19452;
13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
01-NOV-1991, sequence version 3.
07-APR-2021, entry version 200.
RecName: Full=H-2 class II histocompatibility antigen gamma chain {ECO:0000305};
AltName: Full=Ia antigen-associated invariant chain;
Short=Ii {ECO:0000303|PubMed:8977190};
Short=Ii chain {ECO:0000303|PubMed:8977190};
AltName: Full=MHC class II-associated invariant chain;
AltName: CD_antigen=CD74;
Contains:
RecName: Full=Class-II-associated invariant chain peptide {ECO:0000250|UniProtKB:P04233};
Short=CLIP {ECO:0000250|UniProtKB:P04233};
Name=Cd74 {ECO:0000312|MGI:MGI:96534};
Synonyms=Ii {ECO:0000303|PubMed:8977190};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM LONG), AND ALTERNATIVE SPLICING.
STRAIN=AKR/J;
PubMed=3038530; DOI=10.1002/j.1460-2075.1987.tb02417.x;
Koch N., Lauer W., Habicht J., Dobberstein B.;
"Primary structure of the gene for the murine Ia antigen-associated
invariant chains (Ii). An alternatively spliced exon encodes a cysteine-
rich domain highly homologous to a repetitive sequence of thyroglobulin.";
EMBO J. 6:1677-1683(1987).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=AKR/J; TISSUE=Liver;
PubMed=2492095; DOI=10.1093/nar/17.1.447;
Zhu L., Jones P.P.;
"Complete sequence of the murine invariant chain (Ii) gene.";
Nucleic Acids Res. 17:447-448(1989).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
TISSUE=Mammary gland;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-58.
TISSUE=Spleen;
Stone J., Perry R., Todd J.A., McDevitt H.O.;
"Nucleotide sequences of the murine Ia-associated invariant chain (Ii) and
I-E (H-2S, Beta) chain expressible cDNA clones.";
Submitted (MAR-1988) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-25.
PubMed=2111346;
Eades A.-M., Litfin M., Rahmsdorf H.J.;
"The IFN-gamma response of the murine invariant chain gene is mediated by a
complex enhancer that includes several MHC class II consensus elements.";
J. Immunol. 144:4399-4409(1990).
[6]
NUCLEOTIDE SEQUENCE [MRNA] OF 47-279 (ISOFORM SHORT).
PubMed=6327293; DOI=10.1002/j.1460-2075.1984.tb01899.x;
Singer P.A., Lauer W., Dembic Z., Mayer W.E., Lipp J., Koch N.,
Hammerling G., Klein J., Dobberstein B.;
"Structure of the murine Ia-associated invariant (Ii) chain as deduced from
a cDNA clone.";
EMBO J. 3:873-877(1984).
[7]
GLYCOSYLATION AT SER-265, AND MUTAGENESIS OF SER-265.
PubMed=3422739; DOI=10.1073/pnas.85.5.1359;
Miller J., Hatch J.A., Simonis S., Cullen S.E.;
"Identification of the glycosaminoglycan-attachment site of mouse
invariant-chain proteoglycan core protein by site-directed mutagenesis.";
Proc. Natl. Acad. Sci. U.S.A. 85:1359-1363(1988).
[8]
FUNCTION, AND INTERACTION WITH CD44.
PubMed=8343954; DOI=10.1016/0092-8674(93)90417-o;
Naujokas M.F., Morin M., Anderson M.S., Peterson M., Miller J.;
"The chondroitin sulfate form of invariant chain can enhance stimulation of
T cell responses through interaction with CD44.";
Cell 74:257-268(1993).
[9]
FUNCTION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY, AND DISRUPTION
PHENOTYPE.
PubMed=8977190;
Takaesu N.T., Lower J.A., Yelon D., Robertson E.J., Bikoff E.K.;
"In vivo functions mediated by the p41 isoform of the MHC class II-
associated invariant chain.";
J. Immunol. 158:187-199(1997).
[10]
FUNCTION (LONG ISOFORM), TISSUE SPECIFICITY, INTERACTION WITH CTSL, AND
SUBCELLULAR LOCATION.
