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Hepatocyte growth factor (Hepatopoietin-A) (Scatter factor) (SF) [Cleaved into: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain]

 HGF_MOUSE               Reviewed;         728 AA.
Q08048; O55027; Q53WS5; Q61662; Q64007; Q6LBE6;
01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 1.
29-SEP-2021, entry version 190.
RecName: Full=Hepatocyte growth factor;
AltName: Full=Hepatopoietin-A;
AltName: Full=Scatter factor;
Short=SF;
Contains:
RecName: Full=Hepatocyte growth factor alpha chain;
Contains:
RecName: Full=Hepatocyte growth factor beta chain;
Flags: Precursor;
Name=Hgf;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT), AND PROTEIN SEQUENCE
OF 496-504.
TISSUE=Mammary fibroblast;
PubMed=8135822; DOI=10.1006/bbrc.1994.1296;
Sasaki M., Nishio M., Sasaki T., Enami J.;
"Identification of mouse mammary fibroblast-derived mammary growth factor
as hepatocyte growth factor.";
Biochem. Biophys. Res. Commun. 199:772-779(1994).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
PubMed=8081873; DOI=10.3109/15419069309095686;
Lee C.C., Kozak C.A., Yamada K.M.;
"Structure, genetic mapping, and expression of the mouse Hgf/scatter factor
gene.";
Cell Adhes. Commun. 1:101-111(1993).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
PubMed=8241272; DOI=10.1016/0167-4781(93)90159-b;
Liu Y., Michalopoulos G.K., Zarnegar R.;
"Molecular cloning and characterization of cDNA encoding mouse hepatocyte
growth factor.";
Biochim. Biophys. Acta 1216:299-303(1993).
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM NK1).
TISSUE=Lung;
PubMed=9488442; DOI=10.1128/mcb.18.3.1275;
Jakubczak J.L., LaRochelle W.J., Merlino G.;
"NK1, a natural splice variant of hepatocyte growth factor/scatter factor,
is a partial agonist in vivo.";
Mol. Cell. Biol. 18:1275-1283(1998).
[5]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
STRAIN=SWR/J; TISSUE=Fibroblast;
Sharpe M.J.S., Lane K., Gherardi E.;
Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-30.
STRAIN=129;
PubMed=7822318; DOI=10.1074/jbc.270.2.830;
Plaschke-Schluetter A., Behrens J., Gherardi E., Birchmeier W.;
"Characterisation of the scatter factor/hepatocyte growth factor gene
promoter: positive and negative regulatory elements direct gene expression
to mesenchymal cells.";
J. Biol. Chem. 270:830-836(1995).
[9]
PROTEIN SEQUENCE OF 184-197; 357-367; 375-383 AND 653-666.
PubMed=2144630; DOI=10.3181/00379727-195-43115;
Rosen E.M., Meromsky L., Setter E., Vinter D.W., Goldberg I.D.;
"Purified scatter factor stimulates epithelial and vascular endothelial
cell migration.";
Proc. Soc. Exp. Biol. Med. 195:34-43(1990).
[10]
PROTEIN SEQUENCE OF 496-519.
PubMed=2142751; DOI=10.1038/346228b0;
Gherardi E., Stoker M.;
"Hepatocytes and scatter factor.";
Nature 346:228-228(1990).
[11]
PROTEIN SEQUENCE OF 496-519.
PubMed=1831975; DOI=10.1042/bj2780035;
Coffer A., Fellows J., Young S., Pappin D., Rahman D.;
"Purification and characterization of biologically active scatter factor
from ras-transformed NIH 3T3 conditioned medium.";
Biochem. J. 278:35-41(1991).
[12]
X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 29-210, AND DISULFIDE BONDS.
PubMed=17804794; DOI=10.1073/pnas.0704290104;
Tolbert W.D., Daugherty J., Gao C., Xie Q., Miranti C., Gherardi E.,
Woude G.V., Xu H.E.;
"A mechanistic basis for converting a receptor tyrosine kinase agonist to
an antagonist.";
Proc. Natl. Acad. Sci. U.S.A. 104:14592-14597(2007).
[13]
X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 31-127, DISULFIDE BONDS, AND
FUNCTION.
