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Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND)

 HAND2_DANRE             Reviewed;         208 AA.
P57102;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-DEC-2000, sequence version 1.
07-NOV-2018, entry version 97.
RecName: Full=Heart- and neural crest derivatives-expressed protein 2;
AltName: Full=Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2;
Short=dHAND;
Name=hand2; Synonyms=dhand;
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Embryo;
PubMed=10906469; DOI=10.1016/S0925-4773(00)00334-8;
Angelo S., Lohr J., Lee K.H., Ticho B.S., Breitbart R.E., Hill S.,
Yost H.J., Srivastava D.;
"Conservation of sequence and expression of Xenopus and zebrafish
dHAND during cardiac, branchial arch and lateral mesoderm
development.";
Mech. Dev. 95:231-237(2000).
[2]
FUNCTION.
PubMed=10821756;
Yelon D., Ticho B.S., Halpern M.E., Ruvinsky I., Ho R.K., Silver L.M.,
Stainier D.Y.R.;
"The bHLH transcription factor hand2 plays parallel roles in zebrafish
heart and pectoral fin development.";
Development 127:2573-2582(2000).
-!- FUNCTION: Essential for myocardial and pectoral fin
differentiation, patterning and morphogenesis.
{ECO:0000269|PubMed:10821756}.
-!- SUBUNIT: Efficient DNA binding requires dimerization with another
bHLH protein.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00981}.
-!- DEVELOPMENTAL STAGE: Expression first detected at 8 hours post
fertilization (hpf) in a circumferential pattern in the lateral
mesoderm. At 12 hpf, still expressed in the anterior and posterior
lateral plate mesoderm which is partly detached from the yolk at
this stage. By 18-20 hpf, expressed in the cardiac ring and in a
layer of lateral mesoderm surrounding the cardiac region, as well
as in the posterior lateral mesoderm. At 24 hpf, expressed
throughout the nascent cardiac tube and in bilaterally symmetric
clusters of ventrolateral cells that condense to form branchial
arch mesoderm which gives rise to jaw and pharyngeal bones.
Expression continues bilaterally in the posterior lateral
mesoderm. At 36-48 hpf, expressed in defined branchial arch
mesoderm populations. At 48 hpf, strong expression throughout the
heart tube.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
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EMBL; AF228334; AAF67130.1; -; mRNA.
UniGene; Dr.81423; -.
ProteinModelPortal; P57102; -.
SMR; P57102; -.
STRING; 7955.ENSDARP00000022921; -.
PaxDb; P57102; -.
PRIDE; P57102; -.
ZFIN; ZDB-GENE-000511-1; hand2.
eggNOG; KOG4029; Eukaryota.
eggNOG; ENOG411227D; LUCA.
HOGENOM; HOG000232082; -.
HOVERGEN; HBG051880; -.
InParanoid; P57102; -.
PRO; PR:P57102; -.
Proteomes; UP000000437; Unplaced.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
GO; GO:0055007; P:cardiac muscle cell differentiation; IMP:ZFIN.
GO; GO:0010002; P:cardioblast differentiation; IMP:ZFIN.
GO; GO:0035051; P:cardiocyte differentiation; IMP:ZFIN.
GO; GO:0003142; P:cardiogenic plate morphogenesis; IMP:ZFIN.
GO; GO:0071908; P:determination of intestine left/right asymmetry; IMP:ZFIN.
GO; GO:0003144; P:embryonic heart tube formation; IMP:ZFIN.
GO; GO:0035118; P:embryonic pectoral fin morphogenesis; IMP:ZFIN.
GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IMP:ZFIN.
GO; GO:0060047; P:heart contraction; IMP:ZFIN.
GO; GO:0001947; P:heart looping; IGI:ZFIN.
GO; GO:0003007; P:heart morphogenesis; IMP:ZFIN.
GO; GO:0003357; P:noradrenergic neuron differentiation; IMP:ZFIN.
GO; GO:0030859; P:polarized epithelial cell differentiation; IMP:ZFIN.
GO; GO:0003342; P:proepicardium development; IMP:ZFIN.
GO; GO:0048485; P:sympathetic nervous system development; IMP:ZFIN.
GO; GO:0030878; P:thyroid gland development; IMP:ZFIN.
CDD; cd00083; HLH; 1.
Gene3D; 4.10.280.10; -; 1.
InterPro; IPR011598; bHLH_dom.
InterPro; IPR036638; HLH_DNA-bd_sf.
Pfam; PF00010; HLH; 1.
SMART; SM00353; HLH; 1.
SUPFAM; SSF47459; SSF47459; 1.
PROSITE; PS50888; BHLH; 1.
2: Evidence at transcript level;
Complete proteome; Developmental protein; DNA-binding; Nucleus;
Reference proteome; Transcription; Transcription regulation.
CHAIN 1 208 Heart- and neural crest derivatives-
expressed protein 2.
/FTId=PRO_0000127194.
DOMAIN 90 142 bHLH. {ECO:0000255|PROSITE-
ProRule:PRU00981}.
COMPBIAS 21 26 Poly-Ala.
SEQUENCE 208 AA; 23167 MW; F0E63A9329AC6E06 CRC64;
MSLVGGFPHH PVMHHDGYSF AAAAAASRCH EEPPYFHGWL ISHPEMSPPD YTMAPSYSPE
YSTGAPGLDH SHYGGVPGAG AVGMGPRTVK RRPTANRKER RRTQSINSAF AELRECIPNV
PADTKLSKIK TLRLATSYIA YLMDILDKDE QNGETEAFKA EFKKTDAKEE RRKKEMNDVL
KSSGSSNDKK TKGRTGWPQH VWALELKQ


