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Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)

 MET_BOVIN               Reviewed;        1384 AA.
Q769I5; A4D7R6;
06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 1.
29-SEP-2021, entry version 119.
RecName: Full=Hepatocyte growth factor receptor;
Short=HGF receptor;
EC=2.7.10.1;
AltName: Full=HGF/SF receptor;
AltName: Full=Proto-oncogene c-Met;
AltName: Full=Scatter factor receptor;
Short=SF receptor;
AltName: Full=Tyrosine-protein kinase Met;
Flags: Precursor;
Name=MET;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
DEVELOPMENTAL STAGE.
PubMed=16207523; DOI=10.1016/j.domaniend.2005.08.005;
Yamaji D., Kimura K., Watanabe A., Kon Y., Iwanaga T., Soliman M.M.,
Ahmed M.M., Saito M.;
"Bovine hepatocyte growth factor and its receptor c-Met: cDNA cloning and
expression analysis in the mammary gland.";
Domest. Anim. Endocrinol. 30:239-246(2006).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=12917688; DOI=10.1038/nature01858;
Thomas J.W., Touchman J.W., Blakesley R.W., Bouffard G.G.,
Beckstrom-Sternberg S.M., Margulies E.H., Blanchette M., Siepel A.C.,
Thomas P.J., McDowell J.C., Maskeri B., Hansen N.F., Schwartz M.S.,
Weber R.J., Kent W.J., Karolchik D., Bruen T.C., Bevan R., Cutler D.J.,
Schwartz S., Elnitski L., Idol J.R., Prasad A.B., Lee-Lin S.-Q.,
Maduro V.V.B., Summers T.J., Portnoy M.E., Dietrich N.L., Akhter N.,
Ayele K., Benjamin B., Cariaga K., Brinkley C.P., Brooks S.Y., Granite S.,
Guan X., Gupta J., Haghighi P., Ho S.-L., Huang M.C., Karlins E.,
Laric P.L., Legaspi R., Lim M.J., Maduro Q.L., Masiello C.A.,
Mastrian S.D., McCloskey J.C., Pearson R., Stantripop S., Tiongson E.E.,
Tran J.T., Tsurgeon C., Vogt J.L., Walker M.A., Wetherby K.D.,
Wiggins L.S., Young A.C., Zhang L.-H., Osoegawa K., Zhu B., Zhao B.,
Shu C.L., De Jong P.J., Lawrence C.E., Smit A.F., Chakravarti A.,
Haussler D., Green P., Miller W., Green E.D.;
"Comparative analyses of multi-species sequences from targeted genomic
regions.";
Nature 424:788-793(2003).
-!- FUNCTION: Receptor tyrosine kinase that transduces signals from the
extracellular matrix into the cytoplasm by binding to hepatocyte growth
factor/HGF ligand. Regulates many physiological processes including
proliferation, scattering, morphogenesis and survival. Ligand binding
at the cell surface induces autophosphorylation of MET on its
intracellular domain that provides docking sites for downstream
signaling molecules. Following activation by ligand, interacts with the
PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1.
Recruitment of these downstream effectors by MET leads to the
activation of several signaling cascades including the RAS-ERK, PI3
kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with
the morphogenetic effects while PI3K/AKT coordinates prosurvival
effects. During embryonic development, MET signaling plays a role in
gastrulation, development and migration of muscles and neuronal
precursors, angiogenesis and kidney formation. In adults, participates
in wound healing as well as organ regeneration and tissue remodeling.
Promotes also differentiation and proliferation of hematopoietic cells
(By similarity). {ECO:0000250}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
Evidence={ECO:0000255|PROSITE-ProRule:PRU10028};
-!- ACTIVITY REGULATION: In its inactive state, the C-terminal tail
interacts with the catalytic domain and inhibits the kinase activity.
Upon ligand binding, the C-terminal tail is displaced and becomes
phosphorylated, thus increasing the kinase activity (By similarity).
{ECO:0000250}.
-!- SUBUNIT: Heterodimer made of an alpha chain (50 kDa) and a beta chain
(145 kDa) which are disulfide linked. Binds PLXNB1. Interacts when
phosphorylated with downstream effectors including STAT3, PIK3R1, SRC,
PCLG1, GRB2 and GAB1. Interacts with SPSB1, SPSB2 and SPSB4. Interacts
with INPP5D/SHIP1. When phosphorylated at Tyr-1357, interacts with
INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1,
SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the
absence of HGF, however HGF treatment has a positive effect on this
interaction. Interacts with MUC20; prevents interaction with GRB2 and
suppresses hepatocyte growth factor-induced cell proliferation.
Interacts with GRB10. Interacts with PTPN1 and PTPN2. Interacts with
HSP90AA1 and HSP90AB1; the interaction suppresses MET kinase activity.