PubMed=11483509; DOI=10.1093/emboj/20.15.4055;
Lennon-Dumenil A.M., Roberts R.A., Valentijn K., Driessen C.,
Overkleeft H.S., Erickson A., Peters P.J., Bikoff E., Ploegh H.L.,
Wolf Bryant P.;
"The p41 isoform of invariant chain is a chaperone for cathepsin L.";
EMBO J. 20:4055-4064(2001).
[11]
FUNCTION (LONG ISOFORM), TISSUE SPECIFICITY, INTERACTION WITH CTSL, AND
SUBCELLULAR LOCATION.
PubMed=12417635; DOI=10.1084/jem.20020762;
Fiebiger E., Maehr R., Villadangos J., Weber E., Erickson A., Bikoff E.,
Ploegh H.L., Lennon-Dumenil A.M.;
"Invariant chain controls the activity of extracellular cathepsin L.";
J. Exp. Med. 196:1263-1269(2002).
[12]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, AND IDENTIFICATION BY MASS
SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
Thibault P.;
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Immunity 30:143-154(2009).
[13]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver, Lung, and Spleen;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and expression.";
Cell 143:1174-1189(2010).
[14]
INDUCTION BY LPS.
PubMed=32855215; DOI=10.1126/science.abb3753;
Bruchez A., Sha K., Johnson J., Chen L., Stefani C., McConnell H.,
Gaucherand L., Prins R., Matreyek K.A., Hume A.J., Muehlberger E.,
Schmidt E.V., Olinger G.G., Stuart L.M., Lacy-Hulbert A.;
"MHC class II transactivator CIITA induces cell resistance to Ebola virus
and SARS-like coronaviruses.";
Science 370:241-247(2020).
-!- FUNCTION: Plays a critical role in MHC class II antigen processing by
stabilizing peptide-free class II alpha/beta heterodimers in a complex
soon after their synthesis and directing transport of the complex from
the endoplasmic reticulum to compartments where peptide loading of
class II takes place. Enhance also the stimulation of T-cell responses
through interaction with CD44. {ECO:0000269|PubMed:8343954,
ECO:0000269|PubMed:8977190}.
-!- FUNCTION: [Isoform Long]: Stabilizes the conformation of mature CTSL by
binding to its active site and serving as a chaperone to help maintain
a pool of mature enzyme in endocytic compartments and extracellular
space of antigen-presenting cells (APCs). {ECO:0000269|PubMed:11483509,
ECO:0000269|PubMed:12417635}.
-!- FUNCTION: [Class-II-associated invariant chain peptide]: Binds to the
peptide-binding site of MHC class II alpha/beta heterodimers forming an
alpha-beta-CLIP complex, thereby preventing the loading of antigenic
peptides to the MHC class II complex until its release by HLA-DM in the
endosome. {ECO:0000250|UniProtKB:P04233}.
-!- SUBUNIT: Nonamer composed of three alpha/beta/gamma heterotrimers.
Interacts with CD44; this complex is essential for the MIF-induced
signaling cascade that results in B cell survival. {ECO:0000250,
ECO:0000269|PubMed:8343954}.
-!- SUBUNIT: [Isoform Long]: Interacts with the mature form of CTSL; the
complex survive in neutral pH environment.
{ECO:0000269|PubMed:11483509, ECO:0000269|PubMed:12417635}.
-!- SUBCELLULAR LOCATION: [Isoform Long]: Late endosome
{ECO:0000269|PubMed:11483509}. Lysosome {ECO:0000269|PubMed:11483509}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P04233};
Single-pass type II membrane protein {ECO:0000250|UniProtKB:P04233}.
Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P04233}. Golgi
apparatus, trans-Golgi network {ECO:0000250|UniProtKB:P04233}. Endosome
{ECO:0000250|UniProtKB:P04233}. Lysosome
{ECO:0000250|UniProtKB:P04233}. Note=Transits through a number of
intracellular compartments in the endocytic pathway. It can either
undergo proteolysis or reach the cell membrane.
