GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Histatin-3 (Basic histidine-rich protein) (Hst) (Histidine-rich protein 3) (PB) [Cleaved into: Histatin-3; His3-(20-44)-peptide (His3 20/44) (His3-(1-25)-peptide) (His3 1/25) (Histatin-3 1/25) (Histatin-6); His3-(20-43)-peptide (His3 20/43) (His3-(1-24)-peptide) (His3 1/24) (Histatin-3 1/24) (Histatin-5); His3-(20-32)-peptide (His3 20/32) (His3-(1-13)-peptide) (His3 1/13) (Histatin-3 1/13); His3-(20-31)-peptide (His3 20/31) (His3-(1-12)-peptide) (His3 1/12) (Histatin-3 1/12); His3-(20-30)-peptide (His3 20/30) (His3-(1-11)-peptide) (His3 1/11) (Histatin-3 1/11); His3-(24-32)-peptide (His3 24/32) (His3-(5-13)-peptide) (His3 5/13) (Histatin-3 5/13); His3-(24-31)-peptide (His3 24/31) (His3-(5-12)-peptide) (His3 5/12) (Histatin-11) (Histatin-3 5/12); His3-(24-30)-peptide (His3 24/30) (His3-(5-11)-peptide) (His3 5/11) (Histatin-12) (Histatin-3 5/11); His3-(25-32)-peptide (His3 25/32) (His3-(6-13)-peptide) (His3 6/13) (Histatin-3 6/13); His3-(25-30)-peptide (His3 25/30) (His3-(6-11)-peptide) (His3 6/11) (Histatin-3 6/11); His3-(26-32)-peptide (His3 26/32) (His3-(7-13)-peptide) (His3 7/13) (Histatin-3 7/13); His3-(26-31)-peptide (His3 26/31) (His3-(7-12)-peptide) (His3 7/12) (Histatin-3 7/12); His3-(26-30)-peptide (His3 26/30) (His3-(7-11)-peptide) (His3 7/11) (Histatin-3 7/11); His3-(31-51)-peptide (His3 31/51) (His3-(12-32)-peptide) (His3 12/32) (Histatin-3 12/32) (Histatin-4); His3-(31-44)-peptide (His3 31/44) (His3-(12-25)-peptide) (His3 12/25) (Histatin-3 12/25) (Histatin-9); His3-(31-43)-peptide (His3 31/43) (His3-(12-24)-peptide) (His3 12/24) (Histatin-3 12/24) (Histatin-7); His3-(32-44)-peptide (His3 32/44) (His3-(13-25)-peptide) (His3 13/25) (Histatin-10) (Histatin-3 13/25); His3-(32-43)-peptide (His3 32-43) (His3-(13-24)-peptide) (His3 13/24) (Histatin-3 13/24) (Histatin-8); His3-(33-44)-peptide (His3 33/44) (His3-(14-25)-peptide) (His3 14/25) (Histatin-3 14/25); His3-(33-43)-peptide (His3 33/43) (His3-(14-24)-peptide) (His3 14/24) (Histatin-3 14/24); His3-(34-44)-peptide (His3 34/44) (His3-(15-25)-peptide) (His3 15/25) (Histatin-3 15/25); His3-(34-43)-peptide (His3 34/43) (His3-(15-24)-peptide) (His3 15/24) (Histatin-3 15/24); His3-(45-51)-peptide (His3 45/51) (His3-(26-32)-peptide) (His3 26/32) (Histatin-3 26/32); His3-(47-51)-peptide (His3 47/51) (His3-(28-32)-peptide) (His3 28/32) (Histatin-3 28/32); His3-(48-51)-peptide (His3 48/51) (His3-(29-32)-peptide) (His3 29/32) (Histatin-3 29/32)]

 HIS3_HUMAN              Reviewed;          51 AA.
P15516; Q16243; Q502Z1;
01-APR-1990, integrated into UniProtKB/Swiss-Prot.
01-FEB-1991, sequence version 2.
25-MAY-2022, entry version 179.
