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Hepatocyte growth factor (Hepatopoietin-A) (Scatter factor) (SF) [Cleaved into: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain]

 HGF_CANLF               Reviewed;         730 AA.
Q867B7;
06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
01-JUN-2003, sequence version 1.
13-FEB-2019, entry version 101.
RecName: Full=Hepatocyte growth factor;
AltName: Full=Hepatopoietin-A;
AltName: Full=Scatter factor;
Short=SF;
Contains:
RecName: Full=Hepatocyte growth factor alpha chain;
Contains:
RecName: Full=Hepatocyte growth factor beta chain;
Flags: Precursor;
Name=HGF;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Beagle;
PubMed=12963274; DOI=10.1016/S0165-2427(03)00118-1;
Miyake M., Saze K., Yaguchi T., Wang J., Suzuta Y., Haga Y.,
Takahashi S.Y., Yamamoto Y., Iwabuchi S.;
"Canine hepatocyte growth factor: molecular cloning and
characterization of the recombinant protein.";
Vet. Immunol. Immunopathol. 95:135-143(2003).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
Liao A.T., Chien M.B., London C.A.;
"Characterization of the receptor tyrosine kinase Met and its
autocrine loop in canine osteosarcoma cell lines.";
Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Potent mitogen for mature parenchymal hepatocyte cells,
seems to be a hepatotrophic factor, and acts as a growth factor
for a broad spectrum of tissues and cell types. Activating ligand
for the receptor tyrosine kinase MET by binding to it and
promoting its dimerization (By similarity). {ECO:0000250}.
-!- SUBUNIT: Dimer of an alpha chain and a beta chain linked by a
disulfide bond. Interacts with SRPX2; the interaction increases
HGF mitogenic activity (By similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the peptidase S1 family. Plasminogen
subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}.
-!- CAUTION: Has lost two of the three essential catalytic residues
and so probably has no enzymatic activity. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AB090353; BAC57560.1; -; mRNA.
EMBL; AY543632; AAS48570.1; -; mRNA.
RefSeq; NP_001002964.1; NM_001002964.1.
UniGene; Cfa.3443; -.
ProteinModelPortal; Q867B7; -.
SMR; Q867B7; -.
STRING; 9615.ENSCAFP00000009539; -.
MEROPS; S01.976; -.
PaxDb; Q867B7; -.
PRIDE; Q867B7; -.
Ensembl; ENSCAFT00000010288; ENSCAFP00000009539; ENSCAFG00000006370.
GeneID; 403441; -.
KEGG; cfa:403441; -.
CTD; 3082; -.
VGNC; VGNC:41674; HGF.
eggNOG; ENOG410IDXR; Eukaryota.
eggNOG; COG5640; LUCA.
GeneTree; ENSGT00940000156019; -.
HOVERGEN; HBG004381; -.
InParanoid; Q867B7; -.
KO; K05460; -.
OMA; YCAIKMC; -.
OrthoDB; 164039at2759; -.
TreeFam; TF329901; -.
Reactome; R-CFA-114608; Platelet degranulation.
Reactome; R-CFA-1257604; PIP3 activates AKT signaling.
Reactome; R-CFA-5673001; RAF/MAP kinase cascade.
Reactome; R-CFA-6806942; MET Receptor Activation.
Reactome; R-CFA-6807004; Negative regulation of MET activity.
Reactome; R-CFA-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
Reactome; R-CFA-8851805; MET activates RAS signaling.
Reactome; R-CFA-8851907; MET activates PI3K/AKT signaling.
Reactome; R-CFA-8865999; MET activates PTPN11.
Reactome; R-CFA-8874081; MET activates PTK2 signaling.
Reactome; R-CFA-8875513; MET interacts with TNS proteins.
Reactome; R-CFA-8875555; MET activates RAP1 and RAC1.
Reactome; R-CFA-8875656; MET receptor recycling.
Reactome; R-CFA-8875791; MET activates STAT3.
Proteomes; UP000002254; Chromosome 18.
Bgee; ENSCAFG00000006370; Expressed in 3 organ(s), highest expression level in liver.
GO; GO:0042056; F:chemoattractant activity; IEA:Ensembl.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
GO; GO:0060326; P:cell chemotaxis; IEA:Ensembl.
GO; GO:0000902; P:cell morphogenesis; IEA:Ensembl.
GO; GO:0035729; P:cellular response to hepatocyte growth factor stimulus; IBA:GO_Central.
GO; GO:0048012; P:hepatocyte growth factor receptor signaling pathway; IBA:GO_Central.
GO; GO:0001889; P:liver development; IEA:Ensembl.
GO; GO:0051450; P:myoblast proliferation; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Ensembl.
GO; GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
GO; GO:1901299; P:negative regulation of hydrogen peroxide-mediated programmed cell death; IEA:Ensembl.
GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
GO; GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; IEA:Ensembl.
GO; GO:0030335; P:positive regulation of cell migration; IBA:GO_Central.
GO; GO:2000573; P:positive regulation of DNA biosynthetic process; IEA:Ensembl.
GO; GO:0032733; P:positive regulation of interleukin-10 production; IEA:Ensembl.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IEA:Ensembl.
GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
GO; GO:0060665; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; IEA:Ensembl.
GO; GO:1900744; P:regulation of p38MAPK cascade; IEA:Ensembl.
GO; GO:1902947; P:regulation of tau-protein kinase activity; IEA:Ensembl.
CDD; cd00108; KR; 4.
CDD; cd00190; Tryp_SPc; 1.
Gene3D; 2.40.20.10; -; 4.
InterPro; IPR027284; Hepatocyte_GF.
InterPro; IPR024174; HGF-like.
InterPro; IPR000001; Kringle.
