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Hemoglobin subunit beta-A (Alanine beta-globin) (Beta-A-globin) (Hemoglobin beta-A chain)

 HBBA_CAPHI              Reviewed;         145 AA.
P02077; P79429;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
21-JUL-1986, sequence version 1.
16-JAN-2019, entry version 107.
RecName: Full=Hemoglobin subunit beta-A;
AltName: Full=Alanine beta-globin;
AltName: Full=Beta-A-globin;
AltName: Full=Hemoglobin beta-A chain;
Capra hircus (Goat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Capra.
NCBI_TaxID=9925;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=6277503; DOI=10.1016/0092-8674(81)90419-0;
Schon E.A., Cleary M.L., Haynes J.R., Lingrel J.B.;
"Structure and evolution of goat gamma-, beta C- and beta A-globin
genes: three developmentally regulated genes contain inserted
elements.";
Cell 27:359-369(1981).
[2]
PARTIAL PROTEIN SEQUENCE (ALLELE A).
PubMed=6026247;
Huisman T.H.J., Adams H.R., Dimmock M.O., Edwards W.E., Wilson J.B.;
"The structure of goat hemoglobins. I. Structural studies of the beta
chains of the hemoglobins of normal and anemic goats.";
J. Biol. Chem. 242:2534-2541(1967).
[3]
PARTIAL PROTEIN SEQUENCE (ALLELE D).
PubMed=5697993; DOI=10.1016/0003-9861(68)90242-7;
Adams H.R., Boyd E.M., Wilson J.B., Miller A., Huisman T.H.J.;
"The structure of goat hemoglobins. 3. Hemoglobin D, a beta chain
variant with one apparent amino acid substitution (21 Asp-->His).";
Arch. Biochem. Biophys. 127:398-405(1968).
[4]
PARTIAL PROTEIN SEQUENCE (ALLELE E).
PubMed=5433580; DOI=10.1016/0003-9861(70)90368-1;
Wrightstone R.N., Wilson J.B., Miller A., Huisman T.H.J.;
"The structure of goat hemoglobins. IV. A third beta chain variant
(betaE) with three apparent amino acid substitutions.";
Arch. Biochem. Biophys. 138:451-456(1970).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 64-97 AND 114-119.
PubMed=6248519;
Haynes J.R., Rosteck P.R. Jr., Schon E.A., Gallagher P.M., Burks D.J.,
Smith K., Lingrel J.B.;
"The isolation of the beta A-, beta C-, and gamma-globin genes and a
presumptive embryonic globin gene from a goat DNA recombinant
library.";
J. Biol. Chem. 255:6355-6367(1980).
-!- FUNCTION: Involved in oxygen transport from the lung to the
various peripheral tissues.
-!- SUBUNIT: Heterotetramer of two alpha chains and two beta chains.
-!- TISSUE SPECIFICITY: Red blood cells.
-!- POLYMORPHISM: There are at least three alleles. The sequence shown
is that of allele A. {ECO:0000269|PubMed:5433580,
ECO:0000269|PubMed:5697993, ECO:0000269|PubMed:6026247}.
-!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
ProRule:PRU00238}.
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EMBL; M15387; AAA30913.1; -; Genomic_DNA.
EMBL; K00657; AAA30911.1; -; Genomic_DNA.
EMBL; K00658; AAA30912.1; -; Genomic_DNA.
PIR; A90817; HBGTA.
RefSeq; XP_005689872.2; XM_005689815.3.
UniGene; Chi.34344; -.
PDB; 2RI4; X-ray; 2.70 A; B/D/J/L=1-145.
PDB; 3D1A; X-ray; 2.61 A; B/D=1-145.
PDB; 3EU1; X-ray; 3.00 A; B/D=1-145.
PDBsum; 2RI4; -.
PDBsum; 3D1A; -.
PDBsum; 3EU1; -.
ProteinModelPortal; P02077; -.
SMR; P02077; -.
PRIDE; P02077; -.
GeneID; 102175876; -.
KEGG; chx:102175876; -.
HOVERGEN; HBG009709; -.
KO; K13823; -.
OrthoDB; 1370439at2759; -.
EvolutionaryTrace; P02077; -.
GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
GO; GO:0020037; F:heme binding; IEA:InterPro.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0019825; F:oxygen binding; IEA:InterPro.
GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
CDD; cd08925; Hb-beta_like; 1.
Gene3D; 1.10.490.10; -; 1.
InterPro; IPR000971; Globin.
InterPro; IPR009050; Globin-like_sf.
InterPro; IPR012292; Globin/Proto.
InterPro; IPR002337; Haemoglobin_b.
Pfam; PF00042; Globin; 1.
PRINTS; PR00814; BETAHAEM.
SUPFAM; SSF46458; SSF46458; 1.
PROSITE; PS01033; GLOBIN; 1.
1: Evidence at protein level;
3D-structure; Direct protein sequencing; Heme; Iron; Metal-binding;
Oxygen transport; Polymorphism; Transport.
CHAIN 1 145 Hemoglobin subunit beta-A.