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Pathways :
WP2064: Neural Crest Differentiation
WP2074: Neural Crest Differentiation
WP548: neural crest development
WP1502: Mitochondrial biogenesis
WP1624: Bacterial secretion system
WP1713: Two-component system
WP2272: Pathogenic Escherichia coli infection
WP1049: G Protein Signaling Pathways
WP1165: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways
WP1438: Influenza A virus infection
WP1493: Carbon assimilation C4 pathway
WP1528: Physiological and Pathological Hypertrophy of the Heart
WP1531: Vitamin D synthesis
WP1553: heart diagrams
WP1566: Citrate cycle (TCA cycle)
WP1591: Heart Development
WP1613: 1,4-Dichlorobenzene degradation
WP1616: ABC transporters
WP1625: Base excision repair
WP1644: DNA replication
WP1650: Fluorobenzoate degradation
WP1654: gamma-Hexachlorocyclohexane degradation
WP1657: Glycerolipid metabolism
WP1659: Glycine, serine and threonine metabolism

Related Genes :
[SNAI2 SLUG SLUGH] Zinc finger protein SNAI2 (Neural crest transcription factor Slug) (Protein snail homolog 2)
[Snai2 Slug Slugh] Zinc finger protein SNAI2 (Neural crest transcription factor Slug) (Protein snail homolog 2)
[SNAI2 SLUG] Zinc finger protein SNAI2 (Neural crest transcription factor Slug) (Protein snail homolog 2)
[CASP2 ICH1 NEDD2] Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
[Casp2 Ich1 Nedd-2 Nedd2] Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
[Inka1 Fam212a] PAK4-inhibitor INKA1 (Induced in neural crest by AP2-alpha protein homolog) (MInca) (Inka box actin regulator 1)
[hes4-b hairy2 hairy2b] Transcription factor HES-4-B (Hairy and enhancer of split 4-B) (Protein hairy-2) (Xhairy2) (Protein hairy-2a) (Xhairy2b)
[RET CDHF12 CDHR16 PTC RET51] Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
[Erbb4 Mer4] Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]
[Sept2 Nedd-5 Nedd5] Septin-2 (Neural precursor cell expressed developmentally down-regulated protein 5) (NEDD-5)
[Smarca4 Baf190a Brg1 Snf2b Snf2l4] Transcription activator BRG1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA4) (BRG1-associated factor 190A) (BAF190A) (Protein brahma homolog 1) (SNF2-beta) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4)
[Nedd8 Nedd-8] NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8)
[Cited2 Mrg1 Msg2] Cbp/p300-interacting transactivator 2 (MSG-related protein 1) (MRG-1) (P35srj)
[ERBB4 HER4] Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]
[INKA1 C3orf54 FAM212A] PAK4-inhibitor INKA1 (Induced in neural crest by AP2-alpha protein homolog) (HInca) (Inka box actin regulator 1)
[Dact1 Thyex3] Dapper homolog 1 (Dapper antagonist of catenin 1) (Frodo homolog) (MDpr1) (Thymus-expressed novel gene 3 protein)
[FBLN5 DANCE UNQ184/PRO210] Fibulin-5 (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance) (Urine p50 protein) (UP50)
[Erbb4 Tyro-2] Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]
[Tfap2a Ap2tf Tcfap2a] Transcription factor AP-2-alpha (AP2-alpha) (AP-2 transcription factor) (Activating enhancer-binding protein 2-alpha) (Activator protein 2) (AP-2)
[Lrp2] Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin)
[SOX9] Transcription factor SOX-9
[PHOX2B PMX2B] Paired mesoderm homeobox protein 2B (Neuroblastoma Phox) (NBPhox) (PHOX2B homeodomain protein) (Paired-like homeobox 2B)
[Rapgef2 Pdzgef1] Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1)
[GJA1 GJAL] Gap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDa heart protein)
[Phactr4 Kiaa4120] Phosphatase and actin regulator 4 (Protein Humpty dumpty) (Humdy)
[ARID1B BAF250B DAN15 KIAA1235 OSA2] AT-rich interactive domain-containing protein 1B (ARID domain-containing protein 1B) (BRG1-associated factor 250b) (BAF250B) (BRG1-binding protein hELD/OSA1) (Osa homolog 2) (hOsa2) (p250R)
[Gja1 Cxn-43] Gap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDa heart protein)
[SEMA3A SEMAD] Semaphorin-3A (Semaphorin III) (Sema III)
[RAPGEF2 KIAA0313 NRAPGEP PDZGEF1] Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1)
[NTRK1 MTC TRK TRKA] High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)

Bibliography :
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