{ECO:0000250|UniProtKB:P04233}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=Long; Synonyms=p41 {ECO:0000303|PubMed:11483509,
ECO:0000303|PubMed:12417635, ECO:0000303|PubMed:8977190};
IsoId=P04441-1; Sequence=Displayed;
Name=Short; Synonyms=p31 {ECO:0000303|PubMed:8977190};
IsoId=P04441-2; Sequence=VSP_005332;
-!- TISSUE SPECIFICITY: [Isoform Long]: Expressed in thymus and lymph
noodes (PubMed:8977190). Expressed by antigen-presenting cells (APCs)
(PubMed:11483509, PubMed:12417635). {ECO:0000269|PubMed:11483509,
ECO:0000269|PubMed:12417635, ECO:0000269|PubMed:8977190}.
-!- TISSUE SPECIFICITY: [Isoform Short]: Expressed in thymus and lymph
noodes. {ECO:0000269|PubMed:8977190}.
-!- INDUCTION: Expression is induced by IFNG and LPS, through CIITA.
{ECO:0000269|PubMed:32855215}.
-!- DISRUPTION PHENOTYPE: Mutants for Long isoform or Short isoform exhibit
similar functional capabilities. {ECO:0000269|PubMed:8977190}.
---------------------------------------------------------------------------
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EMBL; X05428; CAA29010.1; -; Genomic_DNA.
EMBL; X05429; CAA29012.2; -; Genomic_DNA.
EMBL; X05430; CAB37297.1; -; Genomic_DNA.
EMBL; X13414; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC003476; AAH03476.1; -; mRNA.
EMBL; X07129; CAA30141.1; -; mRNA.
EMBL; M35872; AAA37897.1; -; Genomic_DNA.
EMBL; X00496; CAA25191.1; -; mRNA.
CCDS; CCDS37835.1; -. [P04441-1]
CCDS; CCDS50299.1; -. [P04441-2]
PIR; B27866; HLHMSG.
RefSeq; NP_001036070.1; NM_001042605.1. [P04441-1]
SMR; P04441; -.
BioGRID; 200600; 1.
CORUM; P04441; -.
IntAct; P04441; 2.
MINT; P04441; -.
STRING; 10090.ENSMUSP00000095171; -.
MEROPS; I31.002; -.
GlyGen; P04441; 3 sites.
iPTMnet; P04441; -.
PhosphoSitePlus; P04441; -.
SwissPalm; P04441; -.
PaxDb; P04441; -.
PeptideAtlas; P04441; -.
PRIDE; P04441; -.
ProteomicsDB; 269741; -. [P04441-1]
ProteomicsDB; 269742; -. [P04441-2]
Antibodypedia; 2245; 2329 antibodies.
Ensembl; ENSMUST00000050487; ENSMUSP00000057836; ENSMUSG00000024610. [P04441-2]
Ensembl; ENSMUST00000097563; ENSMUSP00000095171; ENSMUSG00000024610. [P04441-1]
Ensembl; ENSMUST00000167610; ENSMUSP00000126688; ENSMUSG00000024610. [P04441-1]
GeneID; 16149; -.
KEGG; mmu:16149; -.
UCSC; uc008faz.1; mouse. [P04441-1]
CTD; 972; -.
MGI; MGI:96534; Cd74.
eggNOG; KOG1214; Eukaryota.
GeneTree; ENSGT00390000008961; -.
HOGENOM; CLU_086066_1_0_1; -.
InParanoid; P04441; -.
OMA; GTFRPQC; -.
PhylomeDB; P04441; -.
TreeFam; TF317779; -.
Reactome; R-MMU-202733; Cell surface interactions at the vascular wall.
Reactome; R-MMU-2132295; MHC class II antigen presentation.
BioGRID-ORCS; 16149; 1 hit in 54 CRISPR screens.
ChiTaRS; Cd74; mouse.
PRO; PR:P04441; -.
Proteomes; UP000000589; Chromosome 18.
RNAct; P04441; protein.
Bgee; ENSMUSG00000024610; Expressed in spleen and 48 other tissues.