RecName: Full=Histatin-3;
AltName: Full=Basic histidine-rich protein;
Short=Hst;
AltName: Full=Histidine-rich protein 3;
AltName: Full=PB;
Contains:
RecName: Full=Histatin-3;
Contains:
RecName: Full=His3-(20-44)-peptide;
Short=His3 20/44;
AltName: Full=His3-(1-25)-peptide;
Short=His3 1/25;
AltName: Full=Histatin-3 1/25;
AltName: Full=Histatin-6;
Contains:
RecName: Full=His3-(20-43)-peptide;
Short=His3 20/43;
AltName: Full=His3-(1-24)-peptide;
Short=His3 1/24;
AltName: Full=Histatin-3 1/24;
AltName: Full=Histatin-5;
Contains:
RecName: Full=His3-(20-32)-peptide;
Short=His3 20/32;
AltName: Full=His3-(1-13)-peptide;
Short=His3 1/13;
AltName: Full=Histatin-3 1/13;
Contains:
RecName: Full=His3-(20-31)-peptide;
Short=His3 20/31;
AltName: Full=His3-(1-12)-peptide;
Short=His3 1/12;
AltName: Full=Histatin-3 1/12;
Contains:
RecName: Full=His3-(20-30)-peptide;
Short=His3 20/30;
AltName: Full=His3-(1-11)-peptide;
Short=His3 1/11;
AltName: Full=Histatin-3 1/11;
Contains:
RecName: Full=His3-(24-32)-peptide;
Short=His3 24/32;
AltName: Full=His3-(5-13)-peptide;
Short=His3 5/13;
AltName: Full=Histatin-3 5/13;
Contains:
RecName: Full=His3-(24-31)-peptide;
Short=His3 24/31;
AltName: Full=His3-(5-12)-peptide;
Short=His3 5/12;
AltName: Full=Histatin-11;
AltName: Full=Histatin-3 5/12;
Contains:
RecName: Full=His3-(24-30)-peptide;
Short=His3 24/30;
AltName: Full=His3-(5-11)-peptide;
Short=His3 5/11;
AltName: Full=Histatin-12;
AltName: Full=Histatin-3 5/11;
Contains:
RecName: Full=His3-(25-32)-peptide;
Short=His3 25/32;
AltName: Full=His3-(6-13)-peptide;
Short=His3 6/13;
AltName: Full=Histatin-3 6/13;
Contains:
RecName: Full=His3-(25-30)-peptide;
Short=His3 25/30;
AltName: Full=His3-(6-11)-peptide;
Short=His3 6/11;
AltName: Full=Histatin-3 6/11;
Contains:
RecName: Full=His3-(26-32)-peptide;
Short=His3 26/32;
AltName: Full=His3-(7-13)-peptide;
Short=His3 7/13;
AltName: Full=Histatin-3 7/13;
Contains:
RecName: Full=His3-(26-31)-peptide;
Short=His3 26/31;
AltName: Full=His3-(7-12)-peptide;
Short=His3 7/12;
AltName: Full=Histatin-3 7/12;
Contains:
RecName: Full=His3-(26-30)-peptide;
Short=His3 26/30;
AltName: Full=His3-(7-11)-peptide;
Short=His3 7/11;
AltName: Full=Histatin-3 7/11;
Contains:
RecName: Full=His3-(31-51)-peptide;
Short=His3 31/51;
AltName: Full=His3-(12-32)-peptide;
Short=His3 12/32;
AltName: Full=Histatin-3 12/32;
AltName: Full=Histatin-4;
Contains:
RecName: Full=His3-(31-44)-peptide;
Short=His3 31/44;
AltName: Full=His3-(12-25)-peptide;
Short=His3 12/25;
AltName: Full=Histatin-3 12/25;
AltName: Full=Histatin-9;
Contains:
RecName: Full=His3-(31-43)-peptide;
Short=His3 31/43;
AltName: Full=His3-(12-24)-peptide;
Short=His3 12/24;
AltName: Full=Histatin-3 12/24;
AltName: Full=Histatin-7;
Contains:
RecName: Full=His3-(32-44)-peptide;
Short=His3 32/44;
AltName: Full=His3-(13-25)-peptide;
Short=His3 13/25;
AltName: Full=Histatin-10;
AltName: Full=Histatin-3 13/25;
Contains:
RecName: Full=His3-(32-43)-peptide;
Short=His3 32-43;
AltName: Full=His3-(13-24)-peptide;
Short=His3 13/24;
AltName: Full=Histatin-3 13/24;
AltName: Full=Histatin-8;
Contains:
RecName: Full=His3-(33-44)-peptide;
Short=His3 33/44;
AltName: Full=His3-(14-25)-peptide;
Short=His3 14/25;
AltName: Full=Histatin-3 14/25;