PubMed=20624990; DOI=10.1073/pnas.1005183107;
Tolbert W.D., Daugherty-Holtrop J., Gherardi E., Vande Woude G., Xu H.E.;
"Structural basis for agonism and antagonism of hepatocyte growth factor.";
Proc. Natl. Acad. Sci. U.S.A. 107:13264-13269(2010).
-!- FUNCTION: Potent mitogen for mature parenchymal hepatocyte cells, seems
to be a hepatotrophic factor, and acts as a growth factor for a broad
spectrum of tissues and cell types. Activating ligand for the receptor
tyrosine kinase MET by binding to it and promoting its dimerization.
{ECO:0000269|PubMed:20624990}.
-!- SUBUNIT: Dimer of an alpha chain and a beta chain linked by a disulfide
bond. Interacts with SRPX2; the interaction increases HGF mitogenic
activity.
-!- INTERACTION:
Q08048; P08581: MET; Xeno; NbExp=3; IntAct=EBI-15655650, EBI-1039152;
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=Long;
IsoId=Q08048-1; Sequence=Displayed;
Name=Short;
IsoId=Q08048-2; Sequence=VSP_005408;
Name=NK1;
IsoId=Q08048-3; Sequence=VSP_044345, VSP_044346;
-!- SIMILARITY: Belongs to the peptidase S1 family. Plasminogen subfamily.
{ECO:0000255|PROSITE-ProRule:PRU00274}.
-!- CAUTION: Has lost two of the three essential catalytic residues and so
probably has no enzymatic activity. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=CAA51054.1; Type=Erroneous initiation; Evidence={ECO:0000305};
---------------------------------------------------------------------------
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EMBL; D10212; BAA01064.1; -; mRNA.
EMBL; D10213; BAA01065.1; -; mRNA.
EMBL; S71816; AAB31855.1; -; mRNA.
EMBL; X72307; CAA51054.1; ALT_INIT; mRNA.
EMBL; AF042856; AAC40051.1; -; mRNA.
EMBL; X84046; CAA58865.1; -; mRNA.
EMBL; CH466586; EDL03238.1; -; Genomic_DNA.
EMBL; BC119228; AAI19229.1; -; mRNA.
EMBL; X81630; CAA57286.1; -; Genomic_DNA.
CCDS; CCDS19097.1; -. [Q08048-1]
CCDS; CCDS80213.1; -. [Q08048-2]
PIR; JC2117; A60185.
RefSeq; NP_001276387.1; NM_001289458.1. [Q08048-1]
RefSeq; NP_001276388.1; NM_001289459.1. [Q08048-1]
RefSeq; NP_001276389.1; NM_001289460.2. [Q08048-3]
RefSeq; NP_001276390.1; NM_001289461.1. [Q08048-2]
RefSeq; NP_034557.3; NM_010427.5. [Q08048-1]
PDB; 2QJ4; X-ray; 2.50 A; A/B=29-210.
PDB; 3HMR; X-ray; 2.00 A; A=31-127.
PDB; 4IUA; X-ray; 3.05 A; A/B/C/D/E/F/G/H=31-290.
PDBsum; 2QJ4; -.
PDBsum; 3HMR; -.
PDBsum; 4IUA; -.
SMR; Q08048; -.
BioGRID; 200294; 1.
DIP; DIP-46456N; -.
IntAct; Q08048; 1.
STRING; 10090.ENSMUSP00000030683; -.
MEROPS; S01.982; -.
GlyGen; Q08048; 4 sites.
iPTMnet; Q08048; -.
PhosphoSitePlus; Q08048; -.
PaxDb; Q08048; -.
PRIDE; Q08048; -.
ProteomicsDB; 269786; -. [Q08048-1]
ProteomicsDB; 269787; -. [Q08048-2]
ProteomicsDB; 269788; -. [Q08048-3]
Antibodypedia; 4150; 1117 antibodies.
DNASU; 15234; -.
Ensembl; ENSMUST00000030683; ENSMUSP00000030683; ENSMUSG00000028864. [Q08048-1]
Ensembl; ENSMUST00000196645; ENSMUSP00000142517; ENSMUSG00000028864. [Q08048-2]
Ensembl; ENSMUST00000199581; ENSMUSP00000143424; ENSMUSG00000028864. [Q08048-1]
GeneID; 15234; -.
KEGG; mmu:15234; -.