ExpressionAtlas; P04441; baseline and differential.
Genevisible; P04441; MM.
GO; GO:0009986; C:cell surface; ISO:MGI.
GO; GO:0005737; C:cytoplasm; ISO:MGI.
GO; GO:0005783; C:endoplasmic reticulum; IDA:MGI.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
GO; GO:0005794; C:Golgi apparatus; IDA:MGI.
GO; GO:0016021; C:integral component of membrane; ISO:MGI.
GO; GO:0005887; C:integral component of plasma membrane; TAS:MGI.
GO; GO:0005770; C:late endosome; IDA:UniProtKB.
GO; GO:0005764; C:lysosome; IDA:UniProtKB.
GO; GO:0035692; C:macrophage migration inhibitory factor receptor complex; IDA:BHF-UCL.
GO; GO:0005771; C:multivesicular body; IDA:MGI.
GO; GO:0035693; C:NOS2-CD74 complex; IDA:BHF-UCL.
GO; GO:0005634; C:nucleus; ISO:MGI.
GO; GO:0005886; C:plasma membrane; IDA:MGI.
GO; GO:0032991; C:protein-containing complex; ISO:MGI.
GO; GO:0005773; C:vacuole; ISO:MGI.
GO; GO:0001540; F:amyloid-beta binding; ISO:MGI.
GO; GO:0042609; F:CD4 receptor binding; ISO:MGI.
GO; GO:0019955; F:cytokine binding; ISO:MGI.
GO; GO:0004896; F:cytokine receptor activity; IMP:BHF-UCL.
GO; GO:0035718; F:macrophage migration inhibitory factor binding; ISO:MGI.
GO; GO:0042289; F:MHC class II protein binding; IPI:BHF-UCL.
GO; GO:0042658; F:MHC class II protein binding, via antigen binding groove; ISO:MGI.
GO; GO:0023026; F:MHC class II protein complex binding; ISO:MGI.
GO; GO:0050998; F:nitric-oxide synthase binding; IPI:BHF-UCL.
GO; GO:0044183; F:protein folding chaperone; ISO:MGI.
GO; GO:0000187; P:activation of MAPK activity; ISO:MGI.
GO; GO:0019882; P:antigen processing and presentation; IDA:MGI.
GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IMP:MGI.
GO; GO:0008283; P:cell population proliferation; ISO:MGI.
GO; GO:0051085; P:chaperone cofactor-dependent protein refolding; IDA:MGI.
GO; GO:0006952; P:defense response; IMP:MGI.
GO; GO:0016064; P:immunoglobulin mediated immune response; IMP:MGI.
GO; GO:0006886; P:intracellular protein transport; IDA:MGI.
GO; GO:0035691; P:macrophage migration inhibitory factor signaling pathway; IDA:BHF-UCL.
GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0030336; P:negative regulation of cell migration; ISO:MGI.
GO; GO:0043518; P:negative regulation of DNA damage response, signal transduction by p53 class mediator; IMP:BHF-UCL.
GO; GO:1902166; P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IMP:BHF-UCL.
GO; GO:0002906; P:negative regulation of mature B cell apoptotic process; IMP:BHF-UCL.
GO; GO:0002792; P:negative regulation of peptide secretion; ISO:MGI.
GO; GO:0045581; P:negative regulation of T cell differentiation; IMP:MGI.
GO; GO:0046597; P:negative regulation of viral entry into host cell; ISO:MGI.
GO; GO:0045060; P:negative thymic T cell selection; IMP:MGI.
GO; GO:0002821; P:positive regulation of adaptive immune response; NAS:BHF-UCL.
GO; GO:0030890; P:positive regulation of B cell proliferation; ISO:MGI.
GO; GO:2000343; P:positive regulation of chemokine (C-X-C motif) ligand 2 production; IDA:BHF-UCL.
GO; GO:0032722; P:positive regulation of chemokine production; ISO:MGI.
GO; GO:0001961; P:positive regulation of cytokine-mediated signaling pathway; IMP:BHF-UCL.
GO; GO:0002606; P:positive regulation of dendritic cell antigen processing and presentation; IDA:BHF-UCL.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:BHF-UCL.