{ECO:0000250|UniProtKB:P08581, ECO:0000250|UniProtKB:P16056}.
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:16207523}; Single-
pass type I membrane protein {ECO:0000269|PubMed:16207523}.
-!- TISSUE SPECIFICITY: Expressed in many tissues, including liver, lung,
heart, spleen and mammary gland. {ECO:0000269|PubMed:16207523}.
-!- DEVELOPMENTAL STAGE: In the mammary gland, at the mRNA level, expressed
in the inactive and involuting stages, but not in the developing, nor
lactating stages. However, at the protein level, detected on epithelial
cells in the inactive, developing and involuting stages, but not in the
lactating stage, and at all stages on myoepithelial cells, while it is
not found on adipocytes and fibroblasts. {ECO:0000269|PubMed:16207523}.
-!- DOMAIN: The kinase domain is involved in SPSB1 binding. {ECO:0000250}.
-!- DOMAIN: The beta-propeller Sema domain mediates binding to HGF.
{ECO:0000250}.
-!- PTM: Autophosphorylated in response to ligand binding on Tyr-1235 and
Tyr-1236 in the kinase domain leading to further phosphorylation of
Tyr-1350 and Tyr-1357 in the C-terminal multifunctional docking site.
Dephosphorylated by PTPRJ at Tyr-1350 and Tyr-1366. Dephosphorylated by
PTPN1 and PTPN2 (By similarity). {ECO:0000250}.
-!- PTM: Ubiquitinated. Ubiquitination by CBL regulates the receptor
stability and activity through proteasomal degradation (By similarity).
{ECO:0000250}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
---------------------------------------------------------------------------
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EMBL; AB112434; BAD05055.1; -; mRNA.
EMBL; DP000008; AAR16257.1; -; Genomic_DNA.
RefSeq; NP_001013017.2; NM_001012999.2.
SMR; Q769I5; -.
STRING; 9913.ENSBTAP00000008102; -.
PaxDb; Q769I5; -.
PRIDE; Q769I5; -.
GeneID; 280855; -.
KEGG; bta:280855; -.
CTD; 4233; -.
eggNOG; KOG1095; Eukaryota.
eggNOG; KOG3610; Eukaryota.
InParanoid; Q769I5; -.
OrthoDB; 408584at2759; -.
TreeFam; TF317402; -.
Proteomes; UP000009136; Unplaced.
GO; GO:0009925; C:basal plasma membrane; IBA:GO_Central.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0043235; C:receptor complex; IBA:GO_Central.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0005008; F:hepatocyte growth factor-activated receptor activity; IBA:GO_Central.
GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IBA:GO_Central.
GO; GO:0016477; P:cell migration; IBA:GO_Central.
GO; GO:0001889; P:liver development; IBA:GO_Central.
GO; GO:0007399; P:nervous system development; IBA:GO_Central.
GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
GO; GO:0031016; P:pancreas development; IBA:GO_Central.
GO; GO:0006909; P:phagocytosis; IBA:GO_Central.
GO; GO:0050918; P:positive chemotaxis; ISS:UniProtKB.
GO; GO:2001028; P:positive regulation of endothelial cell chemotaxis; ISS:UniProtKB.
GO; GO:0033674; P:positive regulation of kinase activity; IBA:GO_Central.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; IBA:GO_Central.
GO; GO:0071526; P:semaphorin-plexin signaling pathway; ISS:UniProtKB.
GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
Gene3D; 2.130.10.10; -; 1.
Gene3D; 2.60.40.10; -; 2.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR014756; Ig_E-set.
InterPro; IPR002909; IPT_dom.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR031148; Plexin.
InterPro; IPR002165; Plexin_repeat.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR016201; PSI.
InterPro; IPR001627; Semap_dom.
InterPro; IPR036352; Semap_dom_sf.
InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
InterPro; IPR008266; Tyr_kinase_AS.
InterPro; IPR020635; Tyr_kinase_cat_dom.
InterPro; IPR016244; Tyr_kinase_HGF/MSP_rcpt.
InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
PANTHER; PTHR22625; PTHR22625; 1.
Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
Pfam; PF01437; PSI; 1.
Pfam; PF01403; Sema; 1.
Pfam; PF01833; TIG; 3.
PIRSF; PIRSF000617; TyrPK_HGF-R; 1.
PRINTS; PR00109; TYRKINASE.
SMART; SM00429; IPT; 4.
SMART; SM00423; PSI; 1.
SMART; SM00630; Sema; 1.
SMART; SM00219; TyrKc; 1.
SUPFAM; SSF101912; SSF101912; 1.
SUPFAM; SSF56112; SSF56112; 1.
SUPFAM; SSF81296; SSF81296; 3.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PROSITE; PS51004; SEMA; 1.