Contains:
RecName: Full=His3-(33-43)-peptide;
Short=His3 33/43;
AltName: Full=His3-(14-24)-peptide;
Short=His3 14/24;
AltName: Full=Histatin-3 14/24;
Contains:
RecName: Full=His3-(34-44)-peptide;
Short=His3 34/44;
AltName: Full=His3-(15-25)-peptide;
Short=His3 15/25;
AltName: Full=Histatin-3 15/25;
Contains:
RecName: Full=His3-(34-43)-peptide;
Short=His3 34/43;
AltName: Full=His3-(15-24)-peptide;
Short=His3 15/24;
AltName: Full=Histatin-3 15/24;
Contains:
RecName: Full=His3-(45-51)-peptide;
Short=His3 45/51;
AltName: Full=His3-(26-32)-peptide;
Short=His3 26/32;
AltName: Full=Histatin-3 26/32;
Contains:
RecName: Full=His3-(47-51)-peptide;
Short=His3 47/51;
AltName: Full=His3-(28-32)-peptide;
Short=His3 28/32;
AltName: Full=Histatin-3 28/32;
Contains:
RecName: Full=His3-(48-51)-peptide;
Short=His3 48/51;
AltName: Full=His3-(29-32)-peptide;
Short=His3 29/32;
AltName: Full=Histatin-3 29/32;
Flags: Precursor;
Name=HTN3; Synonyms=HIS2;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2719677; DOI=10.1016/0006-291x(89)92460-1;
Sabatini L.M., Azen E.A.;
"Histatins, a family of salivary histidine-rich proteins, are encoded by at
least two loci (HIS1 and HIS2).";
Biochem. Biophys. Res. Commun. 160:495-502(1989).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3426601; DOI=10.1016/0006-291x(87)90436-0;
Dickinson D.P., Ridall A.L., Levine M.J.;
"Human submandibular gland statherin and basic histidine-rich peptide are
encoded by highly abundant mRNA's derived from a common ancestral
sequence.";
Biochem. Biophys. Res. Commun. 149:784-790(1987).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2344289; DOI=10.1016/0003-9969(90)90175-a;
Vanderspek J.C., Offner G.D., Troxler R.F., Oppenheim F.G.;
"Molecular cloning of human submandibular histatins.";
Arch. Oral Biol. 35:137-143(1990).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8336540; DOI=10.1093/oxfordjournals.molbev.a040022;
Chen Z.W.;
"Nucleotide sequence analysis of the human salivary protein genes HIS1 and
HIS2, and evolution of the STATH/HIS gene family.";
Mol. Biol. Evol. 10:497-511(1993).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Skeletal muscle, and Thyroid;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 20-51, VARIANTS HISTATIN-3-2 GLN-41
AND 47-TYR--ASN-51 DEL, AND POLYMORPHISM.
TISSUE=Saliva;
PubMed=7951254; DOI=10.1002/humu.1380040103;
Sabatini L.M., Azen E.A.;
"Two coding change mutations in the HIS2(2) allele characterize the
salivary histatin 3-2 protein variant.";
Hum. Mutat. 4:12-19(1994).
[7]
PROTEIN SEQUENCE OF 20-51.
TISSUE=Parotid gland;
PubMed=3286634; DOI=10.1016/s0021-9258(18)68522-9;
Oppenheim F.G., Xu T., McMillian F.M., Levitz S.M., Diamond R.D.,
Offner G.D., Troxler R.F.;
"Histatins, a novel family of histidine-rich proteins in human parotid
secretion. Isolation, characterization, primary structure, and fungistatic
effects on Candida albicans.";
J. Biol. Chem. 263:7472-7477(1988).
[8]
PROTEIN SEQUENCE OF 20-42.
TISSUE=Saliva;
PubMed=2372245; DOI=10.1016/0003-9969(90)90202-l;
Sugiyama K., Ogino T., Ogata K.;
"Rapid purification and characterization of histatins (histidine-rich
polypeptides) from human whole saliva.";
Arch. Oral Biol. 35:415-419(1990).