GO; GO:0048146; P:positive regulation of fibroblast proliferation; ISO:MGI.
GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI.
GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; ISO:MGI.
GO; GO:0045089; P:positive regulation of innate immune response; IC:BHF-UCL.
GO; GO:0032755; P:positive regulation of interleukin-6 production; ISO:MGI.
GO; GO:0032757; P:positive regulation of interleukin-8 production; ISO:MGI.
GO; GO:0033674; P:positive regulation of kinase activity; ISO:MGI.
GO; GO:0060907; P:positive regulation of macrophage cytokine production; IDA:BHF-UCL.
GO; GO:2000448; P:positive regulation of macrophage migration inhibitory factor signaling pathway; ISO:MGI.
GO; GO:0043410; P:positive regulation of MAPK cascade; ISO:MGI.
GO; GO:0045657; P:positive regulation of monocyte differentiation; ISO:MGI.
GO; GO:0090023; P:positive regulation of neutrophil chemotaxis; IDA:BHF-UCL.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IMP:BHF-UCL.
GO; GO:0031394; P:positive regulation of prostaglandin biosynthetic process; ISO:MGI.
GO; GO:0001934; P:positive regulation of protein phosphorylation; ISO:MGI.
GO; GO:0045582; P:positive regulation of T cell differentiation; IMP:MGI.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:MGI.
GO; GO:0002830; P:positive regulation of type 2 immune response; IMP:BHF-UCL.
GO; GO:0046598; P:positive regulation of viral entry into host cell; ISO:MGI.
GO; GO:0045059; P:positive thymic T cell selection; IMP:MGI.
GO; GO:0001516; P:prostaglandin biosynthetic process; ISS:UniProtKB.
GO; GO:0050821; P:protein stabilization; IMP:UniProtKB.
GO; GO:0070206; P:protein trimerization; IEA:InterPro.
GO; GO:0065003; P:protein-containing complex assembly; IDA:MGI.
GO; GO:0034341; P:response to interferon-gamma; IDA:UniProtKB.
GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
CDD; cd00191; TY; 1.
Gene3D; 1.10.870.10; -; 1.
Gene3D; 4.10.800.10; -; 1.
InterPro; IPR043530; CD74_antigen.
InterPro; IPR015386; MHC_II-assoc_invar/CLIP_MHC-bd.
InterPro; IPR022339; MHC_II-assoc_invar_chain.
InterPro; IPR011988; MHC_II-assoc_invariant_trimer.
InterPro; IPR036613; MHCII_invariant_trimer_sf.
InterPro; IPR000716; Thyroglobulin_1.
InterPro; IPR036857; Thyroglobulin_1_sf.
Pfam; PF09307; MHC2-interact; 1.
Pfam; PF08831; MHCassoc_trimer; 1.
Pfam; PF00086; Thyroglobulin_1; 1.
PIRSF; PIRSF001992; CD74_antigen; 1.
PRINTS; PR01990; CD74ANTIGEN.
SMART; SM00211; TY; 1.
SUPFAM; SSF48305; SSF48305; 1.
SUPFAM; SSF57610; SSF57610; 1.
PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
1: Evidence at protein level;
Adaptive immunity; Alternative splicing; Cell membrane; Chaperone;
Disulfide bond; Endoplasmic reticulum; Endosome; Glycoprotein;
Golgi apparatus; Immunity; Lysosome; Membrane; Phosphoprotein;
Proteoglycan; Reference proteome; Signal-anchor; Transmembrane;
Transmembrane helix.