UCSC; uc008wne.2; mouse. [Q08048-3]
UCSC; uc008wnf.2; mouse. [Q08048-1]
UCSC; uc008wnj.1; mouse. [Q08048-2]
CTD; 3082; -.
MGI; MGI:96079; Hgf.
VEuPathDB; HostDB:ENSMUSG00000028864; -.
eggNOG; ENOG502QR40; Eukaryota.
GeneTree; ENSGT00940000156019; -.
InParanoid; Q08048; -.
OMA; TNIPQCG; -.
PhylomeDB; Q08048; -.
TreeFam; TF329901; -.
Reactome; R-MMU-114608; Platelet degranulation.
Reactome; R-MMU-1257604; PIP3 activates AKT signaling.
Reactome; R-MMU-5673001; RAF/MAP kinase cascade.
Reactome; R-MMU-6806942; MET Receptor Activation.
Reactome; R-MMU-6807004; Negative regulation of MET activity.
Reactome; R-MMU-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
Reactome; R-MMU-8851805; MET activates RAS signaling.
Reactome; R-MMU-8851907; MET activates PI3K/AKT signaling.
Reactome; R-MMU-8865999; MET activates PTPN11.
Reactome; R-MMU-8874081; MET activates PTK2 signaling.
Reactome; R-MMU-8875513; MET interacts with TNS proteins.
Reactome; R-MMU-8875555; MET activates RAP1 and RAC1.
Reactome; R-MMU-8875656; MET receptor recycling.
Reactome; R-MMU-8875791; MET activates STAT3.
BioGRID-ORCS; 15234; 1 hit in 63 CRISPR screens.
ChiTaRS; Met; mouse.
EvolutionaryTrace; Q08048; -.
PRO; PR:Q08048; -.
Proteomes; UP000000589; Chromosome 5.
RNAct; Q08048; protein.
Bgee; ENSMUSG00000028864; Expressed in uterus and 153 other tissues.
Genevisible; Q08048; MM.
GO; GO:0005576; C:extracellular region; TAS:Reactome.
GO; GO:0005615; C:extracellular space; ISO:MGI.
GO; GO:0042056; F:chemoattractant activity; ISO:MGI.
GO; GO:0008083; F:growth factor activity; ISO:MGI.
GO; GO:0042802; F:identical protein binding; ISO:MGI.
GO; GO:0044877; F:protein-containing complex binding; ISO:MGI.
GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
GO; GO:0031100; P:animal organ regeneration; IEA:Ensembl.
GO; GO:0060326; P:cell chemotaxis; ISO:MGI.
GO; GO:0000902; P:cell morphogenesis; IDA:MGI.
GO; GO:0035729; P:cellular response to hepatocyte growth factor stimulus; ISO:MGI.
GO; GO:0050673; P:epithelial cell proliferation; IDA:MGI.
GO; GO:0048012; P:hepatocyte growth factor receptor signaling pathway; IDA:MGI.
GO; GO:0030212; P:hyaluronan metabolic process; IEA:Ensembl.
GO; GO:0001889; P:liver development; IDA:MGI.
GO; GO:0051450; P:myoblast proliferation; IDA:MGI.
GO; GO:0043066; P:negative regulation of apoptotic process; ISO:MGI.
GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; ISO:MGI.
GO; GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; IDA:MGI.
GO; GO:1901299; P:negative regulation of hydrogen peroxide-mediated programmed cell death; ISO:MGI.
GO; GO:0050728; P:negative regulation of inflammatory response; IDA:MGI.
GO; GO:0032715; P:negative regulation of interleukin-6 production; IDA:MGI.
GO; GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; IDA:MGI.
GO; GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; ISO:MGI.
GO; GO:0045766; P:positive regulation of angiogenesis; ISO:MGI.
GO; GO:0030335; P:positive regulation of cell migration; ISO:MGI.
GO; GO:2000573; P:positive regulation of DNA biosynthetic process; ISO:MGI.
GO; GO:0032733; P:positive regulation of interleukin-10 production; IDA:MGI.
GO; GO:0043410; P:positive regulation of MAPK cascade; IDA:MGI.
GO; GO:0031643; P:positive regulation of myelination; ISO:MGI.
GO; GO:0070572; P:positive regulation of neuron projection regeneration; ISO:MGI.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISO:MGI.
GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; ISO:MGI.
GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
GO; GO:0060665; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; IMP:MGI.
GO; GO:1900744; P:regulation of p38MAPK cascade; IDA:MGI.
GO; GO:1902947; P:regulation of tau-protein kinase activity; IDA:MGI.
CDD; cd00108; KR; 4.
CDD; cd00190; Tryp_SPc; 1.
Gene3D; 2.40.10.10; -; 2.
Gene3D; 2.40.20.10; -; 4.
InterPro; IPR027284; Hepatocyte_GF.
InterPro; IPR024174; HGF/MST1.
InterPro; IPR000001; Kringle.
InterPro; IPR013806; Kringle-like.
InterPro; IPR018056; Kringle_CS.
InterPro; IPR038178; Kringle_sf.
InterPro; IPR003609; Pan_app.
InterPro; IPR009003; Peptidase_S1_PA.
InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
InterPro; IPR001314; Peptidase_S1A.
InterPro; IPR001254; Trypsin_dom.
Pfam; PF00051; Kringle; 4.
Pfam; PF00024; PAN_1; 1.
Pfam; PF00089; Trypsin; 1.
PIRSF; PIRSF500183; Hepatocyte_GF; 1.
PIRSF; PIRSF001152; HGF_MST1; 1.
PRINTS; PR00722; CHYMOTRYPSIN.
SMART; SM00130; KR; 4.
SMART; SM00473; PAN_AP; 1.
SMART; SM00020; Tryp_SPc; 1.
SUPFAM; SSF50494; SSF50494; 1.
SUPFAM; SSF57440; SSF57440; 4.
PROSITE; PS00021; KRINGLE_1; 4.
PROSITE; PS50070; KRINGLE_2; 4.
PROSITE; PS50948; PAN; 1.
PROSITE; PS50240; TRYPSIN_DOM; 1.
1: Evidence at protein level;
3D-structure; Alternative splicing; Direct protein sequencing;
Disulfide bond; Glycoprotein; Growth factor; Kringle;
Pyrrolidone carboxylic acid; Reference proteome; Repeat;
Serine protease homolog; Signal.
SIGNAL 1..32
/evidence="ECO:0000250"
CHAIN 33..495
/note="Hepatocyte growth factor alpha chain"
/id="PRO_0000028093"
CHAIN 496..728
/note="Hepatocyte growth factor beta chain"
/id="PRO_0000028094"
DOMAIN 38..124
/note="PAN"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00315"
DOMAIN 129..207
/note="Kringle 1"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00121"
DOMAIN 212..289
/note="Kringle 2"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00121"
DOMAIN 306..384
/note="Kringle 3"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00121"
DOMAIN 392..470
/note="Kringle 4"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00121"
DOMAIN 496..724
/note="Peptidase S1"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
MOD_RES 33
/note="Pyrrolidone carboxylic acid"
/evidence="ECO:0000250|UniProtKB:P14210"
CARBOHYD 295
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 403
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 569
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 656
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 71..97
DISULFID 75..85
DISULFID 129..207
DISULFID 150..190
DISULFID 178..202
DISULFID 212..289
/evidence="ECO:0000250"
DISULFID 233..272
/evidence="ECO:0000250"
DISULFID 261..284
/evidence="ECO:0000250"
DISULFID 306..384
/evidence="ECO:0000250"
DISULFID 327..366
/evidence="ECO:0000250"
DISULFID 355..378
/evidence="ECO:0000250"
DISULFID 392..470
/evidence="ECO:0000250"
DISULFID 413..453
/evidence="ECO:0000250"
DISULFID 441..465
/evidence="ECO:0000250"
DISULFID 488..607
/note="Interchain (between alpha and beta chains)"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00121,
ECO:0000255|PROSITE-ProRule:PRU00274, ECO:0000255|PROSITE-
ProRule:PRU00315"
DISULFID 520..536