2: Evidence at transcript level;
ATP-binding; Disulfide bond; Glycoprotein; Kinase; Membrane;
Nucleotide-binding; Phosphoprotein; Proto-oncogene; Receptor;
Reference proteome; Repeat; Signal; Transferase; Transmembrane;
Transmembrane helix; Tyrosine-protein kinase; Ubl conjugation.
SIGNAL 1..24
/evidence="ECO:0000255"
CHAIN 25..1384
/note="Hepatocyte growth factor receptor"
/id="PRO_0000274195"
TOPO_DOM 25..933
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 934..956
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 957..1384
/note="Cytoplasmic"
/evidence="ECO:0000255"
DOMAIN 27..516
/note="Sema"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
DOMAIN 564..656
/note="IPT/TIG 1"
DOMAIN 658..740
/note="IPT/TIG 2"
DOMAIN 743..837
/note="IPT/TIG 3"
DOMAIN 1079..1346
/note="Protein kinase"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
NP_BIND 1085..1093
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
REGION 1213..1382
/note="Interaction with RANBP9"
/evidence="ECO:0000250"
REGION 1321..1360
/note="Interaction with MUC20"
/evidence="ECO:0000250"
ACT_SITE 1205
/note="Proton acceptor"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
ECO:0000255|PROSITE-ProRule:PRU10028"
BINDING 1111
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SITE 308..309
/note="Cleavage"
/evidence="ECO:0000255"
MOD_RES 967
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P08581"
MOD_RES 978
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:P08581"
MOD_RES 991
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P08581"
MOD_RES 998
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P08581"
MOD_RES 1001
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P08581"
MOD_RES 1004
/note="Phosphotyrosine"
/evidence="ECO:0000250|UniProtKB:P08581"
MOD_RES 1231
/note="Phosphotyrosine"
/evidence="ECO:0000250|UniProtKB:P08581"
MOD_RES 1235
/note="Phosphotyrosine; by autocatalysis"
/evidence="ECO:0000250|UniProtKB:P08581"
MOD_RES 1236
/note="Phosphotyrosine; by autocatalysis"
/evidence="ECO:0000250|UniProtKB:P08581"
MOD_RES 1290
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:P08581"
MOD_RES 1350
/note="Phosphotyrosine; by autocatalysis"
/evidence="ECO:0000250|UniProtKB:P08581"
MOD_RES 1357
/note="Phosphotyrosine; by autocatalysis"
/evidence="ECO:0000250|UniProtKB:P08581"
MOD_RES 1366
/note="Phosphotyrosine"
/evidence="ECO:0000250|UniProtKB:P08581"
CARBOHYD 45
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 106
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 149
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 203
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 359
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 400
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 406
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 608
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 636
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 786
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 880
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 931
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 95..101
/evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
DISULFID 98..160
/evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
DISULFID 133..141
/evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
DISULFID 173..176
/evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
DISULFID 299..364
/evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
DISULFID 386..398
/evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
DISULFID 521..539
/evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
DISULFID 527..562
/evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
DISULFID 530..546
/evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
DISULFID 542..552
/evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
CONFLICT 1052
/note="I -> V (in Ref. 2; AAR16257)"
/evidence="ECO:0000305"
SEQUENCE 1384 AA; 154814 MW; 3DCCC95949264A26 CRC64;
MKAPAVLAPG ILVLLFTFVQ KSNGECKEAL VKSRMNVNMQ YQLPNFTAET SIQNVVLHKH
HIYLGAINYI YVLNDKDLQK VAEYKTGPVL EHPDCFPCQD CSHKANLSGG VWKDNINMAL
LVDTYYDDQL ISCGSVHRGT CQRHVLPPNN TADIESEVHC MYSPQADEET NQCPDCVVSA
