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Histone lysine acetyltransferase CREBBP

 F8VPR5_MOUSE            Unreviewed;      2441 AA.
F8VPR5;
21-SEP-2011, integrated into UniProtKB/TrEMBL.
21-SEP-2011, sequence version 1.
17-JUN-2020, entry version 84.
SubName: Full=Histone lysine acetyltransferase CREBBP {ECO:0000313|Ensembl:ENSMUSP00000023165};
Name=Crebbp {ECO:0000313|Ensembl:ENSMUSP00000023165,
ECO:0000313|MGI:MGI:1098280};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000023165, ECO:0000313|Proteomes:UP000000589};
[1] {ECO:0000313|Ensembl:ENSMUSP00000023165, ECO:0000313|Proteomes:UP000000589}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000023165,
ECO:0000313|Proteomes:UP000000589};
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of the
mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[2] {ECO:0000213|PubMed:21183079}
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and expression.";
Cell 143:1174-1189(2010).
[3] {ECO:0000313|Ensembl:ENSMUSP00000023165}
IDENTIFICATION.
STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000023165};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
[4] {ECO:0000213|PubMed:23806337}
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
"SIRT5-mediated lysine desuccinylation impacts diverse metabolic
pathways.";
Mol. Cell 50:919-930(2013).
---------------------------------------------------------------------------
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EMBL; AC132380; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC132575; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; NP_001020603.1; NM_001025432.1.
SMR; F8VPR5; -.
IntAct; F8VPR5; 14.
EPD; F8VPR5; -.
jPOST; F8VPR5; -.
MaxQB; F8VPR5; -.
PeptideAtlas; F8VPR5; -.
PRIDE; F8VPR5; -.
Antibodypedia; 3781; 680 antibodies.
Ensembl; ENSMUST00000023165; ENSMUSP00000023165; ENSMUSG00000022521.
GeneID; 12914; -.
KEGG; mmu:12914; -.
UCSC; uc007xzl.1; mouse.
CTD; 1387; -.
MGI; MGI:1098280; Crebbp.
eggNOG; KOG1778; Eukaryota.
eggNOG; COG5076; LUCA.
GeneTree; ENSGT00940000155364; -.
HOGENOM; CLU_000162_2_0_1; -.
KO; K04498; -.
OMA; XTISKDQ; -.
OrthoDB; 236283at2759; -.
TreeFam; TF101097; -.
BioGRID-ORCS; 12914; 1 hit in 12 CRISPR screens.
ChiTaRS; Crebbp; mouse.
Proteomes; UP000000589; Chromosome 16.
Bgee; ENSMUSG00000022521; Expressed in rostral migratory stream and 290 other tissues.
ExpressionAtlas; F8VPR5; baseline and differential.
Genevisible; F8VPR5; MM.
GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
GO; GO:0000123; C:histone acetyltransferase complex; IEA:InterPro.
GO; GO:0042025; C:host cell nucleus; IEA:InterPro.
GO; GO:0016604; C:nuclear body; IEA:Ensembl.
GO; GO:0000790; C:nuclear chromatin; IEA:Ensembl.
GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0003684; F:damaged DNA binding; IEA:Ensembl.
GO; GO:0004402; F:histone acetyltransferase activity; IEA:UniProtKB-UniRule.
GO; GO:0043426; F:MRF binding; IEA:Ensembl.
GO; GO:0002039; F:p53 binding; IEA:Ensembl.
GO; GO:0001085; F:RNA polymerase II transcription factor binding; IEA:Ensembl.
GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
GO; GO:0003714; F:transcription corepressor activity; IEA:Ensembl.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0034644; P:cellular response to UV; IEA:Ensembl.
GO; GO:1990258; P:histone glutamine methylation; IEA:Ensembl.
GO; GO:0018076; P:N-terminal peptidyl-lysine acetylation; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
GO; GO:0031648; P:protein destabilization; IEA:Ensembl.
CDD; cd15802; RING_CBP-p300; 1.