CHAIN 1..279
/note="H-2 class II histocompatibility antigen gamma chain"
/id="PRO_0000067955"
PEPTIDE 80..103
/note="Class-II-associated invariant chain peptide"
/evidence="ECO:0000250|UniProtKB:P04233"
/id="PRO_0000448887"
TOPO_DOM 1..29
/note="Cytoplasmic"
/evidence="ECO:0000255"
TRANSMEM 30..55
/note="Helical; Signal-anchor for type II membrane protein"
/evidence="ECO:0000255"
TOPO_DOM 56..279
/note="Extracellular"
/evidence="ECO:0000255"
DOMAIN 193..254
/note="Thyroglobulin type-1"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00500"
MOD_RES 9
/note="Phosphoserine"
/evidence="ECO:0007744|PubMed:19144319"
CARBOHYD 113
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 119
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 265
/note="O-linked (Xyl...) (chondroitin sulfate) serine"
/evidence="ECO:0000269|PubMed:3422739"
DISULFID 196..215
/evidence="ECO:0000255|PROSITE-ProRule:PRU00500"
DISULFID 226..233
/evidence="ECO:0000255|PROSITE-ProRule:PRU00500"
DISULFID 235..254
/evidence="ECO:0000255|PROSITE-ProRule:PRU00500"
VAR_SEQ 192..255
/note="Missing (in isoform Short)"
/evidence="ECO:0000303|PubMed:6327293"
/id="VSP_005332"
MUTAGEN 265
/note="S->A: No addition of glycosaminoglycan; no effect on
the synthesis of the protein."
/evidence="ECO:0000269|PubMed:3422739"
CONFLICT 10
/note="N -> M (in Ref. 2)"
/evidence="ECO:0000305"
CONFLICT 113
/note="N -> Q (in Ref. 2)"
/evidence="ECO:0000305"
CONFLICT 229..231
/note="STG -> RHC (in Ref. 1; CAB37297)"
/evidence="ECO:0000305"
SEQUENCE 279 AA; 31557 MW; 300A85014F170792 CRC64;
MDDQRDLISN HEQLPILGNR PREPERCSRG ALYTGVSVLV ALLLAGQATT AYFLYQQQGR
LDKLTITSQN LQLESLRMKL PKSAKPVSQM RMATPLLMRP MSMDNMLLGP VKNVTKYGNM
TQDHVMHLLT RSGPLEYPQL KGTFPENLKH LKNSMDGVNW KIFESWMKQW LLFEMSKNSL
EEKKPTEAPP KVLTKCQEEV SHIPAVYPGA FRPKCDENGN YLPLQCHGST GYCWCVFPNG
TEVPHTKSRG RHNCSEPLDM EDLSSGLGVT RQELGQVTL


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GWB-EEDE6A CD74 Antigen (invariant Polypeptide Of Major Histocompatibility Complex Class II Antigen-associated) (CD74) Mouse anti-Human Mo
GWB-82D738 CD74 Antigen (invariant Polypeptide Of Major Histocompatibility Complex Class II Antigen-associated) (CD74) Mouse anti-Human Mo
GWB-D368E1 CD74 Antigen (invariant Polypeptide Of Major Histocompatibility Complex Class II Antigen-associated) (CD74) Mouse anti-Human Mo
EIAAB11884 DX alpha chain,HLA class II histocompatibility antigen, DQ alpha 2 chain,HLA class II histocompatibility antigen, DQ(6) alpha chain,HLA-DQA1,HLA-DQA2,HLA-DXA,Homo sapiens,Human,MHC class II DQA2
EIAAB11729 HLA class II histocompatibility antigen, DP beta 1 chain,HLA class II histocompatibility antigen, DP(W4) beta chain,HLA-DP1B,HLA-DPB1,Homo sapiens,Human,MHC class II antigen DPB1
EIAAB11886 HLA class II histocompatibility antigen, DQ beta 2 chain,HLA class II histocompatibility antigen, DX beta chain,HLA-DQB2,HLA-DXB,Homo sapiens,Human,MHC class II antigen DQB2
CSB-EL004956RA Rat HLA class II histocompatibility antigen gamma chain(CD74) ELISA kit 96T
CSB-EL004956MO Mouse HLA class II histocompatibility antigen gamma chain(CD74) ELISA kit 96T
CSB-EL004956HU Human HLA class II histocompatibility antigen gamma chain(CD74) ELISA kit 96T