/FTId=PRO_0000052909.
METAL 62 62 Iron (heme distal ligand).
METAL 91 91 Iron (heme proximal ligand).
VARIANT 20 20 D -> H (in allele D).
{ECO:0000269|PubMed:5697993}.
VARIANT 86 86 Q -> H (in allele E).
{ECO:0000269|PubMed:5433580}.
VARIANT 103 103 K -> R (in allele E).
{ECO:0000269|PubMed:5433580}.
VARIANT 124 124 L -> V (in allele E).
{ECO:0000269|PubMed:5433580}.
HELIX 4 14 {ECO:0000244|PDB:3D1A}.
HELIX 19 33 {ECO:0000244|PDB:3D1A}.
HELIX 35 40 {ECO:0000244|PDB:3D1A}.
HELIX 42 44 {ECO:0000244|PDB:3D1A}.
HELIX 50 54 {ECO:0000244|PDB:3D1A}.
HELIX 57 73 {ECO:0000244|PDB:3D1A}.
HELIX 77 79 {ECO:0000244|PDB:3D1A}.
HELIX 80 83 {ECO:0000244|PDB:3D1A}.
HELIX 85 93 {ECO:0000244|PDB:3D1A}.
HELIX 100 117 {ECO:0000244|PDB:3D1A}.
HELIX 118 120 {ECO:0000244|PDB:3D1A}.
HELIX 123 141 {ECO:0000244|PDB:3D1A}.
HELIX 142 144 {ECO:0000244|PDB:3D1A}.
SEQUENCE 145 AA; 16021 MW; 6C59F105A940F4D0 CRC64;
MLTAEEKAAV TGFWGKVKVD EVGAEALGRL LVVYPWTQRF FEHFGDLSSA DAVMNNAKVK
AHGKKVLDSF SNGMKHLDDL KGTFAQLSEL HCDKLHVDPE NFKLLGNVLV VVLARHHGSE
FTPLLQAEFQ KVVAGVANAL AHRYH


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Pathways :
WP1614: 1- and 2-Methylnaphthalene degradation
WP1566: Citrate cycle (TCA cycle)
WP1628: beta-Alanine metabolism
WP1655: Geraniol degradation
WP542: Electron Transport Chain
WP1045: TGF-beta Receptor Signaling Pathway
WP1048: TGF Beta Signaling Pathway
WP105: Fatty Acid Beta Oxidation 2
WP1058: Senescence and Autophagy
WP1061: Fatty Acid Beta Oxidation
WP1106: Keap1-Nrf2
WP1107: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP113: TGF Beta Signaling Pathway
WP1161: TGF-beta Receptor Signaling Pathway
WP1164: TGF Beta Signaling Pathway
WP1177: Fatty Acid Beta Oxidation
WP1207: Fatty Acid Beta Oxidation
WP1224: EBV LMP1 signaling
WP1225: estrogen signalling
WP1226: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP1237: Fatty Acid Beta Oxidation
WP126: Fatty Acid Beta Oxidation 1
WP1269: Fatty Acid Beta Oxidation
WP1307: Fatty Acid Beta Oxidation
WP1367: TGF-beta Receptor Signaling Pathway

Related Genes :
[HBB] Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain) [Cleaved into: LVV-hemorphin-7; Spinorphin]
[HBG1 PRO2979] Hemoglobin subunit gamma-1 (Gamma-1-globin) (Hb F Agamma) (Hemoglobin gamma-1 chain) (Hemoglobin gamma-A chain)
[HBB] Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain)
[HBA1; HBA2] Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain)
[Hba Hba-a1] Hemoglobin subunit alpha (Alpha-globin) (Hemoglobin alpha chain)
[HBG2] Hemoglobin subunit gamma-2 (Gamma-2-globin) (Hb F Ggamma) (Hemoglobin gamma-2 chain) (Hemoglobin gamma-G chain)
[HBD] Hemoglobin subunit delta (Delta-globin) (Hemoglobin delta chain)
[] Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain)
[HBAA] Hemoglobin subunit alpha-A (Alpha-A-globin) (Hemoglobin alpha-A chain)
[HBB] Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain)
[HBB1] Hemoglobin subunit beta-1 (Beta-1-globin) (Hemoglobin beta-1 chain)
[HBB1] Hemoglobin subunit beta-1 (Beta-1-globin) (Hemoglobin beta-1 chain)
[HBB1] Hemoglobin subunit beta-1 (Beta-1-globin) (Hemoglobin beta-1 chain)
[HBB2] Hemoglobin subunit beta-2 (Beta-2-globin) (Hemoglobin beta-2 chain)
[B4GALT1 GGTB2] Beta-1,4-galactosyltransferase 1 (Beta-1,4-GalTase 1) (Beta4Gal-T1) (b4Gal-T1) (EC 2.4.1.-) (Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase) (Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase) (EC 2.4.1.38) (Lactose synthase A protein) (EC 2.4.1.22) (N-acetyllactosamine synthase) (EC 2.4.1.90) (Nal synthase) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1) [Cleaved into: Processed beta-1,4-galactosyltransferase 1]
[B4GALT1 GALT GGTB2] Beta-1,4-galactosyltransferase 1 (Beta-1,4-GalTase 1) (Beta4Gal-T1) (b4Gal-T1) (EC 2.4.1.-) (Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase) (Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase) (EC 2.4.1.38) (Lactose synthase A protein) (EC 2.4.1.22) (N-acetyllactosamine synthase) (EC 2.4.1.90) (Nal synthase) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1) [Cleaved into: Processed beta-1,4-galactosyltransferase 1]