Gene3D; 1.10.1630.10; -; 1.
Gene3D; 1.10.246.20; -; 1.
Gene3D; 1.20.1020.10; -; 2.
Gene3D; 1.20.920.10; -; 1.
Gene3D; 2.10.110.40; -; 1.
Gene3D; 3.30.40.10; -; 1.
Gene3D; 3.30.60.90; -; 1.
InterPro; IPR001487; Bromodomain.
InterPro; IPR036427; Bromodomain-like_sf.
InterPro; IPR018359; Bromodomain_CS.
InterPro; IPR031162; CBP_P300_HAT.
InterPro; IPR013178; Histone_AcTrfase_Rtt109/CBP.
InterPro; IPR003101; KIX_dom.
InterPro; IPR036529; KIX_dom_sf.
InterPro; IPR009110; Nuc_rcpt_coact.
InterPro; IPR014744; Nuc_rcpt_coact_CREBbp.
InterPro; IPR037073; Nuc_rcpt_coact_CREBbp_sf.
InterPro; IPR010303; RING_CBP-p300.
InterPro; IPR038547; RING_CBP-p300_sf.
InterPro; IPR035898; TAZ_dom_sf.
InterPro; IPR013083; Znf_RING/FYVE/PHD.
InterPro; IPR000197; Znf_TAZ.
InterPro; IPR000433; Znf_ZZ.
InterPro; IPR043145; Znf_ZZ_sf.
Pfam; PF00439; Bromodomain; 1.
Pfam; PF09030; Creb_binding; 1.
Pfam; PF06001; DUF902; 1.
Pfam; PF08214; HAT_KAT11; 1.
Pfam; PF02172; KIX; 1.
Pfam; PF02135; zf-TAZ; 2.
Pfam; PF00569; ZZ; 1.
PRINTS; PR00503; BROMODOMAIN.
SMART; SM00297; BROMO; 1.
SMART; SM01250; KAT11; 1.
SMART; SM00551; ZnF_TAZ; 2.
SMART; SM00291; ZnF_ZZ; 1.
SUPFAM; SSF47040; SSF47040; 1.
SUPFAM; SSF47370; SSF47370; 1.
SUPFAM; SSF57933; SSF57933; 2.
SUPFAM; SSF69125; SSF69125; 1.
PROSITE; PS00633; BROMODOMAIN_1; 1.
PROSITE; PS50014; BROMODOMAIN_2; 1.
PROSITE; PS51727; CBP_P300_HAT; 1.
PROSITE; PS50952; KIX; 1.
PROSITE; PS50134; ZF_TAZ; 2.
PROSITE; PS01357; ZF_ZZ_1; 1.
PROSITE; PS50135; ZF_ZZ_2; 1.
1: Evidence at protein level;
Acyltransferase {ECO:0000256|PROSITE-ProRule:PRU01065};
Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035,
ECO:0000256|SAAS:SAAS00979529};
Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00203,
ECO:0000256|SAAS:SAAS01261576};
Proteomics identification {ECO:0000213|EPD:F8VPR5,
ECO:0000213|MaxQB:F8VPR5, ECO:0000213|PeptideAtlas:F8VPR5};
Reference proteome {ECO:0000313|Proteomes:UP000000589};
Transferase {ECO:0000256|PROSITE-ProRule:PRU01065};
Zinc {ECO:0000256|PROSITE-ProRule:PRU00203, ECO:0000256|SAAS:SAAS01261576};
Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00203,
ECO:0000256|SAAS:SAAS01261576}.