[9]
PROTEIN SEQUENCE OF 20-32, AND IDENTIFICATION BY MASS SPECTROMETRY OF 24
PEPTIDE FRAGMENTS.
TISSUE=Saliva;
PubMed=15272024; DOI=10.1074/jbc.m404322200;
Castagnola M., Inzitari R., Rossetti D.V., Olmi C., Cabras T., Piras V.,
Nicolussi P., Sanna M.T., Pellegrini M., Giardina B., Messana I.;
"A cascade of 24 histatins (histatin 3 fragments) in human saliva.
Suggestions for a pre-secretory sequential cleavage pathway.";
J. Biol. Chem. 279:41436-41443(2004).
[10]
FUNCTION, AND MUTAGENESIS OF ARG-31; LYS-32; LYS-36; HIS-38; HIS-40 AND
ARG-41.
PubMed=8945538; DOI=10.1128/iai.64.12.5000-5007.1996;
Tsai H., Raj P.A., Bobek L.A.;
"Candidacidal activity of recombinant human salivary histatin-5 and
variants.";
Infect. Immun. 64:5000-5007(1996).
[11]
ZINC-BINDING SITE.
PubMed=11226423; DOI=10.1016/s0014-5793(01)02157-3;
Grogan J., McKnight C.J., Troxler R.F., Oppenheim F.G.;
"Zinc and copper bind to unique sites of histatin 5.";
FEBS Lett. 491:76-80(2001).
[12]
FUNCTION.
PubMed=11179305; DOI=10.1128/iai.69.3.1402-1408.2001;
Gusman H., Travis J., Helmerhorst E.J., Potempa J., Troxler R.F.,
Oppenheim F.G.;
"Salivary histatin 5 is an inhibitor of both host and bacterial enzymes
implicated in periodontal disease.";
Infect. Immun. 69:1402-1408(2001).
[13]
INTERACTION WITH SSA1 AND SSA2.
PubMed=12761219; DOI=10.1074/jbc.m300680200;
Li X.S., Reddy M.S., Baev D., Edgerton M.;
"Candida albicans Ssa1/2p is the cell envelope binding protein for human
salivary histatin 5.";
J. Biol. Chem. 278:28553-28561(2003).
[14]
SUBCELLULAR LOCATION.
PubMed=14966203; DOI=10.1177/002215540405200307;
Ahmad M., Piludu M., Oppenheim F.G., Helmerhorst E.J., Hand A.R.;
"Immunocytochemical localization of histatins in human salivary glands.";
J. Histochem. Cytochem. 52:361-370(2004).
[15]
LACK OF SULFATION AT TYR-43; TYR-47 AND TYR-49, AND IDENTIFICATION BY MASS
SPECTROMETRY.
PubMed=17503797; DOI=10.1021/pr0700706;
Cabras T., Fanali C., Monteiro J.A., Amado F., Inzitari R., Desiderio C.,
Scarano E., Giardina B., Castagnola M., Messana I.;
"Tyrosine polysulfation of human salivary histatin 1. A post-translational
modification specific of the submandibular gland.";
J. Proteome Res. 6:2472-2480(2007).
[16]
PEPTIDE NOMENCLATURE.
PubMed=20973643; DOI=10.1586/epr.10.48;
Amado F., Lobo M.J., Domingues P., Duarte J.A., Vitorino R.;
"Salivary peptidomics.";
Expert Rev. Proteomics 7:709-721(2010).
-!- FUNCTION: Histatins are salivary proteins that are considered to be
major precursors of the protective proteinaceous structure on tooth
surfaces (enamel pellicle). In addition, histatins exhibit
antibacterial and antifungal activities. His3-(20-43)-peptide
(histatin-5) is especially effective against C.albicans and
C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from
P.gingivalis. In addition, His3-(20-43)-peptide is a potent inhibitor
of metalloproteinases MMP2 and MMP9. {ECO:0000269|PubMed:11179305,
ECO:0000269|PubMed:8945538}.
-!- SUBUNIT: His3-(20-43)-peptide is a homodimer. Histatin-3 and His3-(20-
43)-peptide interact with yeast SSA1 and SSA2 proteins.