/evidence="ECO:0000250"
DISULFID 615..682
/evidence="ECO:0000250"
DISULFID 645..661
/evidence="ECO:0000250"
DISULFID 672..700
/evidence="ECO:0000250"
VAR_SEQ 163..167
/note="Missing (in isoform Short)"
/evidence="ECO:0000303|PubMed:8135822"
/id="VSP_005408"
VAR_SEQ 210..211
/note="VE -> GK (in isoform NK1)"
/evidence="ECO:0000303|PubMed:9488442"
/id="VSP_044345"
VAR_SEQ 212..728
/note="Missing (in isoform NK1)"
/evidence="ECO:0000303|PubMed:9488442"
/id="VSP_044346"
CONFLICT 189
/note="W -> K (in Ref. 9; AA sequence)"
/evidence="ECO:0000305"
CONFLICT 344
/note="N -> K (in Ref. 2; AAB31855)"
/evidence="ECO:0000305"
CONFLICT 378
/note="C -> E (in Ref. 9; AA sequence)"
/evidence="ECO:0000305"
CONFLICT 380
/note="Q -> E (in Ref. 9; AA sequence)"
/evidence="ECO:0000305"
CONFLICT 479
/note="V -> L (in Ref. 2; AAB31855)"
/evidence="ECO:0000305"
CONFLICT 513
/note="K -> L (in Ref. 10; AA sequence)"
/evidence="ECO:0000305"
CONFLICT 518
/note="H -> T (in Ref. 11; AA sequence)"
/evidence="ECO:0000305"
CONFLICT 564
/note="R -> H (in Ref. 3; CAA51054)"
/evidence="ECO:0000305"
HELIX 40..42
/evidence="ECO:0007829|PDB:3HMR"
STRAND 43..52
/evidence="ECO:0007829|PDB:3HMR"
STRAND 55..57
/evidence="ECO:0007829|PDB:4IUA"
STRAND 61..64
/evidence="ECO:0007829|PDB:3HMR"
HELIX 68..77
/evidence="ECO:0007829|PDB:3HMR"
TURN 78..80
/evidence="ECO:0007829|PDB:3HMR"
STRAND 87..91
/evidence="ECO:0007829|PDB:3HMR"
TURN 92..95
/evidence="ECO:0007829|PDB:3HMR"
STRAND 96..101
/evidence="ECO:0007829|PDB:3HMR"
STRAND 106..108
/evidence="ECO:0007829|PDB:2QJ4"
STRAND 110..122
/evidence="ECO:0007829|PDB:3HMR"
HELIX 123..125
/evidence="ECO:0007829|PDB:3HMR"
STRAND 129..133
/evidence="ECO:0007829|PDB:2QJ4"
STRAND 149..151
/evidence="ECO:0007829|PDB:2QJ4"
STRAND 157..159
/evidence="ECO:0007829|PDB:2QJ4"
TURN 165..167
/evidence="ECO:0007829|PDB:2QJ4"
STRAND 188..194
/evidence="ECO:0007829|PDB:2QJ4"
STRAND 198..201
/evidence="ECO:0007829|PDB:2QJ4"
TURN 207..209
/evidence="ECO:0007829|PDB:4IUA"
STRAND 240..242
/evidence="ECO:0007829|PDB:4IUA"
HELIX 248..250
/evidence="ECO:0007829|PDB:4IUA"
TURN 252..255
/evidence="ECO:0007829|PDB:4IUA"
STRAND 271..275
/evidence="ECO:0007829|PDB:4IUA"
STRAND 280..283
/evidence="ECO:0007829|PDB:4IUA"
SEQUENCE 728 AA; 82945 MW; A0381FC497534328 CRC64;
MMWGTKLLPV LLLQHVLLHL LLLHVAIPYA EGQKKRRNTL HEFKKSAKTT LTKEDPLLKI
KTKKVNSADE CANRCIRNRG FTFTCKAFVF DKSRKRCYWY PFNSMSSGVK KGFGHEFDLY
ENKDYIRNCI IGKGGSYKGT VSITKSGIKC QPWNSMIPHE HSFLPSSYRG KDLQENYCRN
PRGEEGGPWC FTSNPEVRYE VCDIPQCSEV ECMTCNGESY RGPMDHTESG KTCQRWDQQT
PHRHKFLPER YPDKGFDDNY CRNPDGKPRP WCYTLDPDTP WEYCAIKTCA HSAVNETDVP
METTECIQGQ GEGYRGTSNT IWNGIPCQRW DSQYPHKHDI TPENFKCKDL RENYCRNPDG
AESPWCFTTD PNIRVGYCSQ IPKCDVSSGQ DCYRGNGKNY MGNLSKTRSG LTCSMWDKNM
EDLHRHIFWE PDASKLNKNY CRNPDDDAHG PWCYTGNPLI PWDYCPISRC EGDTTPTIVN
LDHPVISCAK TKQLRVVNGI PTQTTVGWMV SLKYRNKHIC GGSLIKESWV LTARQCFPAR
NKDLKDYEAW LGIHDVHERG EEKRKQILNI SQLVYGPEGS DLVLLKLARP AILDNFVSTI
DLPSYGCTIP EKTTCSIYGW GYTGLINADG LLRVAHLYIM GNEKCSQHHQ GKVTLNESEL
CAGAEKIGSG PCEGDYGGPL ICEQHKMRMV LGVIVPGRGC AIPNRPGIFV RVAYYAKWIH
KVILTYKL


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BMDV10160 Hepatocyte Growth Factor (HGF), Scatter Factor (SF), Hepatopoietin A, 82kD, Clone 4C12.1, Mab anti_Human 0.5 ml.