DOMAIN 346..432
/note="TAZ-type"
/evidence="ECO:0000259|PROSITE:PS50134"
DOMAIN 586..665
/note="KIX"
/evidence="ECO:0000259|PROSITE:PS50952"
DOMAIN 1104..1176
/note="Bromo"
/evidence="ECO:0000259|PROSITE:PS50014"
DOMAIN 1324..1701
/note="CBP/p300-type HAT"
/evidence="ECO:0000259|PROSITE:PS51727"
DOMAIN 1702..1745
/note="ZZ-type"
/evidence="ECO:0000259|PROSITE:PS50135"
DOMAIN 1766..1847
/note="TAZ-type"
/evidence="ECO:0000259|PROSITE:PS50134"
ZN_FING 346..432
/note="TAZ-type"
/evidence="ECO:0000256|PROSITE-ProRule:PRU00203"
ZN_FING 1766..1847
/note="TAZ-type"
/evidence="ECO:0000256|PROSITE-ProRule:PRU00203"
REGION 1..29
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 73..168
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 261..292
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 792..1088
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 1435..1437
/note="Acetyl-CoA binding"
/evidence="ECO:0000256|PROSITE-ProRule:PRU01065"
REGION 1447..1448
/note="Acetyl-CoA binding"
/evidence="ECO:0000256|PROSITE-ProRule:PRU01065"
REGION 1557..1616
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 1875..1959
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 2112..2421
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 262..292
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 792..821
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 850..864
/note="Pro-rich"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 875..889
/note="Pro-rich"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 890..930
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 939..991
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 999..1068
/note="Polyampholyte"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1557..1572
/note="Polyampholyte"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1589..1603
/note="Basic"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1884..1917
/note="Pro-rich"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1922..1939
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 1941..1955
/note="Pro-rich"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 2112..2146
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 2169..2265
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 2276..2349
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 2350..2377
/note="Pro-rich"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 2394..2421
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
BINDING 1494
/note="Acetyl-CoA; via carbonyl oxygen"
/evidence="ECO:0000256|PROSITE-ProRule:PRU01065"
BINDING 1499
/note="Acetyl-CoA"
/evidence="ECO:0000256|PROSITE-ProRule:PRU01065"
BINDING 1503
/note="Acetyl-CoA"
/evidence="ECO:0000256|PROSITE-ProRule:PRU01065"
SEQUENCE 2441 AA; 265567 MW; 79A370F30FFB2A7C CRC64;
MAENLLDGPP NPKRAKLSSP GFSANDNTDF GSLFDLENDL PDELIPNGEL SLLNSGNLVP
DAASKHKQLS ELLRGGSGSS INPGIGNVSA SSPVQQGLGG QAQGQPNSTN MASLGAMGKS
PLNQGDSSTP NLPKQAASTS GPTPPASQAL NPQAQKQVGL VTSSPATSQT GPGICMNANF
NQTHPGLLNS NSGHSLMNQA QQGQAQVMNG SLGAAGRGRG AGMPYPAPAM QGATSSVLAE
