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Histone deacetylase 1 (HD1) (EC 3 5 1 98)

 HDAC1_CHICK             Reviewed;         480 AA.
P56517;
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
15-JUL-1998, sequence version 1.
13-FEB-2019, entry version 137.
RecName: Full=Histone deacetylase 1;
Short=HD1;
EC=3.5.1.98;
Name=HDAC1; Synonyms=HDAC1A;
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Takami Y.;
Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA].
Sun J.M., Chen H.Y., Davie J.R.;
Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Responsible for the deacetylation of lysine residues on
the N-terminal part of the core histones (H2A, H2B, H3 and H4).
Histone deacetylation gives a tag for epigenetic repression and
plays an important role in transcriptional regulation, cell cycle
progression and developmental events. Histone deacetylases act via
the formation of large multiprotein complexes (By similarity).
{ECO:0000250}.
-!- CATALYTIC ACTIVITY:
Reaction=Hydrolysis of an N(6)-acetyl-lysine residue of a histone
to yield a deacetylated histone.; EC=3.5.1.98;
-!- SUBUNIT: Forms a complex with RBAP48. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
-!- SIMILARITY: Belongs to the histone deacetylase family. HD type 1
subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
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EMBL; AF039751; AAB96923.1; -; mRNA.
EMBL; AF043328; AAB99850.1; -; mRNA.
EMBL; AF044169; AAC00504.1; -; mRNA.
RefSeq; NP_989487.1; NM_204156.1.
UniGene; Gga.10603; -.
ProteinModelPortal; P56517; -.
SMR; P56517; -.
BioGrid; 675010; 2.
STRING; 9031.ENSGALP00000005212; -.
PaxDb; P56517; -.
PRIDE; P56517; -.
Ensembl; ENSGALT00000084635; ENSGALP00000059784; ENSGALG00000003297.
GeneID; 373961; -.
KEGG; gga:373961; -.
CTD; 3065; -.
eggNOG; KOG1342; Eukaryota.
eggNOG; COG0123; LUCA.
GeneTree; ENSGT00940000154301; -.
HOGENOM; HOG000225180; -.
HOVERGEN; HBG057112; -.
InParanoid; P56517; -.
KO; K06067; -.
OMA; VSIRAHD; -.
OrthoDB; 732770at2759; -.
PhylomeDB; P56517; -.
TreeFam; TF106171; -.
BRENDA; 3.5.1.98; 1306.
Reactome; R-GGA-1538133; G0 and Early G1.
Reactome; R-GGA-201722; Formation of the beta-catenin:TCF transactivating complex.
Reactome; R-GGA-2173795; Downregulation of SMAD2/3:SMAD4 transcriptional activity.
Reactome; R-GGA-3769402; Deactivation of the beta-catenin transactivating complex.
Reactome; R-GGA-6804758; Regulation of TP53 Activity through Acetylation.
Reactome; R-GGA-73762; RNA Polymerase I Transcription Initiation.
Reactome; R-GGA-8936459; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function.
Reactome; R-GGA-8943724; Regulation of PTEN gene transcription.
Reactome; R-GGA-9018519; Estrogen-dependent gene expression.
Reactome; R-GGA-983231; Factors involved in megakaryocyte development and platelet production.
PRO; PR:P56517; -.
Proteomes; UP000000539; Chromosome 23.
Bgee; ENSGALG00000003297; Expressed in 11 organ(s), highest expression level in spleen.
ExpressionAtlas; P56517; baseline.
GO; GO:0005737; C:cytoplasm; TAS:UniProtKB.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0000792; C:heterochromatin; IEA:Ensembl.
GO; GO:0000118; C:histone deacetylase complex; IBA:GO_Central.
GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO; GO:0005634; C:nucleus; TAS:UniProtKB.
GO; GO:0016581; C:NuRD complex; IEA:Ensembl.
GO; GO:0016580; C:Sin3 complex; IEA:Ensembl.
GO; GO:0070822; C:Sin3-type complex; IBA:GO_Central.
GO; GO:0005667; C:transcription factor complex; IEA:Ensembl.
GO; GO:0033613; F:activating transcription factor binding; IEA:Ensembl.
GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:Ensembl.
GO; GO:0070888; F:E-box binding; IEA:Ensembl.
GO; GO:0004407; F:histone deacetylase activity; IBA:GO_Central.
GO; GO:0042826; F:histone deacetylase binding; IEA:Ensembl.
GO; GO:0035851; F:Krueppel-associated box domain binding; IEA:Ensembl.
GO; GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:UniProtKB-EC.
GO; GO:0051059; F:NF-kappaB binding; IEA:Ensembl.
GO; GO:0002039; F:p53 binding; IEA:Ensembl.
GO; GO:1990841; F:promoter-specific chromatin binding; IEA:Ensembl.
GO; GO:0047485; F:protein N-terminus binding; IEA:Ensembl.
GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0001103; F:RNA polymerase II repressing transcription factor binding; IEA:Ensembl.
GO; GO:0001085; F:RNA polymerase II transcription factor binding; IEA:Ensembl.
GO; GO:0003714; F:transcription corepressor activity; IEA:Ensembl.