[B4galt1 Ggtb Ggtb2] Beta-1,4-galactosyltransferase 1 (Beta-1,4-GalTase 1) (Beta4Gal-T1) (b4Gal-T1) (EC 2.4.1.-) (Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase) (Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase) (EC 2.4.1.38) (Lactose synthase A protein) (EC 2.4.1.22) (N-acetyllactosamine synthase) (EC 2.4.1.90) (Nal synthase) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1) [Cleaved into: Processed beta-1,4-galactosyltransferase 1]
[HBB1] Hemoglobin subunit beta-1 (Beta-1-globin) (Hemoglobin beta-1 chain)
[B4GALT2] Beta-1,4-galactosyltransferase 2 (Beta-1,4-GalTase 2) (Beta4Gal-T2) (b4Gal-T2) (EC 2.4.1.-) (Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase) (Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase) (EC 2.4.1.38) (Lactose synthase A protein) (EC 2.4.1.22) (N-acetyllactosamine synthase) (EC 2.4.1.90) (Nal synthase) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 2) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 2)
[B4galt2] Beta-1,4-galactosyltransferase 2 (Beta-1,4-GalTase 2) (Beta4Gal-T2) (b4Gal-T2) (EC 2.4.1.-) (Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase) (Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase) (EC 2.4.1.38) (Lactose synthase A protein) (EC 2.4.1.22) (N-acetyllactosamine synthase) (EC 2.4.1.90) (Nal synthase) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 2) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 2)
[] Hemoglobin subunit alpha-A (Alpha-A-globin) (Hemoglobin alpha-A chain)
[B4GALT2] Beta-1,4-galactosyltransferase 2 (Beta-1,4-GalTase 2) (Beta4Gal-T2) (b4Gal-T2) (EC 2.4.1.-) (Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase) (Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase) (EC 2.4.1.38) (Lactose synthase A protein) (EC 2.4.1.22) (N-acetyllactosamine synthase) (EC 2.4.1.90) (Nal synthase) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 2) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 2)
[St3gal1 Siat4 Siat4a] CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (Alpha 2,3-ST 1) (Beta-galactoside alpha-2,3-sialyltransferase 1) (EC 2.4.99.4) (Gal-NAc6S) (Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase) (ST3Gal I) (ST3GalI) (ST3GalA.1) (ST3O) (Sialyltransferase 4A) (SIAT4-A)
[ST3GAL1 SIAT4A] CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (Alpha 2,3-ST 1) (Beta-galactoside alpha-2,3-sialyltransferase 1) (EC 2.4.99.4) (Gal-NAc6S) (Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase) (ST3Gal I) (ST3GalI) (ST3GalA.1) (ST3O) (Sialyltransferase 4A) (SIAT4-A)
[HSD3B1 3BH HSDB3A] 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I) (3-beta-HSD I) (3-beta-hydroxy-5-ene steroid dehydrogenase) (3-beta-hydroxy-Delta(5)-steroid dehydrogenase) (EC 1.1.1.145) (3-beta-hydroxysteroid 3-dehydrogenase) (EC 1.1.1.270) (Delta-5-3-ketosteroid isomerase) (Dihydrotestosterone oxidoreductase) (EC 1.1.1.210) (Steroid Delta-isomerase) (EC 5.3.3.1) (Trophoblast antigen FDO161G)
[ST3GAL1 SIAT4 SIAT4A] CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (Alpha 2,3-ST 1) (Beta-galactoside alpha-2,3-sialyltransferase 1) (EC 2.4.99.4) (Gal-NAc6S) (Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase) (SIATFL) (ST3Gal I) (ST3GalI) (ST3GalA.1) (ST3O) (Sialyltransferase 4A) (SIAT4-A)
[HEXB HCC7] Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A]
[al-2 B22I21.230 NCU00585] Bifunctional lycopene cyclase/phytoene synthase (Protein albino-2) [Includes: Lycopene beta-cyclase (EC 5.5.1.19) (Carotene cyclase) (Lycopene cyclase); Phytoene synthase (EC 2.5.1.32)]
[SCO5223] Epi-isozizaene 5-monooxygenase/(E)-beta-farnesene synthase (EC 1.14.13.106) (EC 4.2.3.47) (Cytochrome P450 170A1) (CYP170A1)
[HBB2] Hemoglobin subunit beta-2 (Beta-2-globin) (Hemoglobin beta-2 chain)

Bibliography :