CSB-EL004956RA Rat HLA class II histocompatibility antigen gamma chain(CD74) ELISA kit SpeciesRat 96T
CSB-EL004956MO Mouse HLA class II histocompatibility antigen gamma chain(CD74) ELISA kit SpeciesMouse 96T
CSB-EL004956HU Human HLA class II histocompatibility antigen gamma chain(CD74) ELISA kit SpeciesHuman 96T
HG2A_MOUSE ELISA Kit FOR H-2 class II histocompatibility antigen gamma chain; organism: Mouse; gene name: Cd74 96T
E1386h ELISA kit HLA class I histocompatibility antigen, alpha chain G,HLA G antigen,HLA-6.0,HLAG,HLA-G,Homo sapiens,Human,MHC class I antigen G 96T
U1386h CLIA HLA class I histocompatibility antigen, alpha chain G,HLA G antigen,HLA-6.0,HLAG,HLA-G,Homo sapiens,Human,MHC class I antigen G 96T
E1386h ELISA HLA class I histocompatibility antigen, alpha chain G,HLA G antigen,HLA-6.0,HLAG,HLA-G,Homo sapiens,Human,MHC class I antigen G 96T
EIAAB11726 DP(W3),DP(W4),HLA class II histocompatibility antigen, DP alpha 1 chain,HLA-DP1A,HLA-DPA1,HLASB,HLA-SB alpha chain,Homo sapiens,Human,MHC class II DP3-alpha,MHC class II DPA1
U1752h CLIA HLA class I histocompatibility antigen, alpha chain E,HLA-6.2,HLAE,HLA-E,Homo sapiens,Human,MHC class I antigen E 96T
Pathways :
WP2328: Allograft rejection
WP1654: gamma-Hexachlorocyclohexane degradation
WP542: Electron Transport Chain
WP884: Electron Transport Chain
WP1633: Bisphenol A degradation
WP1665: Limonene and pinene degradation
WP772: Electron Transport Chain
WP1339: Electron Transport Chain
WP295: Electron Transport Chain
WP1502: Mitochondrial biogenesis
WP1626: Benzoate degradation via CoA ligation
WP111: Electron Transport Chain
WP1708: Terpenoid backbone biosynthesis
WP59: Electron Transport Chain
WP1002: Electron Transport Chain
WP1996: Linoleate Biosynthesis
WP1614: 1- and 2-Methylnaphthalene degradation
WP1119: Electron Transport Chain
WP1647: Fatty acid biosynthesis
WP1673: Naphthalene and anthracene degradation
WP2347: vitamin B5 (pantothenate) and CoA biosynthesis Pathway
WP2434: very-long-chain-fatty-acid-biosynthesis
WP776: GPCRs, Class B Secretin-like
WP1373: GPCRs, Class C Metabotropic glutamate, pheromone
WP378: GPCRs, Class B Secretin-like

Related Genes :
[Cd74 Ii] H-2 class II histocompatibility antigen gamma chain (Ia antigen-associated invariant chain) (Ii) (Ii chain) (MHC class II-associated invariant chain) (CD antigen CD74) [Cleaved into: Class-II-associated invariant chain peptide (CLIP)]
[Cd74] H-2 class II histocompatibility antigen gamma chain (Ia antigen-associated invariant chain) (Ii) (MHC class II-associated invariant chain) (CD antigen CD74) [Cleaved into: Class-II-associated invariant chain peptide (CLIP)]
[CD74 DHLAG] HLA class II histocompatibility antigen gamma chain (HLA-DR antigens-associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (CD antigen CD74) [Cleaved into: Class-II-associated invariant chain peptide (CLIP)]
[HLA-DQA2 HLA-DXA] HLA class II histocompatibility antigen, DQ alpha 2 chain (DX alpha chain) (HLA class II histocompatibility antigen, DQ(6) alpha chain) (HLA-DQA1) (MHC class II DQA2)
[HLA-DQB2 HLA-DXB] HLA class II histocompatibility antigen, DQ beta 2 chain (HLA class II histocompatibility antigen, DX beta chain) (MHC class II antigen DQB2)