InterPro; IPR013806; Kringle-like.
InterPro; IPR018056; Kringle_CS.
InterPro; IPR038178; Kringle_sf.
InterPro; IPR003609; Pan_app.
InterPro; IPR009003; Peptidase_S1_PA.
InterPro; IPR001314; Peptidase_S1A.
InterPro; IPR001254; Trypsin_dom.
Pfam; PF00051; Kringle; 4.
Pfam; PF00024; PAN_1; 1.
Pfam; PF00089; Trypsin; 1.
PIRSF; PIRSF500183; Hepatocyte_GF; 1.
PIRSF; PIRSF001152; HGF_MST1; 1.
PRINTS; PR00722; CHYMOTRYPSIN.
SMART; SM00130; KR; 4.
SMART; SM00473; PAN_AP; 1.
SMART; SM00020; Tryp_SPc; 1.
SUPFAM; SSF50494; SSF50494; 1.
SUPFAM; SSF57440; SSF57440; 4.
PROSITE; PS00021; KRINGLE_1; 4.
PROSITE; PS50070; KRINGLE_2; 4.
PROSITE; PS50948; PAN; 1.
PROSITE; PS50240; TRYPSIN_DOM; 1.
2: Evidence at transcript level;
Complete proteome; Disulfide bond; Glycoprotein; Growth factor;
Kringle; Pyrrolidone carboxylic acid; Reference proteome; Repeat;
Serine protease homolog; Signal.
SIGNAL 1 31 {ECO:0000250}.
CHAIN 32 494 Hepatocyte growth factor alpha chain.
/FTId=PRO_0000274199.
CHAIN 495 730 Hepatocyte growth factor beta chain.
/FTId=PRO_0000274200.
DOMAIN 37 123 PAN. {ECO:0000255|PROSITE-
ProRule:PRU00315}.
DOMAIN 128 206 Kringle 1. {ECO:0000255|PROSITE-
ProRule:PRU00121}.
DOMAIN 211 288 Kringle 2. {ECO:0000255|PROSITE-
ProRule:PRU00121}.
DOMAIN 305 383 Kringle 3. {ECO:0000255|PROSITE-
ProRule:PRU00121}.
DOMAIN 391 469 Kringle 4. {ECO:0000255|PROSITE-
ProRule:PRU00121}.
DOMAIN 495 723 Peptidase S1. {ECO:0000255|PROSITE-
ProRule:PRU00274}.
MOD_RES 32 32 Pyrrolidone carboxylic acid.
{ECO:0000250|UniProtKB:P14210}.
CARBOHYD 294 294 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 402 402 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 568 568 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 655 655 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 70 96 {ECO:0000250}.
DISULFID 74 84 {ECO:0000250}.
DISULFID 128 206 {ECO:0000250}.
DISULFID 149 189 {ECO:0000250}.
DISULFID 177 201 {ECO:0000250}.
DISULFID 211 288 {ECO:0000250}.
DISULFID 232 271 {ECO:0000250}.
DISULFID 260 283 {ECO:0000250}.
DISULFID 305 383 {ECO:0000250}.
DISULFID 326 365 {ECO:0000250}.
DISULFID 354 377 {ECO:0000250}.
DISULFID 391 469 {ECO:0000250}.
DISULFID 412 452 {ECO:0000250}.
DISULFID 440 464 {ECO:0000250}.
DISULFID 487 606 Interchain (between alpha and beta
chains). {ECO:0000255|PROSITE-
ProRule:PRU00121, ECO:0000255|PROSITE-
ProRule:PRU00274, ECO:0000255|PROSITE-
ProRule:PRU00315}.
DISULFID 519 535 {ECO:0000250}.
DISULFID 614 681 {ECO:0000250}.
DISULFID 644 660 {ECO:0000250}.
DISULFID 671 699 {ECO:0000250}.
SEQUENCE 730 AA; 83398 MW; 4E83F9EA8BFF6DB1 CRC64;
MWVTKLLPLL VLQQLLLHLL LLPVAVPRAE GQKKRRNTLH EFKKSAKTTL IKEDPLLKIK
TKKMNTADQC ANRCIRNKGL PFTCKAFVFD KARKRCLWFP FNSMTSGVKK EFGHEFDLYE
NKDYIRNCII GKGGSYKGTV SITKSGIKCQ PWNSMIPHEH SFLPSSYRGK DLQENYCRNP
RGEEGGPWCF TSNPEVRYEV CDIPQCSEVE CMTCNGESYR GPMDHTESGK ICQRWDHQTP
HRHKFLPERY PDKGFDDNYC RNPDGKPRPW CYTLDPDTPW EYCAIKMCAH STMNDTDVPM
ETTECIQGQG EGYRGTINTI WNGVPCQRWD SQYPHQHDIT PENFKCKDLR ENYCRNPDGA
ESPWCFTTDP NIRVGYCSQI PKCDVSSGQD CYRGNGKNYM GNLSKTRSGL TCSMWEKNME
DLHRHIFWEP DASKLNKNYC RNPDDDAHGP WCYTGNPLIP WDYCPIFRCE GDTTPTIVNL
DHPVISCAKT KQLRVVNGIP TRTNVGWMVS LKYRNKHICG GSLIKESWIL TARQCFPSRN
RDLKDYEAWL GIHDVHGKGD EKRKQVLNVS QLVYGPEGSD LVLLKLARPA ILDDFVSTID
LPNYGCTIPE KTTCSVYGWG YTGSINFDGL LRVAHLYIMG NEKCSQYHQG KVTLNESEIC
AGAENIVSGP CEGDYGGPLV CEQHKMRMVL GVIVPGRGCA IPNRPGIFVR VAYYAKWIHK
IILTYKIQQS


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