LGTKVLLSEK DRFINFFVGN TINSSYLPDY ILHSISVRRL KETQDGFKFL TDQSYIDVLP
ELRDSYPIKY VHAFESNHFI YFLTVQRETL DAQTFHTRII RFCSADSGLH SYMEMPLECI
LTEKRRKRST KQEVFNILQA AYVSKPGAQL ARQIGASLND DILYGVFAQS KPDSSEPMNR
SAVCAFPVKY VNEFFNKIVN KNNVRCLQHF YGPNHEHCFN RTLLRNSSGC EVRNDEYRTE
FTTALPRVDL FTGQFNQVLL TSISTFIKGD LTIANLGTSE GRFMQVVVSR SGSLTPHVNF
HLDSHPVSPE VIVEHPLNQN GYTLVVTGKK ITKIPLNGLG CEHFQSCSQC LSAPSFVQCG
WCHDKCVRLE ECSSGTWTQE TCLPTIYKVF PTSAPLEGGT TLTVCGWDFG FKRNNKFDLK
KTRVLLGNES CTLTLTESTT NMLKCTVGPA MNEHFNMSIV ISNSRGSVEY SAFSYVDPII
TSISPNYGPK TGGTLLTLTG KHLNSGNSRH ISIGGKTCTL KSVSHSILEC YTPAQSAPTE
FSVKLKIDLA NREVNSFIYR EDPIVYEIHP TKSFISGGST ITGVGKNLNS VSVLRMVINV
HEAGRNFTVA CQHRSNSEII CCTTPSIEQL NLQLPLKTKA FFMLDGIHSK YFDLIYVHNP
VFKPFEKPVM ISVGNENVLE IKGNDIDPEA VKGEVLKVGN KSCENIHSHS EAVLCTVPSD
LLKLNSELNI EWKQAISSTV LGKVIVQPDQ NFTGLIVGVV SISIILLLLL GLFLWLKKRK
QIKDLGSELV RYDARVHTPH LDRLVSARSV SPTTEMVSNE SVDYRATFPE DQFPNASQNG
SCRQVQYPLT DLSPILTSGD SDISSPLLQN TIHIDLSALN PELVQAVQHV VIGPSSLIVH
FNEVIGRGHF GCVYHGTLLD NDDKKIHCAV KSLNRITDIG EVSQFLTEGI IMKDFSHPNV
LSLLGICLRS EGSPLVVLPY MKHGDLRNFI RNETHNPTVK DLIGFGLQVA KGMEYLASKK
FVHRDLAARN CMLDEKFTVK VADFGLARDV YDKEYYSVHN KTGAKLPVKW MALESLQTQK
FTTKSDVWSF GVLLWELMTR GAPPYPDVNT FDITVYLLQG RRLLQPEYCP DPLYEVMLKC
WHPKAELRPS FSELVSRISV IFSTFIGEHY VHVNATYVNV KCVAPYPSLL SSQDNVSGED
DDDT


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E0147m ELISA kit Embryonic receptor kinase 2,Emrk2,Flt,Flt1,FLT-1,Fms-like tyrosine kinase 1,Mouse,Mus musculus,Tyrosine-protein kinase receptor FLT,Vascular endothelial growth factor receptor 1,VEGFR-1 96T
18-783-75623 RABBIT ANTI HUMAN EGF RECEPTOR - EPIDERMAL GROWTH FACTOR RECEPTOR; EC 2.7.10.1; Receptor tyrosine-protein kinase ErbB-1 Polyclonal 0.05 mg
15-288-21181 Vascular endothelial growth factor receptor 2 - EC 2.7.10.1; VEGFR-2; Kinase insert domain receptor; Protein-tyrosine kinase receptor Flk-1; CD309 antigen Polyclonal 0.1 mg
15-288-21181 Vascular endothelial growth factor receptor 2 - EC 2.7.10.1; VEGFR-2; Kinase insert domain receptor; Protein-tyrosine kinase receptor Flk-1; CD309 antigen Polyclonal 0.05 mg
Pathways :
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP2292: Chemokine signaling pathway
WP2272: Pathogenic Escherichia coli infection
WP474: Endochondral Ossification
WP2328: Allograft rejection
WP1004: Kit Receptor Signaling Pathway
WP1354: B Cell Receptor Signaling Pathway
WP2079: Serotonin Receptor 2 and STAT3 Signaling
WP878: EPO Receptor Signaling
WP2118: Arrhythmogenic right ventricular cardiomyopathy
WP352: T Cell Receptor Signaling Pathway
WP894: T Cell Receptor Signaling Pathway
WP2355: Corticotropin-releasing hormone
WP733: Serotonin Receptor 2 and STAT3 Signaling
WP1025: B Cell Receptor Signaling Pathway
WP138: Androgen receptor signaling pathway

Related Genes :
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[Met] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[Met] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
[MET] Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)

Bibliography :
[31819003] Aberrant activation of hepatocyte growth factor/MET signaling promotes β-catenin-mediated prostatic tumorigenesis.
[30930049] Inhibition of the MET Kinase Activity and Cell Growth in MET-Addicted Cancer Cells by Bi-Paratopic Linking.
[30670153] Proteolytic cleavages of MET: the divide-and-conquer strategy of a receptor tyrosine kinase.
[30401749] Activation of hepatocyte growth factor/MET signaling initiates oncogenic transformation and enhances tumor aggressiveness in the murine prostate.
[28827556] Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain.
[28212658] c-Met expression and activity in urogenital cancers - novel aspects of signal transduction and medical implications.
[28107696] A mini-review of c-Met as a potential therapeutic target in melanoma.
[28061464] MET receptor variant R970C favors calpain-dependent generation of a fragment promoting epithelial cell scattering.
[27864331] Role of Sphingosine Kinase 1 and S1P Transporter Spns2 in HGF-mediated Lamellipodia Formation in Lung Endothelium.
[26712116] Developing Antagonists for the Met-HGF/SF Protein-Protein Interaction Using a Fragment-Based Approach.