[HLA-DPB1 HLA-DP1B] HLA class II histocompatibility antigen, DP beta 1 chain (HLA class II histocompatibility antigen, DP(W4) beta chain) (MHC class II antigen DPB1)
[HLA-DRB5] HLA class II histocompatibility antigen, DR beta 5 chain (DR beta-5) (DR2-beta-2) (Dw2) (MHC class II antigen DRB5)
[HLA-DPA1 HLA-DP1A HLASB] HLA class II histocompatibility antigen, DP alpha 1 chain (DP(W3)) (DP(W4)) (HLA-SB alpha chain) (MHC class II DP3-alpha) (MHC class II DPA1)
[HLA-DRA HLA-DRA1] HLA class II histocompatibility antigen, DR alpha chain (MHC class II antigen DRA)
[HLA-DQA1] HLA class II histocompatibility antigen, DQ alpha 1 chain (DC-1 alpha chain) (DC-alpha) (HLA-DCA) (MHC class II DQA1)
[HLA-DQB1 HLA-DQB] HLA class II histocompatibility antigen, DQ beta 1 chain (MHC class II antigen DQB1)
[HLA-DRB3] HLA class II histocompatibility antigen, DR beta 3 chain (MHC class II antigen DRB3)
[HLA-DRB4] HLA class II histocompatibility antigen, DR beta 4 chain (MHC class II antigen DRB4)
[HLA-DRB1] HLA class II histocompatibility antigen, DRB1 beta chain (Human leukocyte antigen DRB1) (HLA-DRB1)
[HLA-E HLA-6.2 HLAE] HLA class I histocompatibility antigen, alpha chain E (MHC class I antigen E) [Cleaved into: Soluble HLA class I histocompatibility antigen, alpha chain E (sHLA-E)]
[Mr1 Mr1a] Major histocompatibility complex class I-related gene protein (MHC class I-related gene protein) (Class I histocompatibility antigen-like protein)
[H2-D1] H-2 class I histocompatibility antigen, D-B alpha chain (H-2D(B))
[HLA-F HLA-5.4 HLAF] HLA class I histocompatibility antigen, alpha chain F (CDA12) (HLA F antigen) (Leukocyte antigen F) (MHC class I antigen F)
[H2-L] H-2 class I histocompatibility antigen, L-D alpha chain
[MR1] Major histocompatibility complex class I-related gene protein (MHC class I-related gene protein) (Class I histocompatibility antigen-like protein)
[MR1] Major histocompatibility complex class I-related gene protein (MHC class I-related gene protein) (Class I histocompatibility antigen-like protein)
[HLA-A HLAA] HLA class I histocompatibility antigen, A alpha chain (Human leukocyte antigen A) (HLA-A)
[HLA-B HLAB] HLA class I histocompatibility antigen, B alpha chain (Human leukocyte antigen B) (HLA-B)
[HLA-C HLAC] HLA class I histocompatibility antigen, C alpha chain (HLA-C) (HLA-Cw) (Human leukocyte antigen C)
[Cd44 Ly-24] CD44 antigen (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Hermes antigen) (Hyaluronate receptor) (Lymphocyte antigen 24) (Ly-24) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)
[GP] Envelope glycoprotein (GP1,2) (GP) [Cleaved into: GP1; GP2; Shed GP (GP1,2-delta)]
[Slc3a2 Mdu1] 4F2 cell-surface antigen heavy chain (4F2hc) (Solute carrier family 3 member 2) (CD antigen CD98)
[Patr-DOB] Patr class II histocompatibility antigen, DO beta chain (ChLa class II histocompatibility antigen, DO beta chain) (MHC class II antigen DOB)
[Fcgr2 Fcgr2b Ly-17] Low affinity immunoglobulin gamma Fc region receptor II (Fc gamma receptor IIB) (Fc-gamma RII) (Fc-gamma-RIIB) (FcRII) (IgG Fc receptor II beta) (Lymphocyte antigen 17) (Ly-17) (CD antigen CD32)
[CD1A] T-cell surface glycoprotein CD1a (T-cell surface antigen T6/Leu-6) (hTa1 thymocyte antigen) (CD antigen CD1a)

Bibliography :