TLTQVSPQMA GHAGLNTAQA GGMTKMGMTG TTSPFGQPFS QTGGQQMGAT GVNPQLASKQ
SMVNSLPAFP TDIKNTSVTT VPNMSQLQTS VGIVPTQAIA TGPTADPEKR KLIQQQLVLL
LHAHKCQRRE QANGEVRACS LPHCRTMKNV LNHMTHCQAG KACQVAHCAS SRQIISHWKN
CTRHDCPVCL PLKNASDKRN QQTILGSPAS GIQNTIGSVG AGQQNATSLS NPNPIDPSSM
QRAYAALGLP YMNQPQTQLQ PQVPGQQPAQ PPAHQQMRTL NALGNNPMSI PAGGITTDQQ
PPNLISESAL PTSLGATNPL MNDGSNSGNI GSLSTIPTAA PPSSTGVRKG WHEHVTQDLR
SHLVHKLVQA IFPTPDPAAL KDRRMENLVA YAKKVEGDMY ESANSRDEYY HLLAEKIYKI
QKELEEKRRS RLHKQGILGN QPALPASGAQ PPVIPPAQSV RPPNGPLPLP VNRMQVSQGM
NSFNPMSLGN VQLPQAPMGP RAASPMNHSV QMNSMASVPG MAISPSRMPQ PPNMMGTHAN
NIMAQAPTQN QFLPQNQFPS SSGAMSVNSV GMGQPAAQAG VSQGQVPGAA LPNPLNMLAP
QASQLPCPPV TQSPLHPTPP PASTAAGMPS LQHPTAPGMT PPQPAAPTQP STPVSSGQTP
TPTPGSVPSA AQTQSTPTVQ AAAQAQVTPQ PQTPVQPPSV ATPQSSQQQP TPVHTQPPGT
PLSQAAASID NRVPTPSSVT SAETSSQQPG PDVPMLEMKT EVQTDDAEPE PTESKGEPRS
EMMEEDLQGS SQVKEETDTT EQKSEPMEVE EKKPEVKVEA KEEEENSSND TASQSTSPSQ
PRKKIFKPEE LRQALMPTLE ALYRQDPESL PFRQPVDPQL LGIPDYFDIV KNPMDLSTIK
RKLDTGQYQE PWQYVDDVWL MFNNAWLYNR KTSRVYKFCS KLAEVFEQEI DPVMQSLGYC
CGRKYEFSPQ TLCCYGKQLC TIPRDAAYYS YQNRYHFCEK CFTEIQGENV TLGDDPSQPQ
TTISKDQFEK KKNDTLDPEP FVDCKECGRK MHQICVLHYD IIWPSGFVCD NCLKKTGRPR
KENKFSAKRL QTTRLGNHLE DRVNKFLRRQ NHPEAGEVFV RVVASSDKTV EVKPGMKSRF
VDSGEMSESF PYRTKALFAF EEIDGVDVCF FGMHVQEYGS DCPPPNTRRV YISYLDSIHF
FRPRCLRTAV YHEILIGYLE YVKKLGYVTG HIWACPPSEG DDYIFHCHPP DQKIPKPKRL
QEWYKKMLDK AFAERIINDY KDIFKQANED RLTSAKELPY FEGDFWPNVL EESIKELEQE
EEERKKEEST AASETPEGSQ GDSKNAKKKN NKKTNKNKSS ISRANKKKPS MPNVSNDLSQ
KLYATMEKHK EVFFVIHLHA GPVISTQPPI VDPDPLLSCD LMDGRDAFLT LARDKHWEFS
SLRRSKWSTL CMLVELHTQG QDRFVYTCNE CKHHVETRWH CTVCEDYDLC INCYNTKSHT
HKMVKWGLGL DDEGSSQGEP QSKSPQESRR LSIQRCIQSL VHACQCRNAN CSLPSCQKMK
RVVQHTKGCK RKTNGGCPVC KQLIALCCYH AKHCQENKCP VPFCLNIKHK LRQQQIQHRL
QQAQLMRRRM ATMNTRNVPQ QSLPSPTSAP PGTPTQQPST PQTPQPPAQP QPSPVNMSPA
GFPNVARTQP PTIVSAGKPT NQVPAPPPPA QPPPAAVEAA RQIEREAQQQ QHLYRANINN
GMPPGRAGMG TPGSQMTPVG LNVPRPNQVS GPVMSSMPPG QWQQAPIPQQ QPMPGMPRPV
MSMQAQAAVA GPRMPNVQPP RSISPSALQD LLRTLKSPSS PQQQQQVLNI LKSNPQLMAA
FIKQRTAKYV ANQPGMQPQP GLQSQPGMQP QPGMHQQPSL QNLNAMQAGV PRPGVPPPQP
AMGGLNPQGQ ALNIMNPGHN PNMTNMNPQY REMVRRQLLQ HQQQQQQQQQ QQQQQQNSAS
LAGGMAGHSQ FQQPQGPGGY APAMQQQRMQ QHLPIQGSSM GQMAAPMGQL GQMGQPGLGA
DSTPNIQQAL QQRILQQQQM KQQIGSPGQP NPMSPQQHML SGQPQASHLP GQQIATSLSN
QVRSPAPVQS PRPQSQPPHS SPSPRIQPQP SPHHVSPQTG SPHPGLAVTM ASSMDQGHLG
NPEQSAMLPQ LNTPNRSALS SELSLVGDTT GDTLEKFVEG L


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WP1006: metapathway biotransformation
WP1626: Benzoate degradation via CoA ligation
WP341: Nodal signaling pathway
WP905: Hedgehog Signaling Pathway
WP1148: Notch Signaling Pathway
WP2043: D-GLOCUSE-INS1-RXRA
WP750: IL-6 Signaling Pathway
WP1370: TGF Beta Signaling Pathway
WP1163: TNF-alpha NF-kB Signaling Pathway
WP230: TGF Beta Signaling Pathway
WP780: T Cell Receptor Signaling Pathway
WP1022: Hedgehog Signaling Pathway
WP1648: Fatty acid metabolism
WP387: IL-6 signaling Pathway
WP929: TNF-alpha NF-kB Signaling Pathway
WP1686: Phenylalanine metabolism
WP492: Hedgehog Signaling Pathway
WP937: IL-4 signaling Pathway