E0047h ELISA Hepatocyte growth factor,Hepatopoietin-A,HGF,Homo sapiens,HPTA,Human,Scatter factor,SF 96T
U0047h CLIA Hepatocyte growth factor,Hepatopoietin-A,HGF,Homo sapiens,HPTA,Human,Scatter factor,SF 96T
E0047h ELISA kit Hepatocyte growth factor,Hepatopoietin-A,HGF,Homo sapiens,HPTA,Human,Scatter factor,SF 96T
E0047c ELISA Canis familiaris,Canis lupus familiaris,Dog,Hepatocyte growth factor,Hepatopoietin-A,HGF,Scatter factor,SF 96T
E0047c ELISA kit Canis familiaris,Canis lupus familiaris,Dog,Hepatocyte growth factor,Hepatopoietin-A,HGF,Scatter factor,SF 96T
U0047c CLIA Canis familiaris,Canis lupus familiaris,Dog,Hepatocyte growth factor,Hepatopoietin-A,HGF,Scatter factor,SF 96T
MOS55 Mouse hepatocyte growth factor,HGF per Hepapoietin A per Scatter Factor ELISA kit 96T
BH0001 Bovine hepatocyte growth factor,HGF per Hepapoietin A per Scatter Factor ELISA kit 96T
MH001 Monkey hepatocyte growth factor,HGF per Hepapoietin A per Scatter Factor ELISA kit 96T
E1385097 Fish Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF) ELISA Kit
HH0220 Human hepatocyte growth factor,HGF per Hepapoietin A per Scatter Factor ELISA kit 96T
EH001 Equine hepatocyte growth factor,HGF per Hepapoietin A per Scatter Factor ELISA kit 96T
10-663-45113 Hepatocyte Growth Factor (HGF) Human - Scatter factor; SF; Hepatopoeitin A N_A 0.01 mg
10-663-45113 Hepatocyte Growth Factor (HGF) Human - Scatter factor; SF; Hepatopoeitin A N_A 1 mg
10-663-45113 Hepatocyte Growth Factor (HGF) Human - Scatter factor; SF; Hepatopoeitin A N_A 0.002 mg
Pathways :
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP1983: Splicing factor NOVA regulated synpatic proteins
WP1614: 1- and 2-Methylnaphthalene degradation
WP272: Blood Clotting Cascade
WP2148: Brain derived neurotrophic factor
WP1270: Endochondral Ossification
WP2256: Integrated Pancreatic Cancer Pathway
WP1065: Endochondral Ossification
WP2377: Integrated Pancreatic Cancer Pathway
WP947: Endochondral Ossification
WP1308: Endochondral Ossification
WP1866: NCAM signaling for neurite out-growth
WP828: Endochondral Ossification
WP542: Electron Transport Chain

Related Genes :
[HGF HPTA] Hepatocyte growth factor (Hepatopoietin-A) (Scatter factor) (SF) [Cleaved into: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain]
[MST1 D3F15S2 DNF15S2 HGFL] Hepatocyte growth factor-like protein (Macrophage stimulatory protein) (Macrophage-stimulating protein) (MSP) [Cleaved into: Hepatocyte growth factor-like protein alpha chain; Hepatocyte growth factor-like protein beta chain]
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[Met] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[Met] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)

Bibliography :
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