-!- INTERACTION:
P15516; Q9UBS4: DNAJB11; NbExp=3; IntAct=EBI-738783, EBI-713113;
P15516; P95493: rgpB; Xeno; NbExp=7; IntAct=EBI-738783, EBI-8505881;
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:14966203}.
Note=Secreted by serous acinar and demilune cells.
-!- PTM: 24 proteolytic products are found in saliva.
-!- POLYMORPHISM: There are two alleles of HTN3, HIS2(1) (shown here) and
HIS2(2) that codes for the variant histatin-3-2 found primarily and in
high frequencies in black populations. {ECO:0000269|PubMed:7951254}.
-!- MISCELLANEOUS: The recommended nomenclature of salivary peptides
follows published guidelines (PubMed:20973643). In agreement with the
authors, it has been decided to indicate the boundaries of the peptides
according to the positions within the precursor, and not in the mature
protein, as has formerly been proposed. {ECO:0000305|PubMed:20973643}.
-!- SIMILARITY: Belongs to the histatin/statherin family. {ECO:0000305}.
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; M26665; AAA58646.1; -; mRNA.
EMBL; M18372; AAA51830.1; -; mRNA.
EMBL; L05514; AAA02746.1; -; Genomic_DNA.
EMBL; L05513; AAA02746.1; JOINED; Genomic_DNA.
EMBL; BC009791; AAH09791.1; -; mRNA.
EMBL; BC095438; AAH95438.1; -; mRNA.
EMBL; S74382; AAB32411.1; -; Genomic_DNA.
CCDS; CCDS33999.1; -.
PIR; B32541; B32541.
RefSeq; NP_000191.1; NM_000200.2.
AlphaFoldDB; P15516; -.
SASBDB; P15516; -.
BioGRID; 109579; 32.
IntAct; P15516; 4.
MINT; P15516; -.
STRING; 9606.ENSP00000432561; -.
TCDB; 1.C.79.1.1; the channel-forming histatin antimicrobial peptide (histatin) family.
BioMuta; HTN3; -.
MassIVE; P15516; -.
PaxDb; P15516; -.
PeptideAtlas; P15516; -.
PRIDE; P15516; -.
ProteomicsDB; 53166; -.
Antibodypedia; 24280; 15 antibodies from 8 providers.
DNASU; 3347; -.
Ensembl; ENST00000530128.5; ENSP00000432561.1; ENSG00000205649.9.
Ensembl; ENST00000635585.1; ENSP00000489520.1; ENSG00000282967.4.
Ensembl; ENST00000672568.1; ENSP00000500810.1; ENSG00000282967.4.
Ensembl; ENST00000673563.1; ENSP00000500623.1; ENSG00000205649.9.
Ensembl; ENST00000677679.1; ENSP00000504141.1; ENSG00000282967.4.
GeneID; 3347; -.
KEGG; hsa:3347; -.
MANE-Select; ENST00000673563.1; ENSP00000500623.1; NM_000200.3; NP_000191.1.
UCSC; uc003hew.2; human.
CTD; 3347; -.
DisGeNET; 3347; -.
GeneCards; HTN3; -.
HGNC; HGNC:5284; HTN3.
HPA; ENSG00000205649; Tissue enriched (salivary).
MIM; 142702; gene.
neXtProt; NX_P15516; -.
OpenTargets; ENSG00000205649; -.
PharmGKB; PA29547; -.
VEuPathDB; HostDB:ENSG00000205649; -.
eggNOG; ENOG502TEIC; Eukaryota.
GeneTree; ENSGT00940000164572; -.
InParanoid; P15516; -.
OMA; DSHEEKH; -.
OrthoDB; 1623335at2759; -.
PhylomeDB; P15516; -.
TreeFam; TF341637; -.
PathwayCommons; P15516; -.
Reactome; R-HSA-6803157; Antimicrobial peptides.
SignaLink; P15516; -.
BioGRID-ORCS; 3347; 5 hits in 517 CRISPR screens.
ChiTaRS; HTN3; human.
GeneWiki; HTN3; -.
GenomeRNAi; 3347; -.
Pharos; P15516; Tbio.
PRO; PR:P15516; -.
Proteomes; UP000005640; Chromosome 4.
RNAct; P15516; protein.
Bgee; ENSG00000205649; Expressed in saliva-secreting gland and 67 other tissues.
ExpressionAtlas; P15516; baseline and differential.
Genevisible; P15516; HS.
GO; GO:0005576; C:extracellular region; TAS:Reactome.
GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IDA:UniProtKB.
GO; GO:0031214; P:biomineral tissue development; IEA:UniProtKB-KW.
GO; GO:0042742; P:defense response to bacterium; NAS:UniProtKB.
GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
GO; GO:0031640; P:killing of cells of another organism; IDA:UniProtKB.
DisProt; DP02206; -.
InterPro; IPR030774; Histatin-3.
InterPro; IPR030773; Histatin/statherin.
PANTHER; PTHR15057; PTHR15057; 1.
PANTHER; PTHR15057:SF1; PTHR15057:SF1; 1.
1: Evidence at protein level;
Antibiotic; Antimicrobial; Biomineralization;
Cleavage on pair of basic residues; Direct protein sequencing; Fungicide;
Metal-binding; Reference proteome; Secreted; Signal; Zinc.
SIGNAL 1..19
/evidence="ECO:0000269|PubMed:15272024,
ECO:0000269|PubMed:2372245, ECO:0000269|PubMed:3286634"
CHAIN 20..51
/note="Histatin-3"
/id="PRO_0000021418"
PEPTIDE 20..44
/note="His3-(20-44)-peptide"
/id="PRO_0000021419"
PEPTIDE 20..43
/note="His3-(20-43)-peptide"
/id="PRO_0000021420"
PEPTIDE 20..32
/note="His3-(20-32)-peptide"
/id="PRO_0000021421"
PEPTIDE 20..31
/note="His3-(20-31)-peptide"
/id="PRO_0000021422"
PEPTIDE 20..30
/note="His3-(20-30)-peptide"
/id="PRO_0000021423"
PEPTIDE 24..32
/note="His3-(24-32)-peptide"
/id="PRO_0000021424"
PEPTIDE 24..31
/note="His3-(24-31)-peptide"
/id="PRO_0000021425"
PEPTIDE 24..30
/note="His3-(24-30)-peptide"
/id="PRO_0000021426"
PEPTIDE 25..32
/note="His3-(25-32)-peptide"
/id="PRO_0000021427"
PEPTIDE 25..30
/note="His3-(25-30)-peptide"
/id="PRO_0000021428"
PEPTIDE 26..32
/note="His3-(26-32)-peptide"
/id="PRO_0000021429"
PEPTIDE 26..31
/note="His3-(26-31)-peptide"
/id="PRO_0000021430"
PEPTIDE 26..30
/note="His3-(26-30)-peptide"
/id="PRO_0000021431"
PEPTIDE 31..51
/note="His3-(31-51)-peptide"
/id="PRO_0000021432"
PEPTIDE 31..44
/note="His3-(31-44)-peptide"
/id="PRO_0000021433"
PEPTIDE 31..43
/note="His3-(31-43)-peptide"
/id="PRO_0000021434"
PEPTIDE 32..44
/note="His3-(32-44)-peptide"
/id="PRO_0000021435"
PEPTIDE 32..43
/note="His3-(32-43)-peptide"
/id="PRO_0000021436"
PEPTIDE 33..44
/note="His3-(33-44)-peptide"
/id="PRO_0000021437"
PEPTIDE 33..43
/note="His3-(33-43)-peptide"
/id="PRO_0000021438"
PEPTIDE 34..44
/note="His3-(34-44)-peptide"
/id="PRO_0000021439"
PEPTIDE 34..43
/note="His3-(34-43)-peptide"
/id="PRO_0000021440"
PEPTIDE 45..51
/note="His3-(45-51)-peptide"
/id="PRO_0000021441"
PEPTIDE 47..51
/note="His3-(47-51)-peptide"
/id="PRO_0000021442"
PEPTIDE 48..51
/note="His3-(48-51)-peptide"
/id="PRO_0000021443"
REGION 27..51
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 27..41
/note="Basic residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
METAL 34
/note="Zinc"
SITE 32
/note="Important for candidacidal activity"
SITE 41
/note="Important for candidacidal activity"
SITE 43
/note="Not sulfated"
/evidence="ECO:0000269|PubMed:17503797"
SITE 47
/note="Not sulfated"
/evidence="ECO:0000269|PubMed:17503797"
SITE 49
/note="Not sulfated"
/evidence="ECO:0000269|PubMed:17503797"
VARIANT 41
/note="R -> Q (in histatin-3-2; loss of the proteolytic
cleavage site; dbSNP:rs1136511)"
/evidence="ECO:0000269|PubMed:7951254"
/id="VAR_005288"
VARIANT 47..51
/note="Missing (in histatin-3-2; dbSNP:rs17147990)"
/evidence="ECO:0000269|PubMed:7951254"
/id="VAR_005289"
MUTAGEN 31
/note="R->I: No effect on candidacidal activity of
His3-(20-43)-peptide."
/evidence="ECO:0000269|PubMed:8945538"
MUTAGEN 32
/note="K->T,E: 3-fold reduction in candidacidal activity of
His3-(20-43)-peptide."
/evidence="ECO:0000269|PubMed:8945538"
MUTAGEN 36
/note="K->N: No effect on candidacidal activity of
His3-(20-43)-peptide."
/evidence="ECO:0000269|PubMed:8945538"
MUTAGEN 38
/note="H->P: No effect on candidacidal activity of
His3-(20-43)-peptide."
/evidence="ECO:0000269|PubMed:8945538"
MUTAGEN 40
/note="H->L,R: No effect on candidacidal activity of
His3-(20-43)-peptide."
/evidence="ECO:0000269|PubMed:8945538"
MUTAGEN 41
/note="R->G: 10-fold reduction in candidacidal activity of
His3-(20-43)-peptide; when associated with E-32."
/evidence="ECO:0000269|PubMed:8945538"
SEQUENCE 51 AA; 6149 MW; AFCCB4B32083FD65 CRC64;
MKFFVFALIL ALMLSMTGAD SHAKRHHGYK RKFHEKHHSH RGYRSNYLYD N


Related products :

Catalog number Product name Quantity
orb71669 Histatin 3 (H3) peptide This is Histatin 3 (H3) peptide. For research use only. 1 mg
orb71670 Histatin 5 peptide This is Histatin 5 peptide. For research use only. 1 mg
orb70729 Histatin 8 [Hemagglutination-Inhibiting (HIP)] peptide This is Histatin 8 [Hemagglutination-Inhibiting (HIP)] peptide. For research use only. 1 mg
5-42641 Histatin 5, peptide reagents 2.5 mg
5-42639 Histatin 5, peptide reagents 0.5 mg
5-42640 Histatin 5, peptide reagents 1 mg
SP2283a Histatin - 8 [Hemagglutination - Inhibiting Peptide (HIP)] 1 mg
SP2283b Histatin - 8 [Hemagglutination - Inhibiting Peptide (HIP)] 5 mg
SP2283a Histatin - 8 [Hemagglutination - Inhibiting Peptide (HIP)]
SP2283a Histatin _ 8 [Hemagglutination _ Inhibiting Peptide (HIP)] 1.0 mg
KP0949 Histatin - 8 [Hemagglutination - Inhibiting Peptide (HIP)] 1 mg
SP2283b Histatin - 8 [Hemagglutination - Inhibiting Peptide (HIP)]
SP2283b Histatin _ 8 [Hemagglutination _ Inhibiting Peptide (HIP)] 5.0 mg
SP-88323-5 Histatin-8 [Hemagglutination - Inhibiting Peptide (HIP)] (AA: Lys-Phe-His-Glu-Lys-His-His-Ser-His-Arg-Gly-Tyr) (MW: 1562.73) 5 mg
H-1002 Histatin-8 HIP, Hemagglutination-Inhibiting Peptide (HIP) 98 percent C70H99N25O17 CAS: 127637-03-0 5mg
SP2194a Histatin - 5
RP11240 Histatin 5 0.5mg
GWB-FE3EF0 Histatin 5
SP2194b Histatin - 5
SP2195a Histatin - 3 (H3)
KP0948 Histatin - 5 1 mg
RP11240-0.5 Histatin 5 0,5mg
E02H0313 Rat histatin 5 96 Tests/kit
SP2195b Histatin - 3 (H3)
SP2195b Histatin _ 3 (H3) 5mg