WP1212: metapathway biotransformation
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WP1094: IL-6 Signaling Pathway

Related Genes :
[CREBBP CBP] CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-)
[Crebbp Cbp] Histone lysine acetyltransferase CREBBP (EC 2.3.1.48) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-)
[Crebbp Cbp] Histone lysine acetyltransferase CREBBP (EC 2.3.1.48) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-)
[KAT2B PCAF] Histone acetyltransferase KAT2B (EC 2.3.1.48) (Histone acetyltransferase PCAF) (Histone acetylase PCAF) (Lysine acetyltransferase 2B) (P300/CBP-associated factor) (P/CAF) (Spermidine acetyltransferase KAT2B) (EC 2.3.1.57)
[KAT2A GCN5 GCN5L2] Histone acetyltransferase KAT2A (EC 2.3.1.48) (General control of amino acid synthesis protein 5-like 2) (Histone acetyltransferase GCN5) (hGCN5) (Histone glutaryltransferase KAT2A) (EC 2.3.1.-) (Histone succinyltransferase KAT2A) (EC 2.3.1.-) (Lysine acetyltransferase 2A) (STAF97)
[Kat2a Gcn5l2] Histone acetyltransferase KAT2A (EC 2.3.1.48) (General control of amino acid synthesis protein 5-like 2) (Histone acetyltransferase GCN5) (MmGCN5) (Histone glutaryltransferase KAT2A) (EC 2.3.1.-) (Histone succinyltransferase KAT2A) (EC 2.3.1.-) (Lysine acetyltransferase 2A)
[Kat2b Pcaf] Histone acetyltransferase KAT2B (EC 2.3.1.48) (Histone acetyltransferase PCAF) (Histone acetylase PCAF) (Lysine acetyltransferase 2B) (P300/CBP-associated factor) (P/CAF) (Spermidine acetyltransferase KAT2B) (EC 2.3.1.57)
[kat2b] Histone acetyltransferase KAT2B (EC 2.3.1.48) (Histone acetyltransferase PCAF) (Histone acetylase PCAF) (Lysine acetyltransferase 2B) (P300/CBP-associated factor) (P/CAF) (Spermidine acetyltransferase KAT2B) (EC 2.3.1.57)
[kat2a] Histone acetyltransferase KAT2A (EC 2.3.1.48) (Histone glutaryltransferase KAT2A) (EC 2.3.1.-) (Histone succinyltransferase KAT2A) (EC 2.3.1.-) (Lysine acetyltransferase 2A)
[KAT5 HTATIP TIP60] Histone acetyltransferase KAT5 (EC 2.3.1.48) (60 kDa Tat-interactive protein) (Tip60) (Histone acetyltransferase HTATIP) (HIV-1 Tat interactive protein) (Lysine acetyltransferase 5) (cPLA(2)-interacting protein)
[KAT7 HBO1 HBOa MYST2] Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2)
[Kat7 Hbo1 Myst2] Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2)
[Kat5 Htatip Tip60] Histone acetyltransferase KAT5 (EC 2.3.1.48) (60 kDa Tat-interactive protein) (Tip60) (Histone acetyltransferase HTATIP) (Lysine acetyltransferase 5)
[Kat5 Htatip Tip60 Tip60b] Histone acetyltransferase KAT5 (EC 2.3.1.48) (60 kDa Tat-interactive protein) (Tip60) (Histone acetyltransferase HTATIP) (Lysine acetyltransferase 5)
[Kat7 Hbo1 Myst2] Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2)
[KMT2A ALL1 CXXC7 HRX HTRX MLL MLL1 TRX1] Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.354) (ALL-1) (CXXC-type zinc finger protein 7) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
[EP300 P300] Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