GO; GO:0008134; F:transcription factor binding; TAS:UniProtKB.
GO; GO:0006325; P:chromatin organization; TAS:UniProtKB.
GO; GO:0032922; P:circadian regulation of gene expression; IEA:Ensembl.
GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
GO; GO:0007492; P:endoderm development; IEA:Ensembl.
GO; GO:0009913; P:epidermal cell differentiation; IEA:Ensembl.
GO; GO:0061029; P:eyelid development in camera-type eye; IEA:Ensembl.
GO; GO:0061198; P:fungiform papilla formation; IEA:Ensembl.
GO; GO:0021766; P:hippocampus development; IEA:Ensembl.
GO; GO:0070932; P:histone H3 deacetylation; IBA:GO_Central.
GO; GO:0070933; P:histone H4 deacetylation; IBA:GO_Central.
GO; GO:0006346; P:methylation-dependent chromatin silencing; IEA:Ensembl.
GO; GO:0043922; P:negative regulation by host of viral transcription; IEA:Ensembl.
GO; GO:0060766; P:negative regulation of androgen receptor signaling pathway; IEA:Ensembl.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
GO; GO:2001243; P:negative regulation of intrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0030182; P:neuron differentiation; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
GO; GO:0048714; P:positive regulation of oligodendrocyte differentiation; IEA:Ensembl.
GO; GO:0010870; P:positive regulation of receptor biosynthetic process; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
GO; GO:0052548; P:regulation of endopeptidase activity; IEA:Ensembl.
Gene3D; 3.40.800.20; -; 1.
InterPro; IPR000286; His_deacetylse.
InterPro; IPR003084; His_deacetylse_1.
InterPro; IPR023801; His_deacetylse_dom.
InterPro; IPR037138; His_deacetylse_dom_sf.
InterPro; IPR023696; Ureohydrolase_dom_sf.
PANTHER; PTHR10625; PTHR10625; 1.
Pfam; PF00850; Hist_deacetyl; 1.
PIRSF; PIRSF037913; His_deacetylse_1; 1.
PRINTS; PR01270; HDASUPER.
PRINTS; PR01271; HISDACETLASE.
SUPFAM; SSF52768; SSF52768; 1.
2: Evidence at transcript level;
Chromatin regulator; Complete proteome; Hydrolase; Nucleus;
Reference proteome; Repressor; Transcription;
Transcription regulation.
CHAIN 1 480 Histone deacetylase 1.
/FTId=PRO_0000114689.
REGION 9 321 Histone deacetylase.
COMPBIAS 299 302 Poly-Gly.
COMPBIAS 396 399 Poly-Glu.
COMPBIAS 446 453 Poly-Glu.
ACT_SITE 141 141 {ECO:0000250}.
CONFLICT 3 4 LT -> VM (in Ref. 2; AAB99850).
{ECO:0000305}.
SEQUENCE 480 AA; 54939 MW; 82C78CE285C779D9 CRC64;
MALTQGTKRK VCYYYDGDVG NYYYGQGHPM KPHRIRMTHN LLLNYGLYRK MEIYRPHKAN
AEEMTKYHSD DYIKFLRSIR PDNMSEYSKQ MQRFNVGEDC PVFDGLFEFC QLSAGGSVAS
AVKLNKQQTD IAVNWAGGLH HAKKSEASGF CYVNDIVLAI LELLKYHQRV LYIDIDIHHG
DGVEEAFYTT DRVMTVSFHK YGEYFPGTGD LRDIGAGKGK YYAVNYPLRD GIDDESYEAI
FKPVISKVME TFQPSAVVLQ CGSDSLSGDR LGCFNLTIKG HAKCVEFVKS FNLPMLMLGG
GGYTIRNVAR CWTYETAVAL DTEIPNELPY NDYFEYFGPD FKLHISPSNM TNQNTNEYLE
KIKQRLFENL RMLPHAPGVQ MQPIPEDAVQ EDSGDEEEED PEKRISIRNS DKRISCDEEF
SDSEDEGEGG RKNVANFKKA KRVKTEEEKE EEEKKDEKEE EKAKEEKAEP KGVKEETKST


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Pathways :
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WP1619: Amino sugar and nucleotide sugar metabolism
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WP2366: Butyrate-induced histone acetylation
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WP300: Histone modifications
WP694: Arylamine metabolism
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Related Genes :
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[HDAC1 RPD3L1] Histone deacetylase 1 (HD1) (EC 3.5.1.98)
[Hdac1] Histone deacetylase 1 (HD1) (EC 3.5.1.98)
[Hdac1] Histone deacetylase 1 (HD1) (EC 3.5.1.98)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[HDAC1] Histone deacetylase 1 (HD1) (EC 3.5.1.98)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[PLEC PLEC1] Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[HDAC1] Histone deacetylase 1 (HD1) (EC 3.5.1.98)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
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[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]

Bibliography :
[15857140] Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides.
[14504245] Genetic control of developmental changes induced by disruption of Arabidopsis histone deacetylase 1 (AtHD1) expression.
[9271381] Identification of mouse histone deacetylase 1 as a growth factor-inducible gene.
[9044047] The subcellular distribution of the high molecular mass protein, HD1, is determined by the cytoplasmic domain of the integrin beta 4 subunit.
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