[KAT5 HTATIP TIP60] Histone acetyltransferase KAT5 (EC 2.3.1.48) (60 kDa Tat-interactive protein) (Tip60) (Histone acetyltransferase HTATIP) (Lysine acetyltransferase 5)
[Ep300 P300] Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
[KAT6B KIAA0383 MORF MOZ2 MYST4] Histone acetyltransferase KAT6B (EC 2.3.1.48) (Histone acetyltransferase MOZ2) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (MYST-4) (Monocytic leukemia zinc finger protein-related factor)
[KAT8 MOF MYST1 PP7073] Histone acetyltransferase KAT8 (EC 2.3.1.48) (Lysine acetyltransferase 8) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1) (MYST-1) (hMOF)
[RBBP7 RBAP46] Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46)
[Kat8 Mof Myst1] Histone acetyltransferase KAT8 (EC 2.3.1.48) (Lysine acetyltransferase 8) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1) (MYST-1)
[Kat8 Myst1] Histone acetyltransferase KAT8 (EC 2.3.1.48) (Lysine acetyltransferase 8) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1) (MYST-1)
[Rbbp7 Rbap46] Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46)
[KAT6A MOZ MYST3 RUNXBP2 ZNF220] Histone acetyltransferase KAT6A (EC 2.3.1.48) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (MYST-3) (Monocytic leukemia zinc finger protein) (Runt-related transcription factor-binding protein 2) (Zinc finger protein 220)
[Kmt2a All1 Hrx Mll Mll1] Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.354) (ALL-1) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
[Crebbp] Histone lysine acetyltransferase CREBBP
[MECOM EVI1 MDS1 PRDM3] Histone-lysine N-methyltransferase MECOM (EC 2.1.1.-) (Ecotropic virus integration site 1 protein homolog) (EVI-1) (MDS1 and EVI1 complex locus protein) (Myelodysplasia syndrome 1 protein) (Myelodysplasia syndrome-associated protein 1)
[Crebbp] Histone lysine acetyltransferase CREBBP

Bibliography :
[32173363] A novel histone acetyltransferase inhibitor A485 improves sensitivity of non-small-cell lung carcinoma cells to TRAIL.
[32162442] Metagenomic characterization of lysine acetyltransferases in human cancer and their association with clinicopathologic features.
[32006151] t(11;16)(q23;p13)/KMT2A-CREBBP in hematologic malignancies: presumptive evidence of myelodysplasia or therapy-related neoplasm?
[31856851] The prognostic capacities of CBP and p300 in locally advanced rectal cancer.
[31840914] 20-Hydroxyecdysone receptor-activated Bombyx mori CCAAT/enhancer-binding protein gamma regulates the expression of BmCBP and subsequent histone H3 lysine 27 acetylation in Bo. mori.
[31669559] Depletion of the transcriptional coactivators CREB-binding protein or EP300 downregulates CD20 in diffuse large B-cell lymphoma cells and impairs the cytotoxic effects of anti-CD20 antibodies.
[31533053] Scoring a HAT-Trick against Lymphoma.
[31272713] Alterations of estradiol-induced histone H3 acetylation in the preoptic area and anteroventral periventricular nucleus of middle-aged female rats.
[31182547] CBP/p300 Drives the Differentiation of Regulatory T Cells through Transcriptional and Non-Transcriptional Mechanisms.
[